Mass spectrum ion source device

Abstract

The utility model relates to a mass spectrum ion source device, which is arranged at a sample inlet of a mass spectrometer, and is characterized by comprising an assembly platform detachably arranged at the sample inlet through a locking assembly, the assembly platform is fixedly connected with an optical flat plate supporting platform, the optical flat plate supporting platform is fixedly connected with a displacement assembly, and the displacement assembly is fixedly connected with the assembly platform. The displacement assembly is fixedly connected with an object carrying platform, and the object carrying platform is fixedly connected with a spray needle and an electrode which are matched with the sample injection port. The locking assembly drives the mass spectrum ion source device to be detachably arranged at the sample inlet of the mass spectrometer, the stability of the ion source device in the working process is improved, and meanwhile the displacement assembly drives the optical flat plate supporting platform to conduct multi-dimensional adjustment.

Description

Technical Field

[0001] The utility model relates to a mass spectrometer, and more specifically, the utility model also relates to a mass spectrometer ion source device. Background Art

[0002] A mass spectrometer is an instrument that ionizes compounds into ions and manipulates the resulting ions. It measures the mass-to-charge ratio (m / z) of ionized compounds to achieve qualitative and quantitative analysis of compounds. As a method that can simultaneously perform high-throughput, high-sensitivity detection of multiple components in a sample, mass spectrometry has played a huge role in the fields of bioanalysis, chemical testing, food safety, and environmental monitoring. The electrospray ion source has been proven to be an important tool for ionizing polar analytes in liquid samples and bringing charged gaseous ions into the gas phase. As a medium between analytes and mass spectrometry, the electrospray ion source has unparalleled wide applicability. Commonly used mass analyzers can be combined with the electrospray ion source. Thanks to these advantages, the electrospray ion source has become the most studied and widely used ion source in mass spectrometry.

[0003] In recent years, due to the economical sample usage and excellent ionization efficiency, traditional commercial electrospray ion sources have gradually developed towards nanospray and induced electrospray. Nanospray and induced electrospray have greater electrochemical reaction efficiency, better ionization efficiency, higher sensitivity, and can greatly reduce the ion suppression and matrix effect caused by salt and matrix in complex samples. However, how to simplify and miniaturize the structure and operation of traditional commercial electrospray ion sources, improve the simplicity, operability and improvability of the device, and maximize the advantages of nanospray and induced electrospray has always been a thorny problem. Some existing nanospray ion source devices are often large in size, poor in flexibility, occupy a large space, and are extremely inconvenient to install and disassemble. Each installation requires a cumbersome adjustment process to accurately send the ion spray into the mass spectrometer. Most of these nanospray ion sources are split into an independent unit and cannot be integrated with the mass spectrometer, which makes them susceptible to external interference during operation and unstable spray, resulting in discontinuous signals or low intensity. In addition, the electrodes and spray needles of many nanospray ion sources are relatively fixed, and induced electrospray cannot be carried out. Utility Model Content

[0004] In order to achieve the purpose of the utility model, the technical solution adopted by the utility model is: a mass spectrometry ion source device, arranged at the injection port of a mass spectrometer, including: an assembly platform detachably arranged at the injection port through a locking assembly, the assembly platform is fixedly connected to an optical plate support platform, the optical plate support platform is fixedly connected to a displacement assembly, the displacement assembly is fixedly connected to a carrier platform, and the carrier platform is fixedly connected to a spray needle and an electrode that cooperate with the injection port.

[0005] Preferably, the displacement assembly includes: a support platform adjustably arranged on the optical plate support platform, the support platform is fixed with an X-axis moving assembly, the X-axis moving assembly is matched with a Y-axis moving assembly, the Y-axis moving assembly is matched with an L-shaped support plate, the L-shaped support plate is fixedly connected with a Z-axis moving assembly, the Z-axis moving assembly is matched with a rotating assembly, and the rotating assembly is fixedly connected with a loading platform.

