Rotary dumping type reagent filling device

Abstract

The utility model relates to the technical field of medical inspection equipment, in particular to a rotary dumping type reagent filling device. Comprising a translation conveying mechanism, a dumping mechanism arranged at the terminal of the translation conveying mechanism, a chip assembly bracket arranged on the other side of the dumping mechanism, and a recovery mechanism arranged below the dumping mechanism, the dumping mechanism comprises a rotating shaft, a servo motor arranged at one end of the rotating shaft and used for driving the rotating shaft to rotate and a test tube bracket fixedly connected to the rotating shaft, the servo motor is fixedly installed on a sliding block, and the sliding block is installed on a linear sliding rail in a sliding mode; the chip assembly bracket comprises a left supporting rod and a right supporting rod which are arranged in parallel. And the recovery mechanism is a belt conveyor of which the conveying direction is opposite to that of the translation conveying mechanism. The device is high in automation degree, high in cell enrichment and dyeing operation efficiency and particularly suitable for cell enrichment and dyeing operation of batch CTC chips, and the CTC detection efficiency is improved.

Description

Technical Field

[0001] This utility model relates to the field of medical testing equipment technology, specifically a rotary tilting reagent dispensing device. Background Technology

[0002] CTC, or circulating tumor cell detection, is a newly emerging tumor diagnostic technology that has gained popularity in recent years. Studies have shown that circulating tumor cells can be detected in peripheral blood before solid tumors form, making CTC detection highly suitable for early screening and diagnosis of malignant tumors. Furthermore, CTC detection has shown good results in prognosis, disease progression monitoring, recurrence prediction, postoperative monitoring of small lesions in malignant tumors, and the design and monitoring of targeted drug therapy effects, making it an advanced method for early screening and diagnosis of malignant tumors. However, due to the very low concentration of circulating tumor cells in peripheral blood, the capture and identification of circulating tumor cells in CTC detection presents a significant challenge. Another Chinese patent of the applicant, 2019103326886, discloses an integrated reaction device and method for the enrichment and staining of nucleated cells in body fluids by blotting, authorized publication number CN111855333B. This reaction device includes a microporous membrane with a fixing component, a reaction tank on the fixing component, a top cover on the reaction tank, a liftable platform on one side of the fixing component, and a storage chamber below the fixing component; the storage chamber is filled with an absorbent material. When the cell suspension passes through the microporous membrane, cells larger than the membrane pore size are retained in the reaction vessel and adsorbed onto the membrane surface due to the suction filtration and retention method. Because the water-absorbing substance has a stable suction rate, gentle attraction force, and is slow and essentially pressureless, the cells adhere to the membrane surface. This achieves the capture and enrichment of malignant cells and pathogens in body fluids. The microporous membrane in this device, also called a microfluidic chip, is a key component for enriching circulating tumor cells. Existing microporous membranes all use flexible fiber filter membranes or filter paper as filter media. For example, another Chinese patent of the applicant, 202321916277X, discloses "A Microfluidic Device and Integrated Cell Enrichment and Staining Equipment," with authorization announcement number CN220371064U, in which the microfluidic device includes: a liquid accumulation platform, a filter assembly, and a platform mesh. The liquid collection platform has a funnel-shaped internal structure with guide strips protruding from its surface for guiding the filtrate. The filtration assembly is a microfiltration membrane located above the liquid collection platform for filtering the liquid sample. During CTC testing, blood samples and test reagents need to be added to the microfluidic device one by one, which is cumbersome and inefficient. Utility Model Content

[0003] To address the problems of the prior art, this invention provides a rotary tilting reagent dispensing device capable of efficiently dispensing reagents for batch CTC chip cell enrichment and staining operations, thereby improving CTC detection efficiency.

[0004] To achieve the above objectives, this utility model provides the following technical solution:

[0005] The present invention discloses a rotary tilting reagent dispensing device, comprising a translational conveying mechanism, a tilting mechanism disposed at the end of the translational conveying mechanism, a chip assembly bracket disposed on the other side of the tilting mechanism, and a recovery mechanism disposed below the tilting mechanism. The tilting mechanism includes a rotating shaft, a servo motor disposed at one end of the rotating shaft, and a test tube bracket fixedly connected to the rotating shaft. The servo motor is fixedly mounted on a slider, and the slider is slidably mounted on a linear slide rail.

