Sodium curdate repair dressing for light medicine post-art nursing and preparation method of sodium curdate repair dressing

Abstract

The invention provides a dressing as well as a preparation method and application thereof. The dressings comprise a substrate and a composition comprising: a corac acid salt, a coagulant, a dispersant, water, and optionally a pH adjusting agent and optionally a preservative. Through scientific proportioning, the film forming effect of the dressing is improved, the film forming time is shortened, and the physical barrier effect of the dressing is guaranteed. In the preparation process, a steam pretreatment process is adopted, so that the effect of reducing bacterial endotoxin and pyrogen of the sodium curnaate raw material is achieved. The dressing is used for light medicine post-art nursing, and has relatively strong effects of moisturizing, relieving, physical barrier and promoting wound healing.

Description

Technical Field

[0001] The invention relates to the technical field of medical dressings, and in particular to a sodium colanate repair dressing and a preparation method thereof. Background Art

[0002] In recent years, light medical beauty has become a new force in the development of medical beauty, gradually occupying a dominant position in the market. Compared with traditional surgical medical beauty, light medical beauty has the characteristics of less trauma, low risk, fast recovery, and natural effect. Light medical beauty, such as laser, radio frequency, ultrasound, injection, chemical peeling, etc., mainly acts on the surface layer of the skin or the basal layer of the dermis to achieve the purpose of skin rejuvenation, firming, scar repair, anti-aging, etc. However, although light medical beauty has less trauma, it still inevitably causes certain damage to the skin barrier. On the one hand, light medical beauty may cause discomfort reactions such as redness, swelling, heat, and pain after it; on the other hand, light medical beauty damages the skin barrier after it. Improper treatment may cause desquamation, acne, infection, pigmentation and other problems, which will cause harm to medical beauty patients. Regardless of the type of light medical beauty method, timely light medical beauty aftercare is crucial to reduce postoperative discomfort, repair the skin barrier, reduce the occurrence of complications, and improve postoperative effects. In addition to simple cleaning, sun protection and anti-irritation methods, it is necessary to use some medical repair products for post-care of light medical aesthetics, which can relieve pain, moisturize the skin, and act as a physical barrier in the affected area, thereby accelerating the healing of wounds.

[0003] Colanic acid (CA) is a high molecular weight extracellular capsular polysaccharide secreted by bacteria, also known as claric acid. Colanic acid is mainly composed of D-glucuronic acid, D-glucose, D-galactose and L-fucose, with a composition ratio of approximately 1:2:2:1, and also contains chemically modified structures on various side chains such as O-acetyl and pyruvic acid. In the later separation and purification process, colanic acid is introduced into an alkaline solution, such as sodium salt, to eventually form a more stable sodium colanate, with a maximum molecular weight of more than 10 million Daltons. It is not transdermal and difficult to be absorbed by the human body. Sodium colanate is homologous to the human moisturizing factor, has a porous fiber structure and contains a large number of hydrophilic groups on the surface, and has a super strong water-locking and moisturizing function; at the same time, its macromolecular structure enables it to have good physical film-forming properties, maintain the moisture balance inside and outside the skin, resist the effects of harmful substances and other stimuli, and reduce the symptoms of redness, swelling and pain. In addition, sodium colanate has good biocompatibility and does not have pharmacological effects. It is an ideal light medical art aftercare material.

[0004] The research on sodium colanate has become a new hot topic in recent years. As a new biomaterial, sodium colanate has the potential for application in the post-care of light medical aesthetics. The current research on sodium colanate mainly focuses on the modification of bacterial strain genes, efficient expression of bacterial strains, late fermentation or purification processes, and the realization of small molecules. However, there are few reports on the research of sodium colanate in the application fields of light medical aesthetics and post-care. Summary of the invention

[0005] The present invention provides a sodium colanate repair dressing for post-care of light medical aesthetics and a preparation method thereof.

[0006] One aspect of the present disclosure provides a composition comprising a colanate, a coagulant, a dispersant, water, and optionally a pH adjuster and optionally a preservative.

[0007] According to some embodiments of the present disclosure, the colanate salt is sodium colanate. In some preferred embodiments, the weight average molecular weight of sodium colanate is 400 kDa-8000 kDa.

[0008] According to some embodiments of the present disclosure, the coagulant is one or more selected from carbomer, kaolin and phospholipids.

[0009] According to some preferred embodiments of the present disclosure, the coagulant is carbomer.

[0010] According to some embodiments of the present disclosure, the dispersant is one or more selected from methanol, ethanol, n-propanol, isopropanol, ethyl acetate, n-hexane and polyethylene glycol.

[0011] According to some preferred embodiments of the present disclosure, the dispersant is polyethylene glycol.

[0012] According to some embodiments of the present disclosure, the pH adjuster is one or more selected from citric acid, tartaric acid, citric acid, malic acid, chlorogenic acid, palmitic acid, glacial acetic acid, triethanolamine, sodium hydroxide, potassium hydroxide and tromethamine.

[0013] According to some preferred embodiments of the present disclosure, the pH adjuster is one or more selected from citric acid, tartaric acid, citric acid, malic acid, chlorogenic acid, palmitic acid, glacial acetic acid, triethanolamine, sodium hydroxide, potassium hydroxide and tromethamine.

[0014] According to some preferred embodiments of the present disclosure, the pH adjuster is tromethamine.

[0015] According to some embodiments of the present disclosure, the preservative is one or more selected from sodium benzoate, potassium sorbate, sorbic acid and methylparaben.

[0016] According to some preferred embodiments of the present disclosure, the preservative is methylparaben.

[0017] According to some embodiments of the present disclosure, the composition comprises: water, sodium colanate, carbomer, polyethylene glycol 400, tromethamine and methylparaben.

[0018] According to some embodiments of the present disclosure, the composition comprises: water, sodium colanate, carbomer, glycerin, polyethylene glycol 400, xylitol, tromethamine and methylparaben.

[0019] According to some embodiments of the present disclosure, the content of the colanate is about 0.5 wt % to about 5.0 wt %, in some preferred embodiments, in some preferred embodiments, the content of the colanate is about 0.6 wt % to about 2.5 wt %, in some more preferred embodiments, the content of the colanate is about 0.8 wt % to about 2.0 wt %, in some more preferred embodiments, the content of the colanate is about 1.0 wt % to about 2.0 wt %, in some more preferred embodiments, the content of the colanate is about 1.0 wt % to about 1.5 wt %.

[0020] According to some embodiments of the present disclosure, the content of the coagulant is about 0.1 wt % to about 0.5 wt %. In some preferred embodiments, the content of the coagulant is about 0.1 wt % to about 0.3 wt % or about 0.3 wt % to about 0.5 wt %.

[0021] According to some embodiments of the present disclosure, the content of the dispersant is about 1.0 wt % to about 5.0 wt %, and in some preferred embodiments, the content of the dispersant is about 1.0 wt % to about 3.0 wt % or about 3.0 wt % to about 5.0 wt %.

[0022] According to some embodiments of the present disclosure, the content of the pH adjuster is about 0.1 wt % to about 0.5 wt %, in some preferred embodiments, the content of the pH adjuster is about 0.1 wt % to about 0.4 wt %, and in some more preferred embodiments, the content of the pH adjuster is about 0.2 wt % to about 0.3 wt %.

[0023] According to some embodiments of the present disclosure, the content of the preservative is about 0.01 wt % to about 0.1 wt %, and in some preferred embodiments, the content of the preservative is about 0.01 wt % to 0.02 wt %.

[0024] According to some embodiments of the present disclosure, the composition may further include an auxiliary agent. In some preferred embodiments, the auxiliary agent is selected from one or more of glycerol and xylitol.

[0025] According to some embodiments of the present disclosure, the content of the auxiliary agent is about 0.5wt% to about 15wt%, in some preferred embodiments, the content of the auxiliary agent is about 0.5wt% to about 5wt%, and in some more preferred embodiments, the content of the auxiliary agent is about 0.5wt% to about 8wt%.

[0026] According to some embodiments of the present disclosure, the composition comprises: water, sodium colanate, carbomer, polyethylene glycol 400, tromethamine and methylparaben, wherein the weight average molecular weight of the sodium colanate is 400kDa-8000kDa, and the content of the sodium colanate is about 0.5wt% to about 5.0wt%. In some preferred embodiments, the content of the sodium colanate is about 0.6wt% to about 2.5wt%. In some more preferred embodiments, the content of the sodium colanate is about 0.8wt% to about 2.0wt%. In some more preferred embodiments, the content of the sodium colanate is about 1.0wt% to about 2.0wt%. In some more preferred embodiments, the content of the colanate salt is about 1.0wt% to about 1.5wt%; the content of the carbomer is about 0.1wt% to about 0.5wt%. In some preferred embodiments, In the embodiment, the content of carbomer is about 0.1wt% to about 0.3wt% or about 0.3wt% to about 0.5wt%; the content of polyethylene glycol is about 1.0wt% to about 5.0wt%, in some preferred embodiments, the content of polyethylene glycol is about 1.0wt% to about 3.0wt% or about 3.0wt% to about 5.0wt%; the content of tromethamine is about 0.1wt% to about 0.5wt%, in some preferred embodiments, the content of tromethamine is about 0.1wt% to about 0.4wt%, in some more preferred embodiments, the content of tromethamine is about 0.2wt% to about 0.3wt%; the content of methylparaben is about 0.01wt% to about 0.1wt%, in some preferred embodiments, the content of methylparaben is about 0.01wt% to 0.02wt%.

