Tumor tissue cleaning device

Abstract

The utility model provides a tumor tissue cleaning device, which relates to the technical field of medical supplies and particularly comprises a support, a cleaning part and a filtering part. When the cleaning device is used, the cleaning piece is placed on the supporting part of the support, the sealing cover at the feeding opening is taken down, then a tumor tissue block is placed into the cleaning container through the feeding opening, the tumor tissue block enters the cleaning space and stays on the filtering piece, and then tissue cleaning liquid is introduced through the feeding opening to conduct immersion cleaning on the tumor tissue block. Waste liquid obtained after washing passes through the filtering part and then is discharged out of the washing container through the liquid outlet part, and the tumor tissue blocks are left on the filtering part, so that washing of the tumor tissue blocks is achieved, centrifugal operation is not needed, solid-liquid separation is achieved through the filtering part, washing is convenient, and the washing efficiency is high.

Description

Technical Field

[0001] This utility model relates to the field of medical supplies technology, and more specifically, to a tumor tissue cleaning device. Background Technology

[0002] Tumor-infiltrating lymphocytes (TILs) are infiltrating lymphocytes isolated from tumor tissue.

[0003] Unlike blood-derived cells, TILs originate from within tumor tissue. In practice, many tumor tissues themselves are heavily contaminated with microorganisms, such as those from cervical cancer, ovarian cancer, gastrointestinal tumors, and lung cancer. Furthermore, even non-strictly aseptic surgical procedures can contaminate tumor tissue. Therefore, solid tumor tissue needs to be washed before TIL culture begins to minimize the possibility of such contamination.

[0004] Conventional tumor tissue cleaning methods typically involve washing tumor tissue blocks with tissue cleaning solution in centrifuge tubes, followed by centrifugation, discarding the supernatant, and repeating this process multiple times to obtain a clean tumor tissue sample. However, this cleaning method requires repeated steps to thoroughly clean the tumor tissue blocks, making it very tedious and time-consuming. Utility Model Content

[0005] The purpose of this invention is to provide a tumor tissue cleaning device to alleviate the technical problem that the existing cleaning methods require repeated cleaning, which is very cumbersome and time-consuming.

[0006] This utility model provides a tumor tissue cleaning device, comprising: a support, a cleaning component, and a filter; the support has a supporting portion; the cleaning component is disposed on the supporting portion and includes a cleaning container and a cap, the cleaning container has a cleaning space, the upper part of the cleaning space is connected to a dispensing port, the bottom of the cleaning container is provided with a liquid outlet, and the cap is adapted to the dispensing port; the filter is disposed in the cleaning space and located below the dispensing port.

[0007] Furthermore, the tumor tissue cleaning device also includes a flow guiding component; the flow guiding component includes a liquid guiding tube and a switching valve, one end of the liquid guiding tube is connected to the liquid outlet, and the switching valve is located on the liquid guiding tube.

[0008] Furthermore, the tumor tissue cleaning device also includes a liquid collection component; the liquid collection component is connected to the other end of the liquid guide tube.

[0009] Furthermore, the liquid collection device is a collection bag; the opening of the collection bag is connected to the liquid guiding tube.

[0010] Furthermore, the bracket includes: a base, a support frame, and a load-bearing component; one end of the support frame is connected to the base and is mounted on the base; the load-bearing component is located at the other end of the support frame, and the load-bearing part is located on the load-bearing component.

[0011] Furthermore, the base is a flat plate structure; the support frame is located at the midpoint of one side of the flat plate structure; the bearing member is located on the support frame and extends in the same direction as the base.

[0012] Furthermore, the cleaning container is a cleaning bottle; the outer diameter of the cleaning bottle gradually decreases from the top to the bottom, or the bottom of the cleaning bottle has a tapered structure; the supporting part is an insertion hole, and the cleaning bottle is detachably inserted into the insertion hole.

[0013] Furthermore, a secondary hole is provided on one side of the insertion hole; one end of the secondary hole is connected to the insertion hole, and the other end is located at the edge of the support member and has an open structure.

[0014] Furthermore, the mouth of the cleaning bottle is the dispensing port; the cap is threaded into the mouth of the bottle.

[0015] Furthermore, the filter element is a filter membrane.

[0016] Beneficial effects:

[0017] The tumor tissue cleaning device provided by this utility model has a small overall size, making it easy to move and place. In use, the cleaning component is placed on the support of the bracket, the cap at the inlet is removed, and then the tumor tissue block is placed into the cleaning container through the inlet. The tumor tissue block enters the cleaning space and remains on the filter. Then, tissue cleaning solution is introduced through the inlet to immerse the tumor tissue block. The waste liquid after washing passes through the filter and is discharged outside the cleaning container through the outlet. The tumor tissue block remains on the filter, thereby achieving the cleaning of the tumor tissue block without the need for centrifugation. Solid-liquid separation is achieved through the filter, making cleaning convenient and highly efficient. Attached Figure Description

[0018] To more clearly illustrate the specific embodiments of this utility model or the technical solutions in the prior art, the drawings used in the description of the specific embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are some embodiments of this utility model. For those skilled in the art, other drawings can be obtained from these drawings without creative effort.

