Synergistic preservative blend and compositions containing same

Abstract

Provided herein is a preservative composition of a pyrithione, an organic acid or salt thereof, and an aromatic alcohol which has a synergistic effect that allows for a reduction in the amount of pyrithione necessary to be an effective preservative in an end-use formulation.

Description

[0001] SYNERGISTIC PRESERVATIVE BLEND AND COMPOSITIONS CONTAINING

[0002] SAME

[0003] BACKGROUND

[0004]

[0001] Microbial contamination of personal care products, home care products and other similar products is a matter of great importance to the industry and can become a major cause of product losses. Preservative agents and preservative compositions for protecting and preserving end-use formulations against microbial attack from bacteria or fungi are known in the art. These preservative agents and compositions have a wide variety of applications in fields such as personal care products, cosmetics, home care products, and health and hygiene products. Conventional preservative agents and compositions have used traditional active ingredients, such as benzisothiazolinone, methylisothiazolinone, and methylchloroisothiazolinone, which provide good bacterial and fungicidal properties against microbial attack. However, because of growing governmental scrutiny regarding the use of benzisothiazolinone, methylisothiazolinone, and methylchloroisothiazolinone, alternative preservative compositions which are similarly low cost and broad spectrum have been desired.

[0005]

[0002] One problem with antimicrobial agents, such as pyrithione, is that they often require high concentrations to be effective in preservative compositions. Because such high concentrations are known to be required, the use of pyrithione in personal care products and home care products can be cost prohibitive.

[0006]

[0003] Ideally, a desired preservative agent or composition has broad-spectrum activity against all types of microorganisms at various pH levels. The preservative agent or composition should also have high efficacy so that a minimum amount of the preservative can be used to save cost and to avoid or reduce any possible adverse effects caused by the preservative agent or preservative agents in the preservative composition. Also, it is desirable that the preservative agent or composition is stable to any changes in temperature encountered during manufacturing, packaging, and shipping as well as during storage of the end-use formulation in which the preservative agent or compositions is placed. Further, ideal preservative agents are physically and chemically compatible with ingredients present in various end-use formulations so that one preservative agent or preservative compositions can suitably be incorporated in various products.

[0007]

[0004] In recent developments in the preservative arts, there has been considerable effort given to find compounds that will synergistically interact with the preservative agent(s) in order to boost the efficacy of the preservative agent(s) and / or to effectively reduce the amount of preservative agent(s) needed to have a desired preservation effect. This is a result of continued regulatory pressures to reduce the amount of the preservative agent(s) in end-use formulations.

[0008]

[0005] Similarly, in the field of personal care formulations containing an active agent to treat specific conditions, such as dandruff, there is ongoing regulatory pressures to reduce the amount of the active ingredient in personal care formulations. One way to reduce the amount of the active ingredients is to increase the active ingredients efficacy in the personal care formulation, forming a synergistic mixture of an active ingredient with a potentiator, which increases the efficacy of the active ingredient.

[0009]

[0006] The present disclosure provides an answer to that need, by providing a preservation composition comprising a synergistic mixture of a pyrithione, an organic acid or salt thereof, and an aromatic alcohol which can be used in various compositions as a preservative, including personal or home care formulations.

[0010] SUMMARY

[0011]

[0007] In one aspect, provided is a preservative composition containing (i) a pyrithione; (ii) an organic acid or salt thereof; and (iii) an aromatic alcohol, wherein the preservative composition exhibits a synergistic effect; and wherein a weight ratio of the pyrithione to the organic acid or salt thereof and to the aromatic alcohol is from about 1 :1 :1 to about 1 : 15630: 12500.

[0012]

[0008] In another aspect, provided is a preservative composition wherein the weight ratio of the pyrithione to the organic acid or salt thereof and to the aromatic alcohol is from about 1 :1 :1 to about 1 : 15630: 12500, such as from about 1 :1 :1 to about 1 : 10000: 10000, such as from about 1 :1 :1 to about 1 :5000:5000.

[0013]

[0009] The pyrithione can comprise a water soluble pyrithione. In a particular embodiment, the water soluble pyrithione comprises sodium pyrithione.

[0014]

[0010] In a particular aspect, the aromatic alcohol comprises phenoxyethanol. In an alternative embodiment, the aromatic alcohol comprises benzyl alcohol.

[0011] In an embodiment of the present disclosure, the organic acid or salt thereof comprises itaconic acid. In another embodiment, the organic acid or salt thereof comprises lactic acid, levulinic acid, citric acid, or mixtures thereof.

[0015]

[0012] In a particular aspect, the pyrithione comprises sodium pyrithione, the aromatic alcohol comprises phenoxyethanol, and the organic acid or salt thereof comprises citric acid, lactic acid, sodium benzoate, or potassium sorbate.

[0016]

[0013] In another aspect, the pyrithione comprises sodium pyrithione, the aromatic alcohol comprises benzyl alcohol, and the organic acid or salt thereof comprises citric acid, lactic acid, sodium benzoate, or potassium sorbate.

[0017]

[0014] In another aspect of the present disclosure, provided is a personal care or home composition comprising a base composition and a preservative composition as described in the prior embodiments.

[0018]

[0015] In a further aspect of the present disclosure, the personal care or home care composition comprises a pyrithione. The pyrithione is present in the base composition in an amount less than about 1000 ppm, such as in an amount less than about 500 ppm, such as in an amount less than about 250 ppm, such as in an amount less than about 100 ppm, such as in an amount less than about 50 pm.

[0019]

[0016] In another aspect of the present disclosure, the personal care or home care composition further comprises an organic acid or salt thereof and an aromatic alcohol. In a particular embodiment, the personal care or home care composition has a weight ratio of the pyrithione to the organic acid or salt thereof and to the aromatic alcohol from about 1 :11 to about 1 : 15630: 12500, such as from about 1 :1 :1 to 1 : 10000: 10000, such as from about 1 :1 :1 to about 1 :5000:5000.

[0020]

[0017] In a further embodiment, the personal care or home care composition comprises a liquid, a semi-solid, or a solid.

[0021]

[0018] In a particular embodiment, the personal care or home care composition comprises a color cosmetic product, a deodorant product, a hair care product, an oral care product, a skin care product, or a bathing product.

[0022]

[0019] In another embodiment, the personal care or home care composition comprises hand-dish soaps, machine dish soaps, machine dish rinse-aids, laundry detergents, laundry fabric conditioners, clothing fragrances and / or wrinkle treatments, ironing aids, cleaning wipes, all-purpose cleaners and other similar formulations that are used around the home. In one embodiment, the home care product is a cleaning product selected from the group consisting of hand-dish soaps, laundry detergents, cleaning wipes, and all-purpose cleaners, such as floor, work surface, kitchen, carpet, toilet and bathroom cleaners.

[0023]

[0020] In an embodiment of the present disclosure, the personal care or home care composition comprises a premoistened wipe.

[0024]

[0021] In a further embodiment, the base composition of the personal or home care composition contains at least one of a solvent, a surfactant, a complexing agent, a corrosion inhibitor, an alkalinity builder, a pH adjusting agent, an auxiliary, an acid, a foaming agent, a perfume, a colorant, a humectant, an emulsifier, a thickener, an antioxidant, a UV blocking agent, a wax, a natural extract, or an oil.

[0025]

[0022] In an embodiment of the present disclosure, provided is a method for increasing the efficacy of a preservative agent in an end-use formulation. The method comprises adding to an end-use formulation a blend of preservative agents as described in the prior embodiments.

[0026]

[0023] These and other aspects will become apparent when reading the detailed description of the invention.

[0027] DETAILED DESCRIPTION

[0028]

[0024] It is to be understood by one of ordinary skill in the art that the present discussion is a description of exemplary embodiments only and is not intended as limiting the broader aspects of the present disclosure.

[0029]

[0025] In general, the present disclosure is directed to a preservative composition. As used herein, the term “preservative” means a biocidal agent or biocidal composition which is intended to be blended into an end-use formulation, such as personal care formulations, cosmetics, home care formulations, and health and hygiene products, to prevent microorganisms from destroying the end-use formulation or making the end-use formulation unusable for the particular purpose the end-use formulation was developed.

