Liver cancer screening method and device

A liver cancer and screening technology, applied in the Internet field of medical data, can solve the problems of false positives, low sensitivity and accuracy, low specificity and sensitivity, and achieve high accuracy, high sensitivity, and improved accuracy Effect

Pending Publication Date: 2022-04-29
海南松林生物科技有限责任公司
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Problems solved by technology

Golgi protein-73 (GP73) and α-L-fucosidase AFU are also markers of liver cancer, but their specificity and sensitivity are low, and false negatives or false positives are prone to occur
In addition, the method requires an experienced clinician to interpret the test results
[0006] Liver cancer screening in hospitals is t

Method used

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  • Liver cancer screening method and device
  • Liver cancer screening method and device
  • Liver cancer screening method and device

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Embodiment Construction

[0031] Exemplary embodiments of the present disclosure will be described in more detail below with reference to the accompanying drawings. Although exemplary embodiments of the present disclosure are shown in the drawings, it should be understood that the present disclosure may be embodied in various forms and should not be limited by the embodiments set forth herein. Rather, these embodiments are provided for more thorough understanding of the present disclosure and to fully convey the scope of the present disclosure to those skilled in the art.

[0032] A kind of liver cancer screening method provided by the present invention, refer to figure 1 shown, including the following steps:

[0033] (1) Through a large number of experiments, five liver cancer tumor marker combinations were screened out, namely: alpha-fetoprotein AFP, alpha-fetoprotein heterogeneous AFP-L3, abnormal prothrombin DCP, Golgi protein GP73 and α-L-rock Alcosidase AFU;

[0034] (2) Input the data of the ...

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Abstract

The invention discloses a liver cancer screening method and an application device, and the method comprises the following steps: (1) screening five liver cancer tumor marker combinations through a large number of experiments, namely alpha fetoprotein AFP, alpha fetoprotein variant AFP-L3, abnormal prothrombin DCP, Golgi protein GP73 and alpha-L-fucosidase AFU; (2) inputting the data of the five tumor markers into an ROC curve prediction model to obtain an area AUC value under an ROC curve; and (3) comparing the area AUC value with a preset threshold value, and determining the liver cancer risk levels to which the five tumor markers belong. Compared with the prior art, the kit can significantly improve the accuracy of liver cancer screening, and has the characteristics of high sensitivity and high accuracy.

Description

technical field [0001] The present invention relates to the field of internet technology of medical data, in particular to a liver cancer screening method and device. Background technique [0002] At present, primary hepatocellular carcinoma (hepatocellular carcinoma, HCC) is one of the most common malignant tumors in the world and the most common cause of death in patients with chronic liver disease. The five-year overall survival rate of liver cancer is currently only 14.1%. The morbidity and fatality rates are very close. The main reason for the low long-term survival rate of liver cancer is that the screening of high-risk groups of liver cancer is not popularized, and the early diagnosis rate is low, resulting in 70% to 80% of patients are already in the middle and late stage at the time of diagnosis. If early detection and early diagnosis can be implemented Radical methods such as liver resection and liver transplantation can significantly improve the prognosis of pati...

Claims

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Application Information

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IPC IPC(8): G16H50/20G16H50/70
CPCG16H50/20G16H50/70
Inventor 余跃飞
Owner 海南松林生物科技有限责任公司
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