Benzophenyl ethanol ketone crystallization equipment for medicine synthesis

Abstract

The utility model relates to the technical field, in particular to benzophenone crystallization equipment for medicine synthesis. The benzophenone crystallization equipment for medicine synthesis comprises a support frame, a dissolving bin, a support rod, a first electric heating wire, a second electric heating wire and the like, a dissolving bin is fixedly connected to the supporting frame, a discharging port is formed in the bottom in the dissolving bin, a supporting rod is fixedly connected to the upper side in the dissolving bin, a first electric heating wire is fixedly connected to the lower side of the middle of the supporting rod, and a certain number of second electric heating wires are evenly arranged on the first electric heating wire. When the cooling liquid is injected into the hollow cooling frame body, the motor and the fan blades are used for convection, so that the cooling speed in the cooling frame body is accelerated, and the effect of preventing crystal particles from being too fine or preventing other byproducts from being generated is achieved.

Description

Technical Field

[0001] This utility model relates to the technical field, and in particular to a crystallization apparatus for phenylethanol ketone used in pharmaceutical synthesis. Background Technology

[0002] Diphenylethanol ketone is an important semi-synthetic intermediate and photopolymerization catalyst. It can be used as a pharmaceutical intermediate, a photosensitizer in dye production and photosensitive resins, a photogravure ink, a UV-curable coating, and a catalyst in polyester production, showing broad application prospects.

[0003] The crystallization of benzoethanol ketone used in pharmaceutical synthesis is mainly used to improve the purity and stability of drugs, making them more suitable for drug preparation and application. The crystallization form may also optimize the physical properties of drugs, such as solubility and bioavailability, ensuring their effectiveness and consistency in drugs. Existing benzoethanol ketone crystallization usually uses air cooling or natural cooling, which has a slow cooling rate and can easily lead to excessively fine crystal particles or the generation of other by-products.

[0004] Therefore, it is necessary to design a crystallization device for phenylethanol ketone used in pharmaceutical synthesis. Utility Model Content

[0005] To overcome the shortcomings of traditional methods for preparing phenylethanol ketone crystals, such as slow cooling rates leading to excessively fine crystal particles or the generation of other byproducts, this invention provides a phenylethanol ketone crystallization device for pharmaceutical synthesis.

[0006] The technical implementation scheme of this utility model is as follows: A crystallization device for phenylethanol ketone used in pharmaceutical synthesis includes a support frame, a dissolving chamber, a temperature controller, a support rod, a first heating wire, a second heating wire, a first handle, a first baffle, a spring, a cooling frame, an inlet pipe, a first valve, a fan blade, a motor, a second baffle, a screen, an outlet pipe, and a second valve. A dissolving chamber is fixedly connected to the support frame, with an outlet at the bottom of the dissolving chamber. A support rod is fixedly connected to the upper side of the dissolving chamber, and a first heating wire is fixedly connected to the lower side of the middle of the support rod. A certain number of second heating wires are evenly arranged on the first heating wire. A temperature controller is fixedly connected to the middle of the first heating wire, and its end is fixedly inserted through the outer wall of the dissolving chamber. A sliding mechanism is installed inside the support frame at the lower part of the dissolving chamber. The first baffle has a through hole on its left side and a first handle fixedly connected to its right side. The first handle passes through the outside of the support frame, and a spring is fixedly connected between the end of the first handle and the support frame. A cooling frame is slidably installed in the middle of the support frame. A liquid inlet pipe is opened in the upper left part of the front side of the cooling frame, and a first valve is fixedly connected to the liquid inlet pipe. Motors are fixedly installed on the front and rear sides of the cooling frame, and the output shafts of the motors are directly facing the cooling frame. Fan blades are fixedly installed on the output shafts of the motors. A second baffle is slidably installed in the right side of the middle of the cooling frame. A groove is opened on the right side of the second baffle. A screen is fixedly connected to the cooling frame below the second baffle. A liquid outlet pipe is opened in the right side of the bottom of the cooling frame, and a second valve is fixedly connected to the liquid outlet pipe.