[0027] According to some embodiments of the present disclosure, the composition comprises: water, sodium colanate, carbomer, glycerol, polyethylene glycol 400, xylitol, tromethamine and methylparaben, wherein the weight average molecular weight of the sodium colanate is 400kDa-8000kDa, and the content of the sodium colanate is about 0.5wt% to about 5.0wt%. In some preferred embodiments, the content of the sodium colanate is about 0.6wt% to about 2.5wt%. In some more preferred embodiments, the content of the sodium colanate is about 0.8wt% to about 2.0wt%. In some more preferred embodiments, the content of the sodium colanate is about 1.0wt% to about 2.0wt%. In some more preferred embodiments, the content of the colanate salt is about 1.0wt% to about 1.5wt%; the content of the carbomer is about 0.1wt% to about 0.5wt%. In some preferred embodiments, the content of the sodium colanate is about 0.6wt%. In a preferred embodiment, the content of the carbomer is about 0.1wt% to about 0.3wt% or about 0.3wt% to about 0.5wt%; the content of the polyethylene glycol is about 1.0wt% to about 5.0wt%, in some preferred embodiments, the content of the polyethylene glycol is about 1.0wt% to about 3.0wt% or about 3.0wt% to about 5.0wt%; the content of the tromethamine is about 0.1wt% to about 0.5wt%, in some preferred embodiments, the content of the tromethamine is about 0.1wt% to about 0.4wt%, in some more preferred embodiments, the content of the tromethamine is about 0.2wt% to about 0.3wt%; the content of the methylparaben is about 0.01wt% to about 0.1wt%, in some preferred embodiments, the content of the methylparaben is about 0.01wt% to 0.02wt%.

[0028] According to some embodiments of the present disclosure, the content ratio of the colanate, coagulant and dispersant is about 0.5-5:0.1-0.5:1-5, in some preferred embodiments, the content ratio of the colanate, coagulant and dispersant is about 0.6-2:0.1-0.5:1-5, and in some more preferred embodiments, the content ratio of the colanate, coagulant and dispersant is about 1-2:0.1-0.5:1-5.

[0029] According to some embodiments of the present disclosure, the composition comprises: water, sodium colanate, carbomer, polyethylene glycol 400, tromethamine and methylparaben, wherein the content ratio of sodium colanate, carbomer and polyethylene glycol 400 is about 0.5-5:0.1-0.5:1-5, in some preferred embodiments, the content ratio of sodium colanate, carbomer and polyethylene glycol 400 is about 0.6-2:0.1-0.5:1-5, in some more preferred embodiments, the content ratio of sodium colanate, carbomer and polyethylene glycol 400 is about 1-2:0.1-0.5:1-5.

[0030] According to some embodiments of the present disclosure, the composition comprises: water, sodium colanate, carbomer, glycerol, polyethylene glycol 400, xylitol, tromethamine and methylparaben, wherein the content ratio of sodium colanate, carbomer and polyethylene glycol 400 is about 0.5-5:0.1-0.5:1-5, in some preferred embodiments, the content ratio of sodium colanate, carbomer and polyethylene glycol 400 is about 0.6-2:0.1-0.5:1-5, in some more preferred embodiments, the content ratio of sodium colanate, carbomer and polyethylene glycol 400 is about 1-2:0.1-0.5:1-5.

[0031] Another aspect of the present disclosure provides a dressing comprising: a substrate and the aforementioned composition.

[0032] According to some embodiments of the present disclosure, the substrate serves as a carrier of the dressing.

[0033] According to some embodiments of the present disclosure, the substrate is a hydrophilic fiber membrane.

[0034] According to some embodiments of the present disclosure, the substrate is one or more of non-woven fabric, gauze, fruit fiber membrane, silk membrane, Tencel membrane, bacterial cellulose membrane, trehalose membrane, chitosan membrane and binchotan membrane.

[0035] Another aspect of the present disclosure is a method for preparing the aforementioned composition or the aforementioned dressing, comprising the following steps:

[0036] (1) dissolving colanate in water and pretreating the water to obtain a solution A;

[0037] (2) fully dissolving the coagulant in water to obtain solution B;

[0038] (3) mixing the dispersant and the optional preservative and fully dissolving them in water to obtain a solution C;

[0039] (4) Pour solution C into solution B and stir to obtain solution D, and evenly disperse solution A in solution D;

[0040] (5) optionally adding a pH adjuster to adjust the pH to about 5 to about 7;

[0041] (6) Vacuum degassing;

[0042] (7) Packaging, sealing, and steam sterilization;

[0043] (8) Optionally, the resulting solution is loaded onto a carrier.

[0044] According to some embodiments of the present disclosure, the pretreatment in step (1) is steam sterilization.

[0045] According to some embodiments of the present disclosure, the temperature of the steam sterilization treatment in step (1) and / or step (7) is about 100-130°C.

[0046] According to some embodiments of the present disclosure, the time for the steam sterilization treatment in step (1) and / or step (7) is about 10-60 minutes.

[0047] According to some embodiments of the present disclosure, the colanate salt is sodium colanate. In some preferred embodiments, the number average molecular weight of sodium colanate is 400 kDa-8000 kDa.

[0048] According to some embodiments of the present disclosure, the coagulant is selected from one or more of carbomer, kaolin and phospholipids.

[0049] According to some preferred embodiments of the present disclosure, the coagulant is carbomer.

[0050] According to some embodiments of the present disclosure, the dispersant is one or more selected from methanol, ethanol, n-propanol, isopropanol, ethyl acetate, n-hexane and polyethylene glycol.

[0051] According to some preferred embodiments of the present disclosure, the dispersant is polyethylene glycol.

[0052] According to some embodiments of the present disclosure, the pH adjuster is one or more selected from citric acid, tartaric acid, citric acid, malic acid, chlorogenic acid, palmitic acid, glacial acetic acid, triethanolamine, sodium hydroxide, potassium hydroxide and tromethamine.

[0053] According to some preferred embodiments of the present disclosure, the pH adjuster is tromethamine.

[0054] According to some embodiments of the present disclosure, the preservative is one or more selected from sodium benzoate, potassium sorbate, sorbic acid and methylparaben.

[0055] According to some preferred embodiments of the present disclosure, the preservative is methylparaben.

[0056] According to some embodiments of the present disclosure, the composition or dressing prepared by the method comprises: water, sodium colanate, carbomer, polyethylene glycol 400, tromethamine and methylparaben.

[0057] According to some embodiments of the present disclosure, the composition or dressing prepared by the method comprises: water, sodium colanate, carbomer, glycerin, polyethylene glycol 400, xylitol, tromethamine and methylparaben.

[0058] According to some embodiments of the present disclosure, the content of the colanate is about 0.5 wt % to about 5.0 wt %, in some preferred embodiments, in some preferred embodiments, the content of the colanate is about 0.6 wt % to about 2.0 wt %, in some more preferred embodiments, the content of the colanate is about 0.8 wt % to about 1.5 wt %, in some more preferred embodiments, the content of the colanate is about 1.0 wt % to about 2 wt %, in some more preferred embodiments, the content of the colanate is about 1.0 wt % to about 1.5 wt %.

[0059] According to some embodiments of the present disclosure, the content of the coagulant is about 0.1 wt % to about 0.5 wt %. In some preferred embodiments, the content of the coagulant is about 0.1 wt % to about 0.3 wt % or about 0.3 wt % to about 0.5 wt %.

[0060] According to some embodiments of the present disclosure, the content of the dispersant is about 1.0 wt % to about 5.0 wt %, and in some preferred embodiments, the content of the dispersant is about 1.0 wt % to about 3.0 wt % or about 3.0 wt % to about 5.0 wt %.

[0061] According to some embodiments of the present disclosure, the content of the pH adjuster is about 0.1 wt % to about 0.5 wt %, in some preferred embodiments, the content of the pH adjuster is about 0.1 wt %-about 0.4 wt %, and in some more preferred embodiments, the content of the pH adjuster is about 0.2 wt % to about 0.3 wt %.

[0062] According to some embodiments of the present disclosure, the content of the preservative is about 0.01 wt % to about 0.1 wt %, and in some preferred embodiments, the content of the preservative is about 0.01 wt % to 0.02 wt %.

[0063] According to some embodiments of the present disclosure, the composition or dressing prepared by the method comprises: water, sodium colanate, carbomer, polyethylene glycol 400, tromethamine and methylparaben, wherein the weight average molecular weight of the sodium colanate is 400kDa-8000kDa, and the content of the sodium colanate is about 0.5wt% to about 5.0wt%. In some preferred embodiments, the content of the sodium colanate is about 0.6wt% to about 2.5wt%. In some more preferred embodiments, the content of the sodium colanate is about 0.8wt% to about 2.0wt%. In some more preferred embodiments, the content of the sodium colanate is about 1.0wt% to about 2.0wt%. In some more preferred embodiments, the content of the colanate salt is about 1.0wt% to about 1.5wt%; the content of the carbomer is about 0.1wt% to about 0.5wt%. In some In a preferred embodiment, the content of the carbomer is about 0.1wt% to about 0.3wt% or about 0.3wt% to about 0.5wt%; the content of the polyethylene glycol is about 1.0wt% to about 5.0wt%, in some preferred embodiments, the content of the polyethylene glycol is about 1.0wt% to about 3.0wt% or about 3.0wt% to about 5.0wt%; the content of the tromethamine is about 0.1wt% to about 0.5wt%, in some preferred embodiments, the content of the tromethamine is about 0.1wt% to about 0.4wt%, in some more preferred embodiments, the content of the tromethamine is about 0.2wt% to about 0.3wt%; the content of the methylparaben is about 0.01wt% to about 0.1wt%, in some preferred embodiments, the content of the methylparaben is about 0.01wt% to 0.02wt%.

[0064] According to some embodiments of the present disclosure, the composition or dressing prepared by the method comprises: water, sodium colanate, carbomer, glycerol, polyethylene glycol 400, xylitol, tromethamine and methylparaben, wherein the weight average molecular weight of the sodium colanate is 400kDa-8000kDa, and the content of the sodium colanate is about 0.5wt% to about 5.0wt%. In some preferred embodiments, the content of the sodium colanate is about 0.6wt% to about 2.5wt%. In some more preferred embodiments, the content of the sodium colanate is about 0.8wt% to about 2.0wt%. In some more preferred embodiments, the content of the sodium colanate is about 1.0wt% to about 2.0wt%. In some more preferred embodiments, the content of the colanate salt is about 1.0wt% to about 1.5wt%; the content of the carbomer is about 0.1wt% to about 0.5wt%. In some preferred embodiments, the content of the carbomer is about 0.1wt% to about 0.3wt% or about 0.3wt% to about 0.5wt%; the content of the polyethylene glycol is about 1.0wt% to about 5.0wt%, in some preferred embodiments, the content of the polyethylene glycol is about 1.0wt% to about 3.0wt% or about 3.0wt% to about 5.0wt%; the content of the tromethamine is about 0.1wt% to about 0.5wt%, in some preferred embodiments, the content of the tromethamine is about 0.1wt% to about 0.4wt%, in some more preferred embodiments, the content of the tromethamine is about 0.2wt% to about 0.3wt%; the content of the methylparaben is about 0.01wt% to about 0.1wt%, in some preferred embodiments, the content of the methylparaben is about 0.01wt% to 0.02wt%.

