Esterification reaction device of N-t-butyloxycarbonyl-L-glutamic acid dimethyl ester

Abstract

The utility model discloses an esterification reaction device of N-t-butyloxycarbonyl-L-glutamic acid dimethyl ester. The esterification reaction device comprises a base, a reaction barrel and a feeding hopper, an electric heating seat is fixedly mounted at the top of a base, a reaction barrel is detachably mounted in the electric heating seat, a support is fixedly mounted on one side of the top of the base and movably sleeved with a lifting frame, a servo motor is fixedly mounted on one side of the top of the lifting frame, and a feeding hopper is fixedly mounted on the other side of the top of the lifting frame; supporting arms are fixedly installed at the bottom of the lifting frame, and a conveying pipe is fixedly installed at the bottom of the feeding hopper. The servo motor drives the stirring rod to rotate and stir, the transmission gear is matched with the driven gear, the rotating shaft and the auger blade are driven to accurately and efficiently convey materials in the feeding hopper to the reaction barrel, and the stirring blades stir the materials in all directions, so that all components of a reaction system are uniformly distributed, the reaction rate is greatly increased, and the reaction efficiency is improved. And the production efficiency is obviously improved.

Description

Esterification apparatus for N-tert-butoxycarbonyl-L-glutamic acid dimethyl ester Technical Field

[0001] This invention relates to the field of esterification reaction technology, and in particular to an esterification reaction apparatus for N-tert-butoxycarbonyl-L-glutamic acid dimethyl ester. Background Technology

[0002] In the field of organic synthesis, the esterification reaction of N-tert-butoxycarbonyl-L-glutamic acid dimethyl ester is of great importance, and its products are widely used in pharmaceutical, chemical and other industries. However, traditional esterification reaction equipment has revealed many problems in practical applications.

[0003] Early reaction devices had significant shortcomings in material mixing and conveying. Most devices used a simple gravity feeding method, which lacked precision and efficiency in material addition and could not achieve uniform addition of additives. In addition, the stirring device was poorly designed and could not ensure that the reactants were fully mixed. This resulted in uneven distribution of the components in the reaction system, slow reaction rate, and a lot of time was wasted in the material fusion process, which seriously restricted the improvement of production efficiency.

[0004] Secondly, traditional equipment has a complex structure design. When adding materials, cleaning and maintaining the equipment, operators need to spend a lot of energy and time. Some operations need to be carried out in dangerous environments, which poses a high safety risk. For example, opening and closing the reaction tank lid requires multiple people to work together. If you are not careful, it may lead to material leakage, endangering personnel safety and environmental health.

[0005] Therefore, how to provide an esterification reaction apparatus for N-tert-butoxycarbonyl-L-glutamic acid dimethyl ester is a problem that urgently needs to be solved by those skilled in the art. Summary of the Invention

[0006] One objective of this invention is to provide an esterification reaction apparatus for N-tert-butoxycarbonyl-L-glutamic acid dimethyl ester. This invention can drive the stirring rod to rotate and stir using a servo motor, while simultaneously using the cooperation of the transmission gear and the driven gear to drive the rotating shaft and auger blades to accurately and efficiently transport the material in the feeding hopper to the reaction tank. At the same time, the stirring blades stir the material in all directions, so that the components of the reaction system are evenly distributed, greatly improving the reaction rate and significantly increasing production efficiency.

[0007] An esterification reaction apparatus for N-tert-butoxycarbonyl-L-glutamic acid dimethyl ester according to an embodiment of the present invention includes a base, a reaction tank and a feeding hopper;

[0008] An electric heating base is fixedly installed on the top of the base, the reaction tank is detachably installed inside the electric heating base, a bracket is fixedly installed on one side of the top of the base, a lifting frame is movably sleeved on the bracket, a servo motor is fixedly installed on one side of the top of the lifting frame, and the feeding hopper is fixedly installed on the other side of the top of the lifting frame.

[0009] The lifting frame is fixedly installed with a support arm at the bottom, the feeding hopper is fixedly installed with a conveying pipe at the bottom, the bottom of the conveying pipe is connected to the conveying cylinder, the conveying cylinder is vertically and rotatably installed with a rotating shaft inside, the outer wall of the rotating shaft and located inside the conveying cylinder is fixedly installed with an auger blade, and the outer wall of the rotating shaft and located above the conveying cylinder is fixedly installed with a driven gear.