[0006] With the above structural design, when the servo motor rotates, it drives a group of test tubes on the rotating shaft to tilt and simultaneously pours reagents onto a group of chips on the chip assembly holder. This enables batch cell enrichment and staining operations for CTC chips, which is beneficial to improving CTC detection efficiency.

[0007] Preferably, the translational conveying mechanism is a belt conveyor with the conveying direction facing the rotating shaft, and the test tube holder is a folded plate with an L-shaped cross-section.

[0008] With the above structural design, the translation conveying mechanism and test tube holder are simple in structure, easy to use, and reliable in operation.

[0009] Preferably, the chip assembly bracket includes a left support rod and a right support rod arranged parallel to each other.

[0010] The above structural design incorporates parallel left and right support rods to facilitate the horizontal movement of the CTC chip assembly.

[0011] Preferably, the linear slide rail is provided with a slider driving mechanism for driving the slider to move on the linear slide rail.

[0012] The above structural design enables automatic control of the slider's movement and positioning, facilitating improved automation levels.

[0013] Preferably, a heating platform is provided between the left support rod and the right support rod, and a lifting device for driving the left and right support rods to rise and fall is provided below the left and right support rods.

[0014] Using the above structural design, the CTC chip after enrichment and staining can be pretreated by heating.

[0015] Preferably, the recycling mechanism is a belt conveyor with a conveying direction opposite to that of the translational conveying mechanism. The recycling mechanism is located between the translational conveying mechanism and the heating platform, and the linear slide rail is arranged parallel to the left support rod and the right support rod.

[0016] With the above structural design, a recycling mechanism is set up to facilitate the receipt of test tubes and test tube racks discarded from the pouring mechanism, and to collect and process the test tube racks and empty test tubes.

[0017] Compared with the prior art, the beneficial effects of this utility model are:

[0018] The translational transport mechanism, tilting mechanism, and retrieval mechanism enable batch cell enrichment and staining of CTC chips, which improves CTC detection efficiency and enhances the level of automation in CTC chip operation. Attached Figure Description

[0019] Figure 1 This is a three-dimensional structural diagram of a fixing piece according to an embodiment of the present invention.

[0020] Figure 2 This is a top view of the linear guide rail. Detailed Implementation

[0021] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0022] This utility model discloses a rotary tilting reagent dispensing device, comprising a translational conveying mechanism 1, a tilting mechanism disposed at the end of the translational conveying mechanism 1, a chip assembly bracket 5 disposed on the other side of the tilting mechanism, and a recovery mechanism 3 disposed below the tilting mechanism. The translational conveying mechanism 1 is a horizontally arranged belt conveyor used to horizontally transport test tube racks containing test tubes onto the tilting mechanism. The recovery mechanism 3 is a belt conveyor with a conveying direction opposite to that of the translational conveying mechanism 1, used to recover test tubes and test tube racks that fall from the tilting mechanism. The structure and working principle of the belt conveyor are existing technologies and will not be described in detail here.

[0023] The tilting mechanism includes a rotating shaft 2, a servo motor 6 located at one end of the rotating shaft 2 for driving its rotation, and a test tube holder 7 fixedly connected to the rotating shaft 2. The belt conveyor of the translational conveying mechanism 1 operates with its conveying direction facing the rotating shaft 2. The test tube holder 7 is an L-shaped folded plate; initially, its base plate is horizontal and close to the end of the translational conveying mechanism 1. When the test tube rack containing the test tubes moves to the end of the translational conveying mechanism 1, it can be smoothly transferred to the base plate of the test tube holder 7.

[0024] The servo motor 6 is fixedly mounted on the slider, which is slidably mounted on the linear slide rail 9. The linear slide rail 9 includes two tracks located at both ends of the rotating shaft 2. The two ends of the rotating shaft 2 are respectively mounted on the two tracks via sliders, and at least one slider is equipped with a servo motor 6 for driving the rotating shaft 2 to rotate. Additionally, the linear slide rail 9 is equipped with a slider drive mechanism for driving the slider to move on the linear slide rail 9. Figure 2 As shown, the slider driving mechanism includes a drive motor 10 fixedly mounted at one end of the linear slide rail 9, and a lead screw 8 threadedly inserted into the slider. The front end of the lead screw 8 is connected to the end of the linear slide rail 9 via a bearing, and the rear end is connected to the drive motor 10 via a coupling. The axis of the lead screw 8 is parallel to the sliding trajectory of the linear slide rail 9. When the drive motor 10 operates, it drives the lead screw 8 to rotate. When the lead screw 8 rotates, the slider mounted on the lead screw 8 drives the servo motor 6 and the rotating shaft 2 to move along the axis of the lead screw 8. Of course, as another embodiment of this utility model, other slider driving mechanisms can also be used, as long as they can accurately drive the slider to move on the linear slide rail 9.