[0065] According to some embodiments of the present disclosure, the composition or dressing prepared by the method further comprises an auxiliary agent. In some preferred embodiments, the auxiliary agent is selected from one or more of glycerol and xylitol.

[0066] In a specific embodiment of the present disclosure, the content of the auxiliary agent is about 0.5wt%-about 15wt%, in some preferred embodiments, the content of the auxiliary agent is about 0.5wt% to about 5wt%, and in some more preferred embodiments, the content of the auxiliary agent is about 0.5wt% to about 8wt%.

[0067] According to some embodiments of the present disclosure, the content ratio of the colanate, coagulant and dispersant is about 0.5-5:0.1-0.5:1-5, in some preferred embodiments, the content ratio of the colanate, coagulant and dispersant is about 0.6-2:0.1-0.5:1-5, and in some more preferred embodiments, the content ratio of the colanate, coagulant and dispersant is about 1-2:0.1-0.5:1-5.

[0068] According to some embodiments of the present disclosure, the composition or dressing prepared by the method comprises: water, sodium colanate, carbomer, polyethylene glycol 400, tromethamine and methylparaben, wherein the content ratio of sodium colanate, carbomer and polyethylene glycol 400 is about 0.5-5:0.1-0.5:1-5, in some preferred embodiments, the content ratio of sodium colanate, carbomer and polyethylene glycol 400 is about 0.6-2:0.1-0.5:1-5, in some more preferred embodiments, the content ratio of sodium colanate, carbomer and polyethylene glycol 400 is about 1-2:0.1-0.5:1-5.

[0069] According to some embodiments of the present disclosure, the composition or dressing prepared by the method comprises: water, sodium colanate, carbomer, glycerol, polyethylene glycol 400, xylitol, tromethamine and methylparaben, wherein the content ratio of sodium colanate, carbomer and polyethylene glycol 400 is about 0.5-5:0.1-0.5:1-5, in some preferred embodiments, the content ratio of sodium colanate, carbomer and polyethylene glycol 400 is about 0.6-2:0.1-0.5:1-5, in some more preferred embodiments, the content ratio of sodium colanate, carbomer and polyethylene glycol 400 is about 1-2:0.1-0.5:1-5.

[0070] Another aspect of the present disclosure provides use of the aforementioned composition or the aforementioned dressing in preparing a product for aftercare of light medical aesthetics.

[0071] According to some embodiments of the present disclosure, the light medical beauty includes one or more of laser, radio frequency, ultrasound, fruit acid peel, Thermage, ultrasonic knife, and water light injection treatment.

[0072] According to some embodiments of the present disclosure, the composition or dressing is used after the patient undergoes light medical aesthetics.

[0073] The present invention provides a dressing and a preparation method and use thereof. The colanate provided by the present invention is a new synthetic biomaterial, which is used for post-care of light medical aesthetics, and has strong moisturizing and soothing effects, physical barriers, and promotes wound healing. The steam pretreatment process provided by the present invention adopts a steam pretreatment process to reduce the bacterial endotoxins and pyrogens of the colanate raw material, so that it meets the medical grade requirements and ensures its good biocompatibility. The preparation method provided by the present invention improves the film-forming effect of the dressing through scientific proportioning, shortens the film-forming time, and ensures its physical barrier effect.

[0074] The raw materials used in the present invention are scientifically proportioned, and each component works synergistically. The present invention adopts the core raw material of colanate, has good moisturizing and soothing, physical barrier, and promotes wound healing. At the same time, it has good air permeability and biocompatibility, is easy to use, feels comfortable on the skin, and is easy to promote. BRIEF DESCRIPTION OF THE DRAWINGS

[0075] The invention can be more fully understood with reference to the following drawings.

[0076] Figure 1 The radar chart of human efficacy evaluation of Example 1 is shown, which includes the initial experience of unpacking, the experience during use, and the experience after use. DETAILED DESCRIPTION

[0077] The various features and aspects of the present invention are discussed in more detail below. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not intended to limit the present invention.

[0078] definition

[0079] Unless otherwise defined, all technical terms and scientific terms used herein have the same meaning as those commonly understood by those skilled in the art of the present invention. The terms used in the specification of the present invention herein are only for the purpose of describing specific embodiments and are not intended to limit the present invention.

[0080] All numerical designations used herein, such as pH values, temperatures, times, concentrations, amounts and molecular weights, including ranges, are approximate and vary (+) or (-) in increments of 0.1 or 1.0 where appropriate. It will be understood that all numerical designations may be preceded by the term "about", although not always explicitly stated.

[0081] The terms "about" and "approximately" include amounts within ±10% of the associated numerical value.

[0082] As used herein, the term "solution" is a broad term, which is not limited to the traditional concept and means a composition. The "solution" may be an aqueous or non-aqueous mixture, for example, it may include a homogeneous or heterogeneous mixture of a polymer and water, or it may include a suspension, a colloid, an atomized liquid, a gel, an ointment, a cream or the like.

[0083] As will be understood by those skilled in the art, for any and all purposes, particularly in terms of providing a written description, all ranges disclosed herein also encompass any and all possible subranges and combinations of subranges thereof. Any listed range can be readily identified as fully described, and the same range can be broken down into at least equal halves, thirds, quarters, fifths, tenths, etc. As a non-limiting example, each range discussed herein can be readily broken down into a lower third, a middle third, and an upper third, etc.

[0084] A first aspect of the present disclosure provides a composition comprising a colanate, a coagulant, a dispersant, water, and optionally a pH adjuster and an optional preservative.

[0085] In the present invention, colanate refers to a salt substance formed by the reaction of colanic acid with any alkaline substance. Depending on the specific type of cation in the colanate, the colanate may be sodium colanate, potassium colanate, magnesium colanate, aluminum colanate, calcium colanate, ammonium colanate, etc. The colanate may also contain more than one cation, such as sodium potassium colanate.

[0086] In a specific embodiment of the present disclosure, the colanate salt is sodium colanate. In some preferred embodiments, the weight average molecular weight of sodium colanate is 400 kDa-8000 kDa.

[0087] In a specific embodiment of the present disclosure, the coagulant is selected from one or more of carbomer, kaolin and phospholipids.

[0088] According to some preferred embodiments of the present disclosure, the coagulant is carbomer.

[0089] In a specific embodiment of the present disclosure, the dispersant is one or more selected from methanol, ethanol, n-propanol, isopropanol, ethyl acetate, n-hexane and polyethylene glycol.

[0090] According to some preferred embodiments of the present disclosure, the dispersant is polyethylene glycol.

[0091] In a specific embodiment of the present disclosure, the pH adjuster is one or more selected from citric acid, tartaric acid, citric acid, malic acid, chlorogenic acid, palmitic acid, glacial acetic acid, triethanolamine, sodium hydroxide, potassium hydroxide and tromethamine.

[0092] According to some preferred embodiments of the present disclosure, the pH adjuster is tromethamine.

[0093] In a specific embodiment of the present disclosure, the preservative is one or more selected from sodium benzoate, potassium sorbate, sorbic acid and methylparaben.

[0094] According to some preferred embodiments of the present disclosure, the preservative is methylparaben.

[0095] In a specific embodiment of the present disclosure, the composition comprises: water, sodium colanate, carbomer, polyethylene glycol 400, tromethamine and methylparaben.

[0096] In a specific embodiment of the present disclosure, the composition comprises: water, sodium colanate, carbomer, glycerin, polyethylene glycol 400, xylitol, tromethamine and methylparaben.

[0097] In a specific embodiment of the present disclosure, the content of the colanate is about 0.5 wt % to about 5.0 wt %, in some preferred embodiments, in some preferred embodiments, the content of the colanate is about 0.6 wt % to about 2.5 wt %, in some more preferred embodiments, the content of the colanate is about 0.8 wt % to about 2.0 wt %, in some more preferred embodiments, the content of the colanate is about 1.0 wt % to about 2.0 wt %, in some more preferred embodiments, the content of the colanate is about 1.0 wt % to about 1.5 wt %. For example, the content of the colanate may be about 0.5 wt%, 0.6 wt%, 0.7 wt%, 0.8 wt%, 0.9 wt%, 1.0 wt%, 1.1 wt%, 1.2 wt%, 1.3 wt%, 1.4 wt%, 1.5 wt%, 1.6 wt%, 1.7 wt%, 1.8 wt%, 1.9 wt%, 2.0 wt%, 2.1 wt%, 2.2 wt%, 2.3 wt%, 2.4 wt%, 2.5 wt%, 2.6 wt%. %, 2.7wt%, 2.8wt%, 2.9wt%, 3.0wt%, 3.1wt%, 3.2wt%, 3.3wt%, 3.4wt%, 3.5wt%, 3.6wt%, 3.7wt%, 3.8wt%, 3.9wt%, 4.0wt%, 4.1wt%, 4.2wt%, 4.3wt%, 4.4wt%, 4.5wt%, 4.6wt%, 4.7wt%, 4.8wt%, 4.9wt% or 5.0wt%.

[0098] In a specific embodiment of the present disclosure, the content of the coagulant is about 0.1wt% to about 0.5wt%. In some preferred embodiments, the content of the coagulant is about 0.1wt% to about 0.3wt% or about 0.3wt% to about 0.5wt%. For example, the content of the carbomer can be about 0.1wt%, 0.11wt%, 0.12wt%, 0.13wt%, 0.14wt%, 0.15wt%, 0.16wt%, 0.17wt%, 0.18wt%, 0.19wt%, 0.2wt%, 0.21wt%, 0.22wt%, 0.23wt%, 0.24wt%, 0.25wt%, 0.26wt%, 0.27wt%, 0.28wt%, 0.29wt%, 0.30wt%, 0.31wt%, 0.32wt%, 0.33wt%, 0.34wt%, 0.35wt%, 0.36wt%, 0.37wt%, 0.38wt%, 0.39wt%, 0.40wt%, 0.41wt%, 0.42wt%, 0.43wt%, 0.44wt%, 0.45wt%, 0.46wt%, 0.47wt%, 0.48wt%, 0.49wt%, 0.50wt%, 0.51wt%, 0.52wt%, 0.53wt%, 0.54wt%, 0.55wt%, 0.56wt%, 0.57wt%, 0.58wt%, 0.59wt%, 0.60wt%, 0.61wt%, 0.62wt%, 0.63wt%, 0.64wt%, 0.65wt%, 0.66wt%, 0.67wt%, 0.68wt%, 0.69wt%, 0 wt%, 0.3wt%, 0.31wt%, 0.32wt%, 0.33wt%, 0.34wt%, 0.35wt%, 0.36wt%, 0.37wt%, 0.38wt%, 0.39wt%, 0 .4wt%, 0.41wt%, 0.42wt%, 0.43wt%, 0.44wt%, 0.45wt%, 0.46wt%, 0.47wt%, 0.48wt%, 0.49wt% or 0.5wt%.

