Microsphere cleaning and screening device
By combining a multi-stage sieving device and a spraying device, the problems of difficult diameter control and surface adhesion removal during the microsphere preparation process are solved, achieving efficient sieving and cleaning of microspheres and ensuring the purity and diameter differentiation of microspheres.
Patent Information
- Application Number
- CN202520511651.0
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2025-03-21
- Publication Date
- 2026-02-27
- Estimated Expiration
- 2035-03-21
AI Technical Summary
In the existing technology, the diameter of microspheres is difficult to control during the preparation process, the amount of drug absorbed is uneven, and the debris and active agent adhering to the surface of the microspheres are difficult to clean.
A multi-stage sieving device is used for rotary centrifugal sieving, combined with a spray device to clean the microspheres. The rotating rod drives the multi-stage filter plates for sieving and cleaning, and the centrifugal force and guide plates are used to disperse the microspheres, ensuring cleaning effect and diameter differentiation.
It achieves effective sieving and cleaning of microspheres, ensuring that the surfactants in the microspheres are thoroughly removed, and can collect microspheres of different diameters separately, facilitating subsequent processing.
Smart Images
Figure CN223946117U_ABST
Abstract
Description
TECHNICAL FIELD
[0001] The utility model relates to microsphere production technical field, concretely is a kind of microsphere cleaning and screening device. BACKGROUND
[0002] Microsphere refers to the microparticle dispersion system formed by drug dispersion or being adsorbed in high molecular, polymer matrix, and the carrier material for preparing microsphere is various, mainly divided into natural high molecular microsphere (such as starch microsphere, albumin microsphere, gelatin microsphere, chitosan etc.) and synthetic polymer microsphere (such as polylactic acid microsphere), and the preparation method of drug-loaded microsphere is various, and the common preparation method includes solvent evaporation method, hot, hot melt extrusion grinding method, spray drying method, phase separation method, microfluidic technology etc., and currently solvent evaporation method is to dissolve drug and polymer or other auxiliary materials, to obtain microsphere product loaded with raw drug, then the product is washed with water, to obtain granular microsphere, and the drug distribution state and particle size can be adjusted by dissolving concentration and emulsification condition.
[0003] But in prior art, the diameter of microsphere prepared in the preparation process of microsphere for injection has certain difference, the average of drug suction amount is not easy to control during subsequent drug packaging, thereby affecting the use of microsphere, and a certain amount of debris and active agent is attached to the surface of prepared microsphere, which is not easy to clean. UTILITY MODEL CONTENT
[0004] The technical problem to be solved by the utility model is to overcome the deficiency of prior art, provide a kind of microsphere cleaning and screening device, by the multiple-stage screening device, the microsphere is rotated and centrifuged and screened, and the spraying device is matched with the spraying work of microsphere, can ensure that the broken microsphere and the active agent on the surface of microsphere are completely cleaned, and different diameter microspheres can be collected separately.
[0005] To achieve the above object, the utility model provides the following technical scheme:
[0006] A kind of microsphere cleaning and screening device, including box body, the bottom of the box body is provided with support leg, the top of the box body has top cover, the inside of the box body is provided with rotatable multiple-stage screening device, the top cover is provided with the drive device capable of driving multiple-stage screening device, the upper portion of the sidewall of the box body is provided with spraying device, the side of the box body is provided with multiple discharge outlets capable of cooperating with multiple-stage screening device, the top cover is provided with feed pipe, the bottom of the box body is provided with discharge pipe;The multiple-stage screening device includes rotating rod, the axis of the rotating rod coincides with the axis of the top cover, the axis of the top cover is installed with rotating rod by bearing, the first filter plate and the second filter plate are sequentially arranged on the rotating rod from middle portion downwards, the filter hole diameter on the first filter plate is greater than the filter hole diameter on the second filter plate, and the top of the rotating rod is matched with the drive device.
[0007] Preferably, the driving device comprises a motor, and a power output end of the motor is connected with the top end of the rotating rod through a transmission belt.
