Traditional Chinese medicine prescription with broad-spectrum antiviral and antibacterial functions and time-sharing administration of yin and yang medicines

Abstract

The invention relates to a traditional Chinese medicine prescription which has broad-spectrum antiviral and antibacterial functions and is taken separately from yin and yang at different times. The traditional Chinese medicine prescription with the broad-spectrum antiviral and antibacterial functions for time-sharing administration of yin and yang divided medicines comprises a yang-strengthening and body-protecting prescription and a nourishing and body-protecting prescription, the prescription for strengthening yang and protecting body comprises radix aconiti lateralis praeparata slice, asarum, rhizoma zingiberis, flos farfarae, honey-fried licorice root, cortex acanthopanacis, polygala tenuifolia, ligusticum chuanxiong hort, mangnolia officinalis, bighead atractylodes rhizome, fructus alpiniae oxyphyllae, Chinese yam, ephedra and pericarpium citri reticulatae. The nourishing and body-protecting prescription comprises rhizoma belamcandae, Chinese lobelia, rhizoma paridis, dendrobium officinale, rheum officinale, polygonum aviculare, coptis chinensis, semen lepidii, houttuynia cordata, scutellaria baicalensis, rhizoma anemarrhenae, radix puerariae and momordica grosvenori. According to the traditional Chinese medicine prescription with the broad-spectrum antiviral and antibacterial functions, disclosed by the invention, the Yin and Yang medicines can be taken at different times, so that respiratory diseases caused by viruses and germs can be effectively treated.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine yin-yang medicine-dividing and time-dividing prescription with broad-spectrum antiviral and antibacterial functions. Background Art

[0002] Respiratory disease is one of the common clinical diseases. Its etiology is complex and the virus is highly variable, which can easily cause outbreaks in the population. Diseases caused by viruses are often highly contagious, widely prevalent, and have high mortality rates. With the formation of world integration, viruses spread more rapidly and have a wider impact. Therefore, the treatment of viral diseases is a global problem and a major national need. This type of disease has become a public health issue that cannot be ignored. Viral and bacterial infections are common causes of acute respiratory diseases. Viruses that cause respiratory infections include coronaviruses, influenza viruses, parainfluenza viruses, adenoviruses, respiratory syncytial viruses, etc. There are many pathogens that cause bacterial respiratory infections, among which Streptococcus pneumoniae, beta-hemolytic Streptococcus, Pseudomonas aeruginosa, Staphylococcus aureus, etc. are more common. Acute respiratory infections caused by viruses and bacteria mainly present clinically with nasal congestion, runny nose, sore throat, dry cough and other symptoms of upper respiratory tract infection. When the virus spreads to the lower respiratory tract, it may cause bronchiolitis and interstitial pneumonia. It is highly contagious, spreads rapidly, is prone to epidemics, and is highly harmful. Currently, the number of effective chemical drugs for respiratory infections is limited, and they often have problems such as drug resistance and adverse reactions. It is particularly necessary to explore the role of Chinese patent medicines in the treatment of infectious respiratory diseases. Summary of the invention

[0003] The purpose of the present invention is to provide a traditional Chinese medicine yin-yang medicine-divided time-divided prescription with broad-spectrum antiviral and antibacterial functions. The prescription can not only inhibit Helicobacter pylori, Staphylococcus aureus, hemolytic streptococci and other bacteria that cause respiratory diseases, but also inactivate human respiratory syncytial virus, influenza A virus, human coronavirus and other viruses that cause respiratory diseases, and has good antiviral and antibacterial effects.

[0004] In order to achieve the above purpose, the technical solution adopted by the present invention is:

[0005] A Chinese medicine prescription for taking Yin and Yang medicines at different times with broad-spectrum antiviral and antibacterial functions, including a prescription for supporting Yang and protecting the body and a prescription for nourishing and protecting the body; the prescription for supporting Yang and protecting the body includes Radix Aconiti Lateralis, Asarum, Dry Ginger, Coltsfoot Flos, Roasted Licorice, Cortex Acanthopanacis, Polygala Tenuifolia, Chuanxiong, Magnolia Officinalis, Atractylodes Macrocephala, Alpinia Schisandrae Chinensis, Dioscorea Opposita, Ephedra, and Tangerine Peel; the prescription for nourishing and protecting the body includes Radix Belamcandae, Herba Lobeliae, Paris Polygoni Dorado, Dendrobium Officinale, Rhubarb, Polygonum Multiflorum, Coptis Chinensis, Semen Lepidium, Houttuynia Cordata, Scutellaria Baicalensis, Anemarrhena Rhizoma, Puerariae Root, and Momordica Grosvenori.

[0006] Furthermore, the yang-boosting and body-protecting prescription also includes Evodia rutaecarpa, Panax notoginseng, Schizonepeta tenuifolia, Angelica sinensis, Atractylodes lancea, Astragalus membranaceus, Albizzia julibrissin, Patchouli, Cloves, Cinnamon bark, Psoralea corylifolia, Cardamom, and Perilla frutescens; the nourishing and body-protecting prescription also includes Rehmannia root bark, Taraxacum mongolicum, Polygonum cuspidatum, Artemisia capillaris, Gypsum, Phellodendron chinense, Sterculia lychnophora, Cirsium japonicum, Indigo naturalis, Sanguisorba officinalis, Hedyotis diffusa, Viola yedoensis, Morus alba, Gentiana scabra, Sophora japonica, Qinpi, Artemisia annua, and Forsythia suspensa.