[0099] In a specific embodiment of the present disclosure, the content of the dispersant is about 1.0wt% to about 5.0wt%. In some preferred embodiments, the content of the dispersant is about 1wt% to about 3wt% or about 3wt% to about 5wt%. For example, the content of the polyethylene glycol can be about 1.0wt%, 1.1wt%, 1.2wt%, 1.3wt%, 1.4wt%, 1.5wt%, 1.6wt%, 1.7wt%, 1.8wt%, 1.9wt%, 2.0wt%, 2.1wt%, 2.2wt%, 2.3wt%, 2.4wt%, 2.5wt%, 2.6wt%, 2.7wt%, 2.8wt%, 2.9wt%, 3.0wt%, 3.1wt%, 3.2wt%, 3.3wt%, 3.4wt%, 3.5wt%, 3.6wt%, 3.7wt%, 3.8wt%, 3.9wt%, 4.1wt%, 4.2wt%, 4.3wt%, 4.4wt%, 4.5wt%, 4.6wt%, 4.7wt%, 4.8wt%, 4.9wt%, 4.1wt%, 4. 9wt%, 3.0wt%, 3.1wt%, 3.2wt%, 3.3wt%, 3.4wt%, 3.5wt%, 3.6wt%, 3.7wt%, 3.8wt%, 3.9wt%, 4.0wt%, 4.1wt%, 4.2wt%, 4.3wt%, 4.4wt%, 4.5wt%, 4.6wt%, 4.7wt%, 4.8wt%, 4.9wt% or 5.0wt%.

[0100] In a specific embodiment of the present disclosure, the content of the pH adjuster is about 0.1wt% to about 0.5wt%, in some preferred embodiments, the content of the pH adjuster is about 0.1wt% to about 0.4wt%, and in some more preferred embodiments, the content of the pH adjuster is about 0.2wt% to about 0.3wt%. For example, the content of tromethamine can be about 0.1wt%, 0.11wt%, 0.12wt%, 0.13wt%, 0.14wt%, 0.15wt%, 0.16wt%, 0.17wt%, 0.18wt%, 0.19wt%, 0.2wt%, 0.21wt%, 0.22wt%, 0.23wt%, 0.24wt%, 0.25wt%, 0.26wt%, 0.27wt%, 0.28wt%, 0.29wt%, 0.30wt%, 0.31wt%, 0.32wt%, 0.33wt%, 0.34wt%, 0.35wt%, 0.36wt%, 0.37wt%, 0.38wt%, 0.39wt%, 0.40wt%, 0.41wt%, 0.42wt%, 0.43wt%, 0.44wt%, 0.45wt%, 0.46wt%, 0.47wt%, 0.48wt%, 0.49wt%, 0.50wt%, 0.51wt%, 0.52wt%, 0.53wt%, 0.54wt%, 0.55wt%, 0.56wt%, 0.57wt%, 0.58wt%, 0.59wt%, 0.60wt%, 0.61wt%, 0.62wt%, 0.63wt%, 0.64wt%, 0.65wt%, 0.66wt%, 0.67wt%, 0.6 9wt%, 0.3wt%, 0.31wt%, 0.32wt%, 0.33wt%, 0.34wt%, 0.35wt%, 0.36wt%, 0.37wt%, 0.38wt%, 0.39wt%, 0.4wt%, 0.41wt%, 0.42wt%, 0.43wt%, 0.44wt%, 0.45wt%, 0.46wt%, 0.47wt%, 0.48wt%, 0.49wt% or 0.5wt%.

[0101] In a specific embodiment of the present disclosure, the content of the preservative is about 0.01wt% to about 0.1wt%, and in some preferred embodiments, the content of the preservative is about 0.01wt% to 0.02wt%. For example, the content of the preservative is about 0.01wt%, 0.02wt%, 0.03wt%, 0.04wt%, 0.05wt%, 0.06wt%, 0.07wt%, 0.08wt%, 0.09wt% or 0.1wt%.

[0102] In a specific embodiment of the present disclosure, the composition further comprises an auxiliary agent. In some preferred embodiments, the auxiliary agent is selected from one or more of glycerol and xylitol.

[0103] In a specific embodiment of the present disclosure, the content of the auxiliary agent is about 0.5wt% to about 15wt%, in some preferred embodiments, the content of the auxiliary agent is about 0.5wt% to about 5wt%, and in some more preferred embodiments, the content of the auxiliary agent is about 0.5wt% to about 8wt%. For example, the content of the auxiliary agent is about 0.5wt%, 0.6wt%, 0.6wt%, 0.7wt%, 0.8wt%, 0.9wt%, 1wt%, 2wt%, 3wt%, 4wt%, 5wt%, 6wt%, 7wt%, 8wt%, 9wt%, 10wt%, 11wt%, 12wt%, 13wt%, 14wt% or 15wt%.

