Continuous administration mouse stellate ganglion block catheter

Abstract

The utility model relates to the technical field of medical experiment instruments, in particular to a continuous administration mouse stellate ganglion block catheter which comprises an implantation portion, the implantation portion comprises a catheter head and a catheter which are communicated with each other, and the catheter can be implanted into the neck of a mouse; the protective cap is in threaded connection with the top opening of the catheter head; a rubber seal is arranged in the middle of the protective cap; the built-in column is installed in the cavity of the catheter head, and a liquid control assembly is arranged in the built-in column and used for enabling the inner cavity of the catheter head to be communicated with or separated from the catheter. The catheter is implanted into the body of a mouse, then medicine injection can be completed in the mode that the rubber seal is punctured from the outside, follow-up continuous medicine administration is made possible, meanwhile, stellate ganglion block operation of the mouse is simpler, the catheter is communicated and separated through the liquid injection assembly, and the catheter is more convenient to use. And the guide pipe can be prevented from being directly communicated with the external environment when the protective cap is detached and replaced, so that the internal cleanness of the guide pipe is ensured to the greatest extent.

Description

Technical Field

[0001] The utility model relates to the technical field of medical experimental instruments, in particular to a mouse stellate ganglion blocking catheter for continuous drug administration. Background Art

[0002] The stellate ganglion (SG) is part of the cervical sympathetic nervous system. It is a sympathetic ganglion formed by the fusion of the inferior cervical ganglion and the T1 ganglion, and is located between the C6 and C7 vertebrae. It contains preganglionic sympathetic fibers that innervate the head and neck and postganglionic sympathetic fibers that innervate the upper limbs and heart. Stellate ganglion block (SGB) is a treatment method widely used in the clinical work of pain and anesthesiology. Local anesthetics are injected into the surrounding and nearby tissues of the SG, including the cervical sympathetic trunk, cervical sympathetic ganglia, preganglionic and postganglionic nerves and the areas innervated by them, thereby blocking the sympathetic nerves innervating the head, face, neck, scapula, upper limbs, anterior chest and back, etc., to regulate the tension of the sympathetic nervous system, and ultimately achieve the effect of regulating the body's autonomic nervous system, circulatory system, endocrine system, and immune system to maintain dynamic balance. It is used to treat a variety of pain and non-pain diseases.

[0003] Currently, research on stellate ganglion block is usually conducted on mice, and most of the operations are single operations. However, due to the small size and activeness of mice, the existing mouse stellate ganglion block operations have the disadvantages of poor repeatability and difficult positioning. Therefore, there is an urgent need for a micro-mouse stellate ganglion block catheter that is simple to operate and has high repeatability. Utility Model Content

[0004] The utility model aims to provide a micro implantable mouse stellate ganglion blocking catheter which can enable the catheter tip to accurately reach the vicinity of the stellate ganglion through a single implantation and can subsequently provide sustainable drug administration.

[0005] To achieve the above-mentioned purpose, the utility model provides the following technical solution: a mouse stellate ganglion blocking catheter for continuous drug administration, comprising an implant part, wherein the implant part comprises:

[0006] A catheter head and a catheter are interconnected, and the catheter can be implanted in the neck of a mouse; a protective cap is threadedly connected to the top opening of the catheter head, and the outer wall of the protective cap is provided with a rubber seal; an internal column is installed in the cavity of the catheter head, and a liquid control component is provided inside the internal column, and the liquid control component is used to connect or isolate the inner cavity of the catheter head with the catheter; and also includes a plurality of fixing rings arranged on the catheter head and the outer wall of the catheter.

[0007] Preferably, the liquid control component includes a liquid injection channel opened inside the built-in column, and the built-in column can rotate in the catheter head, a plug rod is fixed to the bottom of the protective cap, and a socket for inserting the plug rod is opened on the top of the built-in column.

[0008] Preferably, the liquid control component includes an infusion channel opened inside the built-in column, and the built-in column is fixed inside the catheter head, the infusion channel includes an installation cavity opened inside the built-in column, a liquid inlet hole connected to the top of the built-in column and a liquid outlet hole connected to the catheter, a blocking bead is installed on the inner bottom of the installation cavity through an elastic member, and the diameter of the blocking bead is larger than the inner diameter of the liquid inlet hole, and a protrusion is also provided at the position of the rubber seal corresponding to the liquid inlet hole.

[0009] Preferably, a sealing ring is provided on the contact surface between the protective cap and the built-in column.

[0010] Preferably, the tip end of the catheter is configured to be in the shape of a microsphere or cone.

[0011] Preferably, the catheter is made of polyethylene or silicone.

[0012] Preferably, the rubber seal is made of medical rubber material.

[0013] Compared with the prior art, the beneficial effects of the utility model are as follows:

[0014] 1. The utility model implants a catheter into the body of a mouse and then completes the injection of the drug by puncturing the rubber seal from the outside, thereby providing the possibility for subsequent continuous drug administration and making the operation of stellate ganglion block in mice simpler and more repeatable.