[0030]

[0026] It has now been surprisingly found that the combination of a pyrithione, an organic acid or salt thereof, and an aromatic alcohol in a preservative composition produce synergistic effects and can be incorporated into end-use formulations at very low levels while providing excellent antimicrobial properties. As used herein, a “synergistic interaction” refers to the fact that the combination of pyrithione, organic acid or salt thereof, and aromatic alcohol has a total antimicrobial / antifungal effect that is greater than the antimicrobial / antifungal properties of the combination of only an organic acid or salt thereof and an aromatic alcohol. In other words, the pyrithione of the present disclosure operates synergistically with an organic acid or salt thereof and an aromatic alcohol so as to have greater antimicrobial / antifungal activity in the presence of each other against certain microorganisms than in comparison to the antimicrobial activity of the pyrithione alone or the antimicrobial activity of the combination of organic acid or salt thereof and aromatic alcohol at the same concentrations. Due to the synergistic effect, the amount of the pyrithione present in the preservative composition can be reduced while still producing the desired efficacy. This effect is also known as “potentiation” of the pyrithione in the preservative composition. This potentiation of the pyrithone is also referred to herein as a “synergistic effect” between the pyrithione and the combination of an organic acid or salt thereof and an aromatic alcohol for boosting the efficacy of the pyrithione.

[0031]

[0027] As used herein, the term “salts thereof” are intended to include cations of sodium, potassium, calcium, magnesium, ammonium and ethanolamines and other similar cations, anions of chloride, bromine, acetate, sulfates and the other similar anions.

[0032]

[0028] The preservative composition disclosed herein comprises (i) a pyrithione; (ii) an organic acid or salt thereof; and (iii) an aromatic alcohol. The weight ratio of the pyrithione to the organic acid or salt thereof and to the aromatic alcohol is from about 1 :1 :1 to about 1 : 15630: 12500, such as from about 1 :1 :1 to about 1 : 10000: 10000, such as from about 1 :1 :1 to about 1 :5000:5000.

[0033]

[0029] Pyrithione compounds are preservative agents known as iron chelators. Pyrithione is known by several names, including 2 mercaptopyridine-N- oxide; 2- pyridinethiol-1 -oxide (CAS Registry No. 1 121 -31 -9); 1 -hydroxypyridine-2- thione and 1 hydroxy-2(1 H)-pyridinethione (CAS Registry No. 1 121 -30-8); 2-pyridinol-1 - oxide (HPNO) and N-hydroxy-6-octyloxypyridine 2(1 H)-one and -hydroxy-6- octyloxypyridine 2(1 H)-one ethanolamine salt. Pyrithione salts are commercially available from Arxada AG such as Sodium OMADINE® or Zinc OMADINE®.

[0030] The pyrithione present as the preservative agent can be present in a water insoluble form or in a water soluble form. Exemplary pyrithione compounds include, for example, sodium pyrithione, zinc pyrithione, barium pyrithione, strontium pyrithione, copper pyrithione, cadmium pyrithione, and / or zirconium pyrithione. Other pyrithiones that may be present in the composition include sodium pyrithione, bismuth pyrithione, potassium pyrithione, lithium pyrithione, ammonium pyrithione, calcium pyrithione, magnesium pyrithione, silver pyrithione, gold pyrithione, manganese pyrithione, and / or an organic amine pyrithione. In a preferred embodiment, the pyrithione is a sodium pyrithione. A single pyrithione may be present as the preservative agent or a combination of any of the above may be included as the preservative agent.

[0034]

[0031] The pyrithione particles can have a particle size such that 100% of the particles have a particle size of less than about 10 microns and at least 70% of the particles have a particle size less than 5 microns, such as at least about 50% of the particles can have a particle size of 1 micron or less. Particle size can be measured using a laser scattering particle size analyzer, such as a HORIBA LA 910 particle size analyzer.

[0035]

[0032] The pyrithione particles can be produced by reacting pyrithione or a water- soluble salt of pyrithione, and a water-soluble polyvalent metal salt in a pressurized, turbulent flow reactor that generates pulverizing forces. The pulverizing forces produced by the pressurized, turbulent flow reactor efficiently generate pyrithione salt particles of micron size. The micron-sized pyrithione salt particles made by the method have a narrow and uniform size distribution, and have excellent surface deposition properties due to the large surface area provided by the population of micron particles.

[0036]

[0033] The pyrithione may be used in the end-use preservative composition formulation in amounts up to about 1 % by weight, such as up to about 0.75% by weight, such as up to about 0.50% by weight, such as up to about 0.25% by weight depending on the use of the end-use preservative composition.

[0037]

[0034] Pyrithione may also have other advantages in the end-use preservative composition, including antidandruff properties in hair care products.

[0038]

[0035] The preservative composition also comprises an organic acid or salt thereof. Examplary organic acids include, for example, lactic acid, levulinic acid, citric acid, itaconic acid, carboxylic acid, hydroxyl acid, succinic acid, methanesulfonic acid, phytic acid, phospoacetic acid, N-(phosphonomethyl)iminodiacetic acid, diethylenetriaminepentakis(methylphosphonoic acid), S,S-ethylenediamine-N'N'- disuccinic acid, or any mixture thereof. Exemplary salts include, for example, sodium benzoate and potassium sorbate. Other salts may also be used. In a preferred embodiment, the organic acid is lactic acid, levulinic acid, citric acid, or itaconic acid, their salts, or any mixture thereof. In another embodiment, the organic acid is itaconic acid. In an alternative embodiment, the organic acid comprises lactic acid, levulinic acid, citric acid, or mixtures thereof.

[0039]

[0036] The preservative composition may include from about 1 % by weight to about 5% by weight of an organic acid such as citric acid, succinic acid, phosphoric acid, lactic acid, or any mixture thereof. In another aspect, the composition may include from about 1 % by weight to about 5% by weight of an organic acid such as citric acid, succinic acid, phosphoric acid, lactic acid, or any mixture thereof, in combination with from about 0.05% by weight to about 5% by weight of another organic acid. In another embodiment, the composition may include from about 2% by weight to about 4% by weight of an organic acid such as citric acid, succinic acid, phosphoric acid, lactic acid, or any mixture thereof, in combination with from about 0.1 % by weight to about 4% by weight of another organic acid.

[0040]

[0037] Organic acid compounds can be present as preservatives in end-use preservative formulations in amounts up to about 3% by weight, depending on the particular organic acid compound. Similar amounts may be used for the salts. In most cases, the amount of the acid or salts thereof are used in amounts up about 1 % by weight, more typically up to about 0.6% by weight. Mixtures of organic acids may also be used in the preservative composition.

[0041]

[0038] The preservative composition also comprises an aromatic alcohol. Exemplary aromatic alcohols include, for example, phenoxyethanol, 2,4- Dichlorophenyl)methanol, benzyl alcohol, 1 -Phenoxypropaneol, chlorphenesin, and benzyl hemiformal. In a preferred embodiment, the aromatic alcohol is a phenoxyethanol, a benzyl alcohol, or mixtures thereof.

[0042]

[0039] The aromatic alcohols can be present in end-use formulations in amounts up to about 1 .5% by weight based on the total weight of the end-use formulation, depending on the particular alcohol compound. In most cases, the amount of the alcohol compounds are typically used in amounts up to about 1 % by weight, more typically up to about 0.5% by weight, based on the weight of the end-use formulation.

[0040] In a one embodiment of the preservative composition, the pyrithione comprises sodium pyrithione, the aromatic alcohol comprises phenoxyethanol, and the organic acid or salt thereof comprises citric acid, lactic acid, sodium benzoate, or potassium sorbate. In an alternative embodiment of the preservative composition, the pyrithione comprises sodium pyrithione, the aromatic alcohol comprises benzyl alcohol, and the organic acid or salt thereof comprises citric acid, lactic acid, sodium benzoate, or potassium sorbate.

