Improved heparin sodium production adsorption device

Abstract

The utility model discloses an improved heparin sodium production adsorption device which comprises an equipment box body with an opening at the top end, a liquid inlet pipe and a liquid outlet pipe are respectively arranged at the two sides of the equipment box body, an electric heating plate is arranged on the inner wall of the equipment box body, a cover plate covers the upper part of the equipment box body, and a liquid outlet pipe is arranged on the upper part of the cover plate. A plurality of inserting plates are vertically and downwards mounted on the cover plate, circulating holes are formed in the inserting plates, and resin adsorption assemblies are mounted on the inserting plates; the utility model has the beneficial effects that the serpentine channel is designed as an adsorption channel of the heparin sodium enzymatic hydrolysate, and the resin adsorption component is designed in the serpentine channel, so that the circulation path and the circulation time of the heparin sodium enzymatic hydrolysate are greatly increased, the heparin sodium enzymatic hydrolysate is fully contacted with resin, the adsorption effect is ensured, and the service life of the heparin sodium enzymatic hydrolysate is prolonged. And meanwhile, the resin adsorption assembly can well protect the vertical particles from being damaged, the reuse efficiency of the resin particles is improved, and the device is worthy of large-scale application and popularization.

Description

TECHNICAL FIELD

[0001] The utility model relates to heparin sodium production adsorption equipment technical field especially relates to an improved heparin sodium production adsorption device. BACKGROUND

[0002] Heparin sodium is an anticoagulant, can interfere with the many links of blood coagulation process, heparin sodium is extracted from the small intestine mucosa of animals, and its production extraction process includes scraping intestine, enzymolysis, resin adsorption, cleaning, elution, drying and other processes, wherein the resin adsorption process refers to adsorbing heparin sodium in the enzymolysis liquid to the resin, so as to achieve the effect of separating heparin sodium, in the prior art, the resin adsorption tank is usually used for this process step, and the existing vertical adsorption tank includes a tank body, resin adsorption particles are placed in the tank body, heating coil and stirring device are arranged in the tank body, so that the enzymolysis liquid and the adsorption resin are fully mixed to realize heparin sodium adsorption, but the adsorption tank with the above structure has the following problems after long time use: 1, the stirring device is easy to adhere to impurities and is difficult to clean; 2, the stirring device is circumferentially stirred, so that the resin particles are not evenly distributed, and the number of resin particles in the lower layer of the tank body is obviously more than that in the upper layer; 3, the resin is damaged and worn out after long time collision with the stirring device, the recycling use life is low, and the subsequent filtration process is affected. UTILITY MODEL CONTENTS

[0003] The utility model aims at providing an improved heparin sodium production adsorption device to solve the technical problems of the resin adsorption tank in the prior art, such as difficult cleaning of the stirring device, uneven distribution of the resin and low recycling rate of the resin.

[0004] The utility model relates to an improved heparin sodium production adsorption device, which comprises a device box body with an open top, liquid inlet pipes and liquid outlet pipes are respectively installed at both sides of the device box body, an electric heating plate is installed on the inner wall of the device box body, a cover plate is arranged above the device box body, a plurality of plug boards are vertically and downwardly installed on the cover plate, flow-through holes are formed in the plug boards, the flow-through holes in any two adjacent plug boards are arranged in a staggered manner, the plug boards and the flow-through holes form a serpentine channel in the inner cavity of the device box body, and a resin adsorption assembly is installed on the plug boards.

[0005] Further, two rows of limiting rods are sequentially installed on the plug boards from top to bottom, and the resin adsorption assembly is located between the two rows of limiting rods.

[0006] Further, the resin adsorption assembly comprises an adsorption box body, sealing covers are installed at both ends of the adsorption box body, resin particles are contained in the adsorption box body, and through holes are formed in the sealing covers.

[0007] Furthermore, several sealing grooves are provided on the equipment housing, and sealing rings are installed in the sealing grooves.

[0008] Furthermore, sealing gaskets are provided between the top of the equipment housing and the cover plate, and between the insert plate and the inner wall of the equipment housing.

[0009] Furthermore, mounting plates are installed on both sides of the equipment housing, and cylinders are vertically mounted on the mounting plates, with the piston rods of the cylinders connected to the cover plates.

