Pearl dressing with sterilization, anti-inflammation and repair functions and preparation method thereof

Abstract

The invention belongs to the technical field of sterilization and inflammation diminishing, and provides a pearl dressing with sterilization, inflammation diminishing and repairing functions and a preparation method thereof.The pearl dressing is prepared from, by weight, 1-2 parts of pearl stock solution, 1-1.5 parts of collagen, 0.4-0.8 part of antioxidant, 0.02-0.06 part of modified fullerene, 10-15 parts of mineral water and 80-90 parts of purified water. The pearl dressing is simple and safe in component, comfortable in body feeling and free of irritation, the pearl stock solution has the functions of sterilization, inflammation diminishing and repairing, the liquid state of the pearl stock solution can provide enough active ingredients for body skin, meanwhile, the modified fullerene can effectively promote absorption of the repairing ingredients by the skin, and therefore the overall repairing effect is improved; good market values are realized.

Description

Technical Field

[0001] The invention belongs to the technical field of sterilization and anti-inflammation, and in particular relates to a pearl dressing with sterilization, anti-inflammation and repairing functions and a preparation method thereof. Background Art

[0002] Pearls vary slightly in content due to their origin, water area, climate and other factors, but the chemical components they contain are generally the same. Pearls are mainly composed of calcium carbonate, rich in amino acids, polysaccharides and trace organic components, and contain a variety of trace elements such as sodium, potassium, magnesium and selenium. They are well used in whitening and anti-aging, detoxification and muscle regeneration, immune regulation, sterilization and anti-inflammatory. However, due to the solid state of pearl powder, it is difficult to provide enough active ingredients for the skin of the body.

[0003] Chinese patent CN114558120 A discloses a skin repair compound liquid, including component A and component B, wherein component A includes deionized water, aloe extract, pearl powder and fullerene particles, and component B includes deionized water, polypeptide, keratin and collagen, and the mass ratio of component A to component B is (2-1):1. This invention uses fullerene particles to adsorb aloe extract, pearl powder, polypeptide, keratin and collagen, so that the effective substances are more tightly combined, and fullerene can absorb and dissolve free radicals in the skin, thereby promoting the skin's good absorption of repair ingredients and improving the overall repair effect; however, the pearl powder of this invention is added to the compound liquid in solid form, and the content of effective ingredients that play a repair function is low.

[0004] Therefore, there is an urgent need for a pearl dressing that can effectively enhance the bactericidal, anti-inflammatory and repairing functions. Summary of the invention

[0005] In view of the existing technical problems, the purpose of the present invention is to provide a pearl dressing with bactericidal, anti-inflammatory and repairing functions and a preparation method thereof. The pearl dressing of the present invention has simple and safe ingredients, comfortable body feeling and no irritation. The pearl stock solution has the functions of bactericidal, anti-inflammatory and repairing, and its liquid state can provide sufficient active ingredients for the body skin. At the same time, the modified fullerene can effectively promote the skin's absorption of the repairing ingredients, thereby improving the overall repairing effect, and has good market value.

[0006] In order to achieve the above object, the technical solution adopted by the present invention is as follows:

[0007] On the one hand, the present invention provides a pearl dressing with bactericidal, anti-inflammatory and repairing functions. The pearl dressing comprises the following raw materials by weight: 1-2 parts of pearl stock solution, 1-1.5 parts of collagen, 0.4-0.8 parts of antioxidant, 0.02-0.06 parts of modified fullerene, 10-15 parts of mineral water, and 80-90 parts of purified water.

[0008] The reaction mechanism and effects of the present invention are as follows:

[0009] 1. Fullerene is an effective free radical scavenger and antioxidant with multiple activities such as antioxidant, cell protection, antimicrobial, and drug carrier. However, its solubility in water is very low.

[0010] The present invention modifies fullerene by adding 1-amino-3,6,9-trioxa-11-undecanol and performs dialysis to enhance the water solubility of fullerene. The applicant further introduces germanium and zinc after ionizing the fullerene with ethyl 2-chloroacetoacetate to make the structure of the modified fullerene more stable. Meanwhile, germanium has anti-inflammatory and antioxidant effects, can inhibit inflammatory reactions, reduce the infiltration of inflammatory cells and the release of inflammatory factors, thereby alleviating the inflammatory symptoms of skin diseases. Zinc, as an essential trace element, can promote the removal of inactivated tissues, reduce the risk of infection, and alleviate inflammation. It is crucial to the activity of different enzymes and transcription factors. Topical zinc has a significant effect in the treatment of wounds and skin around wounds.

