Detection device

Abstract

The embodiment of the utility model provides a detection device, which comprises a plurality of detection liquid paths connected in parallel, each detection liquid path is connected with a flow cell; a pressure sensor is arranged on each detection liquid path; the device further comprises a selection valve, an air inlet pipeline, a lubricating liquid pool and an injection pump. Wherein the injection pump is communicated with one of the air inlet pipeline, the lubricating liquid pool or each detection liquid path through the selector valve; and the controller is in communication connection with the selector valve, the pressure sensor and the injection pump so as to control the work of the detection device and judge the sealing performance of the detection liquid path according to the numerical value of the pressure sensor. According to the technical scheme, the arranged lubricating liquid pool is communicated with the injection pump through the selection valve, before the sealing performance of air pumped into the flowing pool is detected, the lubricating liquid pool can be communicated with the injection pump so that lubricating liquid can be pumped into the injection pump and the selection valve, damage caused by dry grinding during movement of all components is reduced, and the sealing performance of the components is improved. And the reliability of the whole system is improved.

Description

[0001] This application claims the priority of a Chinese patent application numbered 202421237866X and entitled “A Detection Device” filed with the Chinese Patent Office on May 31, 2024, the entire contents of which are incorporated herein by reference. Technical Field

[0002] The present application relates to the field of biological detection technology, and in particular to a detection device. Background Art

[0003] As a key component of gene sequencers, gene sequencing chips are the main place for experimental reactions. The internal sealing between the flow cells and the external sealing between the flow cells and the seals in contact with them are crucial to the experimental reactions. If the internal sealing between the flow cells cannot be guaranteed, the reagents between the flow cells will flow into each other during the operation of the sequencer's liquid path system, causing the experimental reaction to fail; if the external sealing between the flow cells and the seals in contact with them cannot be guaranteed, liquid leakage or gas will enter the flow cells during the operation of the sequencer's liquid path system, affecting the experimental reaction effect.

[0004] In the prior art, when testing a flow cell, air is often injected into the flow cell through a syringe pump for testing. However, during such testing, the piston of the syringe pump moves back and forth, which is very likely to cause wear. Utility Model Content

[0005] The present application provides a detection device to improve the reliability of the detection device.

[0006] The embodiment of the present application provides a detection device, which includes: a plurality of detection liquid circuits connected in parallel, each detection liquid circuit is connected to a flow cell; wherein each detection liquid circuit is provided with a pressure sensor;

[0007] It also includes a selection valve, an air intake pipe, a lubricating liquid pool and an injection pump; wherein the injection pump is selectively connected to the air intake pipe, the lubricating liquid pool or each detection liquid path through the selection valve;

[0008] A controller is connected in communication with the selection valve, the pressure sensor and the injection pump to control the operation of the detection device and determine the sealing performance of the detection fluid circuit according to the value of the pressure sensor.

[0009] In the above technical solution, the lubricating liquid pool is connected to the injection pump through the selection valve. Before air is pumped into the flow pool to detect the sealing, the lubricating liquid pool can be connected to the injection pump to pump lubricating liquid into the injection pump and the selection valve, thereby reducing the damage caused by dry grinding of various components during movement and improving the reliability of the entire system.

[0010] In a specific possible implementation manner, each of the detection liquid paths includes at least two parallel branch paths, and each branch path is used to connect to a flow cell, and the pressure sensor on the detection liquid path is connected in series with the at least two parallel branch paths.

[0011] In a specific possible implementation manner, each of the detection liquid paths further comprises a connecting liquid path, and the connecting liquid path is used to connect an end of the flow cell corresponding to the detection liquid path away from the pressure sensor.

[0012] In a specific implementation scheme, the number of the detection liquid paths is two, namely a first detection liquid path and a second detection liquid path;

[0013] Wherein, the branch path of the first detection liquid path is a first branch path, and the branch path of the second detection liquid path is a second branch path; and the first branch path and the second branch path are arranged alternately.