[0104] In a specific embodiment of the present disclosure, the content ratio of the colanate, coagulant and dispersant is about 0.5-5:0.1-0.5:1-5. In some preferred embodiments, the content ratio of the colanate, coagulant and dispersant is about 0.6-2:0.1-0.5:1-5. In some more preferred embodiments, the content ratio of the colanate, coagulant and dispersant is about 1-2:0.1-0.5:1-5. For example, the content ratio of the colanate, the coagulant and the dispersant may be about 0.5:0.1:0.6, 0.5:0.1:0.7, 0.5:0.1:0.8, 0.5:0.1:0.9, 0.5:0.1:1, 0.5:0.1:2, 0.5:0.1:3, 0.5:0.1:4, 0.5:0.1:5, 0.5:0.2:0.6, 0.5:0.2:0.7, 0.5:0.2:0.8, 0.5:0.2:0.9, 0.5:0.2:1, 0.5:0.2:2, 0.5:0.1:3, 0.5:0.1:4, 0.5:0.1:5, 0.5:0.2:0.6, 0.5:0.2:0.7, 0.5:0.2:0.8, 0.5:0.2:0.9, 0.5:0.2:1, 0.5:0.2:2, 0.5:0.2:3, 0.5:0.1:4, 0.5:0.1:5. .5:0.2:5、0.5:0.3:0.6、0.5:0.3:0.7、0.5:0.3:0.8、0.5:0.3:0.9、0.5:0.3:1、0.5:0.3:2、0.5:0.3:3、0.5:0.3:4、0.5:0.3:5、0.5:0.4:0.6、0.5:0.4:0.7、0.5:0.4:0.8、0.5:0.4:0.9、0.5:0.4:1、0.5:0.4:2、0.5:0.4:3、0.5:0.4:4、0.5:0.4:5、0.5:0.5: 0.6、0.5:0.5:0.7、0.5:0.5:0.8、0.5:0.5:0.9、0.5:0.5:1、0.5:0.5:2、0.5:0.5:3、0.5:0.5:4、0.5:0.5:5、0.6:0.1:0.6、0.6:0.1:0.7、0.6:0.1:0.8、0.6:0.1:0.9、0.6:0.1:1、0.6:0.1:2、0.6:0.1:3、0.6:0.1:4、0.6:0.1:5、0.6:0.2:0.6、0.6:0.2:0.7、0 .6:0.2:0.8, 0.6:0.2:0.9, 0.6:0.2:1, 0.6:0.2:2, 0.6:0.2:3, 0.6:0.2:4, 0.6:0.2:5, 0.6:0.3:0.6, 0.6:0.3:0.7, 0.6:0.3:0.8, 0.6:0.3:0.9, 0.6:0.3:1, 0.6:0.3:2, 0.6:0.3:3, 0.6:0.3:4, 0.6:0.3:5, 0.6:0.4:0.6, 0.6:0.4:0.7, 0.6:0.4:0.8, 0.6:0.4:0.9、0.6:0.4:1、0.6:0.4:2、0.6:0.4:3、0.6:0.4:4、0.6:0.4:5、0.6:0.5:0.6、0.6:0.5:0.7、0.6:0.5:0.8、0.6:0.5:0.9、0.6:0.5:1、0.6:0.5:2、0.6:0.5:3、0.6:0.5:4、0.6:0.5:5、0.7:0.1:0.6、0.7:0.1:0.7、0.7:0.1:0.8、0.7:0.1:0.9、0.7:0.1:1、0.7:0.1:2、0.7:0.1:3、0.7:0.1:4、0.7:0.1:5、0.7:0.2:0.6、0.7:0.2:0.7、0.7:0.2:0.8、0.7:0.2:0.9、0.7:0.2:1、0.7:0.2:2、0.7:0.2:3、0.7:0.2:4、0.7:0.2:5、0.7:0.3:0.6、0.7:0.3:0.7、0.7:0.3:0.8、0.7:0.3:0.9、0.7:0.3:1、0.7:0.3:2、0.7:0.3:3、0.7:0.3:4、0.7:0.3:5、0.7:0.4:0.6、0.7:0.4:0.7、0.7:0.4:0.8、0.7:0.4:0.9、0.7:0.4:1、0.7:0.4:2、0.7:0.4:3、0.7:0.4:4、0.7:0.4:5、0.7:0.5:0.6、0.7:0.5:0.7、0.7:0.5:0.8、0.7:0.5:0.9、0.7:0.5:1、0.7:0.5:2、0.7:0.5:3、0.7:0.5:4、0.7:0.5:5、0.8:0.1:0.6、0.8:0.1:0.7、0.8:0.1:0.8、0.8:0.1:0.9、0.8:0.1:1、0.8:0.1:2、0.8:0.1:3、0.8:0.1:4、0.8:0.1:5、0.8:0.2:0.6、0.8:0.2:0.7、0.8:0.2:0.8、0.8:0.2:0.9、0.8:0.2:1、0.8:0.2:2、0.8:0.2:3、0.8:0.2:4、0.8:0.2:5、0.8:0.3:0.6、0.8:0.3:0.7、0.8:0.3:0.8、0.8:0.3:0.9、0.8:0.3:1、0.8:0.3:2、0.8:0.3:3、0.8:0.3:4、0.8:0.3:5、0.8:0.4:0.6、0.8:0.4:0.7、0.8:0.4:0.8、0.8:0.4:0.9、0.8:0.4:1、0.8:0.4:2、0.8:0.4:3、0.8:0.4:4、0.8:0.4:5、0.8:0.5:0.6、0.8:0.5:0.7、0.8:0.5:0.8、0.8:0.5:0.9、0.8:0.5:1、0.8:0.5:2、0.8:0.5:3、0.8:0.5:4、0.8:0.5:5、0.9:0.1:0.6、0.9:0.1:0.7、0.9:0.1:0.8、0.9:0.1:0.9、0.9:0.1:1、0.9:0.1:2、0.9:0.1:3、0.9:0.1:4、0.9:0.1:5、0.9:0.2:0.6、0.9:0.2:0.7、0.9:0.2:0.8、0.9:0.2:0.9、0.9:0.2:1、0.9:0.2:2、0.9:0.2:3、0.9:0.2:4、0.9:0.2:5、0.9:0.3:0.6、0.9:0.3:0.7、0.9:0.3:0.8、0.9:0.3:0.9、0.9:0.3:1、0.9:0.3:2、0.9:0.3:3、0.9:0.3:4、0.9:0.3:5、0.9:0.4:0.6、0.9:0.4:0.7、0.9:0.4:0.8、0.9:0.4:0.9、0.9:0.4:1、0.9:0.4:2、0.9:0.4:3、0.9:0.4:4、0.9:0.4:5、0.9:0.5:0.6、0.9:0.5:0.7、0.9:0.5:0.8、0.9:0.5:0.9、0.9:0.5:1、0.9:0.5:2、0.9:0.5:3、0.9:0.5:4、0.9:0.5:5、1:0.1:0.6、1:0.1:0.7、1:0.1:0.8、1:0.1:0.9、1:0.1:1、1:0.1:2、1:0.1:3、1:0.1:4、1:0.1:5、1:0.2:0.6、1:0.2:0.7、1:0.2:0.8、1:0.2:0.9、1:0.2:1、1:0.2:2、1:0.2:3、1:0.2:4、1:0.2:5、1:0.3:0.6、1:0.3:0.7、1:0.3:0.8、1:0.3:0.9、1:0.3:1、1:0.3:2、1:0.3:3、1:0.3:4、1:0.3:5、1:0.4:0.6、1:0.4:0.7、1:0.4:0.8、1:0.4:0.9、1:0.4:1、1:0.4:2、1:0.4:3、1:0.4:4、1:0.4:5、1:0.5:0.6、1:0.5:0.7、1:0.5:0.8、1:0.5:0.9、1:0.5:1、1:0.5:2、1:0.5:3、1:0.5:4、1:0.5:5、2:0.1:0.6、2:0.1:0.7、2:0.1:0.8、2:0.1:0.9、2:0.1:1、2:0.1:2、2:0.1:3、2:0.1:4、2:0.1:5、2:0.2:0.6、2:0.2:0.7、2:0.2:0.8、2:0.2:0.9、2:0.2:1、2:0.2:2、2:0.2:3、2:0.2:4、2:0.2:5、2:0.3:0.6、2:0.3:0.7、2:0.3:0.8、2:0.3:0.9、2:0.3:1、2:0.3:2、2:0.3:3、2:0.3:4、2:0.3:5、2:0.4:0.6、2:0.4:0.7、2:0.4:0.8、2:0.4:0.9、2:0.4:1、2:0.4:2、2:0.4:3、2:0.4:4、2:0.4:5、2:0.5:0.6、2:0.5:0.7、2:0.5:0.8、2:0.5:0.9、2:0.5:1、2:0.5:2、2:0.5:3、2:0.5:4、2:0.5:5、3:0.1:0.6、3:0.1:0.7、3:0.1:0.8、3:0.1:0.9、3:0.1:1、3:0.1:2、3:0.1:3、3:0.1:4、3:0.1:5、3:0.2:0.6、3:0.2:0.7、3:0.2:0.8、3:0.2:0.9、3:0.2:1、3:0.2:2、3:0.2:3、3:0.2:4、3:0.2:5、3:0.3:0.6、3:0.3:0.7、3:0.3:0.8、3:0.3:0.9、3:0.3:1、3:0.3:2、3:0.3:3、3:0.3:4、3:0.3:5、3:0.4:0.6、3:0.4:0.7、3:0.4:0.8、3:0.4:0.9、3:0.4:1、3:0.4:2、3:0.4:3、3:0.4:4、3:0.4:5、3:0.5:0.6、3:0.5:0.7、3:0.5:0.8、3:0.5:0.9、3:0.5:1、3:0.5:2、3:0.5:3、3:0.5:4、3:0.5:5、4:0.1:0.6、4:0.1:0.7、4:0.1:0.8、4:0.1:0.9、4:0.1:1、4:0.1:2、4:0.1:3、4:0.1:4、4:0.1:5、4:0.2:0.6、4:0.2:0.7、4:0.2:0.8、4:0.2:0.9、4:0.2:1、4:0.2:2、4:0.2:3、4:0.2:4、4:0.2:5、4:0.3:0.6, 4:0.3:0.7, 4:0.3:0.8, 4:0.3:0.9, 4:0.3:1, 4:0.3:2, 4:0.3:3, 4:0.3:4, 4:0.3:5, 4:0.4:0.6, 4:0.4:0.7, 4:0.4:0.8, 4:0.4:0.9, 4:0.4:1, 4:0.4:2, 4:0.4:3, 4:0.4:4, 4:0.4:5, 4:0.5: 0.6, 4:0.5:0.7, 4:0.5:0.8, 4:0.5:0.9, 4:0.5:1, 4:0.5:2, 4:0.5:3, 4:0.5:4, 4:0.5:5, 5:0.1:0.6, 5:0.1:0.7, 5:0.1:0.8, 5:0.1:0.9, 5:0.1:1, 5:0.1:2, 5:0.1:3, 5:0.1:4, 5:0.1:5, 5:0. 2:0.6、5:0.2:0.7、5:0.2:0.8、5:0.2:0.9、5:0.2:1、5:0.2:2、5:0.2:3、5:0.2:4、5:0.2:5、5:0.3:0.6、5:0.3:0.7、5:0.3:0.8、5:0.3:0.9、5:0.3:1、5:0.3:2、5:0.3:3、5:0.3:4、5:0.3:5、5: 0.4:0.6, 5:0.4:0.7, 5:0.4:0.8, 5:0.4:0.9, 5:0.4:1, 5:0.4:2, 5:0.4:3, 5:0.4:4, 5:0.4:5, 5:0.5:0.6, 5:0.5:0.7, 5:0.5:0.8, 5:0.5:0.9, 5:0.5:1, 5:0.5:2, 5:0.5:3, 5:0.5:4 or 5:0.5:5. .

[0105] In a specific embodiment of the present disclosure, the composition comprises: water, sodium colanate, carbomer, polyethylene glycol 400, tromethamine and methylparaben. The weight average molecular weight of the sodium colanate is 400 kDa-8000 kDa, the content of the sodium colanate is about 0.5 wt% to about 5.0 wt%, in some preferred embodiments, the content of the sodium colanate is about 0.6 wt% to about 2.5 wt%, in some more preferred embodiments, the content of the sodium colanate is about 0.8 wt% to about 2.0 wt%, in some more preferred embodiments, the content of the sodium colanate is about 1.0 wt% to about 2.0 wt%, in some more preferred embodiments, the content of the sodium colanate is about 1.0 wt% to about 1.5 wt%; for example, the content of the sodium colanate can be about 0.5 wt%, 0.6 wt%, 0.7 wt%, 0.8 wt%, 0.9 wt%, 1.0 wt%, 1.1 wt%. %, 1.2wt%, 1.3wt%, 1.4wt%, 1.5wt%, 1.6wt%, 1.7wt%, 1.8wt%, 1.9wt%, 2.0wt%, 2.1wt%, 2.2wt%, 2.3wt%, 2.4wt%, 2.5wt%, 2.6wt%, 2.7wt%, 2.8wt%, 2.9wt%, 3.0wt%, 3.1wt%, 3.2wt%, 3.3wt%, 3.4wt%, 3.5wt%, 3.6wt%, 3.7wt%, 3.8wt%, 3.9wt%, 4.0wt%, 4.1wt%, 4.2wt%, 4.3wt%, 4.4wt%, 4.5wt%, 4.6wt%, 4.7wt%, 4.8wt%, 4.9wt% or 5.0wt%.The content of the carbomer is about 0.1wt% to about 0.5wt%. In some preferred embodiments, the content of the carbomer is about 0.1wt% to about 0.3wt% or about 0.3wt% to about 0.5wt%. For example, the content of the carbomer can be about 0.1wt%, 0.11wt%, 0.12wt%, 0.13wt%, 0.14wt%, 0.15wt%, 0.16wt%, 0.17wt%, 0.18wt%, 0.19wt%, 0.2wt%, 0.21wt%, 0.22wt%, 0.23wt%, 0.24wt%, wt%, 0.25wt%, 0.26wt%, 0.27wt%, 0.28wt%, 0.29wt%, 0.3wt%, 0.31wt%, 0.32wt%, 0.33wt%, 0.34wt%, 0.35wt%, 0.36wt%, 0.37w t%, 0.38wt%, 0.39wt%, 0.4wt%, 0.41wt%, 0.42wt%, 0.43wt%, 0.44wt%, 0.45wt%, 0.46wt%, 0.47wt%, 0.48wt%, 0.49wt% or 0.5wt%. The content of the polyethylene glycol is about 1 wt % to about 5 wt %. In some preferred embodiments, the content of the polyethylene glycol is about 1 wt % to about 3 wt % or about 3 wt % to about 5 wt %; for example, the content of the polyethylene glycol can be about 1.0 wt %, 1.1 wt %, 1.2 wt %, 1.3 wt %, 1.4 wt %, 1.5 wt %, 1.6 wt %, 1.7 wt %, 1.8 wt %, 1.9 wt %, 2.0 wt %, 2.1 wt %, 2.2 wt %, 2.3 wt %, 2.4 wt%, 2.5wt%, 2.6wt%, 2.7wt%, 2.8wt%, 2.9wt%, 3.0wt%, 3.1wt%, 3.2wt%, 3.3wt%, 3.4wt%, 3.5wt%, 3.6wt%, 3.7wt %, 3.8wt%, 3.9wt%, 4.0wt%, 4.1wt%, 4.2wt%, 4.3wt%, 4.4wt%, 4.5wt%, 4.6wt%, 4.7wt%, 4.8wt%, 4.9wt% or 5.0wt%.The content of the tromethamine is about 0.1wt% to about 0.5wt%, in some preferred embodiments, the content of the tromethamine is about 0.1wt% to about 0.4wt%, in some more preferred embodiments, the content of the tromethamine is about 0.2wt% to about 0.3wt%; for example, the content of the tromethamine can be about 0.1wt%, 0.11wt%, 0.12wt%, 0.13wt%, 0.14wt%, 0.15wt%, 0.16wt%, 0.17wt%, 0.18wt%, 0.19wt%, 0.2wt%, 0.21wt%, 0.22wt%, 0.23wt%, 0.24wt%, 0.25wt%, 0.26wt%, 0.27wt%, 0.28wt%, 0.29wt%, 0.3wt%, 0.31wt%, 0.32wt%, 0.33wt%, 0.34wt%, 0.35wt%, 0.36wt%, 0.37wt%, 0.38wt%, 0.39wt%, 0.4wt%, 0.41wt%, 0.42wt%, 0.43wt%, 0.44wt%, 0.45wt%, 0.46wt%, 0.47wt%, 0.48wt%, 0.49wt% or 0.5wt%. The content of the methylparaben is about 0.01wt% to about 0.1wt%. In some preferred embodiments, the content of the methylparaben is about 0.01wt% to 0.02wt%; for example, the content of the methylparaben is about 0.01wt%, 0.02wt%, 0.03wt%, 0.04wt%, 0.05wt%, 0.06wt%, 0.07wt%, 0.08wt%, 0.09wt% or 0.1wt%.