[0011] 2. The present invention adds bean dregs, potassium dihydrogen phosphate, magnesium sulfate, glucose and urea to the culture medium to adjust the content of nutrients such as carbon source and nitrogen source in the culture medium, which is conducive to the growth of composite bacteria. The applicant has found that inoculating a specific ratio of bifidobacteria and phyllotoxin in the fermentation substrate can increase the content of effective ingredients in the obtained fermentation product, improve the antiviral, antibacterial and anti-inflammatory components in the fermentation product, and thus enhance the repair effect.

[0012] In some embodiments, the method for preparing the pearl stock solution comprises the following steps:

[0013] S1. The pearls were washed, dried, and crushed through a 50-150 mesh sieve to obtain pearl powder;

[0014] S2. Add dregs of soybean oil, potassium dihydrogen phosphate, magnesium sulfate, glucose, urea, and ultrapure water to the pearl powder obtained in step S1, stir, and sterilize to obtain a fermentation substrate;

[0015] S3. Adding composite bacteria to the fermentation substrate obtained in step S2, fermenting, centrifuging, and sterilizing to obtain pearl stock solution.

[0016] In some embodiments, the fermentation conditions in step S3 are: fermentation temperature 30-45° C., fermentation pH 6-7, and fermentation time 48-72 h.

[0017] In some embodiments, the amount of the composite bacteria added in step S3 is 5-15% of the mass of the pearl powder.

[0018] Preferably, the amount of the composite bacteria added in step S2 is 8-12 wt % of the mass of the pearl powder.

[0019] In some embodiments, the composite bacteria in step S3 are Bifidobacterium and Familiar porphyria, and the mass ratio of the two is 1:(1.8-2.8).

[0020] In some embodiments, the method for preparing the modified fullerene comprises the following steps:

[0021] A1. Add fullerene and toluene to a reactor, perform ultrasound, add 1-amino-3,6,9-trioxa-11-undecanol and lithium hydroxide, stir and react for 16-24 hours, then add ethyl acetate, precipitate, and centrifuge to obtain a precipitate;

[0022] A2. The precipitate obtained in step A1 was dissolved in ultrapure water, dialyzed for 36-48 hours, during which the ultrapure water was replaced every 3-4 hours, and dried to obtain fullerene nanoparticles;

[0023] A3. The fullerene nanoparticles obtained in step A2 are dispersed in ethanol and ultrapure water, and then ethyl 2-chloroacetoacetate is added thereto, heated to 60-80°C, stirred for 8-12h, centrifuged, and dried to obtain a fullerene intermediate;

[0024] A4. Add the fullerene intermediate, sodium germanate and nano zinc oxide obtained in step A3 into ultrapure water, heat to 70-90°C, stir and react for 8-12h, centrifuge, wash and dry to obtain modified fullerene.

[0025] In some embodiments, the mass ratio of fullerene to 1-amino-3,6,9-trioxa-11-undecanol in step A1 is 1:(15-25).

[0026] In some embodiments, the mass ratio of the fullerene intermediate, sodium germanate and nano zinc oxide in step A4 is (14-18.5):(1.3-1.6):1.

[0027] In some embodiments, the dialysis bag used in the dialysis in step A2 has a molecular weight cutoff of 3-4 kDa.

[0028] Preferably, the dialysis bag for dialysis in step A2 has a molecular weight cutoff of 3.5 kDa.

[0029] In some embodiments, the mass ratio of the fullerene nanoparticles to ethyl 2-chloroacetoacetate in step A3 is (2.4-3):1.

[0030] In some embodiments, the antioxidant is tocopherol acetate and / or hydrolyzed oat protein.

[0031] Another aspect of the present invention is to provide a method for preparing the pearl dressing having bactericidal, anti-inflammatory and repairing functions, comprising the following steps:

[0032] The pearl stock solution, collagen, antioxidant, modified fullerene, mineral water and purified water are mixed, and stirred at a temperature of 5-15° C. for 1-2 hours to obtain a pearl dressing.

[0033] Compared with the prior art, the present invention has the following beneficial effects:

[0034] 1. The pearl dressing of the present invention has simple and safe ingredients, feels comfortable and has no irritation. The pearl stock solution has the functions of sterilization, anti-inflammatory and repair, and its liquid state can provide sufficient active ingredients for the body's skin. At the same time, the modified fullerene can effectively promote the skin's absorption of the repair ingredients, thereby improving the overall repair effect, and has good market value.