[0019] Figure 1 This is a schematic diagram of the structure of the tumor tissue cleaning device provided in an embodiment of the present invention;

[0020] Figure 2This is a schematic diagram of the structure of the scaffold in the tumor tissue cleaning device provided in this embodiment of the utility model;

[0021] Figure 3 A top view of the scaffold in the tumor tissue cleaning device provided in this embodiment of the utility model;

[0022] Figure 4 This is a schematic diagram showing the connection relationship between the cleaning component, the filter component, and the liquid collection component in the tumor tissue cleaning device provided in this embodiment of the utility model.

[0023] icon:

[0024] 100 - Bracket; 110 - Base; 120 - Support frame; 130 - Bearing component; 131 - Insertion hole; 132 - Secondary hole;

[0025] 200 – Cleaning part; 210 – Cleaning container; 220 – Cap;

[0026] 300 - Filter element;

[0027] 400 – Flow guiding assembly; 410 – Liquid guiding tube; 420 – Switch valve;

[0028] 500 - Liquid collection unit. Detailed Implementation

[0029] To make the objectives, technical solutions, and advantages of the embodiments of this utility model clearer, the technical solutions of the embodiments of this utility model will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this utility model, and not all embodiments. The components of the embodiments of this utility model described and shown in the accompanying drawings can generally be arranged and designed in various different configurations.

[0030] Therefore, the following detailed description of the embodiments of the present invention provided in the accompanying drawings is not intended to limit the scope of the claimed invention, but merely to illustrate selected embodiments of the invention. All other embodiments obtained by those skilled in the art based on the embodiments of the present invention without inventive effort are within the scope of protection of the present invention.

[0031] It should be noted that similar labels and letters in the following figures indicate similar items. Therefore, once an item is defined in one figure, it does not need to be further defined and explained in subsequent figures.

[0032] In the description of this utility model, it should be noted that the terms "center," "upper," "lower," "left," "right," "vertical," "horizontal," "inner," and "outer," etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings, or the orientation or positional relationship commonly used when the product of this utility model is in use. They are only for the convenience of describing this utility model and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this utility model. In addition, the terms "first," "second," and "third," etc., are only used to distinguish descriptions and should not be construed as indicating or implying relative importance.

[0033] Furthermore, terms such as "horizontal" and "vertical" do not imply that components must be absolutely horizontal or suspended, but rather that they can be slightly tilted. For example, "horizontal" simply means that its direction is more horizontal than "vertical," and does not mean that the structure must be completely horizontal, but can be slightly tilted.

[0034] In the description of this utility model, it should also be noted that, unless otherwise explicitly specified and limited, the terms "set," "install," "connect," and "link" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection of two components. Those skilled in the art can understand the specific meaning of the above terms in this utility model based on the specific circumstances.

[0035] The present invention will now be described in further detail with reference to specific embodiments and accompanying drawings.

[0036] See Figures 1 to 4 The tumor tissue cleaning device provided in this embodiment includes a support 100, a cleaning component 200, and a filter component 300.

[0037] The support 100 has a supporting portion. The cleaning component 200 is located on the supporting portion and includes a cleaning container 210 and a cap 220. The cleaning container 210 has a cleaning space, with a dispensing port connected to the top of the cleaning space. The bottom of the cleaning container 210 has a liquid outlet, and the cap 220 is adapted to the dispensing port. The filter component 300 is located in the cleaning space and below the dispensing port.

[0038] Specifically, in use, the tumor tissue cleaning device is first installed by placing the support on a flat structure such as a table or workbench, and then placing the cleaning component 200 on the support of the bracket 100 to fix the cleaning component 200 stably on the support, thereby realizing the installation of the tumor tissue cleaning device.

[0039] When cleaning tumor tissue blocks, first remove the cap 220 at the inlet, then place the tumor tissue block into the cleaning container 210 through the inlet. The tumor tissue block enters the cleaning space and remains on the filter element 300. Then, tissue cleaning solution is introduced through the inlet to immerse the tumor tissue block. The waste liquid after washing flows downward under gravity, passes through the filter element 300, and is discharged outside the cleaning container 210 through the outlet. The tumor tissue block remains on the filter element 300, thus achieving the cleaning of the tumor tissue block.

[0040] The tumor tissue cleaning device provided in this embodiment is small in size, easy to move and place, and does not require centrifugation during cleaning. Solid-liquid separation is achieved through the filter element 300, making cleaning convenient and efficient.

