Reaction device for preparing modified hyaluronic acid

Abstract

The utility model discloses a reaction device for preparing modified hyaluronic acid, which comprises a first box body, a second box body and a third box body, the first box body, the second box body and the third box body are stacked from top to bottom, the top of the first box body is provided with a stirring rod, the lower end of the stirring rod is close to the bottom surface of the first box body, and the lower end of the stirring rod is provided with a stirring rotary vane. A feeding port and a liquid inlet are formed in the upper end of the first box body, a first discharging port is formed in the bottom face of the first box body, a second discharging port is formed in the bottom face of the second box body, a filter screen plate is installed in the third box body, and a liquid cavity is formed below the filter screen plate. According to the device disclosed by the utility model, the first box body for stirring reaction, the second box body for precipitation and the third box body for filtering are stacked, so that the preparation of the modified hyaluronic acid is completed in one device, the operation steps are reduced, and the efficiency of the whole preparation process is improved.

Description

Technical Field

[0001] The utility model relates to the technical field of preparing hyaluronic acid, and more specifically, to a reaction device for preparing modified hyaluronic acid. Background Art

[0002] As a natural high-molecular polysaccharide that is ubiquitous in organisms, hyaluronic acid has attracted much attention for its excellent moisturizing, lubrication and biocompatibility. Modified hyaluronic acid has shown great application potential in many fields such as medicine, cosmetics, and food. However, the traditional laboratory modified hyaluronic acid preparation method involves a series of tedious steps such as low-temperature reaction, precipitation treatment, centrifugal re-dissolution, and freeze-drying. These steps are not only time-consuming and labor-intensive, but also difficult to monitor the pH changes of the reaction solution in real time. At the same time, a variety of devices and equipment are required, which greatly increases the complexity and cost of the preparation. Therefore, the development of a modified hyaluronic acid preparation device that is easy to operate, efficient, and can monitor the reaction conditions in real time is of great significance for improving preparation efficiency, reducing costs, and promoting the application of modified hyaluronic acid in a wider range of fields. Therefore, a technical solution is needed to solve the above problems. Utility Model Content

[0003] The purpose of the utility model is to overcome the deficiencies of the above-mentioned prior art, improve preparation efficiency, reduce costs, and provide a reaction device for preparing modified hyaluronic acid.

[0004] In order to achieve the above purpose, the utility model adopts the following technical solutions:

[0005] The utility model discloses a reaction device for preparing modified hyaluronic acid, comprising a first box body, a second box body, and a third box body, wherein the first box body, the second box body, and the third box body are stacked from top to bottom, a stirring rod is installed on the top of the first box body, the lower end of the stirring rod is close to the bottom surface of the first box body, a stirring rotor is installed on the lower end of the stirring rod, a feed inlet and a first liquid inlet are provided at the upper end of the first box body, a first discharge port is provided on the bottom surface of the first box body, the first discharge port is controlled by a first solenoid valve to connect or block the first box body and the second box body, a second discharge port is controlled by a second solenoid valve to connect or block the second box body and the third box body, a filter screen is installed in the third box body, and a liquid cavity is formed below the filter screen.

[0006] Furthermore, a cooling pipe is installed in the first box body, and the cooling pipe is spirally coiled around the inner wall of the first box body. The cooling pipe includes a refrigerant inlet and a refrigerant outlet. The refrigerant inlet is close to the bottom of the first box body, and the refrigerant outlet is close to the top of the first box body.

[0007] Furthermore, a temperature monitor is installed in the first box, and the temperature monitor is installed on the top of the first box, and the lower end of the temperature monitor is immersed below the liquid level of the first box.

[0008] Furthermore, a pH monitor is installed in the first box, the pH monitor is installed on the top of the first box, and the lower end of the pH monitor is immersed below the liquid level of the first box.

[0009] Furthermore, the bottom surfaces of the first box body and the second box body are both conical with diameters gradually decreasing from top to bottom, the first discharge port is located at the center of the bottom surface of the first box body, and the second discharge port is located at the center of the bottom surface of the second box body.

[0010] Furthermore, a second liquid inlet is provided on a side wall of the second box body, and the second liquid inlet is close to the top of the second box body.

[0011] Furthermore, a side wall of the third box body is provided with an air suction port, and a position of the air suction port is lower than a position of the filter screen plate.