[0043]

[0041] It will be understood that the preservative composition of the present disclosure is not limited to only a pyrithione, an organic acid or salt thereof, and an aromatic alcohol. Other preservative agents may also be employed in the preservative composition as well. Suitable preservative agents usable in the present disclosure include, for example, acids, esters and their salts, aldehydes, phenolic compounds, sulfites and iron chelators, quaternary ammonium compounds, aldehydes, pyrone compounds, urea compounds, imidazole compounds, isothiazolines and combinations thereof.

[0044]

[0042] The preservative agent may be formulated in the form of a preservative concentrate. By “preservative concentrate” or “preservative composition” it is meant a composition which is to be added to an end-use formulation in specified amounts. In the preservative concentrate, the amount of the preservative agent will be higher than typical final use amounts. The preservative concentrate may have only the pyrithione, the organic acid or salt thereof, and the aromatic alcohol. Alternatively, the preservative concentrate may contain the pyrithione, the organic acid or salt thereof, the aromatic alcohol and a carrier that is compatible with end-use formulations. Exemplary carriers include, for example, an aqueous solvent such as water, or other solvents acceptable for end-use formulations and uses of these formulations. Generally, the solvent can be a water-miscible solvent, such as an alcohol and / or a glycol ether. Examples of water-miscible solvents include ethanol, propanol, benzyl alcohol, isopropanol, diethylene glycol propyl ether, ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, ethylene glycol monopropyl ether, ethylene glycol monoisopropyl ether, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether, diethylene glycol monobutyl ether, diethylene glycol monoethyl ether, diethylene glycol mono-n-butyl ether, ethylene glycol dimethyl ether, ethylene glycol diethyl ether, ethylene glycol dibutyl ether, propylene glycol n-butyl ether, tripropylene glycol methyl ether, dipropylene glycol methyl ether, dipropylene glycol butyl ether and combinations thereof.

[0045]

[0043] Typically, the preservative concentrate will be added to end-use formulations in an amount necessary to achieve the desired amount of the preservative in the final end-use formulation.

[0046]

[0044] In other embodiments, the pyrithione, the organic acid or salt thereof, and the aromatic alcohol may be added to end-use formulations independent of each other. That is the organic acid or salt thereof and the aromatic alcohol may be added to the end-use formulation prior to the addition of the pyrithione, after the pyrithione is added to the end-use formulation, or concurrently with the pyrithione to the end-use formulation as separate ingredients.

[0047]

[0045] Various different microorganisms may be controlled in accordance with the present disclosure. For instance, the preservative composition of the present disclosure can control gram positive bacteria, gram negative bacteria, and the like. In addition to bacteria, the preservative composition of the present disclosure can also kill and control the growth of various other microorganisms, such as viruses, spores, mycobacteria, and the like. Examples of particular microorganisms that may be controlled in accordance with the present disclosure include Staphylococcus aureus, Streptococcus pneumoniae, Pseudomonas aeruginosa, Serratia marcescens, Salmonella enteritidis, Neisseria gonorrhoeae, Escherichia coli, Enterococcus hirae, Acinetobacter baumannii, Listeria monocytogenes, Enterobacter gergoviae, Klebsiella pneumoniae, Burholderia cepacia, Pseudomonas putida, Kocuria rhizophila, Candida albicans, Saccharomyces cerevisiae, Aspergillus brasiliensis, Penicillium funiculosum, Eupenicillium levitum, Bacillus cereus, Bacillus subtilis, Clostridium difficile, Clostridium perfringens, Mycobacterium tuberculosis, Mycobacterium terrae, Mycobacterium avium, Poliovirus, Adenovirus, Norovirus, Vaccinia virus, Influenza virus, Hepatitis B virus, Human Immunodeficiency virus, Human papilloma virus, or mixtures thereof.

[0048]

[0046] In general, the preservative composition of the present disclosure can be incorporated into many different end-use formulations or products. As used herein, “end-use formulations” or “end use products” is intended to mean personal care or home care products.

[0049]

[0047] The personal care or home care product formulation generally comprises a base composition to which the preservative composition of the present disclosure is added. The base composition may contain numerous and different ingredients depending upon the end use application. The personal care or home care product formulation, for instance, may contain other solvents, surfactants, emulsifiers, complexing agents, corrosion inhibitors, alkalinity builders, pH adjusting agents, auxiliaries, acids, foaming agents, colorants, UV blocking agents, waxes, natural extracts, oils, consistency factors, conditioners, emollients, skin caring ingredients, moisturizers, thickeners, humectants, fillers, anti-oxidants, other preservatives, active ingredients, in particular dermatologically active ingredients, fragrances and the like, as well as mixtures thereof. Active ingredients as mentioned herein comprise, for example, anti-inflammatories, anti-bacterials, anti-fungals and the like agents. Active ingredients suited for topical applications are particularly preferred.

[0050]

[0048] Suitable surfactants for the base composition comprise: alkyl sulfates e.g. sodium lauryl sulfate, ammonium lauryl sulfate; sodium cetearyl sulfate; alkyl sulfoacetates e.g. sodium lauryl sulfoacetate; alkyl ether sulfates e.g. sodium laureth sulfate; sodium trideceth sulfate; sodium oleth sulfate; ammonium laureth sulfate; alkyl ether sulfosuccinates e.g. disodium laureth sulfosuccinate; alkyl glycosides e.g. decyl glucoside; lauryl glucoside; alkyl isethionates amphoterics e.g. cocam idopropyl betaine; sodium cocoamphoacetate; sodium lauroamphoacetate; disodium lauroamphodiacetate; disodium cocoamphodiacetate; sodium lauroamphopripionate; disodium lauroamphodipropionate; potassium or ammonium salts of the aforementioned amphoterics; capryl / capram idopropyl betaine; undecylenam idopropyl betaine; laurom idopropyl betaine; and fatty alcohol polyglycol ethers.

[0051]

[0049] Suitable emulsifiers for the base composition are e.g. anionics as salts of fatty acids e.g. sodium stearate or sodium palmitate, organic soaps e.g. mono-, di- or triethanolaminoeate, sulfated or sulfonated compounds e.g. sodium lauryl sulfate or sodium cetyl sulfonate, saponines, lamepones; cationics as quaternary ammonium salts; nonionics as fatty alcohols, fatty acid ester with saturated or unsaturated fatty acids, polyoxyethylenesters or polyoxyethylenethers of fatty acids, polymers from ethylene oxide and propylene oxide or propylene glycol, amphotherics as phosphatides, proteins as gelatine, casein alkylamidobetaines, alkyl betaines and amphoglycinates, alkyl phosphates, alkylpolyoxyethylene phosphates or the corresponding acids, silicone derivatives, e.g. alkyl dimethiconecoplyol.

[0052]

[0050] Suitable consistency factors for the base composition are e.g. fatty alcohols or their mixtures with fatty acid esters, e.g. acetylated lanolin alcohol, aluminum stearates, carbomer, cetyl alcohol, glyceryl oleate, glyceryl stearate, glyceryl stearate (and) PEG 100 stearate, magnesium stearate, magnesium sulfate, oleic acid, stearic acid, stearyl alcohol, myristyl myristate, isopropyl palmitate, carnuba wax, beeswax and synthetic equivalents thereof, carbomers, and the like. Suitable conditioners are e.g. alkylamido ammonium lactate, cetrimonium chloride and distearoylethyl hydroxyethylmonium methosulfate and cetearyl alcohol, cetyl dimethicone, cetyl ricinoleate, dimethicone, laureth-23, laureth-4, polydecene, retinyl palmitate, quaternized protein hydrolysates, quaternized cellulose and starch derivatives, quaternized copolymers of acrylic or methacrylic acid or salts, quaternized silicone derivatives.