[0041] In this embodiment, the tumor tissue cleaning device further includes a flow guiding assembly 400. The flow guiding assembly 400 includes a liquid guiding pipe 410 and a switching valve 420. One end of the liquid guiding pipe 410 is connected to the liquid outlet, and the switching valve 420 is disposed on the liquid guiding pipe 410.

[0042] After the liquid guide pipe 410 is connected to the liquid outlet, it enables directional flow of the waste liquid, reducing the contact between operators and the waste liquid, thereby ensuring safety. In this embodiment, the switch valve 420 is specifically a flow rate regulation control switch, which is clamped on the liquid guide pipe 410 to realize the discharge control and flow rate control of the waste liquid.

[0043] In this embodiment, the tumor tissue cleaning device further includes a liquid collection component 500. The liquid collection component 500 is connected to the other end of the liquid guide tube 410.

[0044] The liquid collecting device 500 is directly connected to the end of the liquid guiding pipe 410, forming a closed path for waste liquid discharge and avoiding pollution caused by waste liquid discharge.

[0045] Among them, the liquid collection unit 500 can be a large-capacity container to collect and store waste liquid from multiple cleaning processes.

[0046] Specifically, in this embodiment, the liquid collection device 500 is a collection bag. The opening of the collection bag is connected to the liquid guide tube 410.

[0047] In this embodiment, the collection bag is specifically a medical waste liquid bag. Since there are many microorganisms and bacteria in the waste liquid after immersion, the waste liquid can be directly discharged into the medical waste liquid bag through the liquid guide tube 410. After the waste liquid bag is full, it can be directly sealed for disposal, which further ensures safety and avoids waste liquid pollution.

[0048] Please refer to it again. Figure 2 , Figure 3 In this embodiment, the bracket 100 includes a base 110, a support frame 120, and a carrier 130.

[0049] One end of the support frame 120 is connected to the base 110 and is mounted on the base 110. The bearing member 130 is located at the other end of the support frame 120, and the bearing part is located on the bearing member 130.

[0050] In this embodiment, the base 110 and the support frame 120 are connected to form a support structure to provide stable support for the carrier 130. The carrier part is set on the carrier 130, leaving a certain distance between the carrier part and the base 110. After the cleaning part 200 is set on the carrier part, there is space at the bottom of the cleaning part 200 to place the flow guiding component 400 so as to guide the waste liquid.

[0051] The support frame 120 can adopt a telescopic structure to achieve height adjustment of the bearing component 130, thereby improving the applicability of the tumor tissue cleaning device.

[0052] In this embodiment, the base 110 is a flat plate structure. The support frame 120 is located at the midpoint of one side of the flat plate structure. The bearing member 130 is located on the support frame 120 and extends in the same direction as the base 110.

[0053] The support frame 120 is located at the midpoint of one side of the base 110. The areas of the base 110 on both sides of the support frame 120 are symmetrical. In this embodiment, the bearing member 130 is located on the same side of the base 110, and the length of the bearing member 130 is approximately half the length of the base 110. With this structure, the bearing part is positioned close to the straight line where the center of the base 110 is located. After the cleaning member 200 is placed on the bearing part, the overall center of gravity of the bracket 100 will not shift too much, thereby ensuring the stability of the bracket 100.

[0054] In this embodiment, the cleaning container 210 is a cleaning bottle. The bottom of the cleaning bottle has a tapered structure. The supporting part is an insertion hole 131, in which the cleaning bottle is detachably inserted.

[0055] Specifically, in this embodiment, the cleaning bottle can be inserted into the socket 131, and the top of the cleaning bottle has a protrusion with a large outer diameter. The protrusion cannot protrude from the socket 131, so that the cleaning bottle can be inserted and fixed in the socket 131. In this embodiment, the cleaning bottle is installed in the socket 131 by insertion, thereby realizing the installation of the cleaning bottle. The cleaning bottle is inserted into the socket 131, which is very convenient for disassembly and installation. The structure is simple and easy to use.

[0056] As an alternative approach, the cleaning bottle can also be a conical bottle with an outer diameter that gradually decreases from the top to the bottom. This structure facilitates the insertion of the conical bottle into the insertion hole 131.

[0057] In this embodiment, a secondary hole 132 is provided on one side of the insertion hole 131. One end of the secondary hole 132 is connected to the insertion hole 131, and the other end is located at the edge of the support member 130 and has an open structure.

[0058] Specifically, in this embodiment, the secondary hole 132 is provided on one side of the insertion hole 131 and one end is connected to the insertion hole 131. The secondary hole 132 extends horizontally and penetrates the support member 130 vertically. The other end of the secondary hole 132 is open at the edge of the support member 130. Under this structure, the insertion hole 131 is connected to the outside of the support member 130 through the secondary hole 132.