[0012] Furthermore, the third box body is installed with a liquid collecting plate, which is located between the filter screen plate and the air suction port. The liquid collecting plate is a cone with a diameter gradually decreasing from top to bottom. A liquid outlet is provided at the center of the liquid collecting plate, and the liquid outlet connects the filter screen plate and the liquid cavity.

[0013] Furthermore, a flow control valve is installed at the first liquid inlet.

[0014] Furthermore, the first box, the second box and the third box are detachably connected.

[0015] The beneficial effects of the utility model are:

[0016] 1. The utility model completes the preparation of modified hyaluronic acid in one device by stacking a first box for stirring reaction, a second box for precipitation, and a third box for filtration, thereby reducing the operation steps, integrating the entire preparation process, reducing the operation steps, and improving the preparation efficiency.

[0017] 2. The first box, the second box, and the third box of the utility model are detachably connected. After the preparation of the modified hyaluronic acid is completed, each box can be cleaned separately, which is convenient for cleaning the inside of the device.

[0018] 3. The utility model is provided with a cooling tube, a pH monitor and a temperature monitor, which can monitor and control the reaction conditions in real time to ensure product quality. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] Figure 1A schematic diagram of this embodiment.

[0020] Figure 2 It is a top view of this embodiment.

[0021] Figure 3 for Figure 2 Cross-sectional view along the A direction.

[0022] Figure 4 for Figure 2 Cross-sectional view along the B direction.

[0023] Figure numerals: 1. first box body; 11. stirring rod; 111. stirring impeller; 12. cooling pipe; 121. refrigerant inlet; 122. refrigerant outlet; 13. feed port; 14. first liquid inlet; 141. flow control valve; 15. temperature monitor; 16. air valve; 17. first outlet; 171. first solenoid valve; 18. pH monitor; 2. second box body; 21. second liquid inlet; 22. second outlet; 221. second solenoid valve; 3. third box body; 31. exhaust port; 32. filter screen; 33. liquid collecting plate; 331. liquid outlet; 34. liquid cavity. DETAILED DESCRIPTION

[0024] The following will be combined with the drawings in this embodiment to clearly and completely describe the technical solution in this embodiment. Obviously, the described embodiment is only a part of the embodiment of the utility model, not all of the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the utility model.

[0025] like Figure 1 , Figure 2 , Figure 3 , Figure 4 As shown, the present embodiment discloses a reaction device for preparing modified hyaluronic acid, comprising a first box body 1, a second box body 2, and a third box body 3. The first box body 1, the second box body 2, and the third box body 3 are stacked from top to bottom. The first box body 1 serves as a stirring reaction chamber of the reaction device. A stirring rod 11 is installed on the top of the first box body 1. The top plate of the first box body 1 is detachably installed. The upper end of the stirring rod 11 is connected to a motor, and the motor is installed on the upper end surface of the top plate of the first box body 1. The stirring rod 11 extends into the first box body 1, and the lower end of the stirring rod 11 is close to the bottom surface of the first box body 1. A stirring blade 111 is installed at the lower end of the stirring rod 11. The motor drives the stirring blade 111 to stir the material in the first box body 1 to accelerate the reaction speed of hyaluronic acid.

[0026] like Figure 1 , Figure 2 , Figure 3 , Figure 4As shown, a cooling pipe 12 is installed in the first box body 1, and the cooling pipe 12 is spirally coiled around the inner wall of the first box body 1. The cooling pipe 12 includes a refrigerant inlet 121 and a refrigerant outlet 122. The refrigerant inlet 121 is close to the bottom of the first box body 1, and the refrigerant outlet 122 is close to the top of the first box body 1. The refrigerant inlet 121 and the refrigerant outlet 122 of the cooling pipe 12 are connected to an external cold source, which is used to cool the materials stirred in the first box body 1 to keep the solution at the temperature required for the hyaluronic acid reaction. A temperature monitor 15 is installed in the first box body 1, and the temperature monitor 15 is installed on the top of the first box body 1. The lower end of the temperature monitor 15 is immersed below the liquid level of the first box body 1. The temperature monitor 15 can monitor the temperature of the solution in the first box body 1 in real time and then control the cooling pipe 12 to adjust the temperature of the solution.