[0053]

[0051] Suitable emollients for the base composition are e.g. cetearyl isononanoate, cetearyl octanoate, decyl oleate, isooctyl stearate, coco caprylate / caprate, ethylhexyl hydroxystearate, ethylhexyl isononanoate, isopropyl isostearate, isopropyl myristate, oleyl oleate, hexyl laurate, paraffinum liquidum, PEG-75 lanolin, PEG-7 glyceryl cocoate, petrolatum, ozokerite cyclomethicone, dimethicone, dimethicone copolyol, dicaprylyl ether, butyrospermum parkii, buxus chinensis, canola, carnauba cera, copernicia cerifera, oenothera biennis, elaeis guineensis, prunus dulcis, squalane, zea mays, glycine soja, helianthus annuus, lanolin, hydrogenated castor oil, hydrogenated coconut oil, hydrogenated polyisobutene, sucrose cocoate, stearoxy dimethicone, lanolin alcohol, isohexadecane.

[0054]

[0052] Suitable skin care ingredients for the base composition are e.g. plant extracts, bisabolol, anti-inflammatory agents, urea, allantoin, panthenol and panthenol derivatives, phytantriol, vitamins A, E, C, D, ceram ides of animal or plant origin, lecithins, and the like.

[0055]

[0053] Suitable moisturizers for the base composition are e.g. butylenes glycol, cetyl alcohol, dimethicone, dimyristyl tartrate, glucose glycereth-26, glycerin, glyceryl stearate, hydrolyzed milk protein, lactic acid, lactose and other sugars, laureth-8, lecithin, octoxyglycerin, PEG-12, PEG 135, PEG-150, PEG-20, PEG-8, pentylene glycol, hexylene glycol, phytantriol, poly quaternium-39 PPG-20 methyl glucose ether, propylene glycol, sodium hyaluronate, sodium lactate, sodium PCA, sorbitol, succinoglycan, synthetic beeswax, tri-C14-15 alkyl citrate, starch.

[0056]

[0054] Suitable thickeners for the base composition are e.g. acrylates / steareth-20 methacrylate copolymer, carbomer, carboxymethyl starch, cera alba, dimethicone / vinyl dimethicone crosspolymer, propylene glycol alginate, hydroxyethylcellulose, hydroxypropyl methylcellulose, silica, silica dimethyl silylate, xanthan gum, hydrogenated butylenes / ethylene / styrene copolymer.

[0057]

[0055] Suitable humectants for the base composition are e.g. adipic acid, fumaric acid and its salts, benzoic acid and its salts, glycerine triacetate, sodium or magnesium lauryl sulfate, magnesium stearate, solid polyethylenglycol, polyvinylpyrrolidone, boric acid, mono-laurate or mono-palmitate, myristyl alcohol, cetyl alcohol, cetylstearyl alcohol, talcum, calcium or magnesium salts of higher fatty acids, mono-, di- or triglycerides of higher fatty acids, polytetrafluorethylene.

[0058]

[0056] Suitable antioxidants for the base composition are e.g. sulfites, e.g. sodium sulfite, tocopherol or derivates thereof, ascorbic acid or derivates thereof, citric acid, propyl gallate, chitosan glycolate, cysteine, N-acetyl cysteine plus zinc sulfate, thiosulfates, e.g. sodium thiosulfate, polyphenols and the like.

[0059]

[0057] The formulations may further contain active ingredients, e.g. antimicrobials, anti-inflammatories, plant extracts, bisabolol, panthenol, tocopherol, actives for antistinging, anti-irritant or anti-dandruff applications, or anti-aging agents such as retinol, melibiose and the like. Other suitable actives are e.g. Medicago officinalis, Actinidia chinensis, allantoin, Aloe barbadensis, Anona cherimolia, Anthemis nobilis, Arachis hypogaea, Arnica Montana, Avena sativa, beta-carotene, bisabolol, Borago officinalis, butylenes glycol, Calendula officinalis, Camellia sinensis, camphor, Candida bombicola, capryloyl glycine, Carica papaya, Centaurea cyanus, cetylpyridinium chloride, Chamomilla recutita, Chenopodium quinoa, Chinchona succirubra, Chondrus crispus, Citrus aurantium dulcis, Citrus grandis, Citrus limonum, Cocos nucifera, Coffea Arabica, Crataegus monogina, Cucumis melo, dichlorophenyl imidazoldioxolan, Enteromorpha compressa, Equisetum arvense, ethoxydiglycol, ethyl panthenol, farnesol, ferulic acid, Fragaria chiloensis, Gentiana lutea, Ginkgo biloba, glycerin, glyceryl laurate, Glycyrrhiza glabra, Hamamelis virginiana, heliotropine, hydrogenated palm glycerides, citrates, hydrolyzed castor oil, hydrolyzed wheat protein, Hypericum perforatum, Iris florentina, Juniperus communis, Lactis proteinum, lactose, Lawsonia inermis, linalool, Linum usitatissimum, lysine, magnesium aspartate, Magnifera indica, Malva sylvestris, mannitol, Melaleuca alternifolia, Mentha piperita, menthol, menthyl lactate, Mimosa tenuiflora, Nymphaea alba, olaflur, Oryza sativa, panthenol, paraffinum liquidum, PEG-20M, PEG-26 jojoba acid, PEG-26 jojoba alcohol, PEG-35 castor oil, PEG-40 hydrogenated castor oil, PEG-60 hydrogenated castor oil, PEG-8 caprylic / capric acid, Persea gratissima, petrolatum, potassium aspartate, potassium sorbate, propylene glycol, Prunus amygdalus dulcis, Prunus armeniaca, Prunus persica, retinyl palmitate, Ricinus communis, Rosa canina, Rosmarinus officinalis, Rubus idaeus, salicylic acid, Sambucus nigra, sarcosine, Serenoa serrulata, Simmondsia chinensis, sodium carboxymethyl betaglucan, sodium cocoyl amino acids, sodium hyaluronate, sodium palmitoyl praline, stearoxytrimethylsilane, stearyl alcohol, sulfurized TEA-ricinoleate, talc, Thymus vulgaris, Tilia cordata, tocopherol, tocopheryl acetate, trideceth-9, triticum vulgare, tyrosine, undecylenoyl glycine, urea, Vaccinium myrtillus, valine, zinc oxide, zinc sulfate.

[0060]

[0058] The base composition of the personal care or home care product to which the preservative composition of the present disclosure is added can be various types of products.

[0061]

[0059] For instance, personal care products may comprise color cosmetic products, deodorant products, hair care products, oral care products, skin care products, and bathing products. The personal care product formulation may comprise any product for topical application to a user’s skin or hair. When combined with the personal care product formulation as a preservative, the preservative composition of the present disclosure has effective broad spectrum preservation activity over a broad pH range. For instance, the pH of the composition and / or of the personal care product can be generally greater than about 2 and less than about 10, such as from about 3 to about 8, particularly from about 3 to about 6.

[0062]

[0060] Color cosmetic products can include, but are not limited to, body color products, eye color cosmetics such as mascara, eyeliner, brow color, and eyeshadow, face color cosmetics such as blush, bronzer, concealer, foundation, powder, and primer, lip color cosmetics, such as lipstick and lip balm, and nail color cosmetics.

[0063]

[0061] In one aspect, the eye color cosmetic is mascara. The mascara can contain the preservative composition of the present disclosure, water, consistency factors, pigments, emollients, thickeners, and film-forming agents. Particularly suitable consistency factors used in mascara include beeswax and carnuba wax. Particularly suitable emollients used in mascara include cetyl alcohol. Particularly suitable thickeners used in mascara include acacia Senegal gum.

[0064]

[0062] In another aspect, the eye color cosmetic is eyeliner. The eyeliner can contain the preservative composition of the present disclosure, water, pigments, film-forming agents, emollients, thickeners, binders, solvents, and opacifiers. Particularly suitable emollients used in eyeliner include glycerin. Particularly suitable thickeners used in eyeliner include xanthan gum. Particularly suitable solvents used in eyeliner include ethanol and particularly suitable opacifiers used in eyeliner include titanium dioxide.