[0014] In a specific embodiment, the selection valve has a plurality of branch channels and a common channel, wherein the common channel of the selection valve is connected to the injection pump;

[0015] The branch channels of the selection valve are respectively communicated with the air intake pipe, the lubricating liquid pool, and the detection liquid path are respectively communicated with different branch channels of the selection valve.

[0016] In a specific implementation manner, the air intake pipeline is a branch channel of the selection valve.

[0017] In a specific possible implementation, the selection valve is a multi-way valve, and the number of branch channels of the multi-way valve is not less than the total number of the air intake pipe, the lubricating liquid pool, and the detection liquid circuit.

[0018] In a specific implementation scheme, it also includes a waste liquid tank, and the injection pump is connected to one of the air intake pipe, the lubricating liquid tank, the waste liquid tank, and the detection liquid circuit through the selection valve.

[0019] In a specific embodiment, it further includes a support platform;

[0020] The detection liquid circuit, the lubricating liquid pool, the waste liquid pool, the injection pump and the selection valve are all arranged on the supporting platform.

[0021] In a specific implementation manner, a clamp corresponding to each of the flow cells is disposed on the support platform, and each of the flow cells is fixed to the support platform by the corresponding clamp. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] Figure 1A structural block diagram of a detection device provided in an embodiment of the present application;

[0023] Figure 2a to Figure 2e A schematic diagram of the flow path of the detection device provided in an embodiment of the present application. DETAILED DESCRIPTION

[0024] In order to make the objectives, technical solutions and advantages of the present application clearer, the present application will be further described in detail below in conjunction with the accompanying drawings.

[0025] It should be noted that, unless otherwise defined, the technical terms or scientific terms used in one or more embodiments of this specification should be understood by people with ordinary skills in the field to which this disclosure belongs. The "first", "second" and similar words used in one or more embodiments of this specification do not indicate any order, quantity or importance, but are only used to distinguish different components. "Include" or "comprise" and similar words mean that the elements or objects appearing before the word cover the elements or objects listed after the word and their equivalents, without excluding other elements or objects. "Connect" or "connected" and similar words are not limited to physical or mechanical connections, but may include electrical connections, whether direct or indirect. "Up", "down", "left", "right" and the like are only used to indicate relative positional relationships. When the absolute position of the described object changes, the relative positional relationship may also change accordingly.

[0026] To facilitate understanding of the detection device provided in the embodiment of the present application, its application scenario is first described. The detection device provided in the embodiment of the present application is applied to the sealing detection of the flow cell used in gene sequencing. In the existing detection device, air is pumped into the flow cell by a syringe pump, and the sealing of the flow cell is detected by a pressure sensor. However, in the above-mentioned detection process, the syringe pump is very easy to wear under long-term use, resulting in the need for repair or replacement. To this end, the embodiment of the present application provides a detection device to improve the reliability of the detection device and reduce the wear of the syringe pump. It is described in detail below in conjunction with specific drawings and embodiments.

[0027] refer to Figure 1 As shown, Figure 1The structural block diagram of the detection device provided by the embodiment of the present application is shown. The detection device provided by the embodiment of the present application mainly includes multiple detection liquid circuits 100, pressure sensors 70, selection valves 30, air intake pipes 80, lubricating liquid pools 50, controllers 200, and injection pumps 40. Among them, the detection liquid circuit 100 is used to connect the flow cell. The pressure sensor 70 is used to detect the pressure value of the flow cell. The air intake pipe 80 is used to provide air pumped into the detection liquid circuit 100. The lubricating liquid pool 50 is used to carry lubricating liquid, which can be pure water (deionized water) or other liquids that can provide lubrication to provide lubrication for the injection pump 40 and other components. The selection valve 30 is used as a switching component. The injection pump 40 can be connected to the air intake pipe 80, the lubricating liquid pool 50 or each detection liquid circuit 100 through the selection valve 30. The injection pump 40 is a component that provides reagent delivery power. Through the movement of the piston of the injection pump 40, the medium can be driven to move in the liquid circuit of the detection device. The medium can be a lubricating liquid or air. The controller 200 is respectively connected to the selector valve 30, the pressure sensor 70 and the injection pump 40 to control the operation of the detection device and determine the sealing of the detection fluid path 100 according to the value of the pressure sensor 70. The detection device provided by the embodiment of the present application is described in detail below in conjunction with specific drawings.

