Emulsifying equipment for preparing liposome medicine

Abstract

The utility model relates to the technical field of emulsification, and discloses emulsification equipment for preparing liposome medicine, which comprises a reaction tank, a feed pipe arranged on one side of the upper part of the reaction tank, a discharge pipe arranged on the lower side of the middle part of the reaction tank, a lifting stirring mechanism arranged in the middle part of the reaction tank, and a spraying mechanism arranged on the inner top wall of the reaction tank, and valves are mounted at the middle parts of the feeding pipe and the discharging pipe. According to the emulsifying equipment for preparing the lipidosome medicine, the speed reducing motor is driven to enable the shaft rod to drive the stirring blades to rotate so as to stir a solution, meanwhile, the servo motor is driven to enable the driving gear to drive the driven gear to rotate, the sleeve cannot rotate through limiting of the upper portion of the reaction tank on the sleeve, and then the solution is stirred. The driven gear rotates while driving the sleeve to move up and down, so that the stirring blades rotate while moving up and down in the reaction tank, and the emulsifying efficiency is improved.

Description

Technical Field

[0001] The utility model relates to the technical field of emulsification, in particular to an emulsification device for preparing liposome medicines. Background Art

[0002] Emulsification is the process of evenly dispersing a liquid in another immiscible liquid in the form of extremely tiny droplets. Emulsification is a liquid-liquid interface phenomenon. Two immiscible liquids, such as oil and water, are separated into two layers in a container, with the oil with low density in the upper layer and the water with high density in the lower layer. If an appropriate surfactant is added and stirred vigorously, the oil is dispersed in the water to form an emulsion. This process is called emulsification. When preparing liposome drugs, the oil phase solution and the water phase solution need to be emulsified to form liposomes. Traditional emulsification equipment only uses stirring blades to stir and emulsify, but the position of the stirring blades is fixed, and the stirring effect on the liquids on the upper and lower sides of the stirring blades is poor, and the emulsification efficiency is low. Utility Model Content

[0003] The main purpose of the utility model is to provide an emulsification device for preparing liposome drugs, which can effectively solve the problems in the background technology.

[0004] In order to achieve the above purpose, the technical solution adopted by the utility model is:

[0005] An emulsification device for preparing liposome drugs, comprising a reaction tank, a feeding pipe is arranged on one side of the upper part of the reaction tank, a discharging pipe is arranged on the lower side of the middle part of the reaction tank, a lifting and stirring mechanism is arranged in the middle part of the reaction tank, a spray mechanism is arranged on the top wall of the reaction tank, and valves are installed in the middle of the feeding pipe and the discharging pipe;

[0006] The spray mechanism includes a spray head, an annular disk and a delivery pipe. The upper part of the annular disk is installed on the top wall of the reaction tank, the spray head is installed on the lower part of the annular disk, and the other end of the delivery pipe passes through the upper side wall shell of the reaction tank and is fixedly connected to the upper part of the annular disk.

[0007] Preferably, a cavity is provided on the side wall of the reaction tank, and a heating wire is provided inside the cavity.

[0008] Preferably, the diameter of the output hole of the shower head is 0.5 mm-1.5 mm.

[0009] Preferably, the lifting and stirring mechanism includes a stirring mechanism, a sleeve, a driven gear, a driving gear and a servo motor, the stirring mechanism is installed in the middle part of the sleeve, the outer periphery of the sleeve is slidably connected to the upper middle part of the reaction tank, the lower part of the driven gear is rotatably connected to the middle part of the upper side of the reaction tank, the middle part of the driven gear is threadedly connected to the outer periphery of the sleeve, the servo motor is installed on the upper part of the reaction tank, the middle part of the driving gear is fixedly connected to the upper driving end of the servo motor, and the driving gear and the driven gear are meshed with each other.

[0010] Preferably, the stirring mechanism includes a reduction motor, a shaft and a plurality of stirring blades, the upper portion of the shaft is rotatably connected to the middle portion of the sleeve, the middle portions of the plurality of stirring blades are installed on the lower periphery of the shaft, the reduction motor is installed on the upper portion of the sleeve, and the lower driving end of the reduction motor passes through the upper portion of the sleeve and is fixedly connected to the upper end of the shaft.

[0011] Preferably, there are at least two stirring blades.

