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1 results about "GATA4" patented technology

Transcription factor GATA-4 is a protein that in humans is encoded by the GATA4 gene.

Cellular microcompartments comprising human cells undergoing cardiac differentiation, tissues obtained from said microcompartments and uses thereof

ActiveUS12644882B2Drug screeningSkeletal/connective tissue cellsCardiac differentiationCells/microL
The invention relates to cellular microcompartments, each microcompartment successively comprising the following layers, which are organised around at least one lumen: —at least one inner layer of human cells undergoing cardiac differentiation, expressing at least one gene chosen from PDGFRα, MESP-1, NKX2-5, GATA4, MEF2C, TBX20, ISL1 and TBX5, —at least one intermediate layer of isotonic aqueous solution, and—at least one outer hydrogel layer. The invention also relates to the cardiac tissues obtained from said microcompartments and the use thereof, particularly in the treatment of heart disease.
Owner:TREEFROG THERAPEUTICS