[0007] Furthermore, the yang-boosting and body-protecting prescription also includes siler, aster, cinnamon twig, fennel, tangerine peel, epimedium, frankincense, agarwood, and amomum villosum; the nourishing and body-protecting prescription also includes honeysuckle, gardenia, bupleurum, isatis root, and centipede.

[0008] Further, the yang-boosting and body-protecting prescription includes 13-18 parts by weight of Radix Aconiti Lateralis, 2-5 parts by weight of Asarum, 7-11 parts by weight of Radix Glycyrrhizae Preparata, 7-11 parts by weight of Cortex Acanthopanacis, 7-11 parts by weight of Polygala Tenuifolia, 7-11 parts by weight of Cortex Coptidis, 7-11 parts by weight of Rhizoma Chuanxiong, 3-5 parts by weight of Fructus Evodiae, 6-10 parts by weight of Saposhnikovia Divaricata, 6-10 parts by weight of Notoginseng, 6-10 parts by weight of Schizonepeta Tenuifolia, 10-15 parts by weight of Angelica Sinensis, 8-10 parts by weight of Magnolia Bark, 8-10 parts by weight of Atractylodes, 10-15 parts by weight of Atractylodes Macrocephalae, 8-10 parts by weight of Alpinia Oxyphyllae, 8-10 parts by weight of Dried Ginger, and 20-35 parts by weight of Astragalus. by weight, 10-15 weight parts of Albizzia julibrissin, 5-8 weight parts of Amomum villosum, 5-15 weight parts of Patchouli, 5-15 weight parts of Ephedra, 5-15 weight parts of Aster, 5-15 weight parts of Coltsfoot, 5-15 weight parts of Tangerine Peel, 1-5 weight parts of Cloves, 20-35 weight parts of Yam, 6-10 weight parts of Cassia Twig, 1-10 weight parts of Cinnamon Bark, 6-10 weight parts of Psoralea corylifolia, 6-10 weight parts of Epimedium, 3-10 weight parts of Agarwood, 5-15 weight parts of Frankincense, 3-8 weight parts of Fennel, 3-8 weight parts of Cardamom, 10-15 weight parts of Perilla; the nourishing and body-protecting prescription includes Shoot 10-15 weight parts of dried, 10-20 weight parts of Lycium bark, 10-20 weight parts of honeysuckle, 10-20 weight parts of dandelion, 10-20 weight parts of lobelia, 8-12 weight parts of Paris polyphylla, 10-15 weight parts of Dendrobium officinale, 10-20 weight parts of Polygonum cuspidatum, 20-35 weight parts of Rhubarb, 50-65 weight parts of Lysimachia stramonium, 10-20 weight parts of Artemisia capillaris, 10-20 weight parts of Polygonum aviculare, 50-70 weight parts of Gypsum, 3-8 weight parts of Coptis chinensis, 10-15 weight parts of Phellodendron chinense, 8-12 weight parts of Gardenia jasminoides, 8-12 weight parts of Sterculia lychnophora, 45-65 weight parts of Cirsium japonicum. , 8-12 parts by weight of scutellaria baicalensis, 1-5 parts by weight of indigo, 20-30 parts by weight of houttuynia cordata, 10-20 parts by weight of sanguisorba officinalis, 20-40 parts by weight of oldenlandia diffusa, 20-40 parts by weight of viola yedoensis, 10-15 parts by weight of mulberry bark, 8-10 parts by weight of scutellaria baicalensis, 3-10 parts by weight of gentian, 6-12 parts by weight of sophora japonica, 8-15 parts by weight of qinpi, 8-15 parts by weight of artemisia annua, 8-15 parts by weight of anemarrhena, 10-20 parts by weight of kudzu root, 10-20 parts by weight of momordica grosvenori, 8-12 parts by weight of bupleurum, 10-20 parts by weight of forsythia suspensa, and 10-20 parts by weight of isatis root.

