Withania somnifera lactide compound, method for extracting same and application of withania somnifera lactide compound

A lactide compound and a technology for the compound are applied in the field of withanolide compounds, and can solve the problems that the extraction method and application of the withanolide compound have not yet been reported.

Active Publication Date: 2016-10-12
TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, there are no reports on the extraction of

Method used

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  • Withania somnifera lactide compound, method for extracting same and application of withania somnifera lactide compound
  • Withania somnifera lactide compound, method for extracting same and application of withania somnifera lactide compound
  • Withania somnifera lactide compound, method for extracting same and application of withania somnifera lactide compound

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] The extraction method of withanide compound, comprises the steps:

[0039] (1) Take the dry stem and leaf (9.5kg) of bitter mulberry (Physalis angulata L.) as raw material, add 9 times the mass fraction of the raw material as a 75% ethanol aqueous solution, reflux extraction twice, each extraction for 2 hours, and combine to obtain Extract, solvent recovery under reduced pressure, obtain total extract (1370g) after concentrating;

[0040] (2) Disperse the total extract into water of 5 times by mass, extract with equal volumes of petroleum ether and ethyl acetate successively, and recover the solvent under reduced pressure from the ethyl acetate extract to obtain 116g of ethyl acetate layer extract;

[0041] (3) The ethyl acetate layer extract is separated by silica gel column chromatography, and the dichloromethane-methanol with volume ratios of 100:1, 50:1, 30:1 and 15:1 are gradient eluted as eluents to obtain Fractions Fr.1, Fr.2, Fr.3 and Fr.4 (15 g);

[0042] (4)...

Embodiment 2

[0076] The extraction method of withanide compound, comprises the steps:

[0077] (1) Take the dry stem and leaf of A. fraterna as a raw material, add 80% ethanol aqueous solution with a volume fraction of 8 mass times of the raw material, reflux extraction for 3 times, extract for 2 hours each time, combine to obtain the extract, recover the solvent under reduced pressure, and concentrate Obtain the total extract;

[0078] (2) Disperse the total extract into water of 5 times by mass, extract with equal volumes of petroleum ether and ethyl acetate successively, and recover the solvent under reduced pressure from the ethyl acetate extract to obtain the ethyl acetate layer extract;

[0079] (3)-(9) are the same as embodiment 1(3)-(9).

Embodiment 3

[0081] The extraction method of withanide compound, comprises the steps:

[0082] (1) Take the dry stem and leaf of A. fraterna as a raw material, add 10 times the mass fraction of the raw material as a 60% ethanol aqueous solution, reflux extraction for 3 times, and extract for 2 hours each time, combine to obtain the extract, recover the solvent under reduced pressure, and concentrate Obtain the total extract;

[0083] (2) Disperse the total extract into 10 mass times of water, extract with equal volumes of petroleum ether and ethyl acetate successively, and recover the solvent under reduced pressure from the ethyl acetate extract to obtain the ethyl acetate layer extract;

[0084] (3)-(9) are the same as embodiment 1(3)-(9).

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Abstract

The invention discloses a withania somnifera lactide compound, a method for extracting the same and application of the withania somnifera lactide compound. The withania somnifera lactide compound is of a structure shown as a formula (I). The withania somnifera lactide compound, the method and the application have the advantages that release of nitric oxide (NO) can be effectively inhibited by the withania somnifera lactide compound, and accordingly the withania somnifera lactide compound can be used as an anti-inflammatory medicine.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine extraction, and relates to a withanide compound, an extraction method and application. Background technique [0002] Physalis angulata L., also known as lantern grass, Tianpaozi, Tianpao grass, Pupu grass, Daebao, etc., is an annual herbaceous plant of the genus Physalis in the family Solanaceae. "Lu Chuan Materia Medica" and "Chinese Materia Medica" have detailed records on the medicinal effects of bitter fennel. Bitter bean has the functions of promoting qi, reducing swelling, diuresis, curing abdominal distension, clearing away heat and detoxification, diuretic and hemostasis, reducing swelling and dispelling stagnation, and can be used to treat throat Swelling and pain, lung abscess, mumps; dysuria, hematuria, gum swelling and pain, pemphigus and other diseases. Folks are mostly used to treat herpes, swollen gums, damp-heat jaundice, sore throat, lung-heat cough and other diseases....

Claims

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Application Information

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IPC IPC(8): C07J17/00C07J71/00A61K31/585A61K36/81A61P3/00A61P29/00A61P9/12A61P9/10A61P9/04A61P1/16A61P19/02A61P1/00A61P1/18A61P3/10A61P17/00A61P17/06A61P35/00A61P35/02A61P25/16A61P25/28A61P25/24A61P11/00A61P11/06A61P25/00
CPCA61K36/81A61K2236/333A61K2236/39A61K2236/51A61K2236/55C07J17/00C07J71/0026
Inventor 邱峰孙成鹏陈丽霞赵烽康宁丁丽琴
Owner TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
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