[0063] In another embodiment, the lip color cosmetic is lip balm. The lip balm can contain the preservative composition of the present disclosure, emollients, moisturizers, occlusives, flavoring, fragrance, sunscreen ingredients, antioxidants, healing agents, and pigment. Particularly suitable emollients and moisturizers used in lip balm include beeswax, shea butter, cocoa butter, lanolin, coconut oil, and jojoba oil. Particularly suitable occlusives used in lip balm include petroleum jelly and castor seed oil. Particularly suitable antioxidants used in lip balm include vitamin E and aloe vera extract, while particularly suitable healing agents used in lip balm include allantoin and calendula extract.

[0065]

[0064] In a particular embodiment, the personal care product is a deodorant. Deodorant products can include roll-on deodorant products, spray deodorant products, stick deodorant products, or wipe deodorant products. Although the ingredients in deodorant products can vary depending on whether the product is a stick product, a roll-on product, a gel product, a cream product, or a spray product, many of the ingredients remain consistent among all of the deodorant product formulations.

[0066]

[0065] The deodorant product, for instance, can contain the preservative composition of the present disclosure, antiperspirant active ingredients, odor-fighting ingredients, emollients, moisturizers, thickeners, stabliziers, skin conditioners, antibacterial agents, solvents, and propellants. Particularly suitable antiperspirant active ingredients used in deodorant products include aluminum compounds such as aluminum chlorohydrate and aluminum tetrachlorohydrex glycine. Particularly suitable odor-fighting ingredients used in deodorant products include fragrance, sodium bicarbonate, and zinc compounds such as zinc ricinoleate. Particularly suitable emollients and moisturizers used in deodorant products include glycerin, shea butter, cocoa butter, and jojoba oil. Particularly suitable skin conditioners used in deodorant products include aloe vera and Vitamin E (e.g., tocopheryl acetate). Particularly suitable antibacterial agents used in deodorant products include triclosan and particularly suitable solvents used in deodorant products include propylene glycol. Particularly suitable emollients and moisturizers used in deodorant products includes glycerin, shea butter, cocoa butter, and jojoba oil.

[0067]

[0066] Hair care products can include, but are not limited to, conditioner, shampoo, styling products, hair treatment products, and hair colorant.

[0068]

[0067] In one aspect, the hair care product is conditioner. The conditioner can contain the preservative composition of the present disclosure, water, emollients, surfactants, silicones, natural oils, humectants, panthenol, fragrance, and pH adjusters. Particularly suitable emollients used in conditioners include cetyl alcohol and stearyl alcohol. Particularly suitable surfactants used in conditioners include cationic surfactants such as cetrimonium chloride and behentrimonium chloride. Particularly suitable silicones used in conditioners include dimethicone and cyclomethicone. Particularly suitable natural oils used in conditioners include argan oil and coconut oil, and particularly suitable humectants used in conditions include glycerin. Particularly suitable pH adjusters used in conditioners include citric acid.

[0068] In another aspect, the hair care product is shampoo. The shampoo can contain the preservative composition of the present disclosure, water, surfactants, cocam idopropyl betaine, cocamide DEA or cocamide MEA, conditioning agents, fragrance, citric acid, sodium chloride, glycerol distearate, and natural extracts or oils. Particularly suitable surfactants used in shampoo include sodium lauryl sulfate and sodium laureth sulfate. Particularly suitable conditioning agents used in shampoo include polyquaternium-10 and guar hydroxypropyltrimonium chloride. Particularly suitable natural extracts or oils used in shampoo include aloe vera and tea tree oil.

[0069] Oral care products can include, but are not limited to, toothpastes and mouthwashes.

[0069]

[0070] In one aspect, the oral care product is toothpaste. The toothpaste can contain the preservative composition of the present disclosure, abrasive agents, fluoride, detergents, humectants, binding agents, flavoring agents, sweeteners, desensitizing agents, and whitening agents. Particularly suitable abrasive agents used in toothpaste include calcium carbonate and silica. Particularly suitable fluoride compounds used in toothpaste include sodium fluoride and sodium monofluorophosphate. Particularly suitable detergents used in toothpaste include sodium lauryl sulfate. Particularly suitable humectants used in toothpaste include glycerin and sorbital. Particularly suitable binding agents used in toothpaste include xanthan gum. Particularly suitable flavoring agents used in toothpaste include peppermint and spearmint. Particularly suitable sweeteners used in toothpaste include saccharin and sorbital. Particularly suitable desensitizing agents used in toothpaste include potassium nitrate and strontium chloride. Particularly suitable whitening agents used in toothpaste include hydrogen peroxide and sodium bicarbonate.

[0070]

[0071] In another aspect, the oral care product is mouthwash. The mouthwash can contain the preservative composition of the present disclosure, water, alcohol, antibacterial agents, flavoring agents, sweeteners, colorants, pH adjusters, preservatives, fluoride, and desensitizing agents. Particularly suitable alcohol compounds used in mouthwash include ethanol and isopropyl alcohol. Particularly suitable antimicrobial agents used in mouthwash include cetylpyridinium chloride and chlorhexidine. Particularly suitable flavoring agents used in mouthwash include menthol and eucalyptus. Particularly suitable sweeteners used in mouthwash include saccharin and xylitol. Particularly suitable pH adjusters used in mouthwash include sodium hydroxide and citric acid.

[0071]

[0072] Skin care products include, but are not limited to, body care cosmetics, eye care cosmetics, face and neck care cosmetics, foot care cosmetics, lip care cosmetics, sunscreens, after sun cosmetics, and self-tanning cosmetics.

[0072]

[0073] In one aspect, the skin care product is sunscreen. The sunscreen can contain the preservative composition of the present disclosure, active sun-protectant ingredients, emollients, emulsifiers, thickeners, antioxidants, fragrance, water, and pH adjusters. Particularly suitable active sun-protectant ingredients used in sunscreen include avobenzone, octisalate, octocrylene, homosalate, octinoxate, zinc oxide, and titanium dioxide. Particularly suitable emollients used in sunscreen include glycerin and caprylic / capric triglyceride. Particularly suitable emulsifiers used in sunscreen include cetearyl alcohol and polysorbate 60. Particularly suitable thickeners used in sunscreen include xanthan gum. Particularly suitable antioxidants used in sunscreen include Vitamin E and green tea extract. Particularly suitable pH adjusters used in sunscreen include citric acid.

[0073]

[0074] Bathing products include, but are not limited to, face cleansers, body cleansers, hand cleansers, soap bars, liquid soaps, intimate hygiene products, and pre-moistened wipes.

[0074]

[0075] In one aspect, the bathing product is a face cleanser. The face cleanser can contain the preservative composition of the present disclosure, water, surfactants, emollients, emulsifiers, humectants, preservatives, fragrance or essential oils, exfoliating agents, and anti-acne ingredients. Particularly suitable surfactants for the face cleanser include sodium lauryl sulfate and sodium cocoyl isethionate. Particularly suitable emollients for the face cleanser include glycerin and caprylic / capric triglyceride. Particularly suitable emulsifiers for the face cleanser include polysorbate 20. Particularly suitable humectants for the face cleanser include propylene glycol. Particularly suitable exfoliating agents for the face cleanser include salicylic acid and glycolic acid. Particularly suitable anti-acne ingredients for the face cleanser include benzoyl peroxide and salicylic acid.

[0075]

[0076] In another aspect, the bathing product is a body cleanser. The body cleanser can contain the preservative composition of the present disclosure, water, surfactants, emollients, humectants, and fragrance or essential oils. Particularly suitable surfactants for the body cleanser include sodium laureth sulfate or cocam idopropyl betaine. Particularly suitable emollients for the body cleanser include shea butter and jojoba oil. Particularly suitable humectants for the body cleanser include glycerin.

[0076]

[0077] In yet another aspect, the bathing product is a hand cleanser. The hand cleanser may contain the preservative composition of the present disclosure, alcohol compounds, water, emollients and humectants, thickeners, and fragrance.

[0077] Particularly suitable alcohol compounds used in the hand cleanser include ethanol and isopropyl alcohol. Particularly suitable emollients and humectants used in the hand cleanser include aloe vera and glycerin. Particularly suitable thickeners used in the hand cleanser include carbomer.