[0015] Second, the utility model connects and isolates the catheter through the liquid injection component, which can prevent the catheter from being directly connected to the external environment when the protective cap is disassembled and replaced, thereby ensuring the cleanliness of the inside of the catheter to the greatest extent. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1 It is a three-dimensional structural schematic diagram of the utility model;

[0017] Figure 2 It is a front cross-sectional view of the utility model;

[0018] Figure 3 It is an exploded perspective view from above of the present utility model;

[0019] Figure 4 It is a top-down exploded perspective view of the utility model;

[0020] Figure 5 It is a top-down exploded perspective view of the utility model;

[0021] Figure 6 It is an exploded cross-sectional schematic diagram and a partial enlarged diagram of the utility model.

[0022] In the figure: 1. catheter head; 2. catheter; 3. protective cap; 4. rubber seal; 5. fixing ring; 6. built-in column; 7. injection channel; 8. insertion rod; 9. insertion hole; 10. sealing ring; 11. liquid inlet hole; 12. liquid outlet hole; 13. installation cavity; 14. blocking bead; 15. elastic part; 16. bump. DETAILED DESCRIPTION

[0023] In order to make the purpose and advantages of the utility model more clear, the utility model is specifically described in combination with the following embodiments. It should be understood that the following text is only used to describe one or several specific implementations of the utility model, and does not strictly limit the protection scope of the specific request of the utility model.

[0024] Embodiment 1:

[0025] The technical solution adopted by the utility model is as follows Figure 1-4 As shown, a mouse stellate ganglion blocking catheter for continuous drug administration includes an implantation portion, wherein the implantation portion includes:

[0026] A catheter head 1 and a catheter 2 are interconnected, and the catheter 2 can be implanted in the neck of a mouse; a protective cap 3 is threadedly connected to the top opening of the catheter head 1, and a rubber seal 4 is provided on the outer wall of the protective cap 3; an internal column 6 is installed in the cavity of the catheter head 1, and a liquid control component is provided inside the internal column 6, and the liquid control component is used to connect or isolate the inner cavity of the catheter head 1 and the catheter 2; and also includes a plurality of fixing rings 5 ​​provided on the outer walls of the catheter head 1 and the catheter 2.

[0027] The liquid control component of this embodiment includes an injection channel 7 opened inside the built-in column 6, and the built-in column 6 can rotate in the catheter head 1, an insertion rod 8 is fixed to the bottom of the protective cap 3, and a socket 9 for inserting the insertion rod 8 is opened on the top of the built-in column 6.

[0028] The utility model provides a mouse stellate ganglion blocking catheter, which can be implanted in the neck of a mouse. The main purpose is to enable the tip of the catheter 2 to accurately reach the vicinity of the stellate ganglion through a single implantation, thereby providing the possibility for subsequent continuous drug administration.

[0029] The specific operation method is as follows: first find the position of the stellate ganglion on the neck of the mouse, and use microtweezers and a scalpel to create a puncture hole suitable for the diameter of the catheter 2, then slowly insert the catheter 2 into the puncture hole, and ensure that the stellate ganglion is accurately covered by fine-tuning the position of the catheter 2, and then use sutures to bypass the fixing ring 5 to fix part of the length of the catheter 2 at the puncture hole, or it can be completely implanted under the skin, and the fixing ring 5 on the catheter head 1 can be fixed on the skin to ensure its stability.

[0030] After the catheter 2 is implanted, the liquid control component connects the inner cavity of the catheter head 1 with the catheter 2 to facilitate subsequent drug injection. The end of the catheter 2 is fixed to the skin with absorbable sutures or biological glue to prevent displacement or falling off. By implanting the catheter 2 into the body of the mouse, the drug injection can be completed by puncturing the rubber seal 4 from the outside, which makes subsequent continuous drug administration possible and also makes the operation of mouse stellate ganglion block simpler and more repeatable.

[0031] The implantation of the catheter 2 provides the possibility for subsequent repeated injections. At the same time, after multiple punctures, the elastic properties of the rubber seal 4 will be affected, so that the perforation cannot be completely closed, and there may be infection at the rubber seal 4, which will affect the mouse model. To avoid this situation, the protective cap 3 can be removed and replaced to replace the new rubber seal 4. During the rotation and removal of the protective cap 3, the plug rod 8 at the bottom will drive the built-in column 6 to rotate, so that the injection channel 7 and the catheter 2 are staggered, and the catheter 2 is closed. After replacing the new protective cap 3, it is immediately rotated and tightened to connect the injection channel 7 with the catheter 2 again to ensure the normal operation of the subsequent injection process; through the connection and isolation of the catheter 2, the catheter 2 can be prevented from being directly connected to the external environment, thereby ensuring the cleanliness of the inside of the catheter 2 to the greatest extent.

[0032] After catheter 2 is implanted, imaging techniques, such as X-ray or MRI, can be used to verify the position of the catheter and fine-tune it as needed. The behavioral and physiological data of the mice after catheter 2 implantation can then be recorded regularly to evaluate the blocking effect and stability of the catheter. Based on the experimental results, the design and operation techniques of catheter 2 can be adjusted to further improve accuracy and operability.

