Ion transmission efficiency measurement device, method, storage medium and program product

Abstract

The present invention provides an ion transmission efficiency measurement device, method, storage medium and program product, which relate to the field of mass spectrometry technology. The device comprises a controller and at least one group of ion deflection receiving components; wherein the ion deflection receiving components comprise an electric field deflection module and an ion receiving module, the electric field deflection module and the ion receiving module are arranged on the side of the transmission path of the continuously output ion flow and are located between two adjacent modules in the mass spectrometer; the controller is connected with the electric field deflection module and the ion receiving module, and the controller is used to output an electric field deflection voltage to the electric field deflection module and the ion receiving module to change the electric field direction between the electric field deflection module and the ion receiving module, and guide the ion flow to be transmitted toward the ion receiving module. When the electric field direction points to the ion receiving module, the controller collects the current received by the ion receiving module, and the loss of the ion flow in the transmission process can be determined, thereby determining the ion transmission efficiency.

Description

Technical Field

[0001] The present invention relates to the field of mass spectrometry technology, and in particular to a device, method, storage medium and program product for measuring ion transmission efficiency. Background Art

[0002] Mass spectrometer is one of the most basic instruments for studying the basic composition, structural characteristics, physical and chemical properties of matter. The essence of mass spectrometer is to use electric and / or magnetic fields to separate moving ions according to their mass-to-charge ratio for detection.

[0003] The performance of a mass spectrometer is related to its sensitivity, and to determine the sensitivity, it is necessary to determine the transmission efficiency of ions during the transmission process. However, in the prior art, an electrode with a middle opening is set in the direction of ion transmission to receive the ion flow, thereby obtaining the corresponding ion flow size in different links, such as the filtering link and the detection link in the mass spectrometer.

[0004] However, the measurement results of the ion flow sizes in different links in the above scheme are inaccurate, so the accuracy of the obtained ion transmission efficiency measurement results is poor. Summary of the invention

[0005] The present invention provides an ion transmission efficiency measurement device, method, storage medium and program product, which are used to solve the defect of poor accuracy of ion transmission efficiency measurement results obtained in the prior art, measure the loss amount in the ion transmission process, and improve the accuracy of ion transmission efficiency measurement results.

[0006] The present invention provides a device for measuring ion transmission efficiency, comprising a controller and at least one set of ion deflection receiving components; wherein:

[0007] The ion deflection receiving assembly includes an electric field deflection module and an ion receiving module, wherein the electric field deflection module and the ion receiving module are arranged on the side of the transmission path of the continuously output ion flow and between two adjacent modules in the mass spectrometer;

[0008] The controller is connected to the electric field deflection module and the ion receiving module, and is used to output an electric field deflection voltage to the electric field deflection module and the ion receiving module to change the direction of the electric field between the electric field deflection module and the ion receiving module, guide the ion flow to be transmitted toward the ion receiving module, and measure the current received by the ion receiving module.

[0009] In the above solution, the electric field deflection module and the ion receiving module are respectively arranged on both sides of the transmission path, and a gap is provided between the electric field deflection module and the ion receiving module for the ion flow to be transmitted along the transmission path.

[0010] In the above solution, the ion receiving module is in a flat plate type or a tile type.

[0011] In the above solution, when the ion receiving module is in a tile-shaped form, the concave surface of the ion receiving module is arranged toward the electric field deflection module.

[0012] The present invention also provides a method for measuring ion transmission efficiency, which is applied to a controller in any of the above-mentioned devices for measuring ion transmission efficiency, and the method comprises:

[0013] Outputting an electric field deflection voltage to an electric field deflection module and an ion receiving module in the device for measuring ion transmission efficiency, so as to change the direction of the electric field between the electric field deflection module and the ion receiving module, and guide the ion flow to be transmitted toward the ion receiving module;

[0014] collecting the current output by the ion receiving module;

[0015] The measurement result of the ion transmission efficiency of the ion flow is determined according to the current output by the ion receiving module.