[0010] A stirring rod is fixedly installed at the bottom of the servo motor, and a transmission gear is fixedly installed on the upper part of the outer wall of the stirring rod. The transmission gear meshes with the driven gear.

[0011] Furthermore, an electric telescopic rod is fixedly installed on one side of the top of the base, and the top end of the electric telescopic rod is welded and fixed to one side of the lifting frame.

[0012] Furthermore, a feed cylinder is fixedly installed on one side of the support arm, and a bucket cover is fixedly installed at the bottom of the support arm. The bucket cover is placed on top of the reaction tank.

[0013] Furthermore, a reflux port is fixedly installed on one side of the top of the bucket lid, and a temperature sensor is inserted and installed on the front side of the bucket lid.

[0014] Furthermore, two sets of stirring blades are fixedly installed at the bottom of the stirring rod, and each set of stirring blades consists of four blades.

[0015] Furthermore, the electric heating base and the reaction vessel are detachably connected by a snap-fit ​​structure, which includes a slot on the inner wall of the electric heating base and a snap-fit ​​block on the outer wall of the reaction vessel that is adapted to the slot.

[0016] The beneficial effects of this utility model are:

[0017] 1. In this utility model, a servo motor drives the stirring rod to rotate, and the transmission gear on the stirring rod drives the driven gear, so that the rotating shaft and the auger blade operate synchronously. This allows the additives in the feeding hopper to be slowly and accurately transported to the reaction tank. At the same time, the stirring blades fully stir the reaction materials, which greatly improves the mixing uniformity of the materials, accelerates the reaction rate, shortens the reaction time, and significantly improves production efficiency.

[0018] 2. The electric telescopic rod in this utility model controls the lifting of the lifting frame, which facilitates the operation of adding materials and cleaning equipment before and after the reaction. During the reaction, the lifting frame is lowered to ensure the barrel lid is tightly closed and the reaction is sealed. Before and after the reaction, the lifting frame is raised to facilitate operation, thus improving the convenience and safety of the device. Attached Figure Description

[0019] The accompanying drawings are provided to further illustrate the present invention and form part of the specification. They are used together with the embodiments of the present invention to explain the present invention, but do not constitute a limitation thereof. In the drawings:

[0020] Figure 1 is a schematic diagram of the overall structure of the esterification reaction apparatus for N-tert-butoxycarbonyl-L-glutamic acid dimethyl ester proposed in this invention.

[0021] Figure 2 shows the opening of the barrel lid of the esterification reaction apparatus for N-tert-butoxycarbonyl-L-glutamic acid dimethyl ester proposed in this utility model.

[0022] Figure 3 is a bottom view of the esterification reaction apparatus for N-tert-butoxycarbonyl-L-glutamic acid dimethyl ester proposed in this invention.

[0023] Figure 4 is a cross-sectional view of the feed cylinder of the esterification reaction device for N-tert-butoxycarbonyl-L-glutamic acid dimethyl ester proposed in this invention.

[0024] In the diagram: 1. Base; 2. Support; 3. Lifting frame; 4. Electric heating base; 5. Reaction tank; 6. Support arm; 7. Feeding cylinder; 8. Tank lid; 9. Servo motor; 10. Stirring rod; 11. Temperature sensor; 12. Return port; 13. Feeding hopper; 14. Electric telescopic rod; 15. Stirring blade; 16. Transmission gear; 17. Rotating shaft; 18. Driven gear; 19. Feeding pipe; 20. Screwdriver blade. Detailed Implementation

[0025] The present invention will now be described in further detail with reference to the accompanying drawings. These drawings are simplified schematic diagrams, illustrating only the basic structure of the present invention, and therefore only show the components relevant to the present invention.

[0026] Please refer to Figures 1-4. The esterification reaction apparatus for N-tert-butoxycarbonyl-L-glutamic acid dimethyl ester involved in this utility model mainly includes a base 1, a reaction tank 5, and a feeding hopper 13.

