Medicinal composition for colon cancer and method for preparing effective monomers thereof

A composition and technology for colon cancer, applied in drug combinations, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve the problems of unclear material basis and mechanism of action in the treatment of colon cancer

Active Publication Date: 2012-04-18
北京仁众药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Zuojin Pills and Modified Zuojin Pills are currently being used clinically for the treatment of colon cancer and have achieved certain clinical effects, but the real material basis and mechanism of action for the treatment of colon cancer are unclear

Method used

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  • Medicinal composition for colon cancer and method for preparing effective monomers thereof
  • Medicinal composition for colon cancer and method for preparing effective monomers thereof
  • Medicinal composition for colon cancer and method for preparing effective monomers thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] Implementation example 1: the preparation of berberine

[0061] Take an appropriate amount of Coptis rhizome powder, add 5 times the amount of 30% ethanol to reflux and extract for 3 times, extract for 2 hours each time, filter, combine the filtrate, concentrate the filtrate to 40°C and measure the relative density to 1.45, let it cool, add 1% glacial acetic acid, A large amount of precipitate precipitated, and the precipitate was filtered and removed. The solution is added with concentrated hydrochloric acid to adjust the pH value to 3-4, and left overnight to obtain yellow needle-shaped crystals. The yellow needle-shaped crystals are recrystallized with an organic solvent, and calcium hydroxide is used to adjust the pH value to 8.5-9.0, and the obtained product has a purity of more than 98%. Berberine.

Embodiment 2

[0062] Implementation example 2: the preparation of berberine

[0063] Take an appropriate amount of Coptis rhizome powder, add 5 times the amount of 60% ethanol to reflux and extract for 3 times, extract for 2 hours each time, filter, combine the filtrate, concentrate the filtrate to 40°C and measure the relative density to 1.45, let it cool, add 1% glacial acetic acid, A large amount of precipitate precipitated, and the precipitate was filtered and removed. The solution is added with concentrated hydrochloric acid to adjust the pH value to 3-4, and left overnight to obtain yellow needle-shaped crystals. The yellow needle-shaped crystals are recrystallized with an organic solvent, and calcium hydroxide is used to adjust the pH value to 8.5-9.0, and the obtained product has a purity of more than 98%. Berberine.

Embodiment 3

[0064] Implementation example 3: the preparation of berberine

[0065] Take an appropriate amount of Coptis rhizome powder, add 5 times the amount of 75% ethanol to reflux and extract for 3 times, extract for 2 hours each time, filter, combine the filtrate, concentrate the filtrate to 40°C and measure the relative density to 1.45, let it cool, add 1% glacial acetic acid, A large amount of precipitate precipitated, and the precipitate was filtered and removed. The solution is added with concentrated hydrochloric acid to adjust the pH value to 3-4, and left overnight to obtain yellow needle-shaped crystals. The yellow needle-shaped crystals are recrystallized with an organic solvent, and calcium hydroxide is used to adjust the pH value to 8.5-9.0, and the obtained product has a purity of more than 98%. Berberine.

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PUM

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Abstract

The invention relates to a medicinal composition for colon cancer and a method for preparing effective monomers thereof. Based on the clinical classical golden cornus pill formula for treating the colon cancer, the medicinal composition consisting of berberine, evodiamine and rutaecarpine is obtained by compatibility and screening of multiple formulas. Urine of rats at different time points of a dimethylhydrazine-induced intestinal cancer model is measured by adopting gas chromatogram and mass spectrum combined technology, and the measurement result is combined with a mode identification method to discover that the metabolic track of the rats obviously regresses to that of healthy rats when the rats of a dimethylhydrazine-induced cancerous pathological change group and a cancer group takethe medicinal composition consisting of the berberine, the evodiamine and the rutaecarpine in a proper ratio; and the composition consisting of the berberine, the evodiamine and the rutaecarpine can play a certain role in preventing and treating the colon cancer by controlling a body network.

Description

technical field [0001] The invention relates to a pharmaceutical composition for preventing and / or treating colon cancer, wherein the active ingredients of the composition are composed of berberine, evodiamine and evodiamine. Background technique [0002] Intestinal cancer is a malignant tumor that occurs in the mucosal epithelium and glands of the large intestine, including colon cancer and rectal cancer. It is a common malignant tumor. In the past 20 years, the incidence of colorectal cancer has been on the rise in most countries or regions in the world, especially in developing countries with low incidence. Intestinal cancer is one of the main causes of death in Western countries, and it is also one of the most common malignant tumors in my country. Its incidence rate is second only to lung cancer and breast cancer among various malignant tumors. Over the years, the 5-year survival rate of colorectal cancer has not been significantly improved due to surgical progress, an...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/519A61K31/4375A61P35/00C07D455/03C07D471/14G01N30/88
Inventor 陶秀梅陈鹏陈蓉娜庞伟王金龙
Owner 北京仁众药业有限公司
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