[0006] Preferably, the X-axis moving component, the Y-axis moving component and the Z-axis moving component all include: a moving platform, a displacement platform is provided for movement in the length direction of the moving platform, the moving platform is fixedly connected to the guide rod and is rotatably provided with a screw rod, the screw rod drives the displacement platform to move along the length direction of the guide rod, and a rotating handle is provided on one side of the screw rod extending to the moving platform.

[0007] Preferably, the rotating assembly includes: a positioning shell fixedly arranged on the Z-axis moving assembly, the positioning shell being rotatably connected to a rotating disk, the rotating disk being fixedly connected to the loading platform, the rotating disk extending to the positioning shell and being fixedly connected to a driven wheel, a driving wheel rotatably provided in the positioning shell and cooperating with the driven wheel, a first bevel gear being coaxially provided on the driving wheel, a second bevel gear rotatably provided in the positioning shell and cooperating with the first bevel gear, the second bevel gear being coaxially fixedly connected to a driving rod, the driving rod extending to the outside of the positioning shell and being provided with a driving knob.

[0008] Preferably, a bolt is threadedly engaged with the positioning housing, and the bolt passes through the positioning housing and abuts against the outer side wall of the rotating disk.

[0009] Preferably, the outer side wall of the rotating disk is provided with anti-slip grooves that contact the bolts.

[0010] Preferably, the locking assembly includes: a locking portion fixedly arranged at the mass spectrometer inlet, the assembly platform is fixedly connected with a locking assembly cooperating with the locking portion, the mass spectrometer inlet is fixedly connected with a guide column, and the assembly platform is provided with a guide groove cooperating with the guide column.

[0011] Preferably, the assembly platform is provided with a positioning groove cooperating with the locking part, the locking part is provided with a snap-in groove, and the locking assembly includes: a locking rod cooperating with the snap-in groove, the locking rod extends to the upper surface of the assembly platform and is provided with a rotating handle, and the rotating handle drives the locking rod to lock in the snap-in groove.

[0012] Preferably, the locking rod is provided with a locking area and an unlocking area, and the width of the locking area is greater than the width of the unlocking area.

[0013] Preferably, the optical plate supporting platform is provided with a plurality of fixed workstations.

[0014] Compared with the prior art, the beneficial effects of the utility model are:

[0015] 1. The mass spectrometer ion source device is detachably arranged at the inlet of the mass spectrometer through the locking component, which improves the stability of the mass spectrometer ion source device during operation. At the same time, the optical plate support platform is displaced through the displacement component to reduce the overall adjustment difficulty, realize various spray angles and distances, and realize precise control of the distance.

[0016] 2. The rotating assembly drives the loading platform to rotate within a small range, thereby facilitating the installation of other devices on the optical flat-panel support platform, reducing the spatial displacement of the loading platform and reducing the difficulty of subsequent mass spectrometer detection. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 It is a schematic diagram of the overall structure of the mass spectrometer ion source device of the utility model;

[0018] Figure 2 It is an exploded view of the overall structure of the mass spectrometer ion source device of the utility model;

[0019] Figure 3 It is a partial structural exploded diagram of the mass spectrometer ion source device of the utility model.

[0020] In the figure: 1. mass spectrometer; 101. locking part; 102. guide column; 2. assembly platform; 201. guide groove; 3. optical plate support platform; 4. loading platform; 5. support platform; 6. X-axis moving assembly; 7. Y-axis moving assembly; 8. Z-axis moving assembly; 9. positioning housing; 10. rotating disk; 11. driven wheel; 12. driving wheel; 13. first bevel gear; 14. second bevel gear; 15. driving rod; 16. driving knob; 17. bolt; 18. locking rod; 19. rotating handle. DETAILED DESCRIPTION

[0021] The following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.

[0022] Figures 1 to 3 As shown, the utility model provides a technical solution: a mass spectrometry ion source device, which is arranged at the injection port of a mass spectrometer 1, and an assembly platform 2 arranged at the injection port can be detachably arranged through a locking component. The locking component mainly drives the ion source device to be hung at the injection port of the mass spectrometer 1. The mass spectrometry ion source device adopts nanospray or induced electrospray.