[0008] Preferably, the diameters of the first filter plate and the second filter plate are matched with the inner diameter of the box body, and the upper surfaces of the first filter plate and the second filter plate are provided with a plurality of arc-shaped guide plates.
[0009] Preferably, the spraying device comprises a liquid inlet pipe, and a spray head in communication with the liquid inlet pipe is arranged above the inside of the box body.
[0010] Preferably, the side wall of the box body is respectively provided with a first discharge port and a second discharge port, the horizontal height of the first discharge port is the same as the horizontal height of the first filter plate, and the horizontal height of the second discharge port is the same as the horizontal height of the second filter plate.
[0011] Preferably, the end of the arc-shaped guide plate away from the rotating rod is provided with a scraping piece capable of abutting against the inner wall of the box body.
[0012] Preferably, the bottom of the box body is a conical structure, the discharge pipe is located at the bottom end of the conical structure, and the discharge pipe is provided with a valve.
[0013] Preferably, the side of the box body is provided with an observation window, and the observation window is made of tempered glass.
[0014] Preferably, the top of the box body is provided with a vibrator, a power output end of the vibrator is capable of being connected with the top end of the rotating rod, and the driving device is capable of being connected with the vibrator.
[0015] Compared with the prior art, the utility model has the advantages that:
[0016] 1、The utility model discloses a simple structure, under the drive of the driving device, the first filter plate and the second filter plate are driven by the rotating rod to rotate synchronously, because the microspheres fall on the position close to the circle of the first filter plate, when the first filter plate rotates, the subsequent microspheres can be avoided to gather on the first filter plate, the centrifugal force when the first filter plate rotates can drive the microspheres to move and disperse on the first filter plate to the edge of the first filter plate, the microspheres with smaller diameters and chippings fall to the second filter plate through the filter holes on the first filter plate, and the second filter plate rotates synchronously with the rotating rod, and the centrifugal force of the second filter plate drives the microspheres and chippings to move and disperse on the second filter plate to the edge of the second filter plate, and smaller chippings fall to the bottom of the box body through the filter holes on the second filter plate.
[0017] 2. When the microspheres are sieved using the first and second filter plates, the spray device is activated to thoroughly clean the microspheres on the first filter plate. The cleaning solution falls through the filter holes of the first filter plate into the second filter plate, continuing to clean the microspheres on the second filter plate. This ensures that the surfactants adhering to the surface of the microspheres are cleaned while they are being sieved. The upper surfaces of both the first and second filter plates are equipped with multiple arc-shaped guide plates to guide the movement of the microspheres, increasing their movement path and ensuring effective sieving. At the same time, the end of the guide plate away from the rotating rod contacts the housing. Under the rotation of the first and second filter plates, all the microspheres disperse and move to the edges of the first and second filter plates. Through the drive of the guide plates and the cooperation of centrifugal force, the sieved microspheres are discharged from the housing as they pass through multiple discharge ports on the side of the housing. The sieved microspheres are collected separately, facilitating the differentiation of microspheres of different diameters for subsequent processing.
[0018] 3. The microspheres screened by the first filter plate move towards the outer edge of the first filter plate as it rotates. Since the horizontal height of the first discharge port is the same as that of the first filter plate, the microspheres on the first filter plate are easily discharged from the box through the first discharge port under the action of centrifugal force generated by the rotation of the first filter plate, and collected separately. Similarly, the microspheres screened by the second filter plate move towards the outer edge of the second filter plate as it rotates. Since the horizontal height of the second discharge port is the same as that of the second filter plate, the microspheres on the second filter plate are easily discharged from the box through the second discharge port under the action of centrifugal force generated by the rotation of the second filter plate, and collected separately. This distinguishes microspheres of different diameters and collects them separately.
[0019] 4. By setting scrapers on the outer edge of the guide plate, this device can not only ensure that the scrapers drive the microspheres on the first filter plate and the second filter plate to move towards the first discharge port and the second discharge port respectively, but also avoid damage to the guide plate or the inside of the box, thus ensuring the service life of this device.