[0016] In the above scheme, the method further includes:

[0017] Acquiring field axis distribution information between the electric field deflection module and the ion receiving module;

[0018] According to the field axis distribution information, a focusing voltage is output to the electric field deflection module.

[0019] In the above scheme, the measurement result includes transmission position information and transmission efficiency, and the transmission position information represents at least one link in the transmission process of the ion flow corresponding to the electric field deflection module and the ion receiving module;

[0020] The method further comprises:

[0021] The transmission efficiency distribution of the ion flow is determined according to the transmission position information and the transmission efficiency.

[0022] In the above scheme, the method further includes:

[0023] When the transmission efficiency is less than a preset value, the corresponding transmission position information is marked.

[0024] The present invention also provides a non-transitory computer-readable storage medium having a computer program stored thereon, wherein the computer program, when executed by a processor, implements any of the above-mentioned methods for measuring ion transmission efficiency.

[0025] The present invention also provides a computer program product, comprising a computer program, wherein when the computer program is executed by a processor, the computer program implements any of the above-mentioned methods for measuring ion transmission efficiency.

[0026] The present invention provides an ion transmission efficiency measurement device, method, storage medium and program product, which relate to the field of mass spectrometry technology. The above-mentioned device includes a controller and at least one group of ion deflection receiving components; wherein the ion deflection receiving components include an electric field deflection module and an ion receiving module, and the electric field deflection module and the ion receiving module are arranged on the side of the transmission path of the continuously output ion flow and are located between two adjacent modules in the mass spectrometer; the controller is connected to the electric field deflection module and the ion receiving module, and the controller is used to output an electric field deflection voltage to the electric field deflection module and the ion receiving module to change the electric field direction between the electric field deflection module and the ion receiving module, guide the ion flow to be transmitted toward the ion receiving module, and measure the current received by the ion receiving module. During the ion flow transmission process, the controller outputs an electric field deflection voltage to the electric field deflection module and the ion receiving module. The direction of the electric field between the electric field deflection module and the ion receiving module will change, so that the electric field direction points to the ion receiving module. At this time, the ion flow will be transmitted along the electric field direction until it contacts the ion receiving module. The controller collects the current received by the ion receiving module due to contact with the ion flow, obtains the number of ions in the ion flow output by the ion source and the number of ions corresponding to each link in the ion flow transmission process, determines the loss of the ion flow in the transmission process, and thus determines the ion transmission efficiency. In this way, it is possible to determine which link in the ion transmission process needs to be improved based on the ion transmission efficiency to improve the ion transmission efficiency. BRIEF DESCRIPTION OF THE DRAWINGS

[0027] In order to more clearly illustrate the technical solutions in the present invention or the prior art, the following briefly introduces the drawings required for use in the embodiments or the description of the prior art. Obviously, the drawings described below are some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0028] Figure 1 It is a schematic structural diagram of a device for measuring ion transmission efficiency provided by an embodiment of the present invention;

[0029] Figure 2 This is one of the schematic diagrams of ion flow transmission direction provided by the present invention;

[0030] Figure 3 This is the second schematic diagram of the ion flow transmission direction provided by the present invention;

[0031] Figure 4This is a distribution diagram of an ion separation efficiency measurement device provided by an embodiment of the present invention in a mass spectrometer

[0032] Figure 5 It is a schematic flow chart of a method for measuring ion transmission efficiency provided by the present invention;

[0033] Figure 6 The figure is a schematic diagram of the structure of a mass spectrometer provided by the present invention.

[0034] Reference numerals:

[0035] 201, ion flow; 202, controller; 203, ion receiving module; 204, electric field deflection module; 205, first module; 206, second module. DETAILED DESCRIPTION