[0027] like Figure 1 , Figure 2 , Figure 3 , Figure 4 As shown, a feed port 13 and a first liquid inlet 14 are provided at the upper end of the first box body 1. The feed port 13 is located on the top plate of the first box body 1. The feed port 13 is used to put the hyaluronic acid solid that needs to be reacted and other materials that can be quantitatively directly put into the first box body 1. The first liquid inlet 14 is provided with a liquid storage tank. The reagent or solution that needs to be reacted is put into the liquid storage tank. The first liquid inlet 14 is installed with a flow control valve 141. The flow control valve 141 is used to control the flow of the reagent or solution from the liquid storage tank to the first box body 1. At the same time, a pH monitor 18 is installed in the first box body 1. The pH monitor 18 is installed on the top of the first box body 1, and the lower end of the pH monitor 18 is immersed below the liquid surface of the first box body 1. The real-time pH of the solution in the reaction of the first box body 1 can be monitored by the pH monitor 18. The flow control valve 141 is controlled by the pH monitor 18 to control the reagent or solution added to the first box body 1. A breathable valve 16 is also provided on the top of the first box body 1. The breathable valve 16 can balance the internal air pressure of the first box body 1.

[0028] like Figure 1 , Figure 2 , Figure 3 , Figure 4 As shown, a first discharge port 17 is provided on the bottom surface of the first box body 1. The bottom surface of the first box body 1 is a cone with a diameter gradually decreasing from top to bottom. The first discharge port 17 is located at the center of the bottom surface of the first box body 1. The conical bottom surface can allow the material in the first box body 1 to be gathered to the first discharge port 17. The first discharge port 17 is a tubular opening extending downward. The first discharge port 17 is installed with a first solenoid valve 171. The first solenoid valve 171 controls the first discharge port 17 to connect or block the first box body 1 and the second box body 2. When the stirring reaction of the hyaluronic acid in the first box body 1 is completed, the first solenoid valve 171 is opened to send the material in the first box body 1 into the second box body 2 for precipitation.

[0029] like Figure 1 , Figure 2 , Figure 3 , Figure 4 As shown, the upper end of the second box body 2 is open, and the upper end of the second box body 2 can be detachably mounted on the bottom of the first box body 1. The side wall of the second box body 2 is provided with a second liquid inlet 21, and the second liquid inlet 21 is close to the top of the second box body 2. The second liquid inlet 21 is used to inject the precipitant used in the modified precipitation of hyaluronic acid. At the same time, the second liquid inlet 21 also plays a role in balancing the air pressure in the second box body 2. The bottom surface of the second box body 2 is a cone with a diameter gradually decreasing from top to bottom. The bottom surface of the second box body 2 is provided with a second The discharge port 22 is located at the center of the bottom surface of the second box body 2. The conical bottom surface of the second box body 2 can concentrate the material at the second discharge port 22. The second box body 2 is used for the static precipitation of hyaluronic acid after the reaction. The second discharge port 22 is installed with a second solenoid valve 221. The second solenoid valve 221 controls the second discharge port 22 to connect or block the second box body 2 and the third box body 3. The second box body 2 is connected to the third box body 3. The material in the second box body 2 enters the third box body 3 for filtration and solid-liquid separation.

[0030] like Figure 1 , Figure 2 , Figure 3 , Figure 4 As shown, the upper end of the third box body 3 is open, and the third box body 3 is detachably mounted on the bottom of the second box body 2. A filter screen plate 32 is mounted in the third box body 3, and a liquid cavity 34 is formed below the filter screen plate 32. The material entering the third box body 3 from the second box body 2 is filtered at the filter screen plate 32 to separate the solid and the liquid. The solid remains above the filter screen plate 32, and the liquid enters the liquid cavity 34. A liquid collecting plate 33 is mounted on the third box body 3, and the liquid collecting plate 33 is located below the filter screen plate 32. The diameter of the liquid collecting plate 33 gradually decreases from top to bottom. The liquid collecting plate 33 is a small cone, and a liquid outlet 331 is provided in the center thereof. The liquid outlet 331 is connected to the filter screen plate 32 and the liquid cavity 34. The liquid collecting plate 33 can concentrate the liquid at the liquid outlet 331, and has a buffering effect on the material from the second box body 2 entering the third box body 3. The side wall of the third box body 3 is provided with an air suction port 31, and the air suction port 31 is located below the liquid collecting plate 33. The liquid collecting plate 33 can shield the air suction port 31 to prevent the material from entering the air suction port 31. The air suction port 31 is used to balance the air pressure in the third box body 3.