[0027] The base 1 serves as the fundamental support structure for the entire device. An electric heating seat 4 is fixedly mounted on its top. The electric heating seat 4 provides heating for the reaction vessel 5 to meet the temperature requirements of the esterification reaction. The reaction vessel 5 is detachably installed within the electric heating seat 4 via a specific snap-fit ​​structure. This snap-fit ​​structure consists of a slot on the inner wall of the electric heating seat 4 and a locking block on the outer wall of the reaction vessel 5 that matches the slot. This design facilitates the installation and removal of the reaction vessel 5, and allows for easy cleaning or replacement before and after the reaction.

[0028] Please refer to Figures 1-4. A bracket 2 is fixedly installed on one side of the top of the base 1. A lifting frame 3 is movably mounted on the bracket 2. The lifting frame 3 can move up and down along the bracket 2. A servo motor 9 is fixedly installed on one side of the top of the lifting frame 3, and a feeding hopper 13 is fixedly installed on the other side. A support arm 6 is fixedly installed at the bottom of the lifting frame 3. A bucket cover 8 is fixedly installed on one side of the support arm 6. The bucket cover 8 is used to seal the top opening of the reaction tank 5 to ensure that the reaction is carried out in a relatively sealed environment. At the same time, a conveying pipe 19 is fixedly installed at the bottom of the feeding hopper 13. The bottom of the conveying pipe 19 is connected to the conveying cylinder 7.

[0029] Please refer to Figures 1-4. A rotatable shaft 17 is vertically installed inside the conveying cylinder 7. An auger blade 20 is fixedly installed on the outer wall of the shaft 17 and the part located inside the conveying cylinder 7. A driven gear 18 is fixedly installed on the outer wall of the shaft 17 and the part located above the conveying cylinder 7. A stirring rod 10 is fixedly installed at the bottom of the servo motor 9. A transmission gear 16 is fixedly installed on the upper part of the outer wall of the stirring rod 10. The transmission gear 16 and the driven gear 18 mesh with each other. When the servo motor 9 is started, the stirring rod 10 rotates accordingly. The transmission gear 16 on the stirring rod 10 drives the driven gear 18 to rotate, thereby causing the shaft 17 to rotate. The auger blade 20 installed on the shaft 17 rotates accordingly, so as to convey the material in the feeding hopper 13 to the reaction tank 5 through the conveying pipe 19 and the conveying cylinder 7.

[0030] Please refer to Figures 1-4. An electric telescopic rod 14 is also fixedly installed on one side of the top of the base 1. The top of the electric telescopic rod 14 is welded and fixed to one side of the lifting frame 3. By controlling the extension and retraction of the electric telescopic rod 14, the height of the lifting frame 3 can be adjusted, thereby adjusting the position of components such as the feeding hopper 13, the conveying cylinder 7, and the lid 8 relative to the reaction tank 5. For example, when it is necessary to add materials to the reaction tank 5 or perform other operations, the lifting frame 3 can be raised using the electric telescopic rod 14 for easier operation; during the reaction, the lifting frame 3 can be lowered so that the lid 8 tightly covers the reaction tank 5, ensuring the sealing of the reaction.

[0031] Please refer to Figures 1-4. A reflux port 12 is fixedly installed on one side of the top of the barrel lid 8. The reflux port 12 can be used to connect a reflux device to realize the reflux of materials during the reaction process and improve the conversion rate of the reaction. A temperature sensor 11 is inserted and installed on the front side of the barrel lid 8. The temperature sensor 11 is used to monitor the temperature inside the reaction barrel 5 in real time so as to adjust the heating power of the electric heating base 4 in a timely manner and ensure that the reaction is carried out within a suitable temperature range.

[0032] Two sets of stirring blades 15 are fixedly installed at the bottom of the stirring rod 10, and each set of stirring blades 15 consists of four blades. When the servo motor 9 drives the stirring rod 10 to rotate, the stirring blades 15 stir the material in the reaction tank 5, so that the material is fully mixed and the reaction rate is accelerated.