[0036] In order to make the purpose, technical solution and advantages of the present invention clearer, the technical solution of the present invention will be clearly and completely described below in conjunction with the drawings of the present invention. Obviously, the described embodiments are part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0037] Figure 1 FIG. 1 is a schematic diagram of a device for measuring ion transmission efficiency provided by an embodiment of the present invention. Figure 1 As shown, the present invention provides an ion transmission efficiency measuring device, including a controller 202 and at least one group of ion deflection receiving components; wherein the ion deflection receiving components include an electric field deflection module 204 and an ion receiving module 203, the electric field deflection module 204 and the ion receiving module 203 are arranged on the transmission path side of the continuously output ion flow 201 and are located between two adjacent modules in the mass spectrometer; the controller 202 is connected to the electric field deflection module 204 and the ion receiving module 203, and the controller 202 is used to output an electric field deflection voltage to the electric field deflection module 204 and the ion receiving module 203 to change the electric field direction between the electric field deflection module 204 and the ion receiving module 203, guide the ion flow 201 to be transmitted toward the ion receiving module 203, and measure the current received by the ion receiving module 203.

[0038] In the present invention, when the ion source outputs the ion flow 201, the ion flow 201 will move along the field axis direction of the ion source toward the module adjacent to the ion source in the mass spectrometer.

[0039] In the present invention, each ion deflection receiving assembly includes an electric field deflection module 204 and an ion receiving module 203. The electric field deflection module 204 and the ion receiving module 203 are arranged on the side of the transmission path and located between every two adjacent modules in the mass spectrometer.

[0040] In the present invention, the electric field deflection module 204 and the ion receiving module 203 are respectively arranged on both sides of the transmission path, and a gap is provided between the electric field deflection module 204 and the ion receiving module 203 for the ion flow 201 to be transmitted along the transmission path.

[0041] In the present invention, the electric field deflection module 204 and the ion receiving module 203 are respectively arranged on both sides of the transmission path, and a gap is provided between the electric field deflection module 204 and the ion receiving module 203 for transmitting the ion flow 201 from one module in the mass spectrometer to another adjacent module along the transmission path.

[0042] In the present invention, Figure 1 As shown, illustratively, if two adjacent modules are provided in the mass spectrometer, and the two adjacent modules are respectively the first module 205 and the second module 206, then the first module 205 and the second module 206 may be provided with ion deflection receiving components. At this time, the electric field deflection module 204 and the ion receiving module 203 are respectively arranged on both sides of the transmission path of the ion flow 201 between the first module 205 and the second module 206, that is, the electric field deflection module 204 is located on one side of the ion flow 201, and the ion receiving module 203 is located on the other side of the ion flow 201. The controller 202 includes an electric field driver and a current detector. The electric field driver is used to generate a high voltage sufficient to deflect the ions in the ion flow 201, and outputs it to the electric field deflection module 204 through the controller 202. For positive ions, the high voltage is usually a positive high voltage, so that an electric field biased toward the ion receiving module 203 can be formed with the ion receiving module 203, so that the ions can be deflected toward the ion receiving module 203. The current detector is directly connected to the ion receiving module 203 . The ion receiving module 203 is equivalent to a Faraday receiver. Ions passing through the ion receiving module 203 can be detected by the current detector.

[0043] In the present invention, the electric field deflection module 204 includes at least one deflection electrode, and the ion receiving module 203 includes at least one Faraday receiving electrode, and the axial lengths of the deflection electrode and the Faraday receiving electrode can be determined according to actual needs, such as the axial lengths of the deflection electrode and the Faraday receiving electrode are not less than 3 mm.

