Chip holder and mass spectrometer
By arranging the first accommodating grooves in the middle and edge areas on the mass spectrometer chip tray, uniformly distributing the electric field intensity, the problem of low detection accuracy of the existing chip tray is solved, and higher consistency and accuracy are achieved.
Patent Information
- Application Number
- CN202420365466.0
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-02-27
- Publication Date
- 2025-03-07
- Estimated Expiration
- 2034-02-27
AI Technical Summary
The chip trays on existing mass spectrometers cannot meet the high-precision mass spectrometry detection of the sample, resulting in low detection accuracy.
A chip holder is designed, and a first accommodating groove is arranged in the middle area and the edge area, so that the electric field intensity received by each slot is equal or close, thereby improving the consistency and accuracy of the detection value.
By uniformly distributing the electric field intensity, the consistency and accuracy of the mass spectral detection values of the chip to be tested on the chip holder are improved, and the risk of medical accidents is reduced.
Smart Images
Figure CN222581095U_ABST
Abstract
Description
Technical Field
[0001] The present application relates to the field of mass spectrometry technology, and in particular to a chip holder and a mass spectrometer. Background Art
[0002] A mass spectrometer is a device used to measure the mass of an unknown substance. Its principle is to irradiate a mixed matrix chip to be tested with a laser, so that the molecules or atoms in the chip to be tested are converted from their original state to charged ions. These charged ions are then accelerated by an electric field and separated and detected by a time-of-flight mass analyzer. Based on the difference in flight time between each charged ion, ions of different mass numbers are distinguished, thereby achieving the purpose of mass number detection. However, the chip holder on the current mass spectrometer cannot meet the high-precision mass spectrometry detection of samples, and the accuracy of mass spectrometry detection is low. Utility Model Content
[0003] Based on this, an embodiment of the present application provides a chip holder and a mass spectrometer.
[0004] In order to solve the above technical problems, the present application provides a chip tray, which adopts the following technical solution:
[0005] A chip holder is used in a mass spectrometer, wherein the chip holder has a middle area and an edge area, and the edge area is arranged around the middle area;
[0006] The chip support is provided with at least two first accommodating grooves for accommodating the chip to be tested, and each of the first accommodating grooves is arranged in the middle area or the edge area.
[0007] Furthermore, the chip holder has a clamped portion, and the clamped portion is arranged away from the first accommodating groove.
[0008] Furthermore, the clamped portion includes a first clamped hole and a second clamped hole which are opened on the chip holder and cooperate with each other.
[0009] Furthermore, the diameter of the first clamped hole is 0.5-2 mm.
[0010] Furthermore, the diameter of the second clamped hole is 0.5-2 mm.
[0011] Furthermore, the chip tray is provided with a plurality of chip unloading holes;
[0012] The chip unloading holes are arranged in the first containing grooves, and each of the first containing grooves is correspondingly connected to at least one of the chip unloading holes.
[0013] Furthermore, the chip holder also includes a sealing member; the sealing member is slidably mounted on the chip unloading hole and can slide back and forth along the axial direction of the chip unloading hole.
[0014] Furthermore, the diameter of the chip unloading hole is 0.5-2 mm.
[0015] Furthermore, the inner wall surface of the first containing groove is provided with a positioning portion for positioning the chip to be tested.
[0016] Furthermore, the chip tray is provided with a plurality of second accommodating grooves for accommodating the magnetic attraction members;
[0017] The second accommodating grooves are disposed in the first accommodating grooves, and each of the first accommodating grooves is connected to at least one of the second accommodating grooves.
[0018] Furthermore, a fixing portion is provided on the side of the chip holder, and the fixing portion is used to fix the chip holder on the mass spectrometer.
[0019] In order to solve the above technical problems, the present application also provides a mass spectrometer, which adopts the following technical solution:
[0020] A mass spectrometer comprises the chip holder as described above.