[0033] Working principle: In the esterification reaction of N-tert-butoxycarbonyl-L-glutamic acid dimethyl ester, the reaction vessel 5 is first installed in the electric heating base 4 via a snap-fit ​​structure. Then, the electric telescopic rod 14 is activated, causing the lifting frame 3 to rise and the lid 8 to be removed from the top of the reaction vessel 5. An appropriate amount of reaction material is added into the reaction vessel 5. Next, the electric telescopic rod 14 is activated again, causing the lifting frame 3 to descend and the lid 8 to tightly close the reaction vessel 5. At this time, the electric heating base 4 is turned on to heat the reaction vessel 5. Simultaneously, the temperature sensor 11 is activated to monitor the temperature inside the reaction vessel 5 in real time. The required materials are then added to the feeding hopper 13. The servo motor 9 is started, which drives the stirring rod 10 to rotate. The transmission gear 16 on the stirring rod 10 drives the driven gear 18 to rotate, causing the rotating shaft 17 and the auger blade 20 to rotate. The material in the feeding hopper 13 is transported to the reaction tank 5 through the conveying pipe 19 and the conveying cylinder 7. During the reaction, the stirring blade 15 continuously stirs the material to ensure that the reaction is fully carried out. If there is material that needs to be returned during the reaction, it is returned through the return device connected to the return port 12. According to the temperature information fed back by the temperature sensor 11, the heating power of the electric heating base 4 is adjusted in time to ensure that the reaction is carried out under suitable temperature conditions.

[0034] The above description is only a preferred embodiment of the present utility model, but the protection scope of the present utility model is not limited thereto. Any equivalent substitutions or changes made by those skilled in the art within the technical scope disclosed in the present utility model, based on the technical solution and the inventive concept of the present utility model, should be included within the protection scope of the present utility model.

Claims

1. An apparatus for the esterification reaction of N-tert-butoxycarbonyl-L-glutamic acid dimethyl ester, characterized in that, The system includes a base (1), a reaction vessel (5), and a feeding hopper (13). An electric heating base (4) is fixedly installed on the top of the base (1). The reaction vessel (5) is detachably installed inside the electric heating base (4). A bracket (2) is fixedly installed on one side of the top of the base (1). A lifting frame (3) is movably mounted on the bracket (2). A servo motor (9) is fixedly installed on one side of the top of the lifting frame (3). The feeding hopper (13) is fixedly installed on the other side of the top of the lifting frame (3). A support arm (6) is fixedly installed at the bottom of the lifting frame (3). A servo motor (9) is fixedly installed at the bottom of the feeding hopper (13). The bottom of the conveying pipe (19) is connected to the conveying cylinder (7). The conveying cylinder (7) is vertically rotatably mounted with a rotating shaft (17). An auger blade (20) is fixedly mounted on the outer wall of the rotating shaft (17) and inside the conveying cylinder (7). A driven gear (18) is fixedly mounted on the outer wall of the rotating shaft (17) and above the conveying cylinder (7). A stirring rod (10) is fixedly mounted on the bottom of the servo motor (9). A transmission gear (16) is fixedly mounted on the upper part of the outer wall of the stirring rod (10). The transmission gear (16) meshes with the driven gear (18).

2. The esterification apparatus for N-tert-butoxycarbonyl-L-glutamic acid dimethyl ester according to claim 1, characterized in that, An electric telescopic rod (14) is fixedly installed on one side of the top of the base (1), and the top of the electric telescopic rod (14) is welded and fixed to one side of the lifting frame (3).

3. The esterification apparatus for N-tert-butoxycarbonyl-L-glutamic acid dimethyl ester according to claim 1, characterized in that, A feed cylinder (7) is fixedly installed on one side of the support arm (6), and a bucket cover (8) is fixedly installed at the bottom. The bucket cover (8) is placed on top of the reaction tank (5).

4. The esterification apparatus for N-tert-butoxycarbonyl-L-glutamic acid dimethyl ester according to claim 3, characterized in that, A reflux port (12) is fixedly installed on one side of the top of the bucket lid (8), and a temperature sensor (11) is inserted and installed on the front side of the bucket lid (8).

5. The esterification apparatus for N-tert-butoxycarbonyl-L-glutamic acid dimethyl ester according to claim 1, characterized in that, The bottom of the stirring rod (10) is fixedly equipped with two sets of stirring blades (15), and each set of stirring blades (15) consists of four blades.

6. The esterification apparatus for N-tert-butoxycarbonyl-L-glutamic acid dimethyl ester according to claim 1, characterized in that, The electric heating base (4) and the reaction vessel (5) are detachably connected by a snap-fit ​​structure. The snap-fit ​​structure includes a slot on the inner side wall of the electric heating base (4) and a snap block on the outer side wall of the reaction vessel (5) that is adapted to the slot.

Images