The invention discloses anti-alcoholism beverage. The anti-alcoholism beverage consists of the following materials by weight: 20-30 parts of mature vinegar, 60-80 parts of honey, 2-5 parts of kudzu vine root juice, 2-5 parts of kudzu vine flower juice, 0.5-2 parts of salt and 0.5-1 part of propolis. A preparation method of the anti-alcoholism beverage includes the steps as follows: mixing of the mature vinegar, the honey, the kudzu vine root juice, the kudzu vine flower juice, the salt and the propolis, stirring to uniform, vacuum filtration and flash pasteurization, thus obtaining the anti-alcoholism beverage. When needing sobering up, a drunk can drink 100-200ml of the anti-alcoholism beverage and then stay in bed, and usually, the drunk can be sorbered up within 10-30 minutes. The anti-alcoholism beverage has a good anti-alcoholism effect and no side effect to a human body; due to the components such as the mature vinegar, the honey, the propolis and the like with high nutritional value, the anti-alcoholism beverage also has nourishing and health care efficacies; and with unique flavor and good mouthfeel, the anti-alcoholism beverage also can serve as ordinary beverage even forpeople who does not drink. The anti-alcoholism beverage has the advantages of good anti-alcoholism effect, fast effect taking speed, high nutritional value, no side effect, and the like.