[0010] The beneficial effects of this invention are as follows: This invention designs a serpentine channel as the adsorption channel for heparin sodium hydrolysate, and designs a resin adsorption component within the serpentine channel, thereby significantly increasing the flow path and flow time of the heparin sodium hydrolysate, allowing the heparin sodium hydrolysate to fully contact the resin and ensuring the adsorption effect. At the same time, the resin adsorption component can effectively protect the vertical particles from damage, improve the reuse efficiency of the resin particles, save energy and reduce emissions, and is worthy of widespread promotion and use. Attached image description:

[0011] Figure 1 This is a cross-sectional view of the present invention;

[0012] Figure 2 This is a partial three-dimensional view of the structure of this utility model;

[0013] Figure 3 This is a three-dimensional view of the resin adsorption component;

[0014] In the diagram, the components are: 1. Equipment housing; 2. Cover plate; 3. Insert plate; 4. Flow hole; 5. Limiting rod; 6. Adsorption box; 7. Encapsulation cover; 8. Through hole; 9. Resin particles; 10. Cylinder; 11. Sealing ring; 12. Liquid inlet pipe; 13. Liquid outlet pipe; and 14. Heating plate. Detailed implementation method:

[0015] like Figure 1 As shown, an improved adsorption device for producing heparin sodium includes a top-opening housing 1. An inlet pipe 12 and an outlet pipe 13 are installed on both sides of the housing 1. An electric heating plate 14 is installed on the inner wall of the housing 1. A cover plate 2 covers the top of the housing 1. Several insert plates 3 are vertically mounted downwards on the cover plate 2. Flow holes 4 are formed on the insert plates 3, with any two adjacent insert plates 3 having staggered flow holes 4. The insert plates 3 and the flow holes 4 form a serpentine channel within the housing 1. A resin adsorption assembly is installed on the insert plates 3. To improve sealing, sealing gaskets are provided between the top of the housing 1 and the cover plate 2, and between the insert plates 3 and the inner wall of the housing 1.

[0016] likeFigure 2 and Figure 3 As shown, two rows of limiting rods 5 are installed sequentially from top to bottom on the insert plate 3, and the resin adsorption assembly is located between the two rows of limiting rods 5; the resin adsorption assembly includes an adsorption box 6, and sealing caps 7 are installed at both ends of the adsorption box 6. Resin particles 9 are placed inside the adsorption box 6, and through holes 8 are opened on the sealing caps 7; a number of sealing grooves are opened on the equipment box 1, and sealing rings 11 are installed in the sealing grooves.

[0017] To facilitate the installation and disassembly of the resin adsorption components, such as Figure 1 As shown, mounting plates are installed on both sides of the equipment housing 1, and cylinders 10 are vertically mounted on the mounting plates. The piston rod of the cylinder 10 is connected to the cover plate 2.

[0018] Working principle: such as Figures 1 to 3 As shown, the heating plate 14 is turned on for heating, and the heparin sodium enzymatic hydrolysate is introduced into the equipment housing 1 through the inlet pipe 12 by the liquid pump. The heparin sodium enzymatic hydrolysate flows through each flow hole 4 in sequence, and then flows through each resin adsorption component for resin adsorption. After the resin adsorption is completed, the remaining liquid is discharged from the drain pipe 13. Then, the washing liquid is pumped in from the drain pipe 13 and flows through each resin adsorption component in sequence, so that the heparin sodium dissolves in the washing liquid, thus completing the separation of heparin sodium. After a period of use, the cylinder 10 can be activated to open the cover plate 2, thereby exposing the resin adsorption components for easy replacement.

[0019] The above are merely preferred embodiments of the present utility model and are not intended to limit the present utility model. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present utility model shall be included within the protection scope of the present utility model.

Claims

1. An improved heparin sodium production adsorption device, characterized by: It include the device box (1) of top opening, install liquid inlet pipe (12) and liquid outlet pipe (13) respectively in both sides position of the device box (1), install electric heating plate (14) on the inner wall of the device box (1), cover with cover plate (2) above the device box (1), install several plug-in board (3) vertically downwards on the cover plate (2), open through hole (4) on the plug-in board (3), the through hole (4) on any two adjacent plug-in board (3) staggered arrangement, the plug-in board (3), the through hole (4) make the inner chamber of the device box (1) form serpentine channel, install resin adsorption assembly on the plug-in board (3).

2. An improved heparin sodium production adsorption device as claimed in claim 1, wherein: Two rows of limiting rods (5) are installed on the plug-in board (3) from top to bottom in turn, and the resin adsorption assembly is located between the two rows of limiting rods (5).

3. An improved heparin sodium production adsorption device as claimed in claim 2, wherein: The resin adsorption assembly includes an adsorption box (6), sealing covers (7) are installed at both ends of the adsorption box (6), resin particles (9) are contained in the adsorption box (6), and through holes (8) are formed in the sealing covers (7).

4. The improved heparin sodium production adsorption device according to claim 3, characterized in that: A plurality of sealing grooves are formed in the device box (1), and sealing rings (11) are installed in the sealing grooves.

5. The improved heparin sodium production adsorption device as claimed in claim 1, wherein: Sealing pads are arranged between the top end of the device box (1) and the cover plate (2), and between the plug-in board (3) and the inner wall of the device box (1).

6. An improved heparin sodium production adsorption device as claimed in any one of claims 1 to 5, wherein: Mounting plates are installed at both sides of the device box (1), air cylinders (10) are vertically installed on the mounting plates, and piston rods of the air cylinders (10) are connected with the cover plate (2).

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