[0035] 2. The present invention enhances the water solubility of fullerene by adding 1-amino-3,6,9-trioxa-11-undecanol to modify fullerene. The applicant further introduces germanium and zinc after ionizing the fullerene with ethyl 2-chloroacetoacetate to make the structure of the modified fullerene more stable. At the same time, germanium and zinc can inhibit inflammatory reactions and have significant effects in treating wounds and wound surfaces.

[0036] 3. The present invention inoculates a specific ratio of bifidobacterium and schizontia in the fermentation substrate, so that the content of effective ingredients in the obtained fermentation product is higher, the antiviral, antibacterial and anti-inflammatory components in the fermentation product are increased, and the repair effect is thereby improved. DETAILED DESCRIPTION

[0037] The present invention will be described below in conjunction with specific embodiments. It should be noted that the following embodiments are examples of the present invention and are only used to illustrate the present invention, rather than to limit the present invention. Other combinations and various modifications within the concept of the present invention may be performed without departing from the spirit or scope of the present invention.

[0038] According to the ratios of the raw materials and the preparation methods specified in the following examples and comparative examples, various pearl dressings were prepared.

[0039] In order to facilitate those skilled in the art to implement the present invention, the sources of some raw materials in the embodiments and comparative examples are described as follows:

[0040] Bifidobacterium longum: purchased from Hebei Liqia Biotechnology Co., Ltd.;

[0041] Phyllostachys schizophylla: purchased from Lanzhou Waterless Biotechnology Co., Ltd.;

[0042] Collagen: purchased from Guangzhou Miaokefu Biotechnology Co., Ltd.;

[0043] Other raw materials are not specially specified and can be purchased from the market.

[0044] Preparation Example 1

[0045] The preparation method of modified fullerene A comprises the following steps:

[0046] A1. Add 50 mg of fullerene C60 and 50 ml of toluene to a reactor, ultrasonicate for 30 min, add 1 g of 1-amino-3,6,9-trioxa-11-undecanol and 50 mg of lithium hydroxide, stir and react for 20 h, then add 1200 ml of ethyl acetate to terminate the reaction, precipitate, and centrifuge to obtain a precipitate;

[0047] A2. The precipitate obtained in step A1 was dissolved in 1600 ml of ultrapure water, placed in a dialysis bag with a molecular weight cutoff of 3.5 kDa and dialyzed for 42 h, with ultrapure water replaced every 3 h. The aqueous solution in the dialysis bag was dried to constant weight by a freeze dryer to obtain fullerene nanoparticles;

[0048] A3. 40.5 mg of fullerene nanoparticles obtained in step A2 were dispersed in 20 ml of ethanol and 30 ml of ultrapure water, and then 15 mg of ethyl 2-chloroacetoacetate was added thereto, heated to 65 ° C, stirred for 10 h, centrifuged, and dried at 80 ° C for 3 h to obtain a fullerene intermediate;

[0049] A4. Add 35 mg of the fullerene intermediate obtained in step A3, 3 mg of sodium germanate, and 2 mg of nano zinc oxide to 50 ml of ultrapure water, heat to 80°C and stir to react for 10 hours, centrifuge, wash twice with ultrapure water, and dry at 80°C for 3 hours to obtain modified fullerene A.

[0050] Preparation Example 2

[0051] The preparation method of modified fullerene B is the same as that of Preparation Example 1, except that the amount of 1-amino-3,6,9-trioxa-11-undecanol added in step A1 is 0.7 g.

[0052] Preparation Example 3

[0053] The preparation method of modified fullerene C is the same as that of Preparation Example 1, except that step A4:

[0054] 35 mg of the fullerene intermediate obtained in step A3 and 5 mg of sodium germanate were added to 50 ml of ultrapure water, heated to 80° C. and stirred for reaction for 10 h, centrifuged, washed twice with ultrapure water, and dried at 80° C. for 3 h to obtain modified fullerene C.

[0055] Preparation Example 4

[0056] The preparation method of modified fullerene D is the same as that of Preparation Example 1, except that step A4:

[0057] 35 mg of the fullerene intermediate obtained in step A3 and 5 mg of nano zinc oxide were added to 50 ml of ultrapure water, heated to 80° C. and stirred for reaction for 10 h, centrifuged, washed twice with ultrapure water, and dried at 80° C. for 3 h to obtain modified fullerene D.