[0020] 5. This device uses a vibrator installed at the top of the rotating rod, which is driven by a drive device to rotate. This ensures that the first and second filter plates can rotate to centrifuge and disperse the microspheres. At the same time, the vibration of the vibrator improves the screening efficiency of the microspheres, thereby enhancing the practicality of the device. Attached Figure Description
[0021] Figure 1 This is a schematic diagram of the overall structure of the present invention. Figure 1 ;
[0022] Figure 2 This is a schematic diagram of the overall structure of the present invention. Figure 2 ;
[0023] Figure 3 It is a sectional view of the utility model.
[0024] In the figure: 1, box; 2, motor; 3, vibrator; 4, rotating rod; 5, first filter plate; 6, second filter plate; 7, guide plate; 8, liquid inlet pipe; 9, spray head; 10, feed pipe; 11, hopper; 12, first discharge port; 13, second discharge port; 14, discharge pipe; 15, supporting leg; 16, observation window; 17, transmission belt. DETAILED DESCRIPTION
[0025] The technical solutions in the embodiments of the utility model will be clearly and completely described below with reference to the drawings in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model and not all the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by those skilled in the art without creative labor fall within the protection scope of the utility model.
[0026] Embodiment one
[0027] A kind of microsphere cleaning screening device, structure as Figures 1-3 As shown in the figure, including box 1, the bottom of the box 1 is provided with supporting leg 15, the top of the box 1 has top cover, the inside of the box 1 is provided with rotatable multistage screening device, the top cover is provided with driving device capable of driving multistage screening device, the upper portion of the sidewall of the box 1 is provided with spray device, the side of the box 1 is provided with multiple discharge ports capable of cooperating with multistage screening device, the top cover is provided with feed pipe 10, the bottom of the box 1 is provided with discharge pipe 14;The multistage screening device includes rotating rod 4, the axis of the rotating rod 4 coincides with the axis of the top cover, the axis of the top cover is provided with rotating rod 4 by bearing, the rotating rod 4 is sequentially provided with first filter plate 5 and second filter plate 6 from the middle downwards, the filter hole diameter on the first filter plate 5 is greater than the filter hole diameter on the second filter plate 6, and the top of the rotating rod 4 is matched with the driving device.The diameters of the first filter plate 5 and the second filter plate 6 are adapted to the inner diameter of the box 1, and the upper surfaces of the first filter plate 5 and the second filter plate 6 are provided with a plurality of arc-shaped guide plates 7.
[0028] The top of the feeding pipe 10 is a funnel 11, which facilitates the infusion of microspheres into the box 1 when screening and washing the microspheres are needed. Since the bottom end of the feeding pipe 10 is located above the first filter plate 5 near the center of the circle, the first filter plate 5 and the second filter plate 6 can be driven to rotate synchronously by the driving device. Since the microspheres fall on the first filter plate 5 near the center of the circle, the subsequent microspheres can be prevented from gathering on the first filter plate 5 when the first filter plate 5 rotates. The centrifugal force of the first filter plate 5 during rotation can drive the microspheres to move away from the center of the first filter plate 5 to the edge of the first filter plate 5. The microspheres with smaller diameters and debris fall through the filter holes of the first filter plate 5 to the second filter plate 6.
[0029] Similarly, the second filter plate 6 rotates synchronously with the rotating rod 4, and the centrifugal force of the second filter plate 6 drives the microspheres and debris to move away from the center of the second filter plate 6 to the edge of the second filter plate 6. The smaller debris falls through the filter holes of the second filter plate 6 to the bottom of the box 1.
[0030] When the first filter plate 5 and the second filter plate 6 screen the microspheres, the spraying device is started to wash the microspheres on the first filter plate 5. The washing liquid falls through the filter holes of the first filter plate 5 to the second filter plate 6 to continue washing the microspheres on the second filter plate 6, ensuring that the microspheres are screened and the active agents attached to the surface of the microspheres are washed clean.
