A method and system for developing basal medium formula based on artificial intelligence

Abstract

The invention discloses an artificial intelligence-based basic culture medium formulation development method and system. The method includes: (1) establishing a sample formula database; (2) obtaining a sample formula training database; (3) using the sample formula training database obtained in step (2) to train the machine learning model for the optimization target, and obtain the basis (4) In the search space of the addition ratio of each component in the basal medium formula to be optimized, the basal medium formula culture effect prediction model obtained in step (3) is used to optimize the target Regression prediction of culture effect, and recommended basal medium formula. The system includes: a sample formula generation module, a sample formula cultivation database, a regression model training module, and a formula recommendation module. The invention analyzes all the ingredients in the formula at the same time, avoids multiple DOE tests in the traditional method, thereby speeding up the research and development speed and saving the development time of the basic medium formula.

Description

technical field [0001] The invention belongs to the field of biotechnology, and more specifically relates to a method and system for developing basic culture medium formula based on artificial intelligence. Background technique [0002] Although the nutritional requirements of biological samples such as various microorganisms and cells are different, most biological samples require the same basic nutrients. The medium prepared according to the basic nutrients required for the growth and reproduction of general biological samples is called the basic medium. A serum-free, animal-source-free, chemically defined basal medium consisting of carbon sources, amino acids, vitamins, trace metal ions, lipids, buffering agents, and other additives. [0003] The traditional medium formula development method is based on one or several classical medium (such as DEME / F12), by adding a variety of different components, using single factor test or DOE screening test to find the key components...

AI Technical Summary

Problems solved by technology

[0005] Aiming at the above defects or improvement needs of the prior art, the present invention provides a method and system for formula development of basic culture medium based on artificial intelligence. A sufficient number of sample formula databases, select the appropriate machine learning algorithm and optimization algorithm, recommend the basic medium formula that is most likely to have a good cultivation effect in a short period of time, reduce the threshold for formula development, and thus solve the existing basic medium components Complex technical issues resulting in slow development speed and high development costs

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