[0009] Further, the yang-boosting and body-protecting prescription includes 15 parts by weight of light aconite root, 3 parts by weight of asarum, 9 parts by weight of roasted licorice root, 9 parts by weight of acanthopanax bark, 9 parts by weight of polygala tenuifolia, 9 parts by weight of tangerine peel, 9 parts by weight of chuanxiong, 5 parts by weight of evodia rutaecarpa, 9 parts by weight of siler, 9 parts by weight of notoginseng, 9 parts by weight of schizonepeta, 12 parts by weight of angelica, 9 parts by weight of magnolia bark, 9 parts by weight of atractylodes, 12 parts by weight of atractylodes, 9 parts by weight of alkyl oxyphylla, 9 parts by weight of dried ginger, 30 parts by weight of astragalus, and 10 parts by weight of radix scutellariae. parts, 12 parts by weight of Albizzia julibrissin, 6 parts by weight of Amomum villosum, 10 parts by weight of Patchouli, 9 parts by weight of Ephedra, 9 parts by weight of Aster, 9 parts by weight of Coltsfoot, 9 parts by weight of Tangerine Peel, 3 parts by weight of Cloves, 30 parts by weight of Yam, 9 parts by weight of Cinnamon Twig, 5 parts by weight of Cinnamon Bark, 9 parts by weight of Psoralea corylifolia, 9 parts by weight of Epimedium, 5 parts by weight of Agarwood, 10 parts by weight of Frankincense, 6 parts by weight of Fennel, 6 parts by weight of Cardamom, and 9 parts by weight of Perilla; the nourishing and body-protecting prescription includes 9 parts by weight of Belamcanda chinensis, 15 parts by weight of Lycium bark, 15 parts by weight of Honeysuckle, 15 parts by weight of Taraxacum officinale, 15 parts by weight of Lobelia, 9 parts by weight of Paris polyphylla, 12 parts by weight of Dendrobium candidum, 15 parts by weight of Polygonum cuspidatum, 30 parts by weight of Rhubarb, 60 parts by weight of Lysimachia scutellariae, 15 parts by weight of Artemisia capillaris, 15 parts by weight of Polygonum cuspidatum, 60 parts by weight of Gypsum, 5 parts by weight of Coptis chinensis, 12 parts by weight of Phellodendron chinense, 9 parts by weight of Gardenia jasminoides, 9 parts by weight of Sterculia lychnophora, 50 parts by weight of Cirsium scutellariae, 9 parts by weight of Ligusticum chuanxiong, 3 parts by weight of Indigo naturalis, 25 parts by weight of Houttuynia cordata, 15 parts by weight of Sanguisorba officinalis, 30 parts by weight of Hedyotis diffusa, 30 parts by weight of Viola yedoensis, 12 parts by weight of Morus alba, 9 parts by weight of Scutellaria baicalensis, 6 parts by weight of Gentiana scabra, 9 parts by weight of Sophora japonica, 12 parts by weight of Qinpi, 12 parts by weight of Artemisia annua, 12 parts by weight of Anemarrhena asphodeloides, 15 parts by weight of Puerariae, 15 parts by weight of Momordica grosvenori, 9 parts by weight of Bupleurum chinense, 15 parts by weight of Forsythia suspensa, and 15 parts by weight of Radix Isatidis.

[0010] Furthermore, the Yang-boosting and body-protecting prescription and the nourishing and body-protecting prescription need to be prepared as Yang-boosting and body-protecting pills and nourishing and body-protecting pills for taking. The Yang-boosting and body-protecting pills are taken after breakfast, and the nourishing and body-protecting pills are taken after dinner.

[0011] Beneficial effects of the present invention:

[0012] The Chinese medicine Yin-Yang medicine-divided prescription for taking at different times with broad-spectrum antiviral and antibacterial functions of the present invention can inactivate viruses that cause respiratory diseases such as human respiratory syncytial virus, influenza A virus, and human coronavirus, and can effectively treat respiratory diseases caused by human respiratory syncytial virus, influenza A virus, and human coronavirus. In addition, the Chinese medicine Yin-Yang medicine-divided prescription for taking at different times with broad-spectrum antiviral and antibacterial functions of the present invention also has a good inhibitory effect on pathogens that cause respiratory diseases such as Klebsiella pneumoniae, Staphylococcus aureus, hemolytic streptococci, Salmonella typhimurium, Acinetobacter baumannii, and vancomycin-resistant Enterococcus faecalis, and can effectively treat respiratory diseases caused by pathogens such as Klebsiella pneumoniae, Staphylococcus aureus, hemolytic streptococci, Salmonella typhimurium, Acinetobacter baumannii, and vancomycin-resistant Enterococcus faecalis. BRIEF DESCRIPTION OF THE DRAWINGS

[0013] Figure 1 This is a physical picture of the nourishing and protecting pill in Example 1;

[0014] Figure 2 This is a physical picture of the Fuyang Hushen Pill in Example 1. DETAILED DESCRIPTION

[0015] The present invention will be further described below in conjunction with the embodiments of the present invention and the accompanying drawings.

[0016] Example 1

[0017] The antiviral and antibacterial tests of the nourishing and protecting pills and the supporting and protecting pills in this embodiment were entrusted to the Guangxi Zhuang Autonomous Region Institute of Traditional Chinese Medicine for testing.

[0018] The Chinese medicine Yin-Yang prescription with broad-spectrum antiviral and antibacterial functions of this embodiment includes a Yang-boosting and body-protecting prescription and a nourishing and body-protecting prescription. The Yang-boosting and body-protecting prescription is prepared as a Yang-boosting and body-protecting pill for taking, and the nourishing and body-protecting prescription is prepared as a nourishing and body-protecting pill for taking. The Yang-boosting and body-protecting pill is taken after breakfast; the nourishing and body-protecting pill is taken after dinner.