[0078]

[0078] In another aspect, the bathing product is a soap bar. The soap bar may contain the preservative composition of the present disclosure, sodium tallowate or sodium palmate, sodium cocoate, fragrance or essential oils, and colorants.

[0079]

[0079] In one aspect, the bathing product is a liquid soap. The liquid soap may contain the preservative composition of the present disclosure, water, surfactants, emollients, humectants, and fragrances or essential oils. Particularly suitable surfactants used in liquid soap include sodium lauryl sulfate and cocam idopropyl betaine. Particularly suitable emollients used in liquid soap include glycerin and shea butter. Particularly suitable humectants used in liquid soap include propylene glycol.

[0080] The preservative composition may also be incorporated into home care products as well, such as fabric care products, dish wash liquid, hard surface cleaners, and toilet care products. The home care product formulation may comprise all purpose cleaners and other similar formulations that are used around the home.

[0081] Fabric care products include, but are not limited to, fabric conditioners, laundry detergent liquids, laundry detergent pods or capsules, ironing aids, stain removal liquids, carpet cleaners, washing machine cleaning solutions, and fabric brightening solutions.

[0080]

[0082] In one aspect, the fabric care product is a laundry detergent. Although the ingredients in laundry detergents can vary depending on whether the product is a liquid, pod, or capsule, many of the ingredients remain consistent among all of the laundry detergent product formulations.

[0081]

[0083] Therefore, in another embodiment, the laundry detergent can contain the preservative composition of the present disclosure, surfactants, enzymes, dyes, hueing dyes, chelants, stabilizers, radical scavengers, perfumes, fluorescent whitening agents, suds-supressors, soil-suspension polymers, soil release polymers, dye-transfer inhibitors, fabric softening additives, rheology modifiers, washing or cleaning adjuvants, and other polymers.

[0082]

[0084] Particularly suitable surfactants used in laundry detergents include nonionic surfactants, such as alkoxylate fatty alcohol nonionic surfactants, amphoteric surfactants, such as beta-n-alkylaminopropionic acids, n-alkyl-beta-iminodipropionic acids, imidazoline carboxylates, amine oxides, sultaines, betaines, phosphocholines, proprionates, di-propionates, sodium cocam phoacetate, disodium cocoamphodiacetate, 3-[(3-Cholamidopropyl)dimethylammonio]-1 -propanesulfonate (CHAPS), dipalmitoylphosphatidylcholine (DPPtdCho), sodium lauroamphocetate, or any combination of the foregoing.

[0083]

[0085] Particularly suitable enzymes used in laundry detergents include proteases, amylases, cellulose enzymes, lipases, mannanases, pectate lyases, subtilisin, and mixtures thereof.

[0084]

[0086] Particularly suitable hueing dyes used in laundry detergents include Basic Violet 3 (Cl 42555) and Basic Violet 4 (Cl 426000), both commercially available from Standard Dyes.

[0085]

[0087] Particularly suitable chelants used in laundry detergents include DTPA, HEDP, DTPMP, GLDA, MGDA, a citrate, EDTA, IDS, dipicolinic acid, and mixtures thereof.

[0086]

[0088] Particularly suitable radical scavengers used in laundry detergents include trimethoxybenzoic acid.

[0087]

[0089] Particularly suitable fluorescent whitening agents used in laundry detergents include Tinopal CBS-X.

[0088]

[0090] Particularly suitable suds suppressors used in laundry detergents include nonfatty acid suds suppressors, such as silica / silicone, silicone oil, alcohols such as branched alcohols, dimethicone, and mixtures thereof.

[0089]

[0091] Particularly suitable soil suspension polymers used in laundry detergents include PEI ethoxylate, HDMA diquate ethoxylates, sulfonated derivates, and hydrophobically modified copolymers.

[0090]

[0092] Particularly suitable soil release polymers used in laundry detergents include PET alkoxylate short block copolymer.

[0091]

[0093] Particularly suitable dye transfer inhibitors and dye fixatives included in laundry detergents include polyvinylpyrrolidone, poly-4-vinylpyridine-N-oxide, copolymers of N-viny-2-pyrrolidone and N-vinylimidazole and mixtures thereof.

[0094] Particularly suitable fabric softening additives used in laundry detergents include alkyl quaternary ammonium compounds, ester quaternary ammonium compounds, bentonite, silicones, cationic silicones, and mixtures thereof.

[0095] Particularly suitable rheology modifiers used in laundry detergents include methylcellulose, hydroxypropylmethylcellulose, xanthan gum, gellan gum, guar gum and hydroxypropyl guar gum, succinoglycan, and trihydroxystearin.

[0092]

[0096] Particularly suitable wash or cleaning adjuvants used in laundry detergents include ethanol amine citrate, ethanol amine laurate, ethanol amine palmitate, ethanol amine oleate, ethanol amine stearate, C16 to C18 fatty acids, C18 unsaturated fatty acids, pentasodium pentetate, sodium laurate, sodium lauryl sulfate, sodium myristate, sodium oleate, sodium palmitate, sodium polyacrylate, sodium stearate, and mixtures thereof.

[0093]

[0097] Particularly suitable stabilizers and blending aids used in laundry detergents include calcium formate, diethylene glycol, dipropylene glycol, an alcohol, ethanol amine, glycerin, hydrogenated castor oil, monoethanol amine citrate, polyethylene glycol, sodium bisulfite, sodium carbonate, sodium citrate, sodium cumene sulfonate, sodium formate, sodim silicate, trimethylsiloxy silicate, or mixtures thereof.

[0094]

[0098] Hard surface cleaners include, but are not limited to, general purpose cleaners, bathroom cleaners, kitchen cleaners, cleaning creams, floor cleaners, and furniture care products.

[0095]

[0099] In one aspect, the hard surface cleaner is a general purpose cleaner. The general purpose cleaner may contain the preservative composition of the present disclosure, water, surfactants, solvents, emulsifiers, pH adjusters, and fragrance. Particularly suitable surfactants used in general purpose cleaners include sodium lauryl sulfate and decyl glucoside. Particularly suitable solvents used in general purpose cleaners include isopropyl alcohol and ethanol. Particularly suitable emulsifiers used in general purpose cleaners include polysorbate 20. Particularly suitable pH adjusters used in general purpose cleaners include citric acid and sodium hydroxide.

[0096]

[0100] In another aspect, the hard surface cleaner is a bathroom cleaner. The bathroom cleaner may contain the preservative composition of the present disclosure, acid compounds, surfactants, fragrance, and thickeners. Particularly suitable acid compounds used in bathroom cleaners include hydrochloric acid and citric acid.

[0097]

[0101] In yet another aspect, the hard surface cleaner is a kitchen cleaner. The kitchen cleaner may contain the preservative composition of the present disclosure, surfactants, solvents, degreasers, fragrance, and antimicrobial agents. Particularly suitable degreasers used in kitchen cleaners include sodium carbonate and sodium bicarbonate.

[0098]

[0102] In one aspect, the hard surface cleaner is a cleaning cream. The cleaning cream may contain the preservative composition of the present disclosure, an abrasive agent, surfactants, emollients, and fragrance. Particularly suitable abrasive agents used in cleaning creams include calcium carbonate and silica. Particularly suitable emollients used in cleaning creams include glycerin.

[0099]

[0103] In another aspect, the hard surface cleaner is a floor cleaner. The floor cleaner may contain the preservative composition of the present disclosure, water, surfactants, solvents, fragrance, and pH adjusters.

[0100]

[0104] Dishwashing liquids include, but are not limited to, hand wash liquids, machine dish wash liquids, dishwash capsules, rise aids, and dish washing cleaning solutions.

[0101]

[0105] In one aspect, the dishwashing liquid is a hand dish wash liquid. The hand dish wash liquid may contain the preservative composition of the present disclosure, water, surfactants, emollients, solvents, and fragrance. Particularly suitable surfactants used in hand dish wash liquid include sodium lauryl sulfate and cocam idopropyl betaine. Particularly suitable emollients used in hand dish wash liquids include glycerin. Particularly suitable solvents used in hand dish wash liquids include isopropyl alcohol.

