Application of sugar apple lactone compound V in preparing cancer-treating and anti-cancer medicine

A technology of custard apple lactone and anticancer drug, applied in the field of anticancer drugs, can solve the problems of unsatisfactory curative effect, low curative effect of cancer, large toxic and side effects, etc., and achieve the effect of improving clinical curative effect of anticancer
CN101342202AInactive Publication Date: 2009-01-14NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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Patent Information

Authority / Receiving Office
CN Β· China
Current Assignee / Owner
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
Publication Date
2009-01-14
Estimated Expiration
Not applicable Β· inactive patent

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Abstract

The invention relates to the new applications of an annonaceous acetogenins compound V, in particular to the applications of the compound V for preparing an anti-cancer drug. Annonaceous acetogenins is extracted from the scratch stock of a custard apple seed with organic solvent, including ethanol, petroleum ether, ethyl acetate and chloroform, etc.; the annonaceous acetogenins is processed by silicagel column chromatography and eluted with chloroform-methanol, petroleum ether-ethyl acetate and ethyl-acetate-methanol; and the annonaceous acetogenins compound V is made. The content of the annonaceous acetogenins compound V is 50 to 90 percent of mass fraction. An endozoic anti-cancer pharmacological test shows that the annonaceous acetogenins compound V has a significant effect on inhibiting the growth of the cancer cells of a lung, a breast and a liver and the anti-cancer activity of the annonaceous acetogenins compound V is higher than chemo-treatment 5-S-Fu, so the annonaceous acetogenins compound V can be used for preparing the anti-cancer drug.
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Claims

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