[0021] Compared with the prior art, the embodiments of the present application have the following beneficial effects: the present application arranges each first receiving groove in the middle area or the edge area, so that the electric field strength received by each first receiving groove is equal or close, thereby improving the consistency and accuracy of the mass spectrometry detection values of the chip to be tested in each first receiving groove on the chip holder. BRIEF DESCRIPTION OF THE DRAWINGS
[0022] In order to more clearly illustrate the scheme of the present application, a brief introduction is given below to the drawings required for use in the description of the embodiments. Obviously, the drawings described below are some embodiments of the present application. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative work.
[0023] Figure 1 is a schematic diagram of the three-dimensional structure of a chip tray according to an embodiment of the present application;
[0024] Figure 2 is a schematic diagram of a top view of a chip tray according to an embodiment of the present application;
[0025] Figure 3 yes Figure 2 Schematic diagram of the cross-sectional structure of AA.
[0026] Reference numerals:
[0027] 100, chip holder; 110, middle area; 120, edge area; 130, first receiving groove; 140, clamped portion; 141, first clamped hole; 142, second clamped hole; 150, chip unloading hole; 160, sealing member; 170, positioning portion; 180, second receiving groove; 190, fixing portion. DETAILED DESCRIPTION
[0028] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as those commonly understood by technicians in the technical field of this application; the terms used in the specification of the application herein are only for the purpose of describing specific embodiments and are not intended to limit this application; the terms "including" and "having" and any variations thereof in the specification and claims of this application and the above-mentioned drawings are intended to cover non-exclusive inclusions. The terms "first", "second", etc. in the specification and claims of this application or the above-mentioned drawings are used to distinguish different objects, not to describe a specific order.
[0029] Reference to "embodiments" herein means that a particular feature, structure, or characteristic described in conjunction with the embodiments may be included in at least one embodiment of the present application. The appearance of the phrase in various locations in the specification does not necessarily refer to the same embodiment, nor is it an independent or alternative embodiment that is mutually exclusive with other embodiments. It is explicitly and implicitly understood by those skilled in the art that the embodiments described herein may be combined with other embodiments.
[0030] In order to enable those skilled in the art to better understand the solution of the present application, the technical solution in the embodiments of the present application will be clearly and completely described below in conjunction with the accompanying drawings.
[0031] See also Figure 1 and Figure 2 The embodiment of the present application provides a chip holder 100 for use in a mass spectrometer; the chip holder 100 has a central region 110 and an edge region 120, and the edge region 120 is arranged around the central region 110; the chip holder 100 is provided with at least two first accommodating grooves 130 for accommodating a chip to be tested, and each of the first accommodating grooves 130 is arranged in the central region 110 or the edge region 120.
[0032] In this embodiment, at least two first receiving grooves 130 are disposed on the chip holder 100 , which can simultaneously receive a plurality of chips to be tested for mass spectrometry detection, thereby effectively improving the detection efficiency.
[0033] Secondly, when performing mass spectrometry on the chip to be tested on the chip holder 100, due to the influence of the edge effect of the electric field on the chip holder 100, the electric field strength to which the chip holder 100 is subjected gradually decreases along the direction from the middle area 110 to the edge area 120, that is, the middle area 110 is the concentrated action area of the electric field, and the edge area 120 is the non-concentrated action area of the electric field; based on this, the present application arranges each first receiving groove 130 on the middle area 110 or the edge area 120 so that the electric field strength to which each first receiving groove 130 is subjected is equal or close in magnitude, thereby improving the consistency and accuracy of the mass spectrometry detection values of the chip to be tested on each first receiving groove 130 on the chip holder 100, thereby greatly reducing the risk of medical accidents.
[0034] In some embodiments, see Figure 1 and Figure 2 The chip tray 100 has a clamped portion 140, and the clamped portion 140 is disposed away from the first receiving groove 130. In this way, the clamped portion 140 is used to provide a clamping fulcrum for the chip tray 100, so that when the chip tray 100 is clamped, the clamping stability of the chip tray 100 can be effectively improved, so as to facilitate the movement of the chip tray 100.
[0035] In some embodiments, see Figure 1 and Figure 2 The clamped portion 140 includes a first clamped hole 141 and a second clamped hole 142 which are opened in the chip holder 100 and used in conjunction with each other.