[0028] First, the liquid circuit of the entire detection device is explained to facilitate understanding of the detection device. When the above components are specifically connected, the detection liquid circuit 100 is connected to the flow cell, which is connected to the flow cell through a pipeline, and the pressure sensor 70 is connected to the detection liquid circuit 100 so that the pressure sensor 70 is connected to the flow cell. When detecting the sealing of the flow cell, the pressure in the pipeline can be detected by the pressure sensor 70, and pressure data is generated based on the detected pressure, and then the sealing of the flow cell is determined according to the pressure data.

[0029] In the embodiment of the present application, there may be multiple detection liquid circuits 100, multiple detection liquid circuits 100 are arranged in parallel, and each detection liquid circuit 100 is provided with a pressure sensor 70. The pressure sensor 70 is connected to the flow cell on the detection liquid circuit 100, so that the pressure value of the flow cell can be detected. Figure 1 As shown in Figure 1 In the detection device shown, two detection liquid paths 100 are illustrated. For the convenience of description, the two detection liquid paths 100 are named as the first detection liquid path 10 and the second detection liquid path 20 respectively.

[0030] As an optional solution, each detection liquid circuit 100 includes at least two parallel branch circuits, and each branch circuit is used to connect a flow cell, and the pressure sensor 70 on the detection liquid circuit 100 is connected in series with at least two parallel branch circuits. The pressure sensor 70 can synchronously detect the pressure value of the flow cell connected to the branch circuit.

[0031] Exemplarily, the first detection liquid path 10 includes two parallel first branch paths, namely the first branch path A11 and the first branch path B12, wherein the first branch path A11 and the first branch path B12 are respectively connected with a flow cell A110 and a flow cell C130 in a one-to-one correspondence, that is, the flow cell A110 and the flow cell C130 are connected in parallel. And the parallel flow cell A110 and the flow cell C130 are connected in series with the pressure sensor A71. So that the pressure sensor A71 can synchronously detect the pressure values ​​of the flow cell A110 and the flow cell C130.

[0032] Similarly, the second detection liquid path 20 also includes two parallel second branch paths, namely the second branch path A21 and the second branch path B22, wherein the second branch path A21 and the second branch path B22 are respectively connected with the flow cell B120 and the flow cell D140, that is, the flow cell B120 and the flow cell D140 are connected in parallel. And the parallel flow cell B120 and the flow cell D140 are connected in series with the pressure sensor B72. So that the pressure sensor B72 can synchronously detect the pressure values ​​of the flow cell B120 and the flow cell D140.

[0033] When connected to the injection pump 40, the injection pump 40 is connected to each of the above-mentioned detection liquid circuits 100, the lubricating liquid pool 50 and the air intake pipe 80 through the selection valve 30. When the selection valve 30 is specifically set, the selection valve 30 has a plurality of branch channels and a common channel. Any branch channel of the selection valve 30 can be connected to the common channel through the rotation of the valve core, and the branch channels cannot be connected to each other.

[0034] When connected to the components, the common channel of the selection valve 30 is communicated with the injection pump 40, while the air intake pipe 80, the lubricating liquid pool 50, and the detection liquid path 100 are communicated with different branch channels of the selection valve 30. Thus, the valve core of the selection valve 30 can be rotated so that the injection pump 40 can be selectively communicated with the detection liquid path 100, the lubricating liquid pool 50, and the air intake pipe 80. It should be understood that when there are multiple detection liquid paths 100, each detection liquid path 100 is communicated with a branch channel of the selection valve 30 to ensure that the injection pump 40 can pump air into each detection liquid path 100 separately.

[0035] When the air intake pipe 80 is specifically provided, the air intake pipe 80 can be a branch channel of the selector valve 30, so that the air intake through the branch channel meets the demand of the syringe pump 40 to extract air. The air is pumped into the detection liquid path 100 to detect the air tightness of the flow cell.