[0019] The prescription for supporting yang and protecting the body includes 15g of Aconite Root, 3g of Asarum, 9g of Roasted Licorice, 9g of Acanthopanax Cortex, 9g of Polygala Tenuifolia, 9g of Citrus Grandis Cortex, 9g of Ligusticum chuanxiong, 5g of Evodia rutaecarpa, 9g of Saposhnikovia Divaricata, 9g of Panax Notoginseng, 9g of Schizonepeta Tenuifolia, 12g of Angelica Sinensis, 9g of Magnolia Bark, 9g of Atractylodes Macrocephala, 12g of Atractylodes Macrocephala, 9g of Alpinia Oxyphylla, 9g of Dry Ginger, 30g of Astragalus, 12g of Albizzia julibrissin, 6g of Amomum villosum, 10g of Patchouli, 9g of Ephedra, 9g of Aster, 9g of Coltsfoot Flower, 9g of Tangerine Peel, 3g of Clove, 30g of Dioscorea Opposita, 9g of Cassia Twig, 5g of Cinnamon Bark, 9g of Psoralea Corylifolia, 9g of Epimedium, 5g of Agarwood, 10g of Frankincense, 6g of Fennel, 6g of Cardamom, and 9g of Perilla. The preparation method of Fuyang Hushen Pills is as follows: mix the formulated amounts of Aconiti Lateralis Preparata, Asarum, Roasted Licorice, Cortex Acanthopanacis, Polygala, Cortex Cibotii, Rhizoma Chuanxiong, Evodia rutaecarpa, Saposhnikovia, Notoginseng, Schizonepeta, Angelica, Magnolia officinalis, Atractylodes, Atractylodes, Alpinia oxyphylla, Dry ginger, Astragalus, Cortex Albizziae, Tsaoko, Patchouli, Ephedra, Aster, Coltsfoot, Tangerine peel, Clove, Dioscorea batatas, Cassia twig, Cinnamon bark, Psoralea corylifolia, Epimedium, Aquilaria wood, Frankincense, Fennel, Cardamom, and Perilla frutescens into powder, add water to prepare water pills.

[0020] The nourishing and protecting prescription includes 9g of Belamcanda chinensis, 15g of Rehmannia glutinosa, 15g of Honeysuckle, 15g of Taraxacum, 15g of Lobelia, 9g of Paris polyphylla, 12g of Dendrobium officinale, 15g of Polygonum cuspidatum, 30g of Rhubarb, 60g of Centella asiatica, 15g of Artemisia capillaris, 15g of Polygonum aviculare, 60g of Gypsum, 5g of Coptis chinensis, 12g of Phellodendron chinense, 9g of Gardenia jasminoides, 9g of Sterculia lychnophora, 50g of Cirsium japonicum, 9g of Lepidium officinale, 3g of Indigo naturalis, 25g of Houttuynia cordata, 15g of Sanguisorba officinalis, 30g of Hedyotis diffusa, 30g of Viola yedoensis, 12g of Morus alba, 9g of Scutellaria baicalensis, 6g of Gentiana scabra, 9g of Sophora japonica, 12g of Qinpi, 12g of Artemisia annua, 12g of Anemarrhena asphodeloides, 15g of Pueraria root, 15g of Momordica grosvenori, 9g of Bupleurum chinense, 15g of Forsythia suspensa, and 15g of Isatis indigotica. The preparation method of the nourishing and protecting pills is as follows: mix the formulated amounts of Belamcanda chinensis, Rehmannia root bark, Honeysuckle, Taraxacum mongolicum, Lobelia chinensis, Paris polyphylla, Dendrobium officinale, Polygonum cuspidatum, Rhubarb, Lysimachia chinensis, Artemisia capillaris, Polygonum aviculare, Gypsum, Coptis chinensis, Phellodendron chinense, Gardenia jasminoides, Sterculia lychnophora, Cirsium japonicum, Leonuri seeds, Indigo naturalis, Houttuynia cordata, Sanguisorba officinalis, Hedyotis diffusa, Viola yedoensis, Morus alba, Scutellaria baicalensis, Gentiana scabra, Sophora japonica, Qinpi, Artemisia annua, Anemarrhena asphodeloides, Pueraria lobata, Momordica grosvenori, Bupleurum chinense, Lianqiao (Nanthus suspensa) and Radix Isatidis, grind into powder, add water to prepare water pills.

[0021] The virus quantity of human respiratory syncytial virus (ATCC VR-1540) is shown in Table 1, and the host cell of human respiratory syncytial virus is: A549 cell. The virus quantity of influenza A virus H1N1: A / PR / 8 / 34 (ATCC VR-1469) is shown in Table 2, and the host cell of influenza A virus is: MDCK cell. Example 1 The antiviral effect of the nourishing and protective prescription on human respiratory syncytial virus in Table 1, influenza A virus in Table 2, and human coronavirus HCoV-229E (ATCC VR-740) is shown in Table 3, and the host cell of human coronavirus is Vero cell.

[0022] Table 1 Virus counts of human respiratory syncytial virus (ATCC VR-1540)

[0023]

[0024] In Table 1, the virus suspension is a virus suspension of human respiratory syncytial virus, the disinfectant is a nourishing body-protecting stock solution, and the drug removal treatment is to remove the disinfectant from the virus suspension. The preparation method of the nourishing body-protecting stock solution is: add 100g of nourishing body-protecting pills to 400mL of water, boil for 15min after boiling, filter the juice with gauze, add 400mL of water, boil for 20min after boiling, filter the juice with gauze, mix the juices boiled twice, cool, boil and evaporate to 200mL, and obtain 100% nourishing body-protecting stock solution.

[0025] As can be seen from Table 1, the average virus titer of the first group (lgTCID 50 / mL) was 2.60, and the average virus titer of the second group (lgTCID 50 / mL) was 2.97, and the logarithmic value of the average virus titer (lgTCID 50 / mL), and the inter-group errors of the three repeated tests were 1.2%, 1.4%, and 1.4%, respectively.

