Uses of indolinone compounds

A technology of compounds and uses, applied in the field of use of indolinone compounds, can solve problems such as short-term toxicity, poor patient progress, long-term toxicity, etc.

Active Publication Date: 2022-03-25
ONCTERNAL THERAPEUTICS INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, patients with metastatic tumors still do poorly, and the therapy comes with short-term and long-term toxicities

Method used

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  • Uses of indolinone compounds
  • Uses of indolinone compounds
  • Uses of indolinone compounds

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[0030] The following description and examples illustrate in detail preferred embodiments of the invention. Those skilled in the art will recognize that many variations and modifications of the invention are within the scope thereof. Therefore, the description of preferred embodiments should not be taken as limiting the scope of the invention.

[0031] Chromosomal translocations that generate oncogenic transcription factors are hallmarks of a variety of tumors, including many sarcomas. The Ewing sarcoma tumor family (ESFT) is characterized by a t(11;22)(q24;q12) translocation that generates the Ewing sarcoma breakpoint region 1 and Flanders leukemia virus integration 1 (EWS-FLI1) fusion transcription factor , which is responsible for the highly malignant phenotype of this tumor. Sustained expression of EWS-FLI1 is thought to be critical for ESFT cell survival. EWS-FLI1 is an attractive therapeutic target for Ewing sarcoma because of its specificity for malignant cells. Furt...

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Abstract

Methods and compositions for treating acute myeloid leukemia and diffuse large B-cell lymphoma using combinations of venetora and indolinone derivatives are provided.

Description

technical field [0001] Methods and compositions for treating acute myeloid leukemia and diffuse large B-cell lymphoma using indolinone derivatives are provided. Background technique [0002] The EWS-FLI transcription factor present in multiple Ewing sarcoma tumor families (ESFT) was characterized more than a decade ago. Advances in the treatment of Ewing sarcoma, the second most common bone tumor in children and adolescents, have improved survival for patients with localized tumors. However, patients with metastatic tumors still do poorly, and the therapy comes with short-term and long-term toxicities. The Ewing sarcoma tumor family (ESFT) is characterized by a chromosomal translocation on an oncogenic fusion transcription factor that produces EWS-FLI1, and persistent expression of EWS-FLI1 is thought to be critical for ESFT cell survival (Balamuth, NJ, Womer, RB , Lancet Oncology 11, 184-192 (2010)). ETS transcription factors such as FLI1 and SPIB are recurrently dysregu...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/404A61K31/454A61K39/395A61K45/06
CPCA61K31/404A61K31/454A61K45/06A61K31/69A61K38/05A61K31/519A61K31/475A61K31/5377A61K31/4184A61K31/497A61P35/00A61P35/02A61K2300/00A61K39/39558C07K2317/73A61K31/4155A61K31/4439A61K31/496A61K31/551C07K16/2887A61K39/395C07K2317/24
Inventor 布莱恩·兰努蒂卡塔优恩·杰森詹姆斯·布拉德利·布莱特迈尔
Owner ONCTERNAL THERAPEUTICS INC
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