[0031] The upper surfaces of the first filter plate 5 and the second filter plate 6 are provided with a plurality of arc-shaped flow guides 7, which can guide the movement of the microspheres, increase the movement path of the microspheres, and ensure effective screening of the microspheres. The end of the flow guide 7 away from the rotating rod 4 is in contact with the box 1. Under the rotation of the first filter plate 5 and the second filter plate 6, all the microspheres move away from the center to the edge of the first filter plate 5 and the second filter plate 6. With the cooperation of the flow guide 7 and the centrifugal force, the screened microspheres can be discharged from the box 1 when passing through the multiple discharge ports on the side of the box 1. The screened microspheres can be collected separately to facilitate the subsequent processing of microspheres with different diameters.
[0032] The driving device includes a motor 2, and the power output end of the motor 2 is connected to the top end of the rotating rod 4 through a transmission belt 17.
[0033] When the first filter plate 5 and the second filter plate 6 need to rotate synchronously, the motor 2 is started to drive the top end of the rotating rod 4 to move through the transmission belt 17, ensuring that the first filter plate 5 and the second filter plate 6 rotate synchronously to screen the microspheres.
[0034] The spraying device comprises a liquid inlet pipe 8, and a spray head 9 is arranged on the upper portion of the box 1 and connected with the liquid inlet pipe 8.
[0035] One end of the liquid inlet pipe 8 is connected with an external cleaning agent storage barrel, and under the working of an external pump body, the cleaning agent in the cleaning agent storage barrel is transported to the spray head 9 through the liquid inlet pipe 8, and the microspheres in the box 1 can be sprayed and washed through the spray head 9, so as to ensure that the active agent on the surface of the microspheres is completely cleaned.
[0036] The side wall of the box 1 is respectively provided with a first discharge port 12 and a second discharge port 13, the horizontal height of the first discharge port 12 is the same as that of the first filter plate 5, and the horizontal height of the second discharge port 13 is the same as that of the second filter plate 6.
[0037] The microspheres screened by the first filter plate 5 move to the outer edge of the first filter plate 5 under the rotation of the first filter plate 5, and since the horizontal height of the first discharge port 12 is the same as that of the first filter plate 5, the microspheres on the first filter plate 5 can be discharged from the box 1 through the first discharge port 12 under the action of the centrifugal force generated by the rotation of the first filter plate 5, and the microspheres are collected separately; similarly, the microspheres screened by the second filter plate 6 move to the outer edge of the second filter plate 6 under the rotation of the second filter plate 6, and since the horizontal height of the second discharge port 13 is the same as that of the second filter plate 6, the microspheres on the second filter plate 6 can be discharged from the box 1 through the second discharge port 13 under the action of the centrifugal force generated by the rotation of the second filter plate 6, and the microspheres are collected separately, so that the microspheres with different diameters are distinguished and collected separately.
[0038] The arc-shaped flow guide plate 7 is provided with a scraping piece at the end away from the rotating rod 4, and the scraping piece can abut against the inner wall of the box 1.
[0039] The scraping piece can ensure that the microspheres on the first filter plate 5 and the second filter plate 6 move to the first discharge port 12 and the second discharge port 13, respectively, and can avoid damage to the flow guide plate 7 or the box 1, so as to ensure the service life of the device.
[0040] The bottom of the box 1 is a conical structure, the discharge pipe 14 is located at the bottom end of the conical structure, and the discharge pipe 14 is provided with a valve.
[0041] The conical structure can ensure that the debris and cleaning agent at the bottom of the box 1 are quickly discharged from the box 1, and when the valve at the discharge pipe 14 is opened, the debris and cleaning agent accumulated at the bottom of the box 1 can be quickly discharged from the box 1.
[0042] The side surface of the box 1 is provided with an observation window 16, and the observation window 16 is made of tempered glass.
[0043] Through the observation window 16, the operator can clearly observe the working condition inside the box 1, so that the problem inside the box 1 can be observed in time, the microsphere screening and cleaning work can be stopped quickly, and the subsequent problem can be avoided from being expanded, and the normal microsphere screening and cleaning work can be affected.