[0033] Embodiment 2:

[0034] Except for the following technical solutions, the rest are the same as in Example 1:

[0035] like Figure 1 , Figure 5 and Figure 6 As shown, a second embodiment of a liquid control component is provided, wherein the liquid control component includes an infusion channel opened inside the built-in column 6, and the built-in column 6 is fixed inside the catheter head 1, the infusion channel includes an installation cavity 13 opened inside the built-in column 6, a liquid inlet hole 11 connected to the top of the built-in column 6, and a liquid outlet hole 12 connected to the catheter 2, a blocking bead 14 is installed on the inner bottom of the installation cavity 13 through an elastic member 15, and the diameter of the blocking bead 14 is larger than the inner diameter of the liquid inlet hole 11, and a protrusion 16 is also provided at the position of the rubber seal 4 corresponding to the liquid inlet hole 11.

[0036] When the protective cap 3 and the catheter head 1 are in a sealed installation state, the protrusion 16 on the rubber seal 4 will push the blocking bead 14 away from the liquid inlet 11, so that the liquid inlet, the installation cavity 13, the liquid outlet 12 and the catheter 2 remain connected. When the protective cap 3 is removed, the blocking bead 14 will separate from the protrusion 16 and, under the elastic force of the elastic member, will block the liquid inlet 11, thereby isolating the catheter 2 and also preventing the catheter 2 from being directly connected to the external environment.

[0037] In addition, a sealing ring 10 is provided on the contact surface between the protective cap 3 and the built-in column 6. The sealing ring 10 further improves the sealing performance of the protective cap 3. The tip end of the catheter 2 is set to a micro sphere or cone to reduce tissue damage and improve positioning accuracy, and improve the positioning accuracy of the catheter 2 near the stellate ganglion. The catheter 2 is made of polyethylene or silicone. The catheter 2 is made of a thin and soft material to reduce damage to the surrounding tissues of the mouse, and the length is moderate, enough to extend to the stellate ganglion and leave a certain margin, which is convenient for adjusting the position and operation. The rubber seal 4 is made of medical rubber.

[0038] The above describes in detail the implementation modes of the present invention in conjunction with the accompanying drawings, but the present invention is not limited to the above implementation modes. For ordinary technicians in this technical field, after knowing the contents recorded in the present invention, they can make several equivalent changes and substitutions thereto without departing from the principle of the present invention. These equivalent changes and substitutions should also be regarded as belonging to the protection scope of the present invention.

Claims

1. A mouse stellate ganglion blocking catheter for continuous administration, comprising an implant portion, characterized in that: The implantation part comprises: a catheter head (1) and a catheter (2) which are interconnected, and the catheter (2) can be implanted in the neck of a mouse; A protective cap (3) threadedly connected to the top opening of the catheter head (1), wherein the outer wall of the protective cap (3) is provided with a rubber seal (4); An internal column (6) installed in the cavity of the catheter head (1), wherein a liquid control component is provided inside the internal column (6), and the liquid control component is used to connect or disconnect the inner cavity of the catheter head (1) and the catheter (2); It also includes a plurality of fixing rings (5) arranged on the outer wall of the catheter head (1) and the catheter (2).

2. The mouse stellate ganglion block catheter for continuous drug administration according to claim 1, characterized in that: The liquid control component comprises a liquid injection channel (7) opened inside the built-in column (6), and the built-in column (6) can rotate inside the catheter head (1), an insertion rod (8) is fixed to the bottom of the protective cap (3), and a socket (9) for inserting the insertion rod (8) is opened at the top of the built-in column (6).

3. The mouse stellate ganglion block catheter for continuous drug administration according to claim 1, characterized in that: The liquid control component comprises an infusion channel opened inside the built-in column (6), and the built-in column (6) is fixed inside the catheter head (1), the infusion channel comprises a mounting cavity (13) opened inside the built-in column (6), a liquid inlet hole (11) connected to the top of the built-in column (6), and a liquid outlet hole (12) connected to the catheter (2), the inner bottom of the mounting cavity (13) is installed with a blocking bead (14) through an elastic member (15), and the diameter of the blocking bead (14) is larger than the inner diameter of the liquid inlet hole (11), and the rubber seal (4) is also provided with a protrusion (16) at a position corresponding to the liquid inlet hole (11).

4. The mouse stellate ganglion block catheter for continuous drug administration according to claim 1, characterized in that: The rubber seal (4) is made of medical rubber material.

5. The mouse stellate ganglion block catheter for continuous drug administration according to claim 3, characterized in that: A sealing ring (10) is provided on the contact surface between the protective cap (3) and the built-in column (6).

6. The mouse stellate ganglion blocking catheter for continuous administration according to any one of claims 1 to 3, characterized in that: The tip end of the catheter (2) is configured to be in the shape of a micro sphere or a cone.

7. The mouse stellate ganglion blocking catheter for continuous administration according to any one of claims 1 to 3, characterized in that: The catheter (2) is made of polyethylene or silicone.

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