[0102]

[0106] In another aspect, the dishwashing liquid is a machine dish wash liquid. The machine dish wash liquid may contain the preservative composition of the present disclosure, surfactants, enzymes, builders, bleaching agents, antiredeposition agents, and rinse aids. Particularly suitable enzymes used in machine dish wash liquids include protease and amylase. Particularly suitable builders used in machine dish wash liquids include sodium carbonate and sodium citrate. Particularly suitable bleaching agents used in machine dish wash liquids include sodium percarbonate. Particularly suitable antiredeposition agents used in machine dish was liquids include polyacrylate.

[0103]

[0107] In yet another aspect, the dishwashing liquid is a dishwash capsule or pod. The dishwashing capsule or pod may contain the preservative composition of the present disclosure, surfactants, enzymes, builders, bleaching agents, rinse aid, and solvents. Particularly suitable solvents used in dishwash capsules or pods include PEG-75 and PEG-150.

[0104]

[0108] In one aspect, the dishwashing liquid is a rinse aid. The rinse aid may contain the preservative composition of the present disclosure, water, surfactants, acidifiers, chelating agents, and anti-foaming agents. Particularly suitable acidifiers used in the rinse aid include citric acid. Particularly suitable chelating agents used in the rinse aid include tetrasodium EDTA.

[0105]

[0109] Toilet care products include, but are not limited to, toilet cleaners and toilet fresheners.

[0106]

[0110] In one aspect, the toilet care product is a toilet cleaner. The toilet cleaner may contain the preservative composition of the present disclosure, hydrochloric acid or sulfuric acid, surfactants, thickeners, fragrance, colorants, corrosion inhibitors, bleaching agents, thickening agents, solvents, and antibacterial agents. Particularly suitable surfactants used in the toilet cleaners include sodium lauryl sulfate and alkyl dimethyl amine oxides. Particularly suitable thickeners used in the toilet cleaners include xanthan gum and sodium chloride. Particularly suitable thickening agents used in the toilet cleaners include sodium hydroxide and sodium polyacrylate.

[0107] Particularly suitable solvents used in the toilet cleaners include isopropanol.

[0108]

[0111] Within these various types of products, the preservative composition and the base composition can be formulated differently depending on the function of the enduse product. For instance, the preservative composition of the present disclosure can be used in emulsions (both oil-in-water and water-in-oil), in aqueous solutions, in PIT (phase inversion temperature) emulsions, in oily solutions, in foaming cosmetic formulations (foams), and in so-called multiple emulsions, e.g. in triple emulsions (such as water / oil / water emulsions).

[0109]

[0112] The base composition of the present disclosure can also be formulated as a liquid, a semi-solid, or a solid in forms such as creams, gels, liquids or lotions. The liquid, semi-solid, and solid base compositions can be used in hair care products such as shampoos, hair conditioners, hair dyes, hair tonic, hair gel, hair dressings, hair grooming aids and other hair care preparations; shaving applications such as shaving cream, aftershave lotions, and other shaving applications; personal cleaners for the body and hands, such as liquid bath soaps and detergents; fragrance preparations, such as perfumes, after bath splashes, and other similar fragrant preparations, skin care products, such as moisturizers, creams, and lotions and other similar skin care products, make-up products, such as mascara, base foundations and the like; make-up removal products, sun care products, indoor tanning products and other similar personal care products. One particular use of the present preservative composition is to be incorporated into wiping solutions for premoistened wipes. The premoistened wipes can be used for personal cleaning and hygiene, such as baby wipes, wet toilet wipes, make-up removal wipes and exfoliating wipes the like.

[0110]

[0113] When the preservative composition is used to saturate premoistened wipes, the preservative composition serves to preserve the premoistened wipe formulation and the wipe prior to use. Once the premoistened wipe composition is formulated, the premoistened wipe composition is applied to a substrate.

[0111]

[0114] For example, the pre-moistened wipe can be a single use wipe that is impregnated with the formulation or wiping solution and is stored in a container that will dispense the wipe to a user. The container with the wipes may contain a single wipe, or several wipes.

[0112]

[0115] Suitable wipe substrates include woven and nonwoven materials. Essentially any nonwoven web material may be used. Exemplary nonwoven materials may include, but are not limited to meltblown, coform, spunbond, airlaid, airlaced, hydroentangled nonwovens, spunlace, bonded carded webs, and laminates thereof. The fibers used to prepare the wipe substrate may be cellulosic fiber, thermoplastic fibers and mixtures thereof. The fibers may also be continuous fibers, discontinuous fibers, staple fibers and mixtures thereof. Basis weights of the nonwoven web may vary from about 12 grams per square meter to 200 grams per square meter (gsm) or more.

[0113]

[0116] Once incorporated into the substrate, the resulting wiping product can have a weight ratio of liquid to substrate of from about 5:1 to about 1 :1 , such as from about 2:1 to about 4:1 .

[0114]

[0117] As demonstrated, the preservative composition can be incorporated into many different end-use formulations or products, such as personal care or home care products.

[0115]

[0118] Typically, the preservative composition of the present disclosure may be added to an end-use formulation to be preserved in an amount between 0.001 % to about 10% by weight of the formulation. More particularly, the preservative composition is added in an amount which is between about 0.1 and 5.0% by weight of the formulation.

[0116]

[0119] In one aspect, the pyrithione is present in the base composition of the personal care or home care product in an amount less than about 1000 ppm, such as in an amount less than about 500 ppm, such as in an amount less than about 250 ppm, such as in an amount less than about 100 ppm, even such as in an amount less than 50 ppm. Pyrithione can be present in the base composition of the personal care or home care product in an amount greater than about 1 ppm, such as in an amount greater than about 5 ppm, such as in an amount greater than about 10 ppm, such as in an amount greater than about 10 ppm, such as in an amount greater than about 15 ppm, such as in an amount greater than 20 ppm, even such as in an amount greater than about 25 ppm.

[0117]

[0120] The following examples illustrate the invention without limitation. All parts and percentages are given by weight unless otherwise indicated.

[0118]

[0121] To demonstrate the synergistic effect the following examples were performed.

[0119] Example No. 1

[0120]

[0122] The synergistic activity of pyrithione, organic acids or salts thereof, and aromatic alcohols are demonstrated as part of three-component composition.

[0121]

[0123] The sodium pyrithione used was Sodium OMADINE® obtained from Arxada AG.

[0122]

[0124] A wide range of concentrations were tested against: Pseudomonas aeruginosa ATCC 9027 / DSM 1128, and Candida albicans ATCC 10231 / DSM 1386.

[0123]

[0125] The lowest concentration of each mixture or single compound which prevents an observable level of growth was determined to be the minimum inhibitory concentration (MIC) value. The MIC value was determined for each microorganism.

[0124]

[0126] Serial dilutions of each mixture or single compound were prepared. Microorganisms were inoculated into media: Nutrient Broth (bacteria) or Malt Extract Broth (yeast). The final concentrations of micro-organisms in media were approximately 105 CFU / ml. The inoculated media was introduced to each of the serial dilutions at a 1 :1 ratio and incubated at 30±1 °C for 24-48 hours.

[0127] The MICs for each mixture were compared with the MIC of each single compound alone.

[0125]

[0128] Synergy was determined using a synergy index (“SI”) value, calculated using a method based on the Kull equation (F.C. Kull et. al., “Mixtures of Quaternary Ammonium Compounds and Long-chain Fatty Acids as Antifungal Agents”, Appl Microbiol. 1961 Nov; 9(6): 538-541 ):

[0126] SI = Qa / QA + Qb / QB + Qc / QC wherein

[0127] QA= concentration of compound A in ppm, acting alone produced an end point;

[0128] Qa = concentration of compound A in ppm, in the mixture, which produced an end point;

[0129] QB = concentration of compound B in ppm, acting alone produced an end point;

[0130] Qb = concentration of compound B in ppm, in the mixture, which produced an end point;

[0131] QC = concentration of compound C in ppm, acting alone produced an end point; and Qc = concentration of compound C in ppm, in the mixture, which produced an end point.