[0044] Embodiment two
[0045] On the basis of the embodiment one, the vibrator 3 is arranged on the top of the box 1, the power output end of the vibrator 3 is connected with the top end of the rotating rod 4, and the driving device is connected with the vibrator 3.
[0046] Although the microspheres can be screened under the rotation of the first filter plate 5 and the second filter plate 6, in order to further improve the screening effect of the microspheres, the vibrator 3 is arranged on the top of the rotating rod 4, the vibrator 3 is driven to rotate by the driving device, the first filter plate 5 and the second filter plate 6 can rotate to centrifugally screen and disperse the microspheres, and the screening efficiency of the microspheres is improved by the vibration of the vibrator 3, so that the practicability of the device is improved.
[0047] The above is only the preferred embodiment of the present application, but the protection scope of the present application is not limited to this, any skilled person in the art can easily think of the changes or additions and replacements within the technical range disclosed by the present application, which should be covered in the protection scope of the present application. Therefore, the protection scope of the present application should be subject to the protection scope of the claims.
Claims
1. A microsphere cleaning and screening device, comprising a box (1) provided with supporting legs (15) at the bottom and a top cover at the top, characterized in that, The box (1) is internally provided with a rotatable multi-stage screening device, the top cover is provided with a driving device capable of driving the multi-stage screening device, the side wall of the box (1) is provided with a spraying device, the side of the box (1) is provided with a plurality of discharge ports capable of cooperating with the multi-stage screening device, the top cover is provided with a feeding pipe (10), and the bottom of the box (1) is provided with a discharge pipe (14); the multi-stage screening device comprises a rotating rod (4), the axis of the rotating rod (4) coincides with the axis of the top cover, the rotating rod (4) is installed at the axis of the top cover through a bearing, the rotating rod (4) is sequentially provided with a first filter plate (5) and a second filter plate (6) downward from the middle part, the filter hole diameter of the first filter plate (5) is larger than that of the second filter plate (6), and the top of the rotating rod (4) is matched with the driving device.
2. A microsphere cleaning and sizing apparatus according to claim 1, wherein, The driving device comprises a motor (2), and the power output end of the motor (2) is connected with the top end of the rotating rod (4) through a transmission belt (17).
3. A microsphere cleaning and sizing device according to claim 1, wherein, The diameters of the first filter plate (5) and the second filter plate (6) are adapted to the inner diameter of the box (1), and the upper surfaces of the first filter plate (5) and the second filter plate (6) are provided with a plurality of arc-shaped guide plates (7).
4. The microsphere cleaning and sizing device of claim 1, wherein, The spraying device comprises a liquid inlet pipe (8), and the inside of the box (1) is provided with a spray head (9) in communication with the liquid inlet pipe (8).
5. The microsphere cleaning and sizing device of claim 1, wherein, The side wall of the box (1) is respectively provided with a first discharge port (12) and a second discharge port (13), the horizontal height of the first discharge port (12) is the same as that of the first filter plate (5), and the horizontal height of the second discharge port (13) is the same as that of the second filter plate (6).
6. A microsphere cleaning and sizing apparatus according to claim 3, wherein, The end of the guide plate (7) away from the rotating rod (4) is provided with a scraping piece capable of abutting against the inner wall of the box (1).
7. The microsphere cleaning and sizing device of claim 1, wherein, The bottom of the box (1) is a conical structure, the discharge pipe (14) is located at the bottom end of the conical structure, and the discharge pipe (14) is provided with a valve.
8. The microsphere cleaning and sizing apparatus of claim 1, wherein, The side of the box (1) is provided with an observation window (16) made of tempered glass.
9. The microsphere cleaning and sizing device of claim 1, wherein, The top of the box (1) is provided with a vibrator (3), the power output end of the vibrator (3) is capable of being connected with the top end of the rotating rod (4), and the driving device is capable of being connected with the vibrator (3).