[0036] In actual applications, the two clamping arms on the clamping tool are respectively placed in the first clamping hole 141 and the second clamping hole 142, and when the two clamping arms are relatively close to each other, a clamping force is provided to the chip holder 100, thereby clamping the chip holder 100 and facilitating the displacement of the chip holder 100; after the chip holder 100 is moved to the target position, the two clamping arms are relatively far apart and no clamping force is provided to the chip holder 100, and at this time the chip holder 100 is placed at the target position, thereby completing the displacement of the chip holder 100.
[0037] For example, the clamping tool is a tweezers. In this case, the first clamping hole 141 and the second clamping hole 142 provide clamping holes for two clamping arms of the tweezers, thereby avoiding the contamination problem caused by manual placement of the chip tray 100 and further improving the accuracy of the detection results. In addition, the clamping tool can also be a robotic arm, or a clamp, etc., which is not specifically limited here.
[0038] In some embodiments, see Figure 1 and Figure 2, the diameter of the first clamped hole 141 is 0.5-2 mm. Within this range, on the one hand, it is used to accommodate the clamping arm on the clamping tool, which is convenient for the clamping tool to clamp the chip holder 100; on the other hand, it avoids the problem of leakage of the electric field applied to the chip holder 100 due to the excessive diameter of the first clamped hole 141.
[0039] Optionally, the diameter of the first clamped hole 141 is selected from the range formed by any one or two of 0.5mm, 0.6mm, 0.7mm, 0.8mm, 0.9mm, 1mm, 1.1mm, 1.2mm, 1.3mm, 1.4mm, 1.5mm, 1.6mm, 1.7mm, 1.8mm, 1.9mm, and 2mm.
[0040] In some embodiments, see Figure 1 and Figure 2 , the diameter of the second clamped hole 142 is 0.5-2 mm. Within this range, on the one hand, it is used to accommodate the clamping arm on the clamping tool, so that the clamping tool can clamp the chip holder 100; on the other hand, it avoids the problem of leakage of the electric field applied to the chip holder 100 due to the excessive diameter of the second clamped hole 142.
[0041] Optionally, the diameter of the second clamped hole 142 is selected from the range formed by any one or two of 0.5mm, 0.6mm, 0.7mm, 0.8mm, 0.9mm, 1mm, 1.1mm, 1.2mm, 1.3mm, 1.4mm, 1.5mm, 1.6mm, 1.7mm, 1.8mm, 1.9mm, and 2mm.
[0042] In some embodiments, see Figure 1 and Figure 2 The chip holder 100 is provided with a plurality of chip unloading holes 150 ; the chip unloading holes 150 are arranged in the first accommodating grooves 130 , and each of the first accommodating grooves 130 is correspondingly connected to at least one of the chip unloading holes 150 .
[0043] In this embodiment, the chip unloading hole 150 penetrates the chip body along the depth direction of the first accommodating groove 130; when the chip to be tested is placed in the first accommodating groove 130, an unloading tool can be used to pass through the chip unloading hole 150 to eject the chip to be tested in the first accommodating groove 130, thereby facilitating the unloading of the chip to be tested in the first accommodating groove 130.
[0044] For example, the unloading tool is a pair of tweezers, which can not only be used to cooperate with the first clamping hole 141 and the second clamping hole 142 to clamp the chip holder 100, but also can utilize one of the clamping arms on the tweezers to pass through the chip unloading hole 150 to eject the chip to be tested in the first receiving groove 130, which has strong practicality. In addition, the clamping tool can also be a pin, etc., which is not specifically limited here.
[0045] Further, see Figure 1 and Figure 2 The chip unloading hole 150 is disposed in the middle of the first accommodating groove 130, so that after the unloading tool passes through the chip unloading hole 150, a more uniform ejection force can be provided, which helps to maintain the balance and stability of the chip to be tested during the ejection process and improves the movement smoothness of the chip to be tested when being ejected.
[0046] In some embodiments, see Figures 1 to 3 The chip holder 100 further includes a sealing member 160 ; the sealing member 160 is slidably mounted on the chip unloading hole 150 and can slide back and forth along the axial direction of the chip unloading hole 150 .