[0026] Table 2 Virus counts of influenza A viruses

[0027]

[0028] In Table 2, the virus suspension is a virus suspension of influenza A virus, the disinfectant is the nourishing and protective solution, and the drug removal treatment is to remove the disinfectant from the virus suspension.

[0029] The logarithm of the average virus titer of the first group (lgTCID 50 / mL) was 2.74, and the logarithmic value of the average virus titer of the second group (lgTCID 50 / mL) was 3.30, and the logarithmic value of the average virus titer of the third and fourth groups (lgTCID50 / mL), and the inter-group errors of the three repeated tests were 0.7%, 0.6%, and 1.1%, respectively.

[0030] Table 3 Antiviral effect of the nourishing and protecting prescription of Example 1 on human respiratory syncytial virus, influenza A virus, and human coronavirus

[0031]

[0032]

[0033] As can be seen from Table 3, the nourishing and protecting prescription of Example 1 has a virus inactivation rate of up to 99.61%, 99.78% and 99.39% for human respiratory syncytial virus, influenza A virus and human coronavirus, indicating that the nourishing and protecting prescription has a good therapeutic effect on respiratory diseases.

[0034] The antibacterial effect of the nourishing and protecting prescription of Example 1 on pathogens is shown in Table 4.

[0035] Table 4 Antibacterial effect of the nourishing and protecting prescription of Example 1

[0036]

[0037]

[0038] The control group did not use the nourishing and protecting prescription of Example 1, while the test group used the nourishing and protecting prescription of the present application.

[0039] It can be seen from Table 4 that the nourishing and protecting prescription prepared in Example 1 has a good antibacterial effect on Klebsiella pneumoniae, Staphylococcus aureus, hemolytic Streptococcus, Salmonella typhimurium, Acinetobacter baumannii, and vancomycin-resistant Enterococcus faecalis.

[0040] The virus quantity of human respiratory syncytial virus (ATCC VR-1540) is shown in Table 5, and the host cell of human respiratory syncytial virus is: A549 cell. The virus quantity of influenza A virus H1N1: A / PR / 8 / 34 (ATCC VR-1469) is shown in Table 6, and the host cell of influenza A virus is: MDCK cell. Example 1 The antiviral effect of the Yang Fu Hu Shen prescription on human respiratory syncytial virus in Table 5, influenza A virus in Table 6, and human coronavirus HCoV-229E (ATCC VR-740) is shown in Table 7, and the host cell of human coronavirus is Vero cell.

[0041] Table 5 Virus counts of human respiratory syncytial virus (ATCC VR-1540)

[0042]

[0043] In Table 5, the virus suspension is a virus suspension of human respiratory syncytial virus, the disinfectant is the Fuyang Hushen stock solution, and the drug removal treatment is to remove the disinfectant from the virus suspension. The preparation method of the Fuyang Hushen stock solution is: add 100g of Fuyang Hushen pills to 400mL of water, boil for 15min after boiling, filter the juice with gauze, add 400mL of water, boil for 20min after boiling, filter the juice with gauze, mix the juices boiled twice, cool, boil and evaporate to 200mL, and obtain 100% Fuyang Hushen stock solution.

[0044] As can be seen from Table 5, the logarithmic value of the average virus titer of the first group (lgTCID 50 / mL) was 2.59, and the logarithmic value of the average virus titer of the second group (lgTCID 50 / mL) was 3.16, and the logarithmic value of the average virus titer (lgTCID 50 / mL), and the inter-group errors of the three repeated tests were 1.2%, 1.4%, and 1.4%, respectively.

[0045] Table 6 Virus counts of influenza A virus

[0046]

[0047] In Table 6, the virus suspension is a virus suspension of influenza A virus, the disinfectant is the Fuyang Hushen original solution, and the drug removal treatment is to remove the disinfectant from the virus suspension.

[0048] As can be seen from Table 6, the logarithmic value of the average virus titer of the first group (lgTCID 50 / mL) was 2.69, and the logarithmic value of the average virus titer of the second group (lgTCID 50 / mL) was 3.19, and the logarithmic value of the average virus titer (lgTCID 50 / mL), and the inter-group errors of the three repeated tests were 0.7%, 0.6%, and 1.1%, respectively.

[0049] Table 7 Antiviral effect of the Yang-boosting and body-protecting prescription of Example 1 on human respiratory syncytial virus, influenza A virus, and human coronavirus

[0050]

[0051]

[0052] The antibacterial effect of the Yang-boosting and body-protecting prescription of Example 1 on pathogens is shown in Table 8.

[0053] Table 8 Antibacterial effect of Yang Fushen prescription of Example 1

[0054]

[0055]

[0056] It can be seen from Table 8 that the Yang-boosting and body-protecting prescription prepared in Example 1 has a good antibacterial effect on Klebsiella pneumoniae, Staphylococcus aureus, hemolytic Streptococcus, Salmonella typhimurium, Acinetobacter baumannii, and vancomycin-resistant Enterococcus faecalis.

[0057] The control group did not use the Yang-boosting and body-protecting prescription of Example 1, while the experimental group used the Yang-boosting and body-protecting prescription of the present application.