[0044] In the present invention, when the device for measuring ion transmission efficiency is in use, a variable electric field for controlling the ion route can be formed between the deflection electrode and the Faraday receiving electrode. When allowing ions to pass through, the electric field becomes a uniform electric field, so that the ions can pass directly without changing the original trajectory. When used for ion detection, the electric field becomes a deflection electric field, and the ions hit the Faraday receiving electrode. Among them, the electric field can quickly switch between the uniform electric field and the deflection electric field, so that it can be ensured that the ion flow 201 detected hitting the Faraday receiving electrode under the action of the deflection electric field is equal to the ion flow 201 passing through when not deflected. That is, the device for measuring ion transmission efficiency includes two modes, namely: ion transmission mode and ion flow 201 detection mode. Among them, Figure 2 This is one of the schematic diagrams of the transmission direction of an ion flow 201 provided by the present invention, such as Figure 2 As shown, when the measuring device of ion transmission efficiency is operated in ion transmission mode, the ion flow 201 transmitted from the ion source moves along the field axis direction (transmission path). When ions pass through the electrode system (at least one group of ion deflection receiving components), the voltage on the electric field deflection module 204 (deflection electrode) and the ion receiving module 203 (Faraday receiving electrode) output by the controller 202 to the electrode system is equal, and at this time, there is a uniform electric field between the electric field deflection module 204 and the ion receiving module 203, and the ion flow 201 will continue to move along the field axis and no deflection will occur. In an optional scheme, the controller 202 can be distributed according to the field axis of the modules adjacent to the electric field deflection module 204 and the ion receiving module 203, and the focusing voltage output to the electric field deflection module 204 and the ion receiving module 203 is determined by an iterative method, so as to increase the focusing performance of the ions passing between the electric field deflection module 204 and the ion receiving module 203. To reduce the loss of ions in the transmission process.

[0045] Figure 3 This is a second schematic diagram of the transmission direction of an ion flow 201 provided by the present invention, such as Figure 3As shown, when the measuring device of ion transmission efficiency is operated in the ion flow 201 detection mode, the ion flow 201 transmitted from the ion source moves along the field axis direction. When ions pass through the electrode system, the controller 202 outputs an electric field deflection voltage to the electric field deflection module 204 and the ion receiving module 203 inside the electrode system, and now the electric field direction between the electric field deflection module 204 and the ion receiving module 203 will change, so that the electric field direction points to the Faraday receiving electrode. Wherein, the electric field deflection voltage output by the controller 202 includes a deflection voltage and a receiving voltage, and the controller 202 outputs the deflection voltage to the electric field deflection module 204, and outputs the receiving voltage to the ion receiving module 203, so that the electric field direction between the electric field deflection module 204 and the ion receiving module 203 changes. Exemplary, when the ions in the ion flow 201 are positive ions, the controller 202 applies a positive voltage relative to the ion receiving module 203 on the electric field deflection module 204, so that the electric field direction points to the Faraday electrode. In this way, when the positive ions leave the ion source and enter the gap between the electric field deflection module 204 and the ion receiving module 203, the positive ions will be deflected toward the ion receiving module 203, and under the action of the electric field, collide with the ion receiving module 203, and then the controller 202 detects the current received by the ion receiving module 203 through the current detector connected to the Faraday receiving electrode, and sends it to the controller 202, and the controller 202 obtains the current value.

[0046] In the present invention, the ion source continuously emits an ion flow 201 under the same parameters, and the DC voltage applied to the electric field deflection module 204 ensures the switching speed of the voltage on the electric field deflection module 204, so that the current received by the ion receiving module 203 can represent the number of ions in the ion flow 201 passing through the current position of the ion receiving module 203. The number of ions corresponding to the ion flow 201 emitted by the ion source can determine the loss of the ion flow 201 in the process of moving from the ion source to the current ion receiving module 203.

[0047] In the present invention, a plurality of modules are arranged along the field axis in the mass spectrometer during ion transmission, and at least one set of ion deflection receiving components is arranged between different modules; illustratively, Figure 4 is a distribution diagram of an ion separation efficiency measuring device provided by an embodiment of the present invention in a mass spectrometer, such as Figure 4As shown; the mass spectrometer is provided with an ion source, an ion separation module and an ion detection module, wherein the ion flow 201 is transmitted from the ion source to the ion separation module corresponding to the separation link in the mass spectrometer, and the ion flow 201 is transmitted from the ion separation module to the ion detection module corresponding to the detection link in the mass spectrometer. Each link is provided with an ion deflection receiving component to measure the corresponding loss of the ion flow 201 in each link, that is, an ion deflection receiving component is provided between the ion source and the ion separation module, and between the ion separation module and the ion detection module. The two groups of ion deflection receiving components can share the same controller, or they can be provided with one controller respectively.