[0007] More preferably, it also includes a transparent plate, with transparent plates installed around the walls of the dissolving chamber to allow observation of the internal dissolving process.

[0008] More preferably, the bottom of the melting chamber and the upper part of the cooling frame are both inclined.

[0009] More preferably, when the first baffle is moved to the right limit by the first handle, the through hole on the first baffle coincides with the discharge port.

[0010] More preferably, the cooling frame has a hollow internal structure.

[0011] More preferably, it also includes a sealing strip, with the portion of the second baffle that contacts the cooling frame being fixedly provided with a sealing strip.

[0012] More preferably, it also includes a controller and a second handle. The controller is fixedly installed on the upper part of the right end face of the cooling frame, and the second handle is fixedly connected to the lower part of the right end face of the cooling frame. The controller is electrically connected to the two motors.

[0013] Compared with the prior art, the present invention has the following advantages: 1. The present invention accelerates the cooling rate inside the cooling frame by injecting coolant into the hollow cooling frame and using a motor and fan blades for convection, thereby preventing the crystal particles from being too fine or producing other by-products.

[0014] 2. This utility model achieves the effect of layered heating of raw materials by layering a second heating wire on a first heating wire, thereby avoiding local overheating that could lead to decomposition of the raw materials. Attached Figure Description

[0015] Figure 1 This is a three-dimensional structural diagram of the present invention.

[0016] Figure 2 This is a partial cross-sectional view of the support frame, dissolving chamber, and transparent plate of this utility model.

[0017] Figure 3 This is a partial sectional view of the first handle, first baffle, and spring components of this utility model.

[0018] Figure 4 This is a three-dimensional structural diagram of the components of this utility model, including the cooling frame, the liquid inlet pipe, and the first valve.

[0019] Figure 5 This is a partial cross-sectional view of the second baffle, sealing strip, and screen of this utility model.

[0020] Figure 6 This is a three-dimensional structural diagram of the baffle and groove component of this utility model.

[0021] The meanings of the labels in the attached diagram are as follows: 1. Support frame, 2. Dissolving chamber, 21. Discharge port, 3. Transparent plate, 4. Temperature controller, 41. Support rod, 42. First heating wire, 43. Second heating wire, 5. First handle, 51. First baffle, 52. Spring, 53. Through hole, 6. Cooling frame, 61. Liquid inlet pipe, 62. First valve, 63. Fan blade, 64. Motor, 7. Second baffle, 71. Screen, 72. Sealing strip, 73. Groove, 8. Liquid outlet pipe, 9. Second valve, 10. Controller, 11. Second handle. Detailed Implementation

[0022] The present invention will be further described below with reference to the accompanying drawings and embodiments.