[0058] Example 2

[0059] The Chinese medicine Yin-Yang prescription with broad-spectrum antiviral and antibacterial functions of this embodiment includes a Yang-boosting and body-protecting prescription and a nourishing and body-protecting prescription. The Yang-boosting and body-protecting prescription is prepared as a Yang-boosting and body-protecting pill for taking, and the nourishing and body-protecting prescription is prepared as a nourishing and body-protecting pill for taking. The Yang-boosting and body-protecting pill is taken after breakfast; the nourishing and body-protecting pill is taken after dinner.

[0060] The prescription for supporting yang and protecting the body includes 13g of Aconite Root, 2g of Asarum, 7g of Roasted Licorice Root, 7g of Acanthopanax Cortex, 7g of Polygala Tenuifolia, 7g of Citrus Grandis Cortex, 7g of Ligusticum Chuanxiong, 3g of Evodia rutaecarpa, 6g of Saposhnikovia Divaricata, 6g of Panax Notoginseng, 6g of Schizonepeta Tenuifolia, 10g of Angelica Sinensis, 8g of Magnolia Officinalis, 8g of Atractylodes Macrocephala, 10g of Atractylodes Macrocephala, 8g of Alpinia Oxyphylla, 8g of Dry Ginger, 20g of Astragalus, 10g of Albizzia Cocos, 5g of Amomum villosum, 5g of Patchouli, 5g of Ephedra, 5g of Aster, 5g of Coltsfoot Flower, 5g of Tangerine Peel, 5g of Clove, 20g of Dioscorea Opposita, 6g of Cassia Twig, 3g of Cinnamon Bark, 6g of Psoralea Corylifolia, 6g of Epimedium, 3g of Agarwood, 5g of Frankincense, 3g of Fennel, 3g of Cardamom, and 10g of Perilla.

[0061] The nourishing and body-protecting prescription includes 10g of Belamcanda chinensis, 10g of Rehmannia root, 10g of Honeysuckle, 10g of Taraxacum, 10g of Lobelia, 8g of Paris polyphylla, 10g of Dendrobium officinale, 10g of Polygonum cuspidatum, 20g of Rhubarb, 50g of Centella asiatica, 10g of Artemisia capillaris, 10g of Polygonum cuspidatum, 50g of Gypsum, 3g of Coptis chinensis, 10g of Phellodendron chinense, 8g of Gardenia jasminoides, 8g of Sterculia lychnophora, 45g of Cirsium japonicum, 8g of Lepidium officinale, 1g of Indigo naturalis, 20g of Houttuynia cordata, 10g of Sanguisorba officinalis, 20g of Hedyotis diffusa, 20g of Viola yedoensis, 10g of Morus alba, 8g of Scutellaria baicalensis, 3g of Gentiana scabra, 6g of Sophora japonica, 8g of Qinpi, 8g of Artemisia annua, 8g of Anemarrhena asphodeloides, 10g of Pueraria root, 10g of Momordica grosvenori, 8g of Bupleurum chinense, 10g of Lotus forsythia, and 10g of Isatis indigotica.

[0062] Example 3

[0063] The Chinese medicine Yin-Yang prescription with broad-spectrum antiviral and antibacterial functions of this embodiment includes a Yang-boosting and body-protecting prescription and a nourishing and body-protecting prescription. The Yang-boosting and body-protecting prescription is prepared as a Yang-boosting and body-protecting pill for taking, and the nourishing and body-protecting prescription is prepared as a nourishing and body-protecting pill for taking. The Yang-boosting and body-protecting pill is taken after breakfast; the nourishing and body-protecting pill is taken after dinner.

[0064] The prescription for supporting yang and protecting the body includes 18g of Aconite Root, 5g of Asarum, 11g of Roasted Licorice, 11g of Acanthopanax Cortex, 11g of Polygala Tenuifolia, 11g of Citrus Grandis Cortex, 11g of Ligusticum Chuanxiong, 5g of Evodia rutaecarpa, 10g of Saposhnikovia Divaricata, 10g of Panax Notoginseng, 10g of Schizonepeta Tenuifolia, 15g of Angelica Sinensis, 10g of Magnolia Bark, 10g of Atractylodes Macrocephala, 15g of Atractylodes Macrocephala, 10g of Alpinia Oxyphylla, 10g of Dry Ginger, 35g of Astragalus, 15g of Albizzia Cocos, 8g of Amomum Vulgare, 15g of Patchouli, 15g of Ephedra, 15g of Aster, 15g of Coltsfoot Flower, 15g of Tangerine Peel, 5g of Clove, 35g of Yam, 10g of Cassia Twig, 10g of Cinnamon Bark, 10g of Psoralea Corylifolia, 10g of Epimedium, 10g of Agarwood, 15g of Frankincense, 8g of Fennel, 8g of Cardamom, and 15g of Perilla.