[0047] In this embodiment, the sealing member 160 can be slid in the chip unloading hole 150 toward the direction close to the first receiving groove 130 to eject the chip to be tested in the first receiving groove 130, thereby realizing the unloading of the chip to be tested in the first receiving groove 130; when mass spectrometry detection is required for another chip to be tested, during the process of placing the other chip to be tested in the first receiving groove 130, the sealing member 160 will be driven to slide in the chip unloading hole 150 toward the direction away from the first receiving groove 130, thereby realizing the resetting of the sealing member 160, so that in the subsequent operation process, the chip to be tested in the first receiving groove 130 can be ejected by the sealing member 160.
[0048] Furthermore, the sealing member 160 is a sealing plug, a push rod, etc., which is not specifically limited here.
[0049] In some embodiments, see Figure 1 and Figure 2 The diameter of the chip unloading hole 150 is 0.5-2 mm. Within this range, on the one hand, it is used to accommodate the clamping arm on the clamping tool, which is convenient for the clamping tool to clamp the chip holder 100; on the other hand, it avoids the problem of leakage of the electric field applied to the chip holder 100 due to the excessive diameter of the chip unloading hole 150.
[0050] Optionally, the diameter of the chip unloading hole 150 is selected from the range formed by any one or two of 0.5mm, 0.6mm, 0.7mm, 0.8mm, 0.9mm, 1mm, 1.1mm, 1.2mm, 1.3mm, 1.4mm, 1.5mm, 1.6mm, 1.7mm, 1.8mm, 1.9mm, and 2mm.
[0051] In some embodiments, see Figure 1 and Figure 2 The inner wall surface of the first receiving groove 130 is provided with a positioning portion 170 for positioning the chip to be tested. In this way, the chip to be tested in the first receiving groove 130 is positioned and installed by the positioning portion 170, thereby ensuring the accuracy of the installation position of the chip to be tested, and further ensuring the accuracy of mass spectrometry detection of the chip to be tested.
[0052] Furthermore, the positioning portion 170 is a positioning protrusion; accordingly, a positioning groove corresponding to the positioning protrusion structure is opened on the chip to be tested, and the positioning and installation of the chip to be tested is achieved by the snap-fitting cooperation between the positioning protrusion and the positioning groove.
[0053] In some embodiments, see Figure 1 and Figure 2 The chip holder 100 is provided with a plurality of second receiving grooves 180 for receiving magnetic suction components; the second receiving grooves 180 are provided in the first receiving grooves 130, and each of the first receiving grooves 130 is connected to at least one of the second receiving grooves 180. In this way, the second receiving grooves 180 for installing magnetic suction components are reserved on the chip holder 100, so that after the chip to be tested is installed in the first receiving groove 130, the magnetic suction component can be used to adsorb and fix the chip to be tested, thereby improving the installation stability of the chip to be tested in the first receiving groove 130.
[0054] For example, the magnetic attraction member is a magnet; accordingly, another magnet or metal corresponding to the magnet is provided on the chip to be tested, and the chip to be tested is adsorbed in the first receiving groove 130 through the magnetic attraction between the magnet in the second receiving groove 180 and the other magnet / metal on the chip to be tested; in addition, the magnetic attraction member can also be metal, or an electromagnet, etc., which is not specifically limited here.
[0055] It should be noted that when the magnetic attraction member is made of metal, the magnetic attraction member located on the chip to be tested is a magnet.
[0056] In some embodiments, a fixing portion 190 is provided on the side of the chip holder 100, and the fixing portion 190 is used to fix the chip holder 100 on the mass spectrometer. In this way, the chip holder 100 is fixedly mounted on the mass spectrometer through the fixing portion 190 to avoid the chip holder 100 from moving during the mass spectrometry detection process, thereby improving the accuracy of mass spectrometry detection.