[0023] The locking assembly includes: a locking portion 101 fixedly arranged at the injection port of the mass spectrometer 1, a locking assembly fixedly connected to the assembly platform 2 and matched with the locking portion 101, a guide post 102 fixedly connected to the injection port of the mass spectrometer 1, and a guide groove 201 matched with the guide post 102 is provided on the assembly platform 2. The guide groove 201 cooperates with the guide post 102 to realize the preliminary positioning of the assembly platform 2.

[0024] The assembly platform 2 is provided with a positioning groove cooperating with the locking portion 101, and the locking portion 101 is provided with a snap-in groove. The locking assembly includes: a locking rod 18 cooperating with the snap-in groove, the locking rod 18 extends to the upper surface of the assembly platform 2 and is provided with a rotating handle 19, the rotating handle 19 drives the locking rod 18 to be locked in the snap-in groove, the locking rod 18 is provided with a locking area and an unlocking area, and the width of the locking area is greater than the width of the unlocking area.

[0025] When the assembly platform 2 and the injection port of the mass spectrometer 1 are initially positioned, the unlocking area of ​​the locking rod 18 cooperates with the snap-in groove, and the locking rod 18 is driven to rotate by rotating the handle 19, and the locking area is driven to cooperate with the snap-in groove to achieve locking. The snap-in groove adopts a cylindrical through groove, and the snap-in groove is provided with an opening for the locking rod 18 to pass through, and the width of the opening is smaller than the diameter of the snap-in groove.

[0026] The assembly platform 2 is fixedly connected to the optical plate support platform 3, and the optical plate support platform 3 is arranged perpendicular to the assembly platform 2. The optical plate support platform 3 is provided with a plurality of fixed stations, which can be used to fix various processing devices.

[0027] The optical plate support platform 3 is connected to a loading platform 4 through a displacement component, and the displacement component includes: a support platform 5 that can be adjusted on the optical plate support platform 3, and the support platform 5 is provided with a plurality of waist-shaped holes, and the support platform 5 is fixedly connected to the optical plate support platform 3 by screws, and the waist-shaped holes can adjust the position of the support platform 5 well.

[0028] The support platform 5 is fixed with an X-direction moving component 6, the X-direction moving component 6 is matched with a Y-direction moving component 7, the Y-direction moving component 7 is matched with an L-shaped support plate, and the L-shaped support plate is fixedly connected with a Z-direction moving component 8.

[0029] The Z-moving component 8 is matched with a rotating component, the rotating component is fixedly connected to the carrier platform 4, the carrier platform 4 is fixedly connected to the spray needle matched with the injection port, and the carrier platform 4 is driven to move in space through the X-moving component 6, the Y-moving component 7 and the Z-moving component 8.

[0030] The X-axis moving assembly 6, the Y-axis moving assembly 7 and the Z-axis moving assembly 8 all include: a moving platform, a displacement platform is provided for movement in the length direction of the moving platform, the moving platform is fixedly connected to the guide rod and is provided with a screw rod for rotation, the screw rod drives the displacement platform to move along the length direction of the guide rod, and the screw rod extends to one side of the moving platform and is provided with a rotating handle 19. The displacement platform is driven to move along the length direction of the guide rod by rotating the handle 19, thereby driving the object-carrying platform 4 to perform spatial displacement, the Y-axis moving assembly 7 is fixedly provided on the displacement platform of the X-axis moving assembly 6, and the L-shaped support plate is fixedly provided on the displacement platform of the Y-axis moving assembly 7.

[0031] The rotating component mainly drives the carrier platform 4 to rotate in space. The rotating component drives the carrier platform 4 to rotate in a small range, so as to facilitate driving other devices to be installed on the optical plate support platform 3, reduce the spatial displacement of the carrier platform 4, and reduce the difficulty of subsequent mass spectrometer 1 calibration.

[0032] The rotating assembly includes: a positioning housing 9 fixedly arranged on the Z-direction moving assembly 8 , and the positioning housing 9 is fixedly arranged on the displacement platform of the Z-direction moving assembly 8 .