[0012] Compared with the prior art, the utility model has the following beneficial effects:

[0013] 1. Drive the reduction motor to make the shaft drive the stirring blade to rotate, thereby stirring the solution. At the same time, drive the servo motor to make the driving gear drive the driven gear to rotate. By limiting the sleeve at the upper part of the reaction tank, the sleeve cannot rotate, so that the driven gear rotates while driving the sleeve to move up and down, thereby making the stirring blade rotate while moving up and down inside the reaction tank, thereby improving the emulsification efficiency. BRIEF DESCRIPTION OF THE DRAWINGS

[0014] Figure 1 This is a schematic diagram of the three-dimensional structure of an emulsification device for preparing liposome drugs according to the utility model;

[0015] Figure 2 This is a schematic diagram of the internal structure of an emulsification device for preparing liposome drugs according to the utility model;

[0016] Figure 3 The utility model is a schematic diagram of the lifting and stirring mechanism structure of an emulsifying device for preparing liposome drugs.

[0017] In the figure: 1. reaction tank; 2. lifting and stirring mechanism; 201. reduction motor; 202. shaft; 203. stirring blade; 204. sleeve; 205. driven gear; 206. driving gear; 207. servo motor; 3. spray mechanism; 301. spray head; 302. annular disk; 303. conveying pipe; 4. feed pipe; 5. discharge pipe; 6. cavity; 7. heating wire. DETAILED DESCRIPTION

[0018] In order to make the technical means, creative features, objectives and effects achieved by the present invention easy to understand, the present invention is further described below in conjunction with specific implementation methods.

[0019] like Figure 1-3As shown, an emulsification device for preparing liposome drugs includes a reaction tank 1, a feed pipe 4 is arranged on one side of the upper part of the reaction tank 1, a discharge pipe 5 is arranged on the lower side of the middle part of the reaction tank 1, a lifting and stirring mechanism 2 is arranged in the middle part of the reaction tank 1, a spray mechanism 3 is arranged on the top wall of the reaction tank 1, and valves are installed in the middle of the feed pipe 4 and the discharge pipe 5.

[0020] In this embodiment, the spray mechanism 3 includes a spray head 301, an annular disk 302 and a delivery pipe 303. The upper part of the annular disk 302 is installed on the inner top wall of the reaction tank 1, the spray head 301 is installed on the lower part of the annular disk 302, and the other end of the delivery pipe 303 passes through the upper side wall shell of the reaction tank 1 and is fixedly connected to the upper part of the annular disk 302. A cavity 6 is provided on the side wall of the reaction tank 1, and a heating wire 7 is provided inside the cavity 6. The diameter of the output hole of the spray head 301 is 0.5mm-1.5mm.

[0021] Specifically, the delivery pump delivers the oil phase solution into the annular disk 302 through the spray mechanism 3, and discharges it in the form of fine water droplets through the spray head 301, and enters the water phase solution for emulsification, thereby improving the emulsification efficiency.

[0022] In this embodiment, the lifting stirring mechanism 2 includes a stirring mechanism, a sleeve 204, a driven gear 205, a driving gear 206 and a servo motor 207. The stirring mechanism is installed in the middle of the sleeve 204, the outer periphery of the sleeve 204 is slidably connected to the upper middle of the reaction tank 1, the lower part of the driven gear 205 is rotatably connected to the middle of the upper side of the reaction tank 1, the middle part of the driven gear 205 is threadedly connected to the outer periphery of the sleeve 204, the servo motor 207 is installed on the upper part of the reaction tank 1, and the middle part of the driving gear 206 is fixedly connected to the servo motor 2 07 At the upper driving end, the driving gear 206 and the driven gear 205 are meshed with each other. The stirring mechanism includes a reduction motor 201, a shaft 202 and a plurality of stirring blades 203. The upper portion of the shaft 202 is rotatably connected to the middle portion of the sleeve 204. The middle portions of the plurality of stirring blades 203 are mounted on the lower periphery of the shaft 202. The reduction motor 201 is mounted on the upper portion of the sleeve 204. The lower driving end of the reduction motor 201 penetrates through the upper portion of the sleeve 204 and is fixedly connected to the upper end of the shaft 202. There are at least two stirring blades 203.