[0065] The nourishing and protective prescription includes 15g of Belamcanda chinensis, 20g of Radix Lycii, 20g of Honeysuckle, 20g of Taraxacum mongolicum, 20g of Lobelia chinensis, 12g of Paris polyphylla, 15g of Dendrobium officinale, 20g of Polygonum cuspidatum, 35g of Rhubarb, 65g of Centella asiatica, 20g of Artemisia capillaris, 20g of Polygonum multiflorum, 70g of Gypsum, 8g of Coptis chinensis, 15g of Phellodendron chinense, 12g of Gardenia jasminoides, 12g of Sterculia lychnophora, 65g of Cirsium sutchuenensis, 5g, 12g of scutellaria baicalensis, 5g of indigo, 30g of houttuynia cordata, 20g of dandelion, 40g of oldenlandia diffusa, 40g of viola yedoensis, 15g of mulberry bark, 10g of scutellaria baicalensis, 10g of gentiana, 12g of sophora japonica flower, 15g of qinpi, 15g of artemisia annua, 15g of anemarrhena, 20g of kudzu root, 20g of momordica grosvenori, 12g of bupleurum, 20g of forsythia, and 20g of isatis root.

Claims

1. A traditional Chinese medicine prescription for taking in accordance with Yin and Yang with broad-spectrum antiviral and antibacterial functions, characterized in that: It includes prescriptions for supporting yang and protecting the body and prescriptions for nourishing and protecting the body; the prescriptions for supporting yang and protecting the body include Aconiti Lateralis Preparata, Asarum, Dry Ginger, Coltsfoot Flos, Roasted Licorice, Acanthopanax Cortex, Polygala Tenuifolia, Chuanxiong, Magnolia Officinalis, Atractylodes Macrocephala, Alpinia Oxyphylla, Dioscorea Opposita, Ephedra, and Tangerine Peel; the prescriptions for nourishing and protecting the body include Belamcanda chinensis, Lobelia, Paris Polygoni Grandiflora, Dendrobium Officinale, Rhubarb, Polygonum Multiflorum, Coptis Chinensis, Lepidium Cuscuta, Houttuynia Cordata, Scutellaria Baicalensis, Anemarrhena Rhizome, Pueraria lobata, and Momordica grosvenori.

2. The Chinese medicine Yin-Yang medicine prescription for administration at different times with broad-spectrum antiviral and antibacterial functions according to claim 1, characterized in that: The yang-boosting and body-protecting prescription also includes Evodia rutaecarpa, Panax notoginseng, Schizonepeta tenuifolia, Angelica sinensis, Atractylodes lancea, Astragalus membranaceus, Albizzia julibrissin, Patchouli, Cloves, Cinnamon bark, Psoralea corylifolia, Cardamom, and Perilla frutescens; the nourishing and body-protecting prescription also includes Rehmannia root bark, Taraxacum officinale, Polygonum cuspidatum, Artemisia capillaris, Gypsum, Phellodendron chinense, Sterculia lychnophora, Cirsium japonicum, Indigo naturalis, Sanguisorba officinalis, Hedyotis diffusa, Viola yedoensis, Morus alba bark, Gentiana scabra, Sophora japonica, Qinpi, Artemisia 3. The Chinese medicine Yin-Yang medicine prescription for administration at different times with broad-spectrum antiviral and antibacterial functions according to claim 2, characterized in that: The yang-boosting and body-protecting prescription also includes fangfeng, aster, cassia twig, fennel, tangerine peel, epimedium, frankincense, agarwood, and amomum villosum; the nourishing and body-protecting prescription also includes honeysuckle, gardenia, bupleurum, isatis root, and centipede.

4. The Chinese medicine Yin-Yang medicine-divided-drug-divided-time-divided prescription with broad-spectrum antiviral and antibacterial functions according to claim 3, characterized in that: The yang-boosting and body-protecting prescription comprises 13-18 parts by weight of Radix Aconiti Lateralis, 2-5 parts by weight of Asarum, 7-11 parts by weight of Radix Glycyrrhizae Preparata, 7-11 parts by weight of Cortex Acanthopanacis, 7-11 parts by weight of Polygala Tenuifolia, 7-11 parts by weight of Cortex Cervi Panacis, 7-11 parts by weight of Rhizoma Chuanxiong, 3-5 parts by weight of Fructus Evodiae, 6-10 parts by weight of Saposhnikovia Divaricata, 6-10 parts by weight of Notoginseng, 6-10 parts by weight of Schizonepeta Tenuifolia, 10-15 parts by weight of Radix Angelicae Sinensis, 8-10 parts by weight of Magnolia Bark, 8-10 parts by weight of Atractylodes, 10-15 parts by weight of Atractylodes Macrocephalae, 8-10 parts by weight of Alpinia Oxyphyllae, 8-10 parts by weight of Dry Ginger, 20-35 parts by weight of Astragalus, 10-15 weight parts of Albizzia julibrissin bark, 5-8 weight parts of Amomum villosum, 5-15 weight parts of Patchouli, 5-15 weight parts of Ephedra, 5-15 weight parts of Aster, 5-15 weight parts of Coltsfoot Flos, 5-15 weight parts of Tangerine Peel, 1-5 weight parts of Cloves, 20-35 weight parts of Dioscorea opposita, 6-10 weight parts of Cinnamon Twig, 1-10 weight parts of Cinnamon Bark, 6-10 weight parts of Psoralea corylifolia, 6-10 weight parts of Epimedium, 3-10 weight parts of Agarwood, 5-15 weight parts of Frankincense, 3-8 weight parts of Fennel, 3-8 weight parts of Cardamom, 10-15 weight parts of Perilla; the nourishing and body-protecting prescription comprises 10 parts of Belamcanda chinensis, 10 parts of -15 weight parts, Cortex Lycii 10-20 weight parts, Flos Lonicerae 10-20 weight parts, Taraxacum 10-20 weight parts, Lobelia 10-20 weight parts, Paris polyphylla 8-12 weight parts, Dendrobium officinale 10-15 weight parts, Polygonum cuspidatum 10-20 weight parts, Rhubarb 20-35 weight parts, Lysimachia 50-65 weight parts, Artemisia capillaris 10-20 weight parts, Polygonum multiflorum 10-20 weight parts, Gypsum 50-70 weight parts, Coptis chinensis 3-8 weight parts, Cortex Phellodendri 10-15 weight parts, Gardenia 8-12 weight parts, Sterculia lychnophora 8-12 weight parts, Cirsium 45-65 weight parts, Ting 8-12 parts by weight of Ligusticum chuanxiong, 1-5 parts by weight of Indigo, 20-30 parts by weight of Houttuynia cordata, 10-20 parts by weight of Sanguisorba officinalis, 20-40 parts by weight of Hedyotis diffusa, 20-40 parts by weight of Viola yedoensis, 10-15 parts by weight of Morus alba, 8-10 parts by weight of Scutellaria baicalensis, 3-10 parts by weight of Gentiana scabra, 6-12 parts by weight of Sophora japonica, 8-15 parts by weight of Qinpi, 8-15 parts by weight of Artemisia annua, 8-15 parts by weight of Anemarrhena asphodeloides, 10-20 parts by weight of Puerariae, 10-20 parts by weight of Momordica grosvenori, 8-12 parts by weight of Bupleurum chinense, 10-20 parts by weight of Forsythia suspensa, and 10-20 parts by weight of Isatis indigotica.