[0033] The positioning housing 9 is rotatably connected to a rotating disk 10 , which is fixedly connected to the loading platform 4 . The rotating disk 10 extends to the positioning housing 9 and is fixedly connected to a driven wheel 11 . A driving wheel 12 that cooperates with the driven wheel 11 is rotatably provided in the positioning housing 9 .

[0034] The driving wheel 12 is coaxially provided with a first bevel gear 13 , a second bevel gear 14 cooperating with the first bevel gear 13 is rotatably provided in the positioning housing 9 , the second bevel gear 14 is coaxially fixedly connected with a driving rod 15 , and the driving rod 15 extends to the outside of the positioning housing 9 and is provided with a driving knob 16 .

[0035] The driving knob 16 drives the driving rod 15 to rotate, the driving rod 15 drives the second bevel gear 14 to rotate, the second bevel gear 14 drives the first bevel gear 13 to rotate, the first bevel gear 13 drives the driving wheel 12 to rotate, the driving wheel 12 drives the driven wheel 11 to rotate, the driven wheel 11 drives the rotating disk 10 to rotate, and the rotating disk 10 drives the loading platform 4 to rotate within a small range.

[0036] The positioning housing 9 is threadedly fitted with a bolt 17 , which passes through the positioning housing 9 and abuts against the outer wall of the rotating disk 10 . The outer wall of the rotating disk 10 is provided with anti-slip grooves that contact with the bolt 17 .

[0037] The bolt 17 passes through the positioning housing 9 and abuts against the outer side of the rotating disk 10 , thereby achieving locking of the rotating disk 10 after adjustment.

[0038] The loading platform 4 includes: a T-block fixedly connected to the rotating disk 10 and a placement plate for fixing the spray needle and the electrode, the placement plate is connected to the T-block by a first bolt (at this time the placement plate can rotate along the axis of the first bolt), and the placement plate is also provided with three locking holes, one of which is at an angle of 90 degrees with the other two locking holes around the axis of the first bolt. The placement plate is locked with one of the locking holes by a second bolt, but when adjustment is required, the second bolt is used to disengage the locking state and drive the placement plate to rotate 90 degrees around the rotation axis of the first bolt, thereby adjusting the specific position of the placement plate (the adjustment is that the first bolt is not in a locked state).

[0039] By driving the loading platform to perform multi-dimensional displacement through the displacement component, not only can various spray angles and distances be easily achieved, but also micron-level precise control can be achieved; at the same time, the difficulty of sample loading and unloading is reduced, burns from the ion source inlet are prevented, and the spray needle is prevented from colliding with the inlet during loading and unloading and detection, causing glass fragments to enter the mass spectrometer inlet and damage the mass spectrometer, preventing inaccurate experimental results caused by shaking or position changes of the spray needle during detection, and preventing the solution in the spray needle from moving backwards and being unable to be sprayed out from the needle tip during detection.

[0040] like Figures 1 to 3 As shown, during operation, the guide groove 201 cooperates with the guide column 102 to achieve preliminary positioning of the assembly platform 2. At this time, the unlocking area of ​​the locking rod 18 cooperates with the snap-in groove. The locking rod 18 is driven to rotate by rotating the handle 19, and the locking area is driven to cooperate with the snap-in groove to achieve locking. The X-axis moving component 6, the Y-axis moving component 7 and the Z-axis moving component 8 drive the carrier platform 4 to perform spatial displacement, thereby achieving fine-tuning and calibration of the mass spectrometry ion source device.

[0041] When other processing devices need to be installed, the driving knob 16 is used to drive the driving rod 15 to rotate, the driving rod 15 drives the second bevel gear 14 to rotate, the second bevel gear 14 drives the first bevel gear 13 to rotate, the first bevel gear 13 drives the driving wheel 12 to rotate, the driving wheel 12 drives the driven wheel 11 to rotate, the driven wheel 11 drives the rotating disk 10 to rotate, the rotating disk 10 drives the loading platform 4 to rotate within a small range, reducing the movement of the X-axis moving component 6, the Y-axis moving component 7 and the Z-axis moving component 8, and reducing the calibration difficulty.