[0058] Preparation Example 5

[0059] The preparation method of pearl stock solution A comprises the following steps:

[0060] S1. Wash 2 kg of pearls with water three times, dry at 70°C to constant weight, and crush through a 100-mesh sieve to obtain pearl powder;

[0061] S2. Add 10 g of dregs, 1.1 g of potassium dihydrogen phosphate, 0.6 g of magnesium sulfate, 4 g of glucose, 5 g of urea, and 5 L of ultrapure water to 500 g of pearl powder obtained in step S1, stir for 1 h, and sterilize at 120 ° C for 5 min to obtain a fermentation substrate;

[0062] S3. Inoculate 15 g of Bifidobacterium longum and 35 g of Falmioporium schizophyllum into the fermentation substrate obtained in step S1, and ferment in a shaker at a rotation speed of 150 r / min, a fermentation temperature of 35° C., a pH value of 6.5, and centrifuge after fermentation for 72 hours. Take the supernatant and sterilize at 120° C. for 5 minutes to obtain pearl stock solution.

[0063] Preparation Example 6

[0064] The preparation method of pearl stock solution B is the same as that of Example 1, except that 19 g of Bifidobacterium longum and 31 g of Fa. pyrifos schizontii are added instead of 15 g of Bifidobacterium longum and 35 g of Fa. pyrifos schizontii.

[0065] Preparation Example 7

[0066] The preparation method of pearl stock solution C is the same as that of Example 1, except that 50 g of Bifidobacterium longum is added instead of 15 g of Bifidobacterium longum and 35 g of Familiar pyrifos.

[0067] Preparation Example 8

[0068] The preparation method of pearl stock solution D is the same as that of Example 1, except that 50 g of Schizodactylum sphaerocephalum is added instead of 15 g of Bifidobacterium longum and 35 g of Schizodactylum sphaerocephalum.

[0069] Preparation Example 9

[0070] The preparation method of pearl stock solution E is the same as that of Example 1, except that the added amount of Bifidobacterium longum is 6 g and the added amount of Familiar porphyria is 14 g.

[0071] Example 1

[0072] A pearl dressing with bactericidal, anti-inflammatory and repairing functions comprises the following raw materials by weight: 1.5 parts of pearl stock solution A, 1.2 parts of collagen, 0.6 parts of hydrolyzed oat protein, 0.04 parts of modified fullerene A, 12 parts of mineral water and 85 parts of purified water.

[0073] The preparation method of the pearl dressing of this embodiment comprises the following steps:

[0074] Pearl stock solution A, collagen, hydrolyzed oat protein, modified fullerene A, mineral water and purified water were mixed, and stirred at a temperature of 10° C. for 1.5 hours to obtain a pearl dressing.

[0075] Example 2

[0076] A pearl dressing with bactericidal, anti-inflammatory and repairing functions comprises the following raw materials by weight: 1 part of pearl stock solution A, 1 part of collagen, 0.4 parts of hydrolyzed oat protein, 0.02 parts of modified fullerene A, 10 parts of mineral water and 80 parts of purified water.

[0077] The preparation method of the pearl dressing of this embodiment comprises the following steps:

[0078] Pearl stock solution A, collagen, hydrolyzed oat protein, modified fullerene A, mineral water and purified water were mixed, and stirred at a temperature of 5° C. for 2 hours to obtain a pearl dressing.

[0079] Example 3

[0080] A pearl dressing with bactericidal, anti-inflammatory and repairing functions comprises the following raw materials by weight: 2 parts of pearl stock solution A, 1.5 parts of collagen, 0.8 parts of tocopherol acetate, 0.06 parts of modified fullerene A, 15 parts of mineral water and 90 parts of purified water.

[0081] The preparation method of the pearl dressing of this embodiment comprises the following steps:

[0082] Pearl stock solution A, collagen, tocopherol acetate, modified fullerene A, mineral water and purified water were mixed, and stirred at a temperature of 15° C. for 1 hour to obtain a pearl dressing.

[0083] Example 4

[0084] A pearl dressing with bactericidal, anti-inflammatory and repairing functions and a preparation method thereof. The specific implementation method is the same as that of Example 1, except that an equal amount of modified fullerene B is used to replace modified fullerene A.

[0085] Example 5

[0086] A pearl dressing with bactericidal, anti-inflammatory and repairing functions and a preparation method thereof. The specific implementation method is the same as that of Example 1, except that an equal amount of modified fullerene C is used to replace modified fullerene A.

