Contrast agent for MR cholangiopancreatography

Abstract

The invention provides a contrast agent for magnetic resonance cholangiopancreatography use, which is tea water, the manganese concentration of which ranges from 5mg / l to 13mg / l. In the invention, thetea water used as the contrast agent has good taste, stable structure in human body, no changes to gastrointestinal system functions, high security factor, nontoxicity, good relaxation, no fermentation in intestinal cavum and no gas generation, and the intestinal cavum is fully filled with the tea water to ensure uniform signals in the intestinal cavum. The tea water has high solubility, low cost, wide sources, easy acceptability for sufferers, low concentration for orally taking without any obvious discomfort, nausea, vomiting and constipation, and the application of the contrast agent is realized by requiring no drug test; disease diagnosis can be realized by drinking the tea water, which is more acceptable for patients compared with chemical medicines. Furthermore, the application of the contrast agent is realized by requiring no drug test, thus greatly reducing the diagnosis charges of the patients.

Description

technical field [0001] The invention relates to the technical field of reagents for medical detection, in particular to a contrast agent for magnetic resonance cholangiopancreatography. Background technique [0002] Due to the wide range and degree of pancreaticobiliary disease, the clinical manifestations are very complicated, which brings difficulties to clinical diagnosis. In the past, the main basis for diagnosis was endoscopic retrograde cholangiopancreatography (ERCP) or percutaneous hepatic cholangiography (PTC). However, ERCP and PTC are invasive examinations, especially unsuitable for patients with biliary system infection and biliary obstruction in the elderly, which are far from meeting clinical requirements. [0003] Magnetic resonance cholangiopancreatography (MRCP) is a non-invasive examination technique developed rapidly in recent years and widely used in clinics to display the pancreaticobiliary duct. Its principle is to use the long T2 characteristic of wat...

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Problems solved by technology

But above-mentioned two kinds of oral contrast agents have following deficiencies: 1. special-purpose Gd-DTPA oral liquid can obviously reduce gastrointestinal fluid hyperintensity, and mouthfeel is better, there is no adverse reaction after taking, but this method cost increases, so increases the number of patients 2. Iron-containing contrast agents have their contraindications (iron allergy, gastrointestinal perforation, high obstruction, hyperferremia, pregnant women and infants), and ingestion of high-concentration iron-containing contrast agents can cause nausea , severe vomiting, abdominal pain, diarrhea and other gastrointestinal discomforts. In addition, the stool is black after administration, and false positives for occult blood may occur; 3. The mechanism of action of barium sulfate suspension (BaSO4) suspension and paramagnetic contrast agent Similarly, oral administration of 500 mL of BaSO4 suspension with a concentration ratio (W / V%) of 50% once, followed by MRCP scanning 20 minutes later to ensure that the contrast agent has entered the duodenum, can better suppress the high signal of fluid in the gastrointestinal tract

Through experiments, barium is very prone to stratification, and when there is a lot of fluid retention in the stomach of the subject, the effect of barium on the water signal in the gastrointestinal tract is not good, which affects the observation of the pancreaticobiliary duct; 4. Pineapple juice and Blueberry juice, the price is more expensive, the source is not very wide

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