[0042] After the processing device is installed, it drives the driving rotation direction to rotate, thereby driving the mass spectrometer ion source device back to the initial position again, and drives the carrier platform 4 to rotate within a small range through the rotating assembly, thereby reducing the difficulty of subsequent calibration and improving overall work efficiency.

[0043] The embodiments disclosed in the present utility model are preferred embodiments, but are not limited thereto. Ordinary technicians in this field can easily understand the spirit of the present utility model based on the above embodiments and make different extensions and changes. However, as long as they do not deviate from the spirit of the present utility model, they are all within the protection scope of the present utility model.

Claims

1. A mass spectrometer ion source device, arranged at the inlet of a mass spectrometer, characterized in that: include: An assembly platform detachably arranged at the injection port through a locking assembly is fixedly connected to an optical plate support platform, which is fixedly connected to a displacement assembly, which is fixedly connected to a carrier platform, and the carrier platform is fixedly connected to a spray needle and an electrode that cooperate with the injection port.

2. The mass spectrometry ion source device according to claim 1, characterized in that: The displacement assembly includes: a support platform adjustably arranged on an optical plate support platform, the support platform is fixed with an X-axis moving assembly, the X-axis moving assembly is matched with a Y-axis moving assembly, the Y-axis moving assembly is matched with an L-shaped support plate, the L-shaped support plate is fixedly connected with a Z-axis moving assembly, the Z-axis moving assembly is matched with a rotating assembly, and the rotating assembly is fixedly connected with a loading platform.

3. The mass spectrometry ion source device according to claim 2, characterized in that: The X-axis moving assembly, the Y-axis moving assembly and the Z-axis moving assembly all include: a moving platform, a displacement platform is arranged for movement in the length direction of the moving platform, the moving platform is fixedly connected to a guide rod and is rotatably arranged with a screw rod, the screw rod drives the displacement platform to move along the length direction of the guide rod, and a rotating handle is arranged on one side of the screw rod extending to the moving platform.

4. The mass spectrometry ion source device according to claim 2, characterized in that: The rotating assembly includes: a positioning shell fixedly arranged on the Z-axis moving assembly, the positioning shell being rotatably connected to a rotating disk, the rotating disk being fixedly connected to the loading platform, the rotating disk extending to the positioning shell being fixedly connected to a driven wheel, a driving wheel rotatably provided in the positioning shell and cooperating with the driven wheel, a first bevel gear being coaxially provided on the driving wheel, a second bevel gear rotatably provided in the positioning shell and cooperating with the first bevel gear, the second bevel gear being coaxially fixedly connected to a driving rod, and the driving rod extending to the outside of the positioning shell being provided with a driving knob.

5. The mass spectrometry ion source device according to claim 4, characterized in that: The positioning housing is threadably matched with a bolt, and the bolt passes through the positioning housing and abuts against the outer side wall of the rotating disk.

6. The mass spectrometry ion source device according to claim 5, characterized in that: The outer side wall of the rotating disk is provided with anti-skid patterns that contact with the bolts.

7. The mass spectrometry ion source device according to claim 1, characterized in that: The locking assembly includes: a locking part fixedly arranged at the mass spectrometer injection port, the assembly platform is fixedly connected with a locking assembly cooperating with the locking part, the mass spectrometer injection port is fixedly connected with a guide column, and the assembly platform is provided with a guide groove cooperating with the guide column.

8. The mass spectrometry ion source device according to claim 7, characterized in that: The assembly platform is provided with a positioning groove cooperating with the locking part, and the locking part is provided with a clamping groove. The locking assembly includes: a locking rod cooperating with the clamping groove, and the locking rod extends to the upper surface of the assembly platform and is provided with a rotating handle, and the rotating handle drives the locking rod to lock in the clamping groove.

9. The mass spectrometry ion source device according to claim 8, characterized in that: The locking rod is provided with a locking area and an unlocking area, and the width of the locking area is greater than the width of the unlocking area.

10. The mass spectrometry ion source device according to claim 8, characterized in that: The optical plate supporting platform is provided with a plurality of fixed workstations.

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