[0048] It is understandable that based on the current received by the ion receiving module 203, the loss of the ion flow 201 during the transmission process can be determined, thereby determining the ion transmission efficiency, and then determining which link in the ion transmission process needs to be improved based on the ion transmission efficiency to improve the ion transmission efficiency.

[0049] In the present invention, the ion receiving module 203 is in a flat plate or tile type. In an optional solution, the electric field deflection module 204 is also in a flat plate or tile type. Wherein, when the ion receiving module 203 is in a tile type, the concave surface of the ion receiving module 203 is arranged toward the electric field deflection module 204. When the electric field deflection module 204 is in a tile type, the concave surface of the electric field deflection module 204 is arranged toward the ion receiving module 203.

[0050] It can be understood that when the ion receiving module 203 is in a tile shape, it can focus the ions that are about to collide with the ion receiving module 203, increase the contact area between the ions and the ion receiving module 203, and improve the accuracy of the current received by the ion receiving module 203 collected by the controller 202, thereby improving the transmission loss of the ion flow 201 and the accuracy of the ion transmission efficiency.

[0051] Figure 5 It is a schematic diagram of a flow chart of a method for measuring ion transmission efficiency provided by the present invention, such as Figure 5 As shown, the present invention also provides a method for measuring ion transmission efficiency, which is applied to a controller in any of the above-mentioned ion transmission efficiency measuring devices, and the method includes:

[0052] S101, outputting an electric field deflection voltage to an electric field deflection module and an ion receiving module in a device for measuring ion transmission efficiency, so as to change the direction of the electric field between the electric field deflection module and the ion receiving module and guide the ion flow to be transmitted toward the ion receiving module.

[0053] In the present invention, the controller outputs electric field deflection voltage to the electric field deflection module and ion receiving module in the ion transmission efficiency measurement device to change the electric field direction between the electric field deflection module and the ion receiving module and guide the ion flow to be transmitted toward the ion receiving module.

[0054] In the present invention, Figure 6 Schematic diagram of a mass spectrometer provided by the present invention, such as Figure 6 As shown, the mass spectrometer includes an ion source, an ion filtration module and an ion detection module. Among them, after the ions are generated in the ion source, they pass through the ion filtration module and the ion detection module in sequence. The measuring device of ion transmission efficiency is arranged between each two adjacent modules to perform online detection of ions, such as between the ion source and the ion filtration module, and between the ion filtration module and the ion detection module. Among them, the ion source refers to the ionization chamber in the mass spectrometer. In actual applications, the sample to be detected is input into the ionization chamber, and the ionization chamber can ionize the atoms and molecules in the sample to be detected into ions by electron bombardment and / or chemical ionization.

[0055] S102, collecting the current output by the ion receiving module.

[0056] In the present invention, the controller collects the current output by the ion receiving module.

[0057] S103 . Determine a measurement result of the ion transmission efficiency of the ion flow according to the current output by the ion receiving module.

[0058] In the present invention, the controller determines the measurement result of the ion transmission efficiency of the ion flow according to the current output by the ion receiving module.

[0059] In the present invention, the current corresponding to the number of ions in the ion flow output by the ion source arranged at the ion source outlet is determined as the initial current, and the current corresponding to the number of ions corresponding to the ion flow output by any one of the ion sources during the transmission process is determined as the final current, and the difference between the initial current and the final current is obtained. According to the difference, the loss in the ion flow transmission process can be determined, thereby determining the measurement result of the ion transmission efficiency of the ion flow. In an optional scheme, the difference in the number of ions between the number of ions in the ion flow output by the ion source arranged at the ion source outlet and the number of ions corresponding to the ion flow output by any one of the ion sources during the transmission process can also be obtained, and then the loss of the ion flow in the transmission process is determined according to the difference in the number of ions.

[0060] It can be understood that based on the current received by the ion receiving module, the loss of ion flow during the transmission process can be determined, thereby determining the ion transmission efficiency, and based on the ion transmission efficiency, it can be determined which link in the ion transmission process needs to be improved to improve the ion transmission efficiency.

[0061] In some embodiments of the present invention, a method for measuring ion transmission efficiency provided by the present invention further includes:

[0062] S104, obtaining field axis distribution information between the electric field deflection module and the ion receiving module.