[0036] In an optional solution, the selection valve 30 is a multi-way valve, and the number of branch channels of the multi-way valve is not less than the total number of the intake pipe 80, the lubricating liquid pool 50, and the detection liquid circuit 100. Exemplarily, in the embodiment of the present application, the selection valve 30 can be a 6-way valve, an 8-way valve, a 24-way valve, or other different types of multi-way valves, which can all be applied to the embodiments of the present application.

[0037] In an optional solution, the detection device further includes a waste liquid pool 60, and the injection pump 40 is connected to one of the air intake pipe 80, the lubricating liquid pool 50, the waste liquid pool 60, and the detection liquid path 100 through the selection valve 30. The waste liquid pool 60 is used to carry the lubricating liquid pumped out by the injection pump 40.

[0038] When inspecting the flow cell, the injection pump 40 can be connected to different components through the selection valve 30. The working process is described in detail below. Before checking the air tightness, the injection pump 40 is first connected to the lubricating liquid pool 50 through the selection valve 30 to extract the lubricating liquid. Afterwards, the injection pump 40 is connected to the waste liquid pool 60 through the selection valve 30, and the lubricating liquid extracted by the injection pump 40 is pumped into the waste liquid pool 60. In the process of the lubricating liquid being pumped into the waste liquid pool 60, the lubricating liquid flows through the injection pump 40 and the selection valve 30, so that the injection pump 40 and the selection valve 30 can be lubricated by the lubricating liquid, thereby reducing the friction resistance of the selection valve 30 and the injection pump 40 during operation, protecting the injection pump 40 and the components in the selection valve 30, and improving the reliability of the injection pump 40 and the selection valve 30. Afterwards, the injection pump 40 is connected to the air inlet pipe 80 through the selection valve 30 to extract air, and then the valve core of the selection valve 30 is rotated to connect the injection pump 40 with the detection liquid circuit 100 to pump air into the detection liquid circuit 100, and the pressure change value in the detection liquid circuit 100 is detected through the detection liquid circuit 100 to determine the leakage rate of the flow cell, and determine whether it meets the requirements based on the leakage rate.

[0039] It should be understood that the waste liquid pool 60 is an optional component. When the waste liquid pool 60 is not used, other components can carry the lubricating liquid pumped out by the injection pump 40. In another practicable solution, the lubricating liquid pumped out by the injection pump 40 can flow back into the lubricating liquid pool 50 so that the lubricating liquid can be reused.

[0040] When specifically controlling the injection pump 40 and the selection valve 30, the controller 200 can be used for control, such as Figure 1 As shown in FIG. 1 , the controller 200 is in communication with the selection valve 30, the injection pump 40, and the pressure sensor 70 (pressure sensor A 71 and pressure sensor B 72). Figure 1The communication connection between the various components is indicated by dot-dashed lines in the figure), so as to control the operation of the monitoring system through the controller 200, specifically, the control valve 200 controls the selection valve 30 and the injection pump 40 to realize the actions described above. In addition, the controller 200 can also judge the sealing of the detection liquid circuit 100 according to the value of the pressure sensor 70. Exemplarily, taking the data detected by the pressure sensor A71 as an example, the current pressure value Pm of the pressure sensor A71 after filling with gas is detected, and the pressure value Pn is read again after a set interval. The pressure leakage rate is calculated based on the pressure value Pm, the pressure value Pn and the interval time. The controller 200 determines whether the pressure leakage is within the set threshold range to determine whether the sealing of the detection liquid circuit 100 where the pressure sensor A71 is located does not meet the standard.

[0041] It should be understood that the controller 200 in the present application can be a common control device such as a common PLC (Programmable Logic Controller) or an industrial computer. And the controller 200 controls the selection valve 30 to select different connecting devices and controls the injection pump 40 to inject or absorb liquid, which are all conventional control methods. In the embodiment of the present application, the control logic of the controller 200 is not changed, but only the controller 200 realizes automatic control of the actions of the selection valve 30 and the injection pump 40. In addition, the controller 200 determines the sealing of the detection liquid circuit 100 according to the detection value of the pressure sensor 70, which is also a conventional judgment method, which will not be repeated in detail here.