[0087] Example 6

[0088] A pearl dressing with bactericidal, anti-inflammatory and repairing functions and a preparation method thereof. The specific implementation method is the same as that of Example 1, except that an equal amount of modified fullerene D is used to replace modified fullerene A.

[0089] Example 7

[0090] A pearl dressing with bactericidal, anti-inflammatory and repairing functions and a preparation method thereof, wherein the specific implementation manner is the same as that of Example 1, except that an equal amount of pearl stock solution B is used to replace pearl stock solution A.

[0091] Example 8

[0092] A pearl dressing with bactericidal, anti-inflammatory and repairing functions and a preparation method thereof, wherein the specific implementation manner is the same as that of Example 1, except that an equal amount of pearl stock solution C is used to replace pearl stock solution A.

[0093] Example 9

[0094] A pearl dressing with bactericidal, anti-inflammatory and repairing functions and a preparation method thereof, wherein the specific implementation manner is the same as that of Example 1, except that an equal amount of pearl stock solution D is used to replace pearl stock solution A.

[0095] Example 10

[0096] A pearl dressing with bactericidal, anti-inflammatory and repairing functions and a preparation method thereof, wherein the specific implementation manner is the same as that of Example 1, except that an equal amount of pearl stock solution E is used to replace pearl stock solution A.

[0097] Comparative Example 1

[0098] A pearl dressing with bactericidal, anti-inflammatory and repairing functions and a preparation method thereof, the specific implementation method is the same as that of Example 1, except that an equal amount of commercially available fullerene C60 is used to replace modified fullerene A.

[0099] Comparative Example 2

[0100] A pearl dressing with bactericidal, anti-inflammatory and repairing functions and a preparation method thereof, the specific implementation method is the same as that of Example 1, except that an equal amount of commercially available pearl powder is used to replace pearl stock solution A.

[0101] Effect evaluation:

[0102] The pearl dressings prepared in the above Examples 1-10 and Comparative Examples 1-2 were tested, and the specific results are shown in Table 1.

[0103] Performance Test:

[0104] (1) Inhibition rate: The total inhibition rates of Candida albicans, Escherichia coli and Staphylococcus aureus were measured according to the antibacterial and antibacterial effect evaluation method of WS / T 650-2019.

[0105] (2) Repair performance:

[0106] ①Establishment of a mouse full-thickness skin lesion model:

[0107] Male mice aged 5-6 weeks were raised according to animal care and handling procedures, anesthetized by intraperitoneal injection of 350 mg / kg chloral hydrate, and after depilation and disinfection of the back skin, a round hole was punched on the back of the mouse with an 8 mm diameter puncher, and the full-thickness skin was excised. Each animal was raised in a separate cage;

[0108] ②Administer medication to mice with trauma model:

[0109] Apply 200 mg of pearl dressing to the wound until it is completely covered, once a day for 28 consecutive days; after application, starting from day 0, take photos at the same fixed height every 5 days to record the wound surface condition, and calculate the 5-day and 15-day healing rates of the wound;

[0110] The formula for determining wound healing rate is:

[0111] Wound healing rate on day n (%) = (wound area on day 0 - wound area on day n) / wound area on day 0 * 100, where n is the number of days after modeling.

[0112] Table 1

[0113]

[0114]

[0115] From the results in Table 1, it can be seen that the pearl auxiliary materials prepared in Examples 1-3 have good antibacterial properties and good repair effects.

[0116] Examples 4-6 and Comparative Example 1 Compared with Example 1, when preparing modified fullerene, Example 4 changes the mass ratio of fullerene and 1-amino-3,6,9-trioxa-11-undecanol; at the same time, Comparative Example 1 replaces modified fullerene A with an equal amount of commercially available fullerene, which makes the water solubility of fullerene worse and affects the antibacterial effect; Examples 5-6 change the mass ratio of fullerene intermediates, sodium germanate and nano zinc oxide, which reduces the structural stability of fullerene, thereby reducing the skin's absorption performance of repair components, affecting the antibacterial and repair effects.

[0117] Compared with Example 1, when preparing the pearl stock solution, Example 7 changed the mass ratio of the composite bacteria Bifidobacterium and the schizothionine, Examples 8-9 changed the types of bacteria, and Example 10 changed the ratio of the amount of composite bacteria added to the mass of pearl powder, which affected the fermentation effect. At the same time, Comparative Example 2 replaced the pearl stock solution A with an equal amount of commercially available pearl powder, which reduced the content of effective ingredients, decreased the antibacterial effect, and weakened the repair performance.