[0106] In a specific embodiment of the present disclosure, the composition comprises: water, sodium colanate, carbomer, glycerin, polyethylene glycol 400, xylitol, tromethamine and methylparaben. Wherein, the weight average molecular weight of the sodium colanate is 400kDa-8000kDa, the content of the sodium colanate is about 0.5wt% to about 5.0wt%, in some preferred embodiments, the content of the sodium colanate is about 0.6wt% to about 2.5wt%, in some more preferred embodiments, the content of the sodium colanate is about 0.8wt% to about 2.0wt%, in some more preferred embodiments, the content of the sodium colanate is about 1.0wt% to about 2.0wt%, in some more preferred embodiments, the content of the sodium colanate is about 1.0wt% to about 1.5wt%; for example, the content of the sodium colanate can be about 0.5wt%, 0.6wt%, 0.7wt%, 0.8wt%, 0.9wt%, 1.0wt%, 1.1wt%, 1.2wt%, 1.3wt%, 1.4wt%, 1.6wt%, 1.7wt%, 1.8wt%, 1.9wt%, 2.0wt%, 2.1wt%, 2.2wt%, 2.3wt%, 2.4wt%, 2.5wt%, 2.6wt%, 2.7wt%, 2.8wt%, 2.9wt%, 2.1wt%, 2.2wt%, 2.4wt%, 2.6wt%, 2.7wt%, 2.8wt%, 2.9wt%, 2. %, 1.2wt%, 1.3wt%, 1.4wt%, 1.5wt%, 1.6wt%, 1.7wt%, 1.8wt%, 1.9wt%, 2.0wt%, 2.1wt%, 2.2wt%, 2.3wt%, 2.4wt%, 2.5wt%, 2.6wt%, 2.7wt%, 2.8wt%, 2.9wt%, 3.0wt%, 3.1wt%, 3.2wt%, 3.3wt%, 3.4wt%, 3.5wt%, 3.6wt%, 3.7wt%, 3.8wt%, 3.9wt%, 4.0wt%, 4.1wt%, 4.2wt%, 4.3wt%, 4.4wt%, 4.5wt%, 4.6wt%, 4.7wt%, 4.8wt%, 4.9wt% or 5.0wt%.The content of the carbomer is about 0.1wt% to about 0.5wt%. In some preferred embodiments, the content of the carbomer is about 0.1wt% to about 0.3wt% or about 0.3wt% to about 0.5wt%. For example, the content of the carbomer can be about 0.1wt%, 0.11wt%, 0.12wt%, 0.13wt%, 0.14wt%, 0.15wt%, 0.16wt%, 0.17wt%, 0.18wt%, 0.19wt%, 0.2wt%, 0.21wt%, 0.22wt%, 0.23wt%, 0.24wt%, wt%, 0.25wt%, 0.26wt%, 0.27wt%, 0.28wt%, 0.29wt%, 0.3wt%, 0.31wt%, 0.32wt%, 0.33wt%, 0.34wt%, 0.35wt%, 0.36wt%, 0.37w t%, 0.38wt%, 0.39wt%, 0.4wt%, 0.41wt%, 0.42wt%, 0.43wt%, 0.44wt%, 0.45wt%, 0.46wt%, 0.47wt%, 0.48wt%, 0.49wt% or 0.5wt%. The content of the polyethylene glycol is about 1 wt % to about 5 wt %. In some preferred embodiments, the content of the polyethylene glycol is about 1 wt % to about 3 wt % or about 3 wt % to about 5 wt %; for example, the content of the polyethylene glycol can be about 1.0 wt %, 1.1 wt %, 1.2 wt %, 1.3 wt %, 1.4 wt %, 1.5 wt %, 1.6 wt %, 1.7 wt %, 1.8 wt %, 1.9 wt %, 2.0 wt %, 2.1 wt %, 2.2 wt %, 2.3 wt %, 2.4 wt%, 2.5wt%, 2.6wt%, 2.7wt%, 2.8wt%, 2.9wt%, 3.0wt%, 3.1wt%, 3.2wt%, 3.3wt%, 3.4wt%, 3.5wt%, 3.6wt%, 3.7wt %, 3.8wt%, 3.9wt%, 4.0wt%, 4.1wt%, 4.2wt%, 4.3wt%, 4.4wt%, 4.5wt%, 4.6wt%, 4.7wt%, 4.8wt%, 4.9wt% or 5.0wt%.The content of the tromethamine is about 0.1wt% to about 0.5wt%, in some preferred embodiments, the content of the tromethamine is about 0.1wt% to about 0.4wt%, in some more preferred embodiments, the content of the tromethamine is about 0.2wt% to about 0.3wt%; for example, the content of the tromethamine can be about 0.1wt%, 0.11wt%, 0.12wt%, 0.13wt%, 0.14wt%, 0.15wt%, 0.16wt%, 0.17wt%, 0.18wt%, 0.19wt%, 0.2wt%, 0.21wt%, 0.22wt%, 0.23wt%, 0.24wt%, 0.25wt%, 0.26wt%, 0.27wt%, 0.28wt%, 0.29wt%, 0.3wt%, 0.31wt%, 0.32wt%, 0.33wt%, 0.34wt%, 0.35wt%, 0.36wt%, 0.37wt%, 0.38wt%, 0.39wt%, 0.4wt%, 0.41wt%, 0.42wt%, 0.43wt%, 0.44wt%, 0.45wt%, 0.46wt%, 0.47wt%, 0.48wt%, 0.49wt% or 0.5wt%. The content of the methylparaben is about 0.01wt% to about 0.1wt%. In some preferred embodiments, the content of the methylparaben is about 0.01wt% to 0.02wt%; for example, the content of the methylparaben is about 0.01wt%, 0.02wt%, 0.03wt%, 0.04wt%, 0.05wt%, 0.06wt%, 0.07wt%, 0.08wt%, 0.09wt% or 0.1wt%.