[0023] Example: A crystallization apparatus for phenylethanol ketone used in pharmaceutical synthesis, such as... Figures 1-6As shown, the device includes a support frame 1, a dissolving chamber 2, a temperature controller 4, a support rod 41, a first heating wire 42, a second heating wire 43, a first handle 5, a first baffle 51, a spring 52, a cooling frame 6, an inlet pipe 61, a first valve 62, a fan blade 63, a motor 64, a second baffle 7, a screen 71, an outlet pipe 8, and a second valve 9. The dissolving chamber 2 is fixedly connected to the support frame 1. An outlet 21 is opened at the bottom of the dissolving chamber 2, and a support rod is fixedly connected to the upper side of the dissolving chamber 2. 41. A first heating wire 42 is fixedly connected to the lower side of the middle of the support rod 41. A certain number of second heating wires 43 are evenly arranged on the first heating wire 42. A thermostat 4 is fixedly connected to the middle of the first heating wire 42. The end of the thermostat 4 is fixedly inserted through the outer wall of the melting chamber 2. A first baffle 51 is slidably provided in the support frame 1 at the lower part of the melting chamber 2. A through hole 53 is opened on the left side of the first baffle 51. A first handle 5 is fixedly connected to the right side of the first baffle 51. The first handle 5 is inserted through the outside of the support frame 1. Furthermore, a spring 52 is fixedly connected between the end of the first handle 5 and the support frame 1. A cooling frame 6 is slidably provided in the middle of the support frame 1. An inlet pipe 61 is provided on the upper left front side of the cooling frame 6. A first valve 62 is fixedly connected to the inlet pipe 61. Motors 64 are fixedly installed on the front and rear sides of the cooling frame 6 by screws. The output shafts of the motors 64 are directly facing the cooling frame 6, and fan blades 63 are fixedly provided on the output shafts of the motors 64. A slidable passage is provided on the right side of the middle of the cooling frame 6. A second baffle 7 is provided, and a groove 73 is opened on the right side of the second baffle 7. A screen 71 is fixedly connected to the cooling frame 6 below the second baffle 7. A liquid outlet pipe 8 is opened on the bottom right side of the cooling frame 6, and a second valve 9 is fixedly connected to the liquid outlet pipe 8. The bottom of the dissolving chamber 2 and the upper part of the cooling frame 6 are both inclined. When the first baffle 51 is moved to the right limit by the first handle 5, the through hole 53 on the first baffle 51 coincides with the discharge port 21. The interior of the cooling frame 6 is a hollow structure.

[0024] like Figure 1 and Figure 2 As shown, it also includes a transparent plate 3. The walls of the dissolving chamber 2 are equipped with transparent plates 3 to observe the internal dissolution process.

[0025] like Figure 5 As shown, it also includes a sealing strip 72, and the part of the second baffle 7 that contacts the cooling frame 6 is fixedly provided with the sealing strip 72.

[0026] like Figure 4 As shown, it also includes a controller 10 and a second handle 11. The controller 10 is fixedly installed on the upper part of the right end face of the cooling frame 6, and the second handle 11 is fixedly connected to the lower part of the right end face of the cooling frame 6. The controller 10 is electrically connected to two motors 64.

[0027] This equipment is used when preparing benzophenone crystals for pharmaceutical synthesis. First, the benzophenone raw material is added through the inlet at the top of the dissolving chamber 2. The first heating wire 42 and the second heating wire 43 are then activated to heat and dissolve the raw material. The dissolution effect is observed through the temperature controller 4 and the transparent plate 3 to ensure no undissolved particles remain. After dissolution, the first handle 5 is manually pulled to move the first baffle 51 to the right. When the first baffle 51 reaches its limit position, the spring 52 is stretched to its limit, and the through hole 53 of the first baffle 51 completely overlaps with the outlet 21 at the bottom of the dissolving chamber 2. The dissolved high-temperature solution flows through the through hole 53 into the cooling frame 6 below the support frame 1. Once sufficient solution exists in the cooling frame 6, the handle is released, and the spring 52 resets the first baffle 51, preventing liquid backflow during subsequent operations. Then, the first valve of the inlet pipe 61 is opened. 62. Inject low-temperature coolant. Since the cooling frame 6 is a hollow structure, the coolant rapidly reduces the solution temperature through its internal channels until the coolant evaporates. At the same time as injecting the coolant, the motors 64 on the front and rear sides of the cooling frame 6 are started by the controller 10. The motors 64 drive the fan blades 63 to rotate. The fan blades 63 accelerate the cooling of the solution through convection, causing diphenylethanol ketone to precipitate crystals. After crystallization, pull the pull groove 73 on the right side of the second baffle 7 to pull it out. During the pulling process of the second baffle 7, the sealing strip 72 prevents the second baffle 7 from carrying out the internal solution. After the second baffle 7 is pulled out, the crystals and mother liquor are initially separated by the screen 71. The screen 71 intercepts the crystal particles, and the mother liquor is discharged from the outlet pipe 8. During the discharge of the mother liquor, the flow rate is controlled by the second valve 9. After the mother liquor is discharged, the cooling frame 6 is pulled out by the second handle 11, and the crystals can be removed.