[0132]

[0129] In this study the end point is measured by the MIC. Synergy is demonstrated by an SI value of less than 1 . An additive effect is demonstrated by an SI value of equal to 1 . Antagonism is demonstrated by an SI value of greater than 1 .

[0133] Table 1.

[0134] Synergy Index: Summary of Synergistic Interactions of Aromatic Alcohols and

[0135] Organic Acids or Salts Thereof With Sodium Pyrithione.

[0136] *Data is currently being generated, and thus, the synergistic interaction between benzyl alcohol, itaconic acid, and sodium pyrithione is prophetic.

[0137] Table 2.

[0138] Sodium Pyrithione: Phenoxyethanol: Sodium benzoate

[0139] Pseudomonas aeruginosa Table 3.

[0140] Sodium Pyrithione: Phenoxyethanol: Sodium benzoate

[0141] Candida albicans Table 4.

[0142] Ternary FIC: Sodium Pyrithione: Phenoxyethanol: Potassium Sorbate

[0143] Pseudomonas aeruginosa

[0144] Table 5.

[0145] Ternary FIC: Sodium Pyrithione: Phenoxyethanol: Potassium Sorbate

[0146] Candida albicans

[0147] Table 6.

[0148] Ternary FIC: Sodium Pyrithione: Phenoxyethanol: Lactic Acid

[0149] Pseudomonas aeruginosa

[0150] Table 7.

[0151] Ternary FIC: Sodium Pyrithione: Phenoxyethanol: Lactic Acid

[0152] Candida albicans Table 8.

[0153] Ternary FIC: Sodium Pyrithione: Phenoxyethanol: Levulinic Acid

[0154] Pseudomonas aeruginosa

[0155] Table 9.

[0156] Ternary FIC: Sodium Pyrithione: Phenoxyethanol: Levulinic Acid

[0157] Candida albicans

[0158] Table 10.

[0159] Ternary FIC: Sodium Pyrithione: Phenoxyethanol: Itaconic Acid

[0160] Pseudomonas aeruginosa Table 11.

[0161] Ternary FIC: Sodium Pyrithione: Phenoxyethanol: Itaconic Acid

[0162] Candida albicans

[0163] Table 12.

[0164] Ternary FIC: Sodium Pyrithione: Benzyl Alcohol: Sodium Benzoate

[0165] Pseudomonas aeruginosa

[0166] Table 13.

[0167] Ternary FIC: Sodium Pyrithione: Benzyl Alcohol: Sodium Benzoate

[0168] Candida albicans

[0169] Table 14.

[0170] Ternary FIC: Sodium Pyrithione: Benzyl Alcohol: Potassium Sorbate

[0171] Pseudomonas aeruginosa

[0172] Table 15.

[0173] Ternary FIC: Sodium Pyrithione: Benzyl Alcohol: Potassium Sorbate

[0174] Candida albicans

[0175] Table 16.

[0176] Ternary FIC: Sodium Pyrithione: Benzyl Alcohol: Citric Acid

[0177] Pseudomonas aeruginosa Table 17.

[0178] Ternary FIC: Sodium Pyrithione: Benzyl Alcohol: Citric Acid

[0179] Candida albicans

[0180] Table 18.

[0181] Ternary FIC: Sodium Pyrithione: Benzyl Alcohol: Levulinic Acid

[0182] Pseudomonas aeruginosa

[0183] Table 19.

[0184] Ternary FIC: Sodium Pyrithione: Benzyl Alcohol: Lactic Acid

[0185] Pseudomonas aeruginosa Table 20.

[0186] Ternary FIC: Sodium Pyrithione: Benzyl Alcohol: Lactic Acid

[0187] Candida albicans

Claims

What is claimed is:1 . A preservative composition comprising:(a) a pyrithione,(b) an organic acid or salt thereof; and(c) an aromatic alcohol; wherein the preservative composition exhibits a synergistic effect; and wherein a weight ratio of the pyrithione to the organic acid or salt thereof and to the aromatic alcohol is from about 1 :1 :1 to about 1 :15630:12500.

2. The preservative composition according to claim 1 , wherein the weight ratio of the pyrithione to the organic acid or salt thereof and to the aromatic alcohol is from about 1 :1 :1 to about 1 : 15630: 12500, such as from about 1 :1 :1 to about1 : 10000: 10000, such as from about 1 :1 :1 to about 1 :5000:5000.

3. The preservative composition according to claim 1 or 2, wherein the pyrithione comprises a water soluble pyrithione.

4. The preservative composition according to any of the preceding claims, wherein the pyrithione comprises sodium pyrithione.

5. The preservative composition according to any of the preceding claims, wherein the aromatic alcohol comprises phenoxyethanol.

6. The preservative composition according to any of claim 1 through 4, wherein the aromatic alcohol comprises benzyl alcohol.

7. The preservative composition according to any of the preceding claims, wherein the organic acid or salt thereof comprises itaconic acid.

8. The preservative composition according to any of claims 1 through 6, wherein the organic acid or salt thereof comprises lactic acid, levulinic acid, citric acid, or mixtures thereof.

9. The preservative composition according to any of claims 1 or 2, wherein the pyrithione comprises sodium pyrithione, the aromatic alcohol comprises phenoxyethanol, and the organic acid or salt thereof comprises citric acid, lactic acid, benzoic acid, or sorbic acid.

10. The preservative composition according to any of claims 1 or 2, wherein the pyrithione comprises sodium pyrithione, the aromatic alcohol comprisesbenzyl alcohol, and the organic acid or salt thereof comprises citric acid, lactic acid, benzoic acid, or sorbic acid.

11. A personal care or home care composition comprising: a base composition; and the preservative composition as defined in any of claims 1 through 10.

12. The personal care or home care composition according to claim 11 , wherein the pyrithione is present in the base composition in an amount less than about 1000 ppm, such as in an amount less than about 500 ppm, such as in an amount less than about 250 ppm, such as in an amount less than about 100 ppm, such as in amount less than about 50 ppm.

13. The personal care or home care composition according to claim 11 or 12, wherein a weight ratio of the pyrithione to the organic acid or salt thereof and to the aromatic alcohol is from about 1 :1 :1 to about 1 : 15630: 12500, such as from about 1 :1 :1 to about 1 :10000: 10000, such as from about 1 :1 :1 to about 1 :5000:5000.

14. The personal care or home care composition according to any of claims 11 through 13, wherein the base composition comprises a liquid, a semi-solid, or a solid.

15. The personal care or home care composition according to any of claims 11 through 14, wherein the personal care or home care composition comprises a color cosmetic product, a deodorant product, a hair care product, an oral care product, a skin care product, or a bathing product.

16. The personal care or home care composition according to any of claims 11 through 14, wherein the personal care or home care composition comprises a hand-dish soaps, machine dish soaps, machine dish rinse-aids, laundry detergents, laundry fabric conditioners, clothing fragrance and / or wrinkle treatments, ironing aids, cleaning wipes, all-purpose cleaners and other similar formulations that are used around the home. In one embodiment, the home care product is a cleaning product selected from the group consisting of hand-dish soaps, laundry detergents, cleaning wipes, and all-purpose cleaners, such as floor, work surface, kitchen, carpet, toilet and bathroom cleaners.

17. The personal care or home care composition according to any of claims 11 through 14, wherein personal care or home care composition comprises a premoistened wipe.

18. The personal care or home care composition according to any of claims 11 through 17, wherein the base composition contains at least one of a solvent, a surfactant, a complexing agent, a corrosion inhibitor, an alkalinity builder, a pH adjusting agent, an auxiliary, an acid, a foaming agent, a perfume, a colorant, a humectant, an emulsifier, a thickener, an antioxidant, a UV blocking agent, a wax, a natural extract, or an oil.

19. A method for increasing the efficacy of a preservative agent in an enduse formulation, said method comprising adding to an end-use formulation a preservative agent comprising the composition according to any of claims 1 through 10.

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