[0042] It can be seen from the above description that the detection device provided in the embodiment of the present application can be connected to the injection pump 40 through the set lubricating liquid pool 50 through the selection valve 30. Before pumping air into the flow pool to detect the sealing, it can be connected to the injection pump 40 through the lubricating liquid pool 50 to pump lubricating liquid into the injection pump 40 and the selection valve 30, thereby reducing the damage caused by dry grinding of various components during movement and improving the reliability of the entire system.

[0043] Continue to refer Figure 1In another optional embodiment, each detection liquid circuit 100 also includes a connecting liquid circuit, which is used to connect the end of the flow cell corresponding to the detection liquid circuit 100 away from the detection liquid circuit 100. Exemplarily, when the first detection liquid circuit 10 includes the first branch road A11 and the first branch road B12, the end of the flow cell A110 and the flow cell C130 away from the pressure sensor A71 are connected through the first connecting liquid circuit 13, so that the gas in the flow cell A110 and the flow cell C130 can be connected to form a loop. Similarly, when the second detection liquid circuit 20 includes the second branch road B22 and the second branch road B23, the end of the flow cell B120 and the flow cell D140 away from the pressure sensor B72 is connected through the second connecting liquid circuit 23, so that the gas in the flow cell B120 and the flow cell D140 can be connected to form a loop.

[0044] In another optional embodiment, the first branch paths and the second branch paths are arranged alternately. Figure 1 As shown in the figure, the arrangement of the four branch roads is: first branch road A11, second branch road A21, first branch road B12, second branch road B22. The corresponding arrangement of the flow cells is: flow cell A110, flow cell B120, flow cell C130 and flow cell D140. Among them, flow cell A110 and flow cell C130 are located in the same detection liquid path 100 (first detection liquid path 10), and flow cell B120 and flow cell D140 are located in the same liquid path (second detection liquid path 20).

[0045] When the first branch path and the second branch path are arranged alternately, whether there is leakage between adjacent flow cells can be detected by the detection liquid path 100. For example, if the pressure value of the pressure sensor A71 increases, while the pressure value of the pressure sensor B72 decreases, it means that the flow cell in the second detection liquid path 20 is connected to the flow cell in the first detection liquid path 10, and an internal leakage occurs. Similarly, if the pressure value of the pressure sensor A71 decreases, while the pressure value of the pressure sensor B72 increases, it also means that there is an internal leakage between the flow cells.

[0046] For ease of understanding, Figure 1 The detection device shown in the figure is used as an example to describe the process of detecting the sealing of the flow cell in detail. Figure 2a to Figure 2e The controller is not shown in the example. The connection method between the controller and other devices can be referred to Figure 1 as shown in .

[0047] Step 1. Reference Figure 2aAs shown in the path of the straight line with an arrow, the selection valve 30 connects the lubricating liquid pool 50 with the injection pump 40 connected to the common passage by rotating the valve core, and the piston of the injection pump 40 moves in a direction away from the pipeline connection to generate negative pressure. Under the action of the negative pressure, the entire passage draws the lubricating liquid from the selection valve 30 to the cavity of the injection pump 40.

[0048] Step 2: Reference Figure 2b As shown in the path of the straight line with an arrow, the selection valve 30 connects the waste liquid box with the injection pump 40 connected to the common passage by rotating the valve core, and the piston of the injection pump 40 moves toward the direction close to the pipeline connection to generate positive pressure. Under the action of the positive pressure, the entire passage pushes the lubricating liquid from the cavity of the injection pump 40 through the selection valve 30 and the corresponding pipeline to the waste liquid tank 60.

[0049] Step 3: Repeat the above steps 1 and 2 several times to allow a small amount of lubricating liquid to exist in the cavity of the injection pump 40 and the selection valve 30 for lubrication, so as to prevent the injection pump 40 and the selection valve 30 from dry grinding and affecting their use.