Claims

1. A crystallization apparatus for phenylethanol ketone used in pharmaceutical synthesis, characterized in that: The system includes a support frame (1), a dissolving chamber (2), a temperature controller (4), a support rod (41), a first heating wire (42), a second heating wire (43), a first handle (5), a first baffle (51), a spring (52), a cooling frame (6), an inlet pipe (61), a first valve (62), a fan blade (63), a motor (64), a second baffle (7), a screen (71), an outlet pipe (8), and a second valve (9). The dissolving chamber (2) is fixedly connected to the support frame (1). 2) An outlet (21) is provided at the bottom of the inner chamber. A support rod (41) is fixedly connected to the upper side of the dissolving chamber (2). A first heating wire (42) is fixedly connected to the lower side of the middle part of the support rod (41). A certain number of second heating wires (43) are evenly arranged on the first heating wire (42). A temperature controller (4) is fixedly connected to the middle of the first heating wire (42). The end of the temperature controller (4) is fixedly inserted through the outer wall of the dissolving chamber (2). A first baffle (51) is slidably provided in the support frame (1) at the bottom of the dissolving chamber (2). (51) A through hole (53) is provided on the left side. A first handle (5) is fixedly connected to the right side of the first baffle (51). The first handle (5) passes through the outside of the support frame (1), and a spring (52) is fixedly connected between the end of the first handle (5) and the support frame (1). A cooling frame (6) is slidably provided in the middle of the support frame (1). An inlet pipe (61) is provided on the upper left front side of the cooling frame (6). A first valve (62) is fixedly connected to the inlet pipe (61). The front and rear sides of the cooling frame (6) are both fixed. A motor (64) is installed, and the output shaft of the motor (64) is directly facing the cooling frame (6). A fan blade (63) is fixed on the output shaft of the motor (64). A second baffle (7) is slidably installed on the right side of the middle part of the cooling frame (6). A groove (73) is opened on the right side of the second baffle (7). A screen (71) is fixed on the cooling frame (6) below the second baffle (7). A liquid outlet pipe (8) is opened on the right side of the bottom of the cooling frame (6). A second valve (9) is fixed on the liquid outlet pipe (8).

2. A phenylethanol ketone crystallization apparatus for pharmaceutical synthesis according to claim 1, characterized in that: It also includes a transparent plate (3), and the walls of the dissolving chamber (2) are provided with transparent plates (3).

3. A diphenylethanol ketone crystallization apparatus for pharmaceutical synthesis according to claim 2, characterized in that: The bottom of the dissolving chamber (2) and the top of the cooling frame (6) are both inclined.

4. A phenylethanol ketone crystallization apparatus for pharmaceutical synthesis according to claim 3, characterized in that: When the first baffle (51) is moved to the right limit by the first handle (5), the through hole (53) on the first baffle (51) coincides with the discharge port (21).

5. A phenylethanol ketone crystallization apparatus for pharmaceutical synthesis according to claim 4, characterized in that: The cooling frame (6) has a hollow structure inside.

6. A phenylethanol ketone crystallization apparatus for pharmaceutical synthesis according to claim 5, characterized in that: It also includes a sealing strip (72), and the part of the second baffle (7) that contacts the cooling frame (6) is fixedly provided with a sealing strip (72).

7. A phenylethanol ketone crystallization apparatus for pharmaceutical synthesis according to claim 6, characterized in that: It also includes a controller (10) and a second handle (11). The controller (10) is fixedly installed on the upper part of the right end face of the cooling frame (6), and the second handle (11) is fixedly connected to the lower part of the right end face of the cooling frame (6). The controller (10) is electrically connected to two motors (64).

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