[0118] The above is only a preferred embodiment of the present invention and does not constitute any form of limitation to the present application. Although the present application is disclosed as above in the preferred embodiment, it is not intended to limit the present application. Any technician familiar with the profession, without departing from the scope of the technical solution of the present application, using the technical content disclosed above to make slight changes or modifications are equivalent to equivalent implementation cases. However, any simple modifications, equivalent changes and modifications made to the above embodiments based on the technical essence of the present invention without departing from the content of the technical solution of the present invention are still within the scope of the technical solution.

Claims

1. A pearl dressing with bactericidal, anti-inflammatory and repairing functions, characterized in that: The pearl dressing comprises the following raw materials by weight: 1-2 parts of pearl stock solution, 1-1.5 parts of collagen, 0.4-0.8 parts of antioxidant, 0.02-0.06 parts of modified fullerene, 10-15 parts of mineral water, and 80-90 parts of purified water.

2. The pearl dressing with bactericidal, anti-inflammatory and repairing functions according to claim 1, characterized in that: The method for preparing the pearl stock solution comprises the following steps: S1. The pearls were washed, dried, and crushed through a 50-150 mesh sieve to obtain pearl powder; S2. Add dregs of soybean oil, potassium dihydrogen phosphate, magnesium sulfate, glucose, urea, and ultrapure water to the pearl powder obtained in step S1, stir, and sterilize to obtain a fermentation substrate; S3. Adding composite bacteria to the fermentation substrate obtained in step S2, fermenting, centrifuging, and sterilizing to obtain pearl stock solution.

3. The pearl dressing with bactericidal, anti-inflammatory and repairing functions according to claim 2, characterized in that: The fermentation conditions in step S3 are: fermentation temperature 30-45° C., fermentation pH 6-7, and fermentation time 48-72 h.

4. The pearl dressing with bactericidal, anti-inflammatory and repairing functions according to claim 2, characterized in that: The amount of the composite bacteria added in step S3 is 5-15% of the mass of the pearl powder.

5. The pearl dressing with bactericidal, anti-inflammatory and repairing functions according to claim 2, characterized in that: The composite bacteria in step S3 are Bifidobacterium and Familiar porphyria, and the mass ratio of the two is 1:(1.8-2.8).

6. The pearl dressing with bactericidal, anti-inflammatory and repairing functions according to claim 1, characterized in that: The preparation method of the modified fullerene comprises the following steps: A1. Add fullerene and toluene to a reactor, perform ultrasound, add 1-amino-3,6,9-trioxa-11-undecanol and lithium hydroxide, stir and react for 16-24 hours, then add ethyl acetate, precipitate, and centrifuge to obtain a precipitate; A2. The precipitate obtained in step A1 was dissolved in ultrapure water, dialyzed for 36-48 hours, during which the ultrapure water was replaced every 3-4 hours, and dried to obtain fullerene nanoparticles; A3. The fullerene nanoparticles obtained in step A2 are dispersed in ethanol and ultrapure water, and then ethyl 2-chloroacetoacetate is added thereto, heated to 60-80°C, stirred for 8-12h, centrifuged, and dried to obtain a fullerene intermediate; A4. Add the fullerene intermediate, sodium germanate and nano zinc oxide obtained in step A3 into ultrapure water, heat to 70-90°C, stir and react for 8-12h, centrifuge, wash and dry to obtain modified fullerene.

7. The pearl dressing with bactericidal, anti-inflammatory and repairing functions according to claim 6, characterized in that: The mass ratio of fullerene to 1-amino-3,6,9-trioxa-11-undecanol in step A1 is 1:(15-25).

8. The pearl dressing with bactericidal, anti-inflammatory and repairing functions according to claim 6, characterized in that: The mass ratio of the fullerene intermediate, sodium germanate and nano zinc oxide in step A4 is (14-18.5):(1.3-1.6):

1.

9. The pearl dressing with bactericidal, anti-inflammatory and repairing functions according to claim 1, characterized in that: The antioxidant is tocopherol acetate and / or hydrolyzed oat protein.

10. A method for preparing the pearl dressing with bactericidal, anti-inflammatory and repairing functions as claimed in any one of claims 1 to 9, characterized in that: The following steps are included: The pearl stock solution, collagen, antioxidant, modified fullerene, mineral water and purified water are mixed, and stirred at a temperature of 5-15° C. for 1-2 hours to obtain a pearl dressing.

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