[0057] Further, the fixing portion 190 is a fixing protrusion or a fixing groove. When the fixing portion 190 is a fixing protrusion, a fixing groove that is snap-fitted with the fixing protrusion is provided on the mass spectrometer. After the chip holder 100 is installed on the mass spectrometer, the chip holder 100 is fixed by snap-fitting with the fixing protrusion and the fixing groove; when the fixing portion 190 is a fixing groove, a fixing protrusion that is snap-fitted with the fixing groove is provided on the mass spectrometer. After the chip holder 100 is installed on the mass spectrometer, the chip holder 100 is fixed by snap-fitting with the fixing protrusion and the fixing groove.
[0058] The embodiment of the present application further provides a mass spectrometer, comprising the chip holder 100 as described above.
[0059] When the chip to be tested on the chip holder 100 is tested by using a mass spectrometer, since at least two first receiving grooves 130 are provided on the chip holder 100, a plurality of chips to be tested can be simultaneously received for mass spectrometry testing, thereby effectively improving the testing efficiency.
[0060] Secondly, when performing mass spectrometry on the chip to be tested on the chip holder 100, due to the influence of the electric field edge effect on the chip holder 100, the electric field strength to which the chip holder 100 is subjected gradually decreases along the direction from the middle area 110 toward the edge area 120; based on this, the present application arranges each first receiving groove 130 on the middle area 110 or the edge area 120 so that the electric field strength to which each first receiving groove 130 is subjected is equal or close in magnitude, thereby improving the consistency and accuracy of the mass spectrometry detection values of the chip to be tested on each first receiving groove 130 on the chip holder 100, thereby greatly reducing the risk of medical accidents.
[0061] Obviously, the embodiments described above are only some embodiments of the present application, rather than all embodiments. The preferred embodiments of the present application are given in the accompanying drawings, but they do not limit the patent scope of the present application. The present application can be implemented in many different forms. On the contrary, the purpose of providing these embodiments is to make the understanding of the disclosure of the present application more thorough and comprehensive. Although the present application is described in detail with reference to the aforementioned embodiments, for those skilled in the art, it is still possible to modify the technical solutions recorded in the aforementioned specific implementation methods, or to perform equivalent replacement of some of the technical features therein. Any equivalent structure made using the contents of the specification and drawings of this application, directly or indirectly used in other related technical fields, is similarly within the scope of patent protection of this application.
Claims
1. A chip holder, used in a mass spectrometer, characterized in that: The chip holder has a middle area and an edge area, and the edge area is arranged around the middle area; The chip support is provided with at least two first accommodating grooves for accommodating the chip to be tested, and each of the first accommodating grooves is arranged in the middle area or the edge area.
2. The chip holder according to claim 1, characterized in that: The chip holder has a clamped portion, and the clamped portion is arranged away from the first containing groove.
3. The chip holder according to claim 2, characterized in that: The clamped portion includes a first clamped hole and a second clamped hole which are opened on the chip holder and used in conjunction with each other.
4. The chip holder according to claim 3, characterized in that: The diameter of the first clamped hole is 0.5 to 2 mm; and / or, The diameter of the second clamped hole is 0.5-2 mm.
5. The chip holder according to claim 1, characterized in that: The chip tray is provided with a plurality of chip unloading holes; The chip unloading holes are arranged in the first containing grooves, and each of the first containing grooves is correspondingly connected to at least one of the chip unloading holes.
6. The chip holder according to claim 5, characterized in that: The chip holder further comprises a sealing member; the sealing member is slidably mounted on the chip unloading hole and can slide back and forth along the axial direction of the chip unloading hole; and / or, The diameter of the chip unloading hole is 0.5-2 mm.
7. The chip holder according to claim 1, characterized in that: The inner wall surface of the first containing groove is provided with a positioning portion for positioning the chip to be tested.
8. The chip holder according to any one of claims 1 to 7, characterized in that: The chip tray is provided with a plurality of second accommodating grooves for accommodating magnetic attracting members; The second accommodating grooves are disposed in the first accommodating grooves, and each of the first accommodating grooves is connected to at least one of the second accommodating grooves.
9. The chip holder according to any one of claims 1 to 7, characterized in that: A fixing portion is provided on the side of the chip holder, and the fixing portion is used to fix the chip holder on the mass spectrometer.
10. A mass spectrometer, characterized in that: The invention comprises a chip holder as claimed in any one of claims 1 to 9.