[0107] In a specific embodiment of the present disclosure, the composition comprises: water, sodium colanate, carbomer, polyethylene glycol 400, tromethamine and methylparaben, wherein the content ratio of sodium colanate, carbomer and polyethylene glycol 400 is about 0.5-5:0.1-0.5:1-5, in some preferred embodiments, the content ratio of sodium colanate, carbomer and polyethylene glycol 400 is about 0.6-2:0.1-0.5:1-5, in some more preferred embodiments, the content ratio of sodium colanate, carbomer and polyethylene glycol 400 is about 1-2:0.1-0.5:1-5. For example, the content ratio of sodium colanate, carbomer and polyethylene glycol 400 can be about 0.5:0.1:0.6, 0.5:0.1:0.7, 0.5:0.1:0.8, 0.5:0.1:0.9, 0.5:0.1:1, 0.5:0.1:2, 0.5:0.1:3, 0.5:0.1:4, 0.5:0.1:5, 0.5:0.2:0.6, 0.5:0.2:0.7, 0.5:0.2:0.8, 0.5:0.2:0.9, 0.5:0.1:1, 0.5:0.1:2, 0.5:0.1:3, 0.5:0.1:4, 0.5:0.1:5, 0.5:0.2:0.6, 0.5:0.2:0.7, 0.5:0.2:0.8, 0.5:0.2:0.9, 0.5:0.2:1, 0.5:0.2:2, 0.5:0.1:3. 0.2:3、0.5:0.2:4、0.5:0.2:5、0.5:0.3:0.6、0.5:0.3:0.7、0.5:0.3:0.8、0.5:0.3:0.9、0.5:0.3:1、0.5:0.3:2、0.5:0.3:3、0.5:0.3:4、0.5:0.3:5、0.5:0.4:0.6、0.5:0.4:0.7、0.5:0.4:0.8、0.5:0.4:0.9、0.5:0.4:1、0.5:0.4:2、0.5:0.4: 3. 0.5:0.4:4. 0.5:0.4:5. 0.5:0.5:0.6. 0.5:0.5:0.7. 0.5:0.5:0.8. 0.5:0.5:0.9. 0.5:0.5:1. 0.5:0.5:2. 0.5:0.5:3. 0.5:0.5:4. 0.5:0.5:5. 0.6:0.1:0.6. 0.6:0.1:0.7. 0.6:0.1:0.8. 0.6:0.1:0.9. 0.6:0.1:1. 0.6:0.1:2. 0.6:0.1:3. 0. 6:0.1:4, 0.6:0.1:5, 0.6:0.2:0.6, 0.6:0.2:0.7, 0.6:0.2:0.8, 0.6:0.2:0.9, 0.6:0.2:1, 0.6:0.2:2, 0.6:0.2:3, 0.6:0.2:4, 0.6:0.2:5, 0.6:0.3:0.6, 0.6:0.3:0.7, 0.6:0.3:0.8, 0.6:0.3:0.9, 0.6:0.3:1, 0.6:0.3:2, 0.6:0.3:3, 0.6:0.3:4、0.6:0.3:5、0.6:0.4:0.6、0.6:0.4:0.7、0.6:0.4:0.8、0.6:0.4:0.9、0.6:0.4:1、0.6:0.4:2、0.6:0.4:3、0.6:0.4:4、0.6:0.4:5、0.6:0.5:0.6、0.6:0.5:0.7、0.6:0.5:0.8、0.6:0.5:0.9、0.6:0.5:1、0.6:0.5:2、0.6:0.5:3、0.6:0.5:4、0.6:0.5:5、0.7:0.1:0.6、0.7:0.1:0.7、0.7:0.1:0.8、0.7:0.1:0.9、0.7:0.1:1、0.7:0.1:2、0.7:0.1:3、0.7:0.1:4、0.7:0.1:5、0.7:0.2:0.6、0.7:0.2:0.7、0.7:0.2:0.8、0.7:0.2:0.9、0.7:0.2:1、0.7:0.2:2、0.7:0.2:3、0.7:0.2:4、0.7:0.2:5、0.7:0.3:0.6、0.7:0.3:0.7、0.7:0.3:0.8、0.7:0.3:0.9、0.7:0.3:1、0.7:0.3:2、0.7:0.3:3、0.7:0.3:4、0.7:0.3:5、0.7:0.4:0.6、0.7:0.4:0.7、0.7:0.4:0.8、0.7:0.4:0.9、0.7:0.4:1、0.7:0.4:2、0.7:0.4:3、0.7:0.4:4、0.7:0.4:5、0.7:0.5:0.6、0.7:0.5:0.7、0.7:0.5:0.8、0.7:0.5:0.9、0.7:0.5:1、0.7:0.5:2、0.7:0.5:3、0.7:0.5:4、0.7:0.5:5、0.8:0.1:0.6、0.8:0.1:0.7、0.8:0.1:0.8、0.8:0.1:0.9、0.8:0.1:1、0.8:0.1:2、0.8:0.1:3、0.8:0.1:4、0.8:0.1:5、0.8:0.2:0.6、0.8:0.2:0.7、0.8:0.2:0.8、0.8:0.2:0.9、0.8:0.2:1、0.8:0.2:2、0.8:0.2:3、0.8:0.2:4、0.8:0.2:5、0.8:0.3:0.6、0.8:0.3:0.7、0.8:0.3:0.8、0.8:0.3:0.9、0.8:0.3:1、0.8:0.3:2、0.8:0.3:3、0.8:0.3:4、0.8:0.3:5、0.8:0.4:0.6、0.8:0.4:0.7、0.8:0.4:0.8、0.8:0.4:0.9、0.8:0.4:1、0.8:0.4:2、0.8:0.4:3、0.8:0.4:4、0.8:0.4:5、0.8:0.5:0.6、0.8:0.5:0.7、0.8:0.5:0.8、0.8:0.5:0.9、0.8:0.5:1、0.8:0.5:2、0.8:0.5:3、0.8:0.5:4、0.8:0.5:5、0.9:0.1:0.6、0.9:0.1:0.7、0.9:0.1:0.8、0.9:0.1:0.9、0.9:0.1:1、0.9:0.1:2、0.9:0.1:3、0.9:0.1:4、0.9:0.1:5、0.9:0.2:0.6、0.9:0.2:0.7、0.9:0.2:0.8、0.9:0.2:0.9、0.9:0.2:1、0.9:0.2:2、0.9:0.2:3、0.9:0.2:4、0.9:0.2:5、0.9:0.3:0.6、0.9:0.3:0.7、0.9:0.3:0.8、0.9:0.3:0.9、0.9:0.3:1、0.9:0.3:2、0.9:0.3:3、0.9:0.3:4、0.9:0.3:5、0.9:0.4:0.6、0.9:0.4:0.7、0.9:0.4:0.8、0.9:0.4:0.9、0.9:0.4:1、0.9:0.4:2、0.9:0.4:3、0.9:0.4:4、0.9:0.4:5、0.9:0.5:0.6、0.9:0.5:0.7、0.9:0.5:0.8、0.9:0.5:0.9、0.9:0.5:1、0.9:0.5:2、0.9:0.5:3、0.9:0.5:4、0.9:0.5:5、1:0.1:0.6、1:0.1:0.7、1:0.1:0.8、1:0.1:0.9、1:0.1:1、1:0.1:2、1:0.1:3、1:0.1:4、1:0.1:5、1:0.2:0.6、1:0.2:0.7、1:0.2:0.8、1:0.2:0.9、1:0.2:1、1:0.2:2、1:0.2:3、1:0.2:4、1:0.2:5、1:0.3:0.6、1:0.3:0.7、1:0.3:0.8、1:0.3:0.9、1:0.3:1、1:0.3:2、1:0.3:3、1:0.3:4、1:0.3:5、1:0.4:0.6、1:0.4:0.7、1:0.4:0.8、1:0.4:0.9、1:0.4:1、1:0.4:2、1:0.4:3、1:0.4:4、1:0.4:5、1:0.5:0.6、1:0.5:0.7、1:0.5:0.8、1:0.5:0.9、1:0.5:1、1:0.5:2、1:0.5:3、1:0.5:4、1:0.5:5、2:0.1:0.6、2:0.1:0.7、2:0.1:0.8、2:0.1:0.9、2:0.1:1、2:0.1:2、2:0.1:3、2:0.1:4、2:0.1:5、2:0.2:0.6、2:0.2:0.7、2:0.2:0.8、2:0.2:0.9、2:0.2:1、2:0.2:2、2:0.2:3、2:0.2:4、2:0.2:5、2:0.3:0.6、2:0.3:0.7、2:0.3:0.8、2:0.3:0.9、2:0.3:1、2:0.3:2、2:0.3:3、2:0.3:4、2:0.3:5、2:0.4:0.6、2:0.4:0.7、2:0.4:0.8、2:0.4:0.9、2:0.4:1、2:0.4:2、2:0.4:3、2:0.4:4、2:0.4:5、2:0.5:0.6、2:0.5:0.7、2:0.5:0.8、2:0.5:0.9、2:0.5:1、2:0.5:2、2:0.5:3、2:0.5:4、2:0.5:5、3:0.1:0.6、3:0.1:0.7、3:0.1:0.8、3:0.1:0.9、3:0.1:1、3:0.1:2、3:0.1:3、3:0.1:4、3:0.1:5、3:0.2:0.6、3:0.2:0.7、3:0.2:0.8、3:0.2:0.9、3:0.2:1、3:0.2:2、3:0.2:3、3:0.2:4、3:0.2:5、3:0.3:0.6、3:0.3:0.7、3:0.3:0.8、3:0.3:0.9、3:0.3:1、3:0.3:2、3:0.3:3、3:0.3:4、3:0.3:5、3:0.4:0.6、3:0.4:0.7、3:0.4:0.8、3:0.4:0.9、3:0.4:1、3:0.4:2、3:0.4:3、3:0.4:4、3:0.4:5、3:0.5:0.6、3:0.5:0.7、3:0.5:0.8、3:0.5:0.9、3:0.5:1、3:0.5:2、3:0.5:3、3:0.5:4、3:0.5:5、4:0.1:0.6、4:0.1:0.7、4:0.1:0.8、4:0.1:0.9、4:0.1:1、4:0.1:2、4:0.1:3、4:0.1:4、4:0.1:5、4:0.2:0.6、4:0.2:0.7、4:0.2:0.8、4:0.2:0.9, 4:0.2:1, 4:0.2:2, 4:0.2:3, 4:0.2:4, 4:0.2:5, 4:0.3:0.6, 4:0.3:0.7, 4:0.3:0.8, 4:0.3:0.9, 4:0.3:1, 4:0.3:2, 4:0.3:3, 4:0.3:4, 4:0.3:5, 4:0.4:0.6, 4:0.4:0.7, 4:0.4:0.8, 4:0.4:0.9, 4:0.4 :1, 4:0.4:2, 4:0.4:3, 4:0.4:4, 4:0.4:5, 4:0.5:0.6, 4:0.5:0.7, 4:0.5:0.8, 4:0.5:0.9, 4:0.5:1, 4:0.5:2, 4:0.5:3, 4:0.5:4, 4:0.5:5, 5:0.1:0.6, 5:0.1:0.7, 5:0.1:0.8, 5:0.1:0.9, 5:0.1:1, 5:0.1:2, 5 :0.1:3, 5:0.1:4, 5:0.1:5, 5:0.2:0.6, 5:0.2:0.7, 5:0.2:0.8, 5:0.2:0.9, 5:0.2:1, 5:0.2:2, 5:0.2:3, 5:0.2:4, 5:0.2:5, 5:0.3:0.6, 5:0.3:0.7, 5:0.3:0.8, 5:0.3:0.9, 5:0.3:1, 5:0.3:2, 5:0.3:3, 5:0. 3:4, 5:0.3:5, 5:0.4:0.6, 5:0.4:0.7, 5:0.4:0.8, 5:0.4:0.9, 5:0.4:1, 5:0.4:2, 5:0.4:3, 5:0.4:4, 5:0.4:5, 5:0.5:0.6, 5:0.5:0.7, 5:0.5:0.8, 5:0.5:0.9, 5:0.5:1, 5:0.5:2, 5:0.5:3, 5:0.5:4 or 5:0.5:5. .