[0023] Specifically, the reduction motor 201 is driven so that the shaft 202 drives the stirring blade 203 to rotate, thereby stirring the solution. At the same time, the servo motor 207 is driven so that the driving gear 206 drives the driven gear 205 to rotate. The sleeve 204 is limited by the upper part of the reaction tank 1 so that the sleeve 204 cannot rotate, so that the driven gear 205 rotates while driving the sleeve 204 to move up and down, thereby causing the stirring blade 203 to rotate while moving up and down inside the reaction tank 1, thereby improving the emulsification efficiency.

[0024] Working principle:

[0025] The delivery pump delivers the oil phase solution into the annular disk 302 through the spray mechanism 3, and discharges it in the form of fine water droplets through the spray head 301, and enters the aqueous solution for emulsification, thereby improving the emulsification efficiency, driving the reduction motor 201, so that the shaft 202 drives the stirring blade 203 to rotate, thereby stirring the solution, and at the same time driving the servo motor 207, so that the driving gear 206 drives the driven gear 205 to rotate, and the sleeve 204 is limited by the upper part of the reaction tank 1, so that the sleeve 204 cannot rotate, so that the driven gear 205 rotates while driving the sleeve 204 to move up and down, thereby causing the stirring blade 203 to rotate while moving up and down inside the reaction tank 1, thereby improving the emulsification efficiency.

[0026] The above shows and describes the basic principle and main features of the utility model and the advantages of the utility model. Those skilled in the art should understand that the utility model is not limited by the above embodiments. The above embodiments and descriptions are only for explaining the principle of the utility model. Without departing from the spirit and scope of the utility model, the utility model may have various changes and improvements, which fall within the scope of the utility model to be protected. The scope of protection claimed by the utility model is defined by the attached claims and their equivalents.

Claims

1. An emulsification device for preparing liposome drugs, comprising a reaction tank (1), characterized in that: A feed pipe (4) is provided on one side of the upper part of the reaction tank (1), a discharge pipe (5) is provided on the lower side of the middle part of the reaction tank (1), a lifting and stirring mechanism (2) is provided in the middle part of the reaction tank (1), a spray mechanism (3) is provided on the top wall of the reaction tank (1), and valves are installed in the middle of the feed pipe (4) and the discharge pipe (5); The spray mechanism (3) comprises a spray head (301), an annular disk (302) and a delivery pipe (303); the upper portion of the annular disk (302) is mounted on the inner top wall of the reaction tank (1); the spray head (301) is mounted on the lower portion of the annular disk (302); and the other end of the delivery pipe (303) passes through the upper side wall shell of the reaction tank (1) and is fixedly connected to the upper portion of the annular disk (302); The lifting stirring mechanism (2) comprises a stirring mechanism, a sleeve (204), a driven gear (205), a driving gear (206) and a servo motor (207); the stirring mechanism is installed in the middle of the sleeve (204); the outer periphery of the sleeve (204) is slidably connected to the upper middle of the reaction tank (1); the lower part of the driven gear (205) is rotatably connected to the middle of the upper side of the reaction tank (1); the middle part of the driven gear (205) is threadedly connected to the outer periphery of the sleeve (204); the servo motor (207) is installed on the upper part of the reaction tank (1); the middle part of the driving gear (206) is fixedly connected to the upper driving end of the servo motor (207); and the driving gear (206) and the driven gear (205) are meshed with each other.

2. An emulsification device for preparing liposome drugs according to claim 1, characterized in that: The side wall of the reaction tank (1) is provided with a cavity (6), and an electric heating wire (7) is provided inside the cavity (6).

3. An emulsification device for preparing liposome drugs according to claim 1, characterized in that: The diameter of the output hole of the shower head (301) is 0.5 mm-1.5 mm.

4. An emulsification device for preparing liposome drugs according to claim 1, characterized in that: The stirring mechanism comprises a reduction motor (201), a shaft (202) and a plurality of stirring blades (203); the upper portion of the shaft (202) is rotatably connected to the middle portion of a sleeve (204); the middle portions of the plurality of stirring blades (203) are mounted on the lower periphery of the shaft (202); the reduction motor (201) is mounted on the upper portion of the sleeve (204); and the lower driving end of the reduction motor (201) passes through the upper portion of the sleeve (204) and is fixedly connected to the upper end of the shaft (202).

5. An emulsification device for preparing liposome drugs according to claim 4, characterized in that: The number of the stirring blades (203) is at least two.

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