5. The Chinese medicine Yin-Yang medicine-divided-drug-divided-time-divided prescription with broad-spectrum antiviral and antibacterial functions according to claim 4, characterized in that: The yang-boosting and body-protecting prescription includes 15 parts by weight of Radix Aconiti Lateralis, 3 parts by weight of Asarum, 9 parts by weight of Radix Glycyrrhizae Preparata, 9 parts by weight of Cortex Acanthopanacis, 9 parts by weight of Polygala, 9 parts by weight of Cortex Cervi Panacis, 9 parts by weight of Rhizoma Chuanxiong, 5 parts by weight of Evodia, 9 parts by weight of Saposhnikovia, 9 parts by weight of Notoginseng, 9 parts by weight of Schizonepeta, 12 parts by weight of Angelica Sinensis, 9 parts by weight of Magnolia Bark, 9 parts by weight of Atractylodes, 12 parts by weight of Atractylodes, 9 parts by weight of Alpinia Oxyphyllae, 9 parts by weight of Dry Ginger, 30 parts by weight of Astragalus, 12 parts by weight of Albizzia julibrissin bark, 6 parts by weight of Amomum villosum, 10 parts by weight of Patchouli, 9 parts by weight of Ephedra, 9 parts by weight of Aster, 9 parts by weight of Coltsfoot, 9 parts by weight of Tangerine peel, 3 parts by weight of Clove, 30 parts by weight of Dioscorea opposita, 9 parts by weight of Cinnamon twig, 5 parts by weight of Cinnamon bark, 9 parts by weight of Psoralea corylifolia, 9 parts by weight of Epimedium, 5 parts by weight of Agarwood, 10 parts by weight of Frankincense, 6 parts by weight of Fennel, 6 parts by weight of Cardamom, and 9 parts by weight of Perilla; the nourishing and body-protecting prescription includes Belamcanda chinensis 9 weight parts, 15 weight parts of Lycium bark, 15 weight parts of honeysuckle, 15 weight parts of dandelion, 15 weight parts of lobelia, 9 weight parts of Paris polyphylla, 12 weight parts of Dendrobium candidum, 15 weight parts of Polygonum cuspidatum, 30 weight parts of Rhubarb, 60 weight parts of Lysimachia foetida, 15 weight parts of Artemisia capillaris, 15 weight parts of Polygonum aviculare, 60 weight parts of Gypsum, 5 weight parts of Coptis chinensis, 12 weight parts of Phellodendron chinense, 9 weight parts of Gardenia jasminoides, 9 weight parts of Sterculia lychnophora, 50 weight parts of Cirsium japonicum, and 10 weight parts of Herba Lycopodii. 9 weight parts, Indigo naturalis 3 weight parts, Houttuynia cordata 25 weight parts, Sanguisorba officinalis 15 weight parts, Oldenlandia diffusa 30 weight parts, Viola yedoensis 30 weight parts, Morus alba 12 weight parts, Scutellaria baicalensis 9 weight parts, Gentiana 6 weight parts, Sophora japonica 9 weight parts, Qinpi 12 weight parts, Artemisia annua 12 weight parts, Anemarrhena asphodeloides 12 weight parts, Pueraria lobata 15 weight parts, Momordica grosvenori 15 weight parts, Bupleurum 9 weight parts, Forsythia suspensa 15 weight parts, Isatis indigotica 15 weight parts.

6. The Chinese medicine Yin-Yang medicine prescription for administration at different times with broad-spectrum antiviral and antibacterial functions according to claim 4, characterized in that: The yang-boosting and body-protecting prescriptions and the nourishing and body-protecting prescriptions need to be prepared into yang-boosting and body-protecting pills and nourishing and body-protecting pills for oral administration.

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