[0050] Step 4. Reference Figure 2c As shown in the path of the straight line with an arrow, the selection valve 30 connects the air intake pipe 80 with the injection pump 40 connected to the common passage by rotating the valve core, and then the piston of the injection pump 40 moves in a direction away from the pipeline connection to generate negative pressure. Under the action of the negative pressure, the entire passage sucks the air through the selection valve 30 and the corresponding pipeline into the cavity of the injection pump 40.

[0051] Step 5. Reference Figure 2d As shown in the path of the straight line with an arrow, the selection valve 30 connects the pressure sensor A71 with the injection pump 40 connected to the common passage by rotating the valve core, and the piston of the injection pump 40 moves toward the direction close to the pipeline connection to generate positive pressure. Under the action of the positive pressure, the entire passage pushes the air from the cavity of the injection pump 40 through the selection valve 30, the pressure sensor A71 and the corresponding pipelines to the flow pool A110 and the flow pool C130 in turn.

[0052] Step 6. Repeat steps 4 and 5 above several times to increase the pressure in flow pool A110 and flow pool C130. During this period, the pressure sensor A71 continuously reads the pressure value until the pressure rises to a predetermined range, and then stops pressurizing. Read the current pressure value P1, and then read the pressure value P2 after 30 seconds. The pressure leakage rate is calculated based on the pressure value P1, the pressure value P2, and the time (30 seconds). By judging whether the pressure leakage is within the threshold range, the processing and assembly of the flow pool A110 and the flow pool C130 in the gene sequencing chip are detected to see whether they meet the design requirements. It should be understood that the pressure leakage rate is calculated using the detection data of the pressure sensor A71.

[0053] Step 7. Reference Figure 2c As shown in the path of the straight line with an arrow, the selection valve 30 connects the air intake pipe 80 with the injection pump 40 connected to the common passage by rotating the valve core, and then the piston of the injection pump 40 moves in a direction away from the pipeline connection to generate negative pressure. Under the action of the negative pressure, the entire passage sucks the air through the selection valve 30 and the corresponding pipeline into the cavity of the injection pump 40.

[0054] Step 8. Reference Figure 2e The path shown by the straight line with an arrow in the figure, the selection valve 30 connects the branch of the pressure sensor B72 with the injection pump 40 connected to the common passage by rotating the valve core, and the piston of the injection pump 40 moves toward the direction close to the pipeline connection to generate positive pressure. Under the action of the positive pressure, the entire passage pushes the air from the cavity of the injection pump 40 through the selection valve 30, the pressure sensor B72 and the corresponding pipelines to the flow pool B120 and the flow pool D140 in turn.

[0055] Step 9, repeat the above steps 7 and 8 several times to increase the pressure in the flow pool B120 and the flow pool D140 continuously, during which the pressure sensor B72 continuously reads the pressure value until the pressure rises to a predetermined range, stops pressurizing, reads the current pressure value P3, and reads the pressure value P4 again after 30 seconds. The pressure leakage rate is calculated, and by judging whether the pressure leakage is within the threshold range, it is detected whether the processing and assembly of the flow pool B120 and the flow pool D140 in the gene sequencing chip meet the design requirements.

[0056] Step 10, after the set time interval, read the pressure value P5 of the pressure sensor A71 and the pressure value P6 of the pressure sensor B72 read in step 9, compare the pressure value P5 with the pressure value P2, and compare the pressure value P6 with the pressure value P4. If the pressure value of the pressure sensor A71 increases or decreases, and the corresponding pressure value of the pressure sensor B72 decreases or increases, it is determined whether there is an internal leakage between the flow cell A110 and the flow cell C130 and the flow cell B120 and the flow cell D140. In the above steps, the judgment can be made by the controller 200, and the controller 200 makes the above judgment according to the pressure values ​​detected by the pressure sensor A71 and the pressure sensor B72 as a conventional judgment method, and does not involve changes to the control logic.

[0057] It can be seen from the above steps that the detection device provided in the embodiment of the present application can achieve lubrication of the selection valve 30 and the injection pump 40 through the cooperation of the selection valve 30, the lubricating liquid pool 50 and the injection pump 40, thereby improving the reliability of the injection pump 40 and the selection valve 30 and reducing their maintenance costs. In addition, the arrangement of the flow cells in the detection liquid circuit 100 can be used to detect whether there is external leakage and internal leakage in the flow cells, thereby improving the detection effect.