[0031] like Figure 1 , Figure 2 , Figure 3 , Figure 4 As shown, the first box body 1, the second box body 2, and the third box body 3 are detachably connected. After the preparation of the modified hyaluronic acid is completed, each box body can be cleaned separately, which is very convenient.

[0032] The above is only a preferred embodiment of the present invention. The protection scope of the present invention is not limited to the above embodiments. All technical solutions under the concept of the present invention belong to the protection scope of the present invention. It should be pointed out that for ordinary technicians in this technical field, some improvements and modifications without departing from the principle of the present invention should also be regarded as the protection scope of the present invention.

Claims

1. A reaction device for preparing modified hyaluronic acid, characterized in that: The invention comprises a first box body (1), a second box body (2) and a third box body (3), wherein the first box body (1), the second box body (2) and the third box body (3) are stacked from top to bottom, a stirring rod (11) is installed on the top of the first box body (1), the lower end of the stirring rod (11) is close to the bottom surface of the first box body (1), and a stirring impeller (111) is installed on the lower end of the stirring rod (11), a feed inlet (13) and a first liquid inlet (14) are provided on the upper end of the first box body (1), a first discharge port (17) is provided on the bottom surface of the first box body (1), and the first discharge port (17) is controlled to be connected or blocked by a first electromagnetic valve (171), a second discharge port (22) is provided on the bottom surface of the second box body (2), and the second discharge port (22) is controlled to be connected or blocked by a second electromagnetic valve (221), and a filter screen (32) is installed in the third box body (3), and a liquid cavity (34) is formed below the filter screen (32).

2. A reaction device for preparing modified hyaluronic acid according to claim 1, characterized in that: A cooling pipe (12) is installed in the first box body (1), and the cooling pipe (12) is spirally coiled around the inner wall of the first box body (1). The cooling pipe (12) includes a refrigerant inlet (121) and a refrigerant outlet (122). The refrigerant inlet (121) is close to the bottom of the first box body (1), and the refrigerant outlet (122) is close to the top of the first box body (1).

3. A reaction device for preparing modified hyaluronic acid according to claim 1, characterized in that: The first box (1) is equipped with a temperature monitor (15), which is installed on the top of the first box (1), and the lower end of the temperature monitor (15) is immersed below the liquid level of the first box (1).

4. A reaction device for preparing modified hyaluronic acid according to claim 1, characterized in that: A pH monitor (18) is installed in the first box (1); the pH monitor (18) is installed on the top of the first box (1), and the lower end of the pH monitor (18) is immersed below the liquid level of the first box (1).

5. A reaction device for preparing modified hyaluronic acid according to claim 1, characterized in that: The bottom surfaces of the first box body (1) and the second box body (2) are both conical in shape, the diameter of which gradually decreases from top to bottom; the first discharge port (17) is located at the center of the bottom surface of the first box body (1), and the second discharge port (22) is located at the center of the bottom surface of the second box body (2).

6. A reaction device for preparing modified hyaluronic acid according to claim 1, characterized in that: A second liquid inlet (21) is provided on the side wall of the second box body (2), and the second liquid inlet (21) is close to the top of the second box body (2).

7. A reaction device for preparing modified hyaluronic acid according to claim 1, characterized in that: The side wall of the third box body (3) is provided with an air suction port (31), and the position of the air suction port (31) is lower than the position of the filter screen plate (32).

8. A reaction device for preparing modified hyaluronic acid according to claim 7, characterized in that: The third box body (3) is provided with a liquid collecting plate (33), the liquid collecting plate (33) being located between the filter screen plate (32) and the air suction port (31), the liquid collecting plate (33) being in a cone shape with a diameter gradually decreasing from top to bottom, and a liquid outlet (331) being provided at the center of the liquid collecting plate (33), the liquid outlet (331) being connected to the filter screen plate (32) and the liquid cavity (34).

9. The reaction device for preparing modified hyaluronic acid according to claim 1, characterized in that: The first liquid inlet (14) is equipped with a flow control valve (141).

10. The reaction device for preparing modified hyaluronic acid according to claim 1, characterized in that: The first box body (1), the second box body (2) and the third box body (3) are detachably connected.

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