[0025] The chip assembly bracket 5 includes a left support rod 501 and a right support rod 502 arranged parallel to each other. In use, both ends of the CTC chip assembly are supported on the left and right support rods 501 and 502 respectively to facilitate the pouring of reagents. Additionally, a heating platform 4 is provided between the left and right support rods 501 and 502 for heating the CTC chip assembly after reagent application. Below the left and right support rods 501 and 502, a lifting device 503 is provided to drive their lifting and lowering. This lifting device 503 can be a hydraulic cylinder or a screw-type lifting mechanism, used to raise or lower the height of the CTC chip assembly.

[0026] In use, test tubes containing enrichment or staining reagents are installed on a test tube rack. Multiple test tubes can be installed on the same rack, which is placed on a translational conveyor mechanism 1. The CTC chip assembly is placed on a chip assembly holder 5. After operation begins, the translational conveyor mechanism 1 operates, transferring the test tube rack to the test tube holder 7. Subsequently, the slider drive mechanism activates, moving the slider and rotating shaft 2, along with the test tube holder 7, above the CTC chip assembly. The test tube holder 7 then becomes actuated by the servo motor 6, causing the rotating shaft 2 and the test tube holder 7 to deflect at a certain angle, pouring the reagents from the test tubes onto the CTC chip assembly, completing the reagent dispensing. After reagent dispensing is complete, the servo motor 6 rotates in the opposite direction, discarding the test tubes and test tube rack onto the recovery mechanism 3. The recovery mechanism 3 collects and processes the test tube rack and empty test tubes. The servo motor 6 drives the test tube holder 7 back to its original position, and the slider drive mechanism resets the test tube holder 7, preparing for the next work cycle. After the reagent is added to the CTC chip assembly, the height of the CTC chip assembly can be lowered by the lifting device 503 and placed on the heating platform 4 for heating. This increases the temperature of the reagent in the CTC chip assembly, keeping the reagent highly reactive. After the reagent reaction is complete, the lifting device 503 raises the height of the CTC chip assembly so that it is removed from the heating platform 4, making it easier for staff to pick up the CTC chip assembly.

[0027] Contents not described in detail in this specification are existing technologies known to those skilled in the art. Although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

Claims

1. A rotary tilting reagent dispensing device, comprising a translational conveying mechanism (1), a tilting mechanism disposed at the end of the translational conveying mechanism (1), a chip assembly holder (5) disposed on the other side of the tilting mechanism, and a recovery mechanism (3) disposed below the tilting mechanism, characterized in that: The tilting mechanism includes a rotating shaft (2), a servo motor (6) disposed at one end of the rotating shaft (2), and a test tube holder (7) fixedly connected to the rotating shaft (2). The servo motor (6) is fixedly mounted on a slider, and the slider is slidably mounted on a linear slide rail (9).

2. The rotary tilting reagent dispensing device according to claim 1, characterized in that: The translational conveying mechanism (1) is a belt conveyor with the conveying direction facing the rotating shaft (2).

3. The rotary tilting reagent dispensing device according to claim 1, characterized in that: The chip assembly bracket (5) includes a left support rod (501) and a right support rod (502) arranged parallel to each other.

4. The rotary tilting reagent dispensing device according to claim 1, characterized in that: The test tube holder (7) is a folded plate with an L-shaped cross-section.

5. The rotary tilting reagent dispensing device according to claim 1 or 2, characterized in that: The linear slide rail (9) is provided with a slider driving mechanism that drives the slider to move on the linear slide rail (9).

6. The rotary tilting reagent dispensing device according to claim 3, characterized in that: A heating platform (4) is provided between the left support rod (501) and the right support rod (502), and a lifting device (503) for driving the left support rod (501) and the right support rod (502) to rise and fall is provided below them.

7. The rotary tilting reagent dispensing device according to claim 6, characterized in that: The recycling mechanism (3) is a belt conveyor with a conveying direction opposite to that of the translational conveying mechanism (1), and the recycling mechanism (3) is located between the translational conveying mechanism (1) and the heating platform (4).

8. The rotary tilting reagent dispensing device according to claim 3, characterized in that: The linear slide rail (9) is arranged parallel to the left support rod (501) and the right support rod (502).

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