[0058] In another optional solution, the detection device provided in the embodiment of the present application further includes a support platform, which serves as a base for carrying the above components. In the specific configuration, the detection liquid circuit 100, the lubricating liquid pool 50, the waste liquid pool 60, the injection pump 40 and the selection valve 30 are all arranged on the support platform. For example, the above components are fixed to the support platform by bonding or connecting lamps in different connection methods.

[0059] In another feasible solution, a clamp corresponding to each flow cell is provided on the support platform, and each flow cell is fixed to the support platform by the corresponding clamp. Thus, the flow cell can be in a stable state during detection. The clamp can be a conventional clamping claw, or other clamping device. In addition, when the flow cell is connected to the detection liquid circuit 100, it can be connected through a sealing member to ensure the sealing effect between the two.

[0060] One or more embodiments of this specification are intended to cover all such substitutions, modifications and variations that fall within the broad scope of the appended claims. Therefore, any omissions, modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of one or more embodiments of this specification should be included in the scope of protection of this disclosure.

[0061] The above are only specific implementations of the present application, but the protection scope of the present application is not limited thereto. Any technician familiar with the technical field can easily think of changes or substitutions within the technical scope disclosed in the present application, which should be included in the protection scope of the present application. Therefore, the protection scope of the present application should be based on the protection scope of the claims.

Claims

1. A detection device, characterized in that: include: A plurality of detection liquid paths connected in parallel, each detection liquid path being connected to a flow cell; wherein each detection liquid path is provided with a pressure sensor; It also includes a selection valve, an air intake pipe, a lubricating liquid pool and an injection pump; wherein the injection pump is selectively connected to the air intake pipe, the lubricating liquid pool or each detection liquid path through the selection valve; A controller is connected in communication with the selection valve, the pressure sensor and the injection pump to control the operation of the detection device and determine the sealing performance of the detection fluid circuit according to the value of the pressure sensor.

2. The detection device according to claim 1, characterized in that: Each of the detection liquid paths includes at least two parallel branch paths, and each branch path is used to connect a flow cell. The pressure sensor on the detection liquid path is connected in series with the at least two parallel branch paths.

3. The detection device according to claim 2, characterized in that: Each of the detection liquid paths further comprises a connecting liquid path, and the connecting liquid path is used to connect an end of the flow cell corresponding to the detection liquid path away from the pressure sensor.

4. The detection device according to claim 2, characterized in that: The number of the detection liquid paths is two, namely a first detection liquid path and a second detection liquid path; Wherein, the branch path of the first detection liquid path is a first branch path, and the branch path of the second detection liquid path is a second branch path; and the first branch path and the second branch path are arranged alternately.

5. The detection device according to claim 1, characterized in that: The selection valve has a plurality of branch channels and a common channel, wherein the common channel of the selection valve is communicated with the injection pump; The air intake pipeline, the lubricating liquid pool, and the detection liquid path are respectively communicated with different branch channels of the selection valve.

6. The detection device according to claim 5, characterized in that: The air intake pipeline is a branch channel of the selection valve.

7. The detection device according to claim 6, characterized in that: The selection valve is a multi-way valve, and the number of branch channels of the multi-way valve is not less than the total number of the air intake pipeline, the lubricating liquid pool, and the detection liquid circuit.

8. The detection device according to any one of claims 1 to 7, characterized in that: It also includes a waste liquid pool, and the injection pump is connected to one of the air intake pipeline, the lubricating liquid pool, the waste liquid pool, and the detection liquid path through the selection valve.

9. The detection device according to claim 8, characterized in that: Also includes a support platform; The detection liquid circuit, the lubricating liquid pool, the waste liquid pool, the injection pump and the selection valve are all arranged on the supporting platform.

10. The detection device according to claim 9, characterized in that: A clamp corresponding to each of the flow cells is disposed on the support platform, and each of the flow cells is fixed to the support platform through the corresponding clamp.

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