[0063] In some embodiments of the present invention, the controller obtains field axis distribution information between the electric field deflection module and the ion receiving module, wherein the field axis distribution information between the electric field deflection module and the ion receiving module refers to the current electric field direction between the electric field deflection module and the ion receiving module.

[0064] S105 . Output a focusing voltage to an electric field deflection module according to the field axis distribution information.

[0065] In some embodiments of the present invention, the controller outputs a focusing voltage to the electric field deflection module according to the field axis distribution information, wherein the focusing voltage is obtained by iterative calculation by the controller according to the field axis distribution information.

[0066] It can be understood that the controller outputs a focusing voltage to the electric field deflection module, which can increase the focusing of the ion flow passing through the electric field deflection module and the ion receiving module, reduce the loss of the ion flow due to dispersion during transmission, and thus improve the ion transmission efficiency.

[0067] In some embodiments of the present invention, the measurement results include transmission position information and transmission efficiency, and the transmission position information represents at least one link in the transmission process of the ion flow corresponding to the electric field deflection module and the ion receiving module.

[0068] In some embodiments of the present invention, at least one link refers to each module that ions pass through when transmitting in the mass spectrometer, such as an ion filtering module.

[0069] In some embodiments of the present invention, a method for measuring ion transmission efficiency provided by the present invention further includes:

[0070] S106. Determine the transmission efficiency distribution of the ion flow according to the transmission position information and the transmission efficiency.

[0071] In some embodiments of the present invention, the controller determines the transmission efficiency distribution of the ion flow based on the transmission position information and the transmission efficiency.

[0072] It can be understood that after determining the transmission efficiency distribution of the ion flow, the link with the largest ion loss in the mass spectrometer can be determined, so that improvements can be made to this link.

[0073] In some embodiments of the present invention, a method for measuring ion transmission efficiency provided by the present invention further includes:

[0074] S107: When the transmission efficiency is less than a preset value, mark the corresponding transmission position information.

[0075] In some embodiments of the present invention, the controller determines whether the transmission efficiency corresponding to each transmission position information is less than the preset value based on the preset value, and marks the corresponding transmission position information when the transmission efficiency is less than the preset value.

[0076] In some embodiments of the present invention, the transmission efficiency evaluation refers to whether the loss of ion flow in the current link meets the preset requirements. For example, if the loss of ion flow in the current link is greater than a preset threshold value according to the current output by the ion receiving module, the transmission efficiency evaluation corresponding to the transmission position information is determined to be low efficiency. If the loss of ion flow in the current link is less than or equal to the preset threshold value, the transmission efficiency evaluation corresponding to the transmission position information is determined to be normal efficiency.

[0077] In some embodiments of the present invention, the controller may also output voice prompt information while marking the corresponding transmission location information.

[0078] It can be understood that after determining the transmission efficiency evaluation corresponding to the transmission position information, the link with the largest ion loss in the mass spectrometer can be determined according to the mark, so that improvements can be made to this link without the need for manual comparison of data, which can improve work efficiency.

[0079] The present invention also provides a computer program product, which includes a computer program. The computer program can be stored on a non-transitory computer-readable storage medium. When the computer program is executed by a processor, the computer can execute the measurement methods of ion transmission efficiency provided by the above methods.

[0080] On the other hand, the present invention also provides a non-transitory computer-readable storage medium having a computer program stored thereon, which is implemented when the computer program is executed by a processor to perform the ion transmission efficiency measurement method provided by the above methods.

[0081] The device embodiments described above are merely illustrative, wherein the units described as separate components may or may not be physically separated, and the components displayed as units may or may not be physical units, that is, they may be located in one place, or they may be distributed on multiple network units. Some or all of the modules may be selected according to actual needs to achieve the purpose of the scheme of this embodiment. Ordinary technicians in this field can understand and implement it without paying creative labor.