[0059] In this embodiment, one end of the liquid guide tube 410 is fixedly connected to the liquid outlet. When the cleaning component 200 is inserted into the insertion hole 131, the cleaning component 200 can be moved from the open end of the secondary hole 132 towards the insertion hole 131, allowing the liquid guide tube 410 to enter the insertion hole 131 through the secondary hole 132. Then, the cleaning bottle is inserted into the insertion hole 131. The secondary hole 132 can accommodate the liquid guide tube 410, preventing the liquid guide tube 410 from being unable to move directly into the insertion hole 131 horizontally during the insertion of the cleaning bottle into the insertion hole 131.

[0060] In this embodiment, the mouth of the cleaning bottle is the dispensing port. The cap 220 is threaded into the bottle mouth.

[0061] Specifically, in this embodiment, the cleaning bottle has a transparent body made of medical-grade plastic. The cleaning bottle is connected to the cap 220 via a threaded connection, and the cap 220 can be tightened to connect to the bottle opening before and after use. This prevents the cleaning bottle from being contaminated before use or from being splashed by residual waste liquid after cleaning.

[0062] Furthermore, during the cleaning process, the cap 220 can be tightened to ensure a tight connection between the cap 220 and the bottle opening. Then, the bottle can be held and shaken to vibrate the bottle, thereby enhancing the cleaning effect on the tumor tissue block.

[0063] In this embodiment, the filter element 300 is a filter membrane.

[0064] The small pore design of the filter membrane can completely trap tumor tissue blocks, preventing them from being lost with the waste liquid during the washing process.

[0065] Specifically, in this embodiment, the pore size of the filter membrane is less than 0.5 mm. At this size, microorganisms (such as bacteria with a diameter of 1-5 μm) or cell debris mixed in the tumor tissue can pass through the filter membrane and be discharged with the waste liquid, while tumor tissue blocks will be retained due to their larger size (mostly millimeter or centimeter scale), thereby achieving selective filtration, reducing the risk of contamination and residue, and improving the culture purity of TIL.

[0066] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of this utility model, and are not intended to limit it. Although this utility model has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some or all of the technical features therein. Such modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of the embodiments of this utility model.

Claims

1. A tumor tissue cleaning device, characterized in that, include: The bracket (100) has a load-bearing part; A cleaning component (200) is provided on the support part and includes a cleaning container (210) and a cover (220). The cleaning container (210) has a cleaning space, and an inlet is connected to the top of the cleaning space. The bottom of the cleaning container (210) is provided with a liquid outlet, and the cover (220) is adapted to the inlet. A filter element (300) is disposed in the cleaning space and located below the inlet.

2. The tumor tissue cleaning device according to claim 1, characterized in that, The tumor tissue cleaning device also includes a flow guiding component (400); The flow guiding assembly (400) includes a liquid guiding pipe (410) and a switching valve (420). One end of the liquid guiding pipe (410) is connected to the liquid outlet, and the switching valve (420) is located on the liquid guiding pipe (410).

3. The tumor tissue cleaning device according to claim 2, characterized in that, The tumor tissue cleaning device also includes a liquid collection unit (500); The liquid collecting device (500) is connected to the other end of the liquid guiding tube (410).

4. The tumor tissue cleaning device according to claim 3, characterized in that, The liquid collection device (500) is a collection bag; The opening of the collection bag is connected to the liquid guide tube (410).

5. The tumor tissue cleaning device according to any one of claims 1-4, characterized in that, The support (100) includes: Base (110); A support frame (120) is connected at one end to the base (110) and is mounted on the base (110); A support member (130) is provided at the other end of the support frame (120), and the support portion is provided on the support member (130).

6. The tumor tissue cleaning device according to claim 5, characterized in that, The base (110) is a flat plate structure; The support frame (120) is located at the midpoint of one side of the flat plate structure; The bearing member (130) is disposed on the support frame (120) and extends in the same direction as the base (110).

7. The tumor tissue cleaning device according to claim 5, characterized in that, The cleaning container (210) is a cleaning bottle; The outer diameter of the cleaning bottle gradually decreases from the top to the bottom. or, The bottom of the cleaning bottle has a tapered structure; The supporting part is a socket (131), and the cleaning bottle is detachably inserted into the socket (131).

8. The tumor tissue cleaning device according to claim 7, characterized in that, A secondary hole (132) is provided on one side of the insertion hole (131); One end of the secondary hole (132) is connected to the insertion hole (131), and the other end is located at the edge of the support member (130) and has an open structure.

9. The tumor tissue cleaning device according to claim 7, characterized in that, The opening of the cleaning bottle is the dispensing port; The cap (220) is threaded into the bottle neck.

10. The tumor tissue cleaning device according to claim 1, characterized in that, The filter element (300) is a filter membrane.

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