[0082] Through the description of the above implementation methods, those skilled in the art can clearly understand that each implementation method can be implemented by means of software plus a necessary general hardware platform, and of course, it can also be implemented by hardware. Based on this understanding, the above technical solution is essentially or the part that contributes to the prior art can be embodied in the form of a software product, and the computer software product can be stored in a computer-readable storage medium, such as ROM / RAM, a disk, an optical disk, etc., including a number of instructions for a computer device (which can be a personal computer, a server, or a network device, etc.) to execute the methods described in each embodiment or some parts of the embodiments.

[0083] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit it. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that they can still modify the technical solutions described in the aforementioned embodiments, or make equivalent replacements for some of the technical features therein. However, these modifications or replacements do not deviate the essence of the corresponding technical solutions from the spirit and scope of the technical solutions of the embodiments of the present invention.

Claims

1. A device for measuring ion transmission efficiency, characterized in that: It includes a controller and at least one set of ion deflection receiving components; wherein, The ion deflection receiving assembly includes an electric field deflection module and an ion receiving module, wherein the electric field deflection module and the ion receiving module are arranged on the side of the transmission path of the continuously output ion flow and between two adjacent modules in the mass spectrometer; The controller is connected to the electric field deflection module and the ion receiving module, and is used to determine the focusing voltage output to the electric field deflection module and the ion receiving module by an iterative method according to the field axis distribution of the modules adjacent to the electric field deflection module and the ion receiving module, and the focusing voltage is used to increase the focusing performance of the ions passing between the electric field deflection module and the ion receiving module; The controller is used to output an electric field deflection voltage to the electric field deflection module and the ion receiving module to change the direction of the electric field between the electric field deflection module and the ion receiving module, guide the ion flow to be transmitted toward the ion receiving module, and measure the current received by the ion receiving module during the ion flight.

2. The device for measuring ion transmission efficiency according to claim 1, characterized in that: The electric field deflection module and the ion receiving module are respectively arranged on both sides of the transmission path, and a gap is provided between the electric field deflection module and the ion receiving module for the ion flow to be transmitted along the transmission path.

3. The device for measuring ion transmission efficiency according to claim 1 or 2, characterized in that: The ion receiving module is in a flat plate shape or a tile shape.

4. The device for measuring ion transmission efficiency according to claim 3, characterized in that: When the ion receiving module is in a tile-type, the concave surface of the ion receiving module is arranged toward the electric field deflection module.

5. A method for measuring ion transmission efficiency, characterized in that: The method is applied to a controller in a device for measuring ion transmission efficiency as claimed in any one of claims 1 to 4, and the method comprises: Outputting an electric field deflection voltage to an electric field deflection module and an ion receiving module in the device for measuring ion transmission efficiency, so as to change the direction of the electric field between the electric field deflection module and the ion receiving module, and guide the ion flow to be transmitted toward the ion receiving module; collecting the current output by the ion receiving module; The measurement result of the ion transmission efficiency of the ion flow is determined according to the current output by the ion receiving module.

6. The method for measuring ion transmission efficiency according to claim 5, characterized in that: The method further comprises: Acquiring field axis distribution information between the electric field deflection module and the ion receiving module; According to the field axis distribution information, a focusing voltage is output to the electric field deflection module.

7. The method for measuring ion transmission efficiency according to claim 5, characterized in that: The measurement result includes transmission position information and transmission efficiency, wherein the transmission position information represents at least one link in the transmission process of the ion flow corresponding to the electric field deflection module and the ion receiving module; The method further comprises: The transmission efficiency distribution of the ion flow is determined according to the transmission position information and the transmission efficiency.

8. The method for measuring ion transmission efficiency according to claim 7, characterized in that: The method further comprises: When the transmission efficiency is less than a preset value, the corresponding transmission position information is marked.

9. A non-transitory computer-readable storage medium having a computer program stored thereon, characterized in that: When the computer program is executed by a processor, the method for measuring ion transmission efficiency according to any one of claims 5 to 8 is implemented.

10. A computer program product, comprising a computer program, characterized in that When the computer program is executed by a processor, the method for measuring ion transmission efficiency according to any one of claims 5 to 8 is implemented.

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