[0108] In a specific embodiment of the present disclosure, the composition comprises: water, sodium colanate, carbomer, glycerin, polyethylene glycol 400, xylitol, tromethamine and methylparaben, wherein the content ratio of sodium colanate, carbomer and polyethylene glycol 400 is about 0.5-5:0.1-0.5:1-5, in some preferred embodiments, the content ratio of sodium colanate, carbomer and polyethylene glycol 400 is about 0.6-2:0.1-0.5:1-5, in some more preferred embodiments, the content ratio of sodium colanate, carbomer and polyethylene glycol 400 is about 1-2:0.1-0.5:1-5. For example, the content ratio of sodium colanate, carbomer and polyethylene glycol 400 can be about 0.5:0.1:0.6, 0.5:0.1:0.7, 0.5:0.1:0.8, 0.5:0.1:0.9, 0.5:0.1:1, 0.5:0.1:2, 0.5:0.1:3, 0.5:0.1:4, 0.5:0.1:5, 0.5:0.2:0.6, 0.5:0.2:0.7, 0.5:0.2:0.8, 0.5:0.2:0.9, 0.5:0.1:1, 0.5:0.1:2, 0.5:0.1:3, 0.5:0.1:4, 0.5:0.1:5, 0.5:0.2:0.6, 0.5:0.2:0.7, 0.5:0.2:0.8, 0.5:0.2:0.9, 0.5:0.2:1, 0.5:0.2:2, 0.5:0.1:3. 5:0.2:3, 0.5:0.2:4, 0.5:0.2:5, 0.5:0.3:0.6, 0.5:0.3:0.7, 0.5:0.3:0.8, 0.5:0.3:0.9, 0.5:0.3:1, 0.5:0.3:2, 0.5:0.3:3, 0.5:0.3:4, 0.5:0.3:5, 0.5:0.4:0.6, 0.5:0.4:0.7, 0.5:0.4:0.8, 0.5:0.4:0.9, 0.5:0.4:1, 0.5:0.4:2, 0.5 :0.4:3、0.5:0.4:4、0.5:0.4:5、0.5:0.5:0.6、0.5:0.5:0.7、0.5:0.5:0.8、0.5:0.5:0.9、0.5:0.5:1、0.5:0.5:2、0.5:0.5:3、0.5:0.5:4、0.5:0.5:5、0.6:0.1:0.6、0.6:0.1:0.7、0.6:0.1:0.8、0.6:0.1:0.9、0.6:0.1:1、0.6:0.1:2、0.6: 0.1:3, 0.6:0.1:4, 0.6:0.1:5, 0.6:0.2:0.6, 0.6:0.2:0.7, 0.6:0.2:0.8, 0.6:0.2:0.9, 0.6:0.2:1, 0.6:0.2:2, 0.6:0.2:3, 0.6:0.2:4, 0.6:0.2:5, 0.6:0.3:0.6, 0.6:0.3:0.7, 0.6:0.3:0.8, 0.6:0.3:0.9, 0.6:0.3:1, 0.6:0.3:2, 0.6:0.3:3、0.6:0.3:4、0.6:0.3:5、0.6:0.4:0.6、0.6:0.4:0.7、0.6:0.4:0.8、0.6:0.4:0.9、0.6:0.4:1、0.6:0.4:2、0.6:0.4:3、0.6:0.4:4、0.6:0.4:5、0.6:0.5:0.6、0.6:0.5:0.7、0.6:0.5:0.8、0.6:0.5:0.9、0.6:0.5:1、0.6:0.5:2、0.6:0.5:3、0.6:0.5:4、0.6:0.5:5、0.7:0.1:0.6、0.7:0.1:0.7、0.7:0.1:0.8、0.7:0.1:0.9、0.7:0.1:1、0.7:0.1:2、0.7:0.1:3、0.7:0.1:4、0.7:0.1:5、0.7:0.2:0.6、0.7:0.2:0.7、0.7:0.2:0.8、0.7:0.2:0.9、0.7:0.2:1、0.7:0.2:2、0.7:0.2:3、0.7:0.2:4、0.7:0.2:5、0.7:0.3:0.6、0.7:0.3:0.7、0.7:0.3:0.8、0.7:0.3:0.9、0.7:0.3:1、0.7:0.3:2、0.7:0.3:3、0.7:0.3:4、0.7:0.3:5、0.7:0.4:0.6、0.7:0.4:0.7、0.7:0.4:0.8、0.7:0.4:0.9、0.7:0.4:1、0.7:0.4:2、0.7:0.4:3、0.7:0.4:4、0.7:0.4:5、0.7:0.5:0.6、0.7:0.5:0.7、0.7:0.5:0.8、0.7:0.5:0.9、0.7:0.5:1、0.7:0.5:2、0.7:0.5:3、0.7:0.5:4、0.7:0.5:5、0.8:0.1:0.6、0.8:0.1:0.7、0.8:0.1:0.8、0.8:0.1:0.9、0.8:0.1:1、0.8:0.1:2、0.8:0.1:3、0.8:0.1:4、0.8:0.1:5、0.8:0.2:0.6、0.8:0.2:0.7、0.8:0.2:0.8、0.8:0.2:0.9、0.8:0.2:1、0.8:0.2:2、0.8:0.2:3、0.8:0.2:4、0.8:0.2:5、0.8:0.3:0.6、0.8:0.3:0.7、0.8:0.3:0.8、0.8:0.3:0.9、0.8:0.3:1、0.8:0.3:2、0.8:0.3:3、0.8:0.3:4、0.8:0.3:5、0.8:0.4:0.6、0.8:0.4:0.7、0.8:0.4:0.8、0.8:0.4:0.9、0.8:0.4:1、0.8:0.4:2、0.8:0.4:3、0.8:0.4:4、0.8:0.4:5、0.8:0.5:0.6、0.8:0.5:0.7、0.8:0.5:0.8、0.8:0.5:0.9、0.8:0.5:1、0.8:0.5:2、0.8:0.5:3、0.8:0.5:4、0.8:0.5:5、0.9:0.1:0.6、0.9:0.1:0.7、0.9:0.1:0.8、0.9:0.1:0.9、0.9:0.1:1、0.9:0.1:2、0.9:0.1:3、0.9:0.1:4、0.9:0.1:5、0.9:0.2:0.6、0.9:0.2:0.7、0.9:0.2:0.8、0.9:0.2:0.9、0.9:0.2:1、0.9:0.2:2、0.9:0.2:3、0.9:0.2:4、0.9:0.2:5、0.9:0.3:0.6、0.9:0.3:0.7、0.9:0.3:0.8、0.9:0.3:0.9、0.9:0.3:1、0.9:0.3:2、0.9:0.3:3、0.9:0.3:4、0.9:0.3:5、0.9:0.4:0.6、0.9:0.4:0.7、0.9:0.4:0.8、0.9:0.4:0.9、0.9:0.4:1、0.9:0.4:2、0.9:0.4:3、0.9:0.4:4、0.9:0.4:5、0.9:0.5:0.6、0.9:0.5:0.7、0.9:0.5:0.8、0.9:0.5:0.9、0.9:0.5:1、0.9:0.5:2、0.9:0.5:3、0.9:0.5:4、0.9:0.5:5、1:0.1:0.6、1:0.1:0.7、1:0.1:0.8、1:0.1:0.9、1:0.1:1、1:0.1:2、1:0.1:3、1:0.1:4、1:0.1:5、1:0.2:0.6、1:0.2:0.7、1:0.2:0.8、1:0.2:0.9、1:0.2:1、1:0.2:2、1:0.2:3、1:0.2:4、1:0.2:5、1:0.3:0.6、1:0.3:0.7、1:0.3:0.8、1:0.3:0.9、1:0.3:1、1:0.3:2、1:0.3:3、1:0.3:4、1:0.3:5、1:0.4:0.6、1:0.4:0.7、1:0.4:0.8、1:0.4:0.9、1:0.4:1、1:0.4:2、1:0.4:3、1:0.4:4、1:0.4:5、1:0.5:0.6、1:0.5:0.7、1:0.5:0.8、1:0.5:0.9、1:0.5:1、1:0.5:2、1:0.5:3、1:0.5:4、1:0.5:5、2:0.1:0.6、2:0.1:0.7、2:0.1:0.8、2:0.1:0.9、2:0.1:1、2:0.1:2、2:0.1:3、2:0.1:4、2:0.1:5、2:0.2:0.6、2:0.2:0.7、2:0.2:0.8、2:0.2:0.9、2:0.2:1、2:0.2:2、2:0.2:3、2:0.2:4、2:0.2:5、2:0.3:0.6、2:0.3:0.7、2:0.3:0.8、2:0.3:0.9、2:0.3:1、2:0.3:2、2:0.3:3、2:0.3:4、2:0.3:5、2:0.4:0.6、2:0.4:0.7、2:0.4:0.8、2:0.4:0.9、2:0.4:1、2:0.4:2、2:0.4:3、2:0.4:4、2:0.4:5、2:0.5:0.6、2:0.5:0.7、2:0.5:0.8、2:0.5:0.9、2:0.5:1、2:0.5:2、2:0.5:3、2:0.5:4、2:0.5:5、3:0.1:0.6、3:0.1:0.7、3:0.1:0.8、3:0.1:0.9、3:0.1:1、3:0.1:2、3:0.1:3、3:0.1:4、3:0.1:5、3:0.2:0.6、3:0.2:0.7、3:0.2:0.8、3:0.2:0.9、3:0.2:1、3:0.2:2、3:0.2:3、3:0.2:4、3:0.2:5、3:0.3:0.6、3:0.3:0.7、3:0.3:0.8、3:0.3:0.9、3:0.3:1、3:0.3:2、3:0.3:3、3:0.3:4、3:0.3:5、3:0.4:0.6、3:0.4:0.7、3:0.4:0.8、3:0.4:0.9、3:0.4:1、3:0.4:2、3:0.4:3、3:0.4:4、3:0.4:5、3:0.5:0.6、3:0.5:0.7、3:0.5:0.8、3:0.5:0.9、3:0.5:1、3:0.5:2、3:0.5:3、3:0.5:4、3:0.5:5、4:0.1:0.6、4:0.1:0.7、4:0.1:0.8、4:0.1:0.9、4:0.1:1、4:0.1:2、4:0.1:3、4:0.1:4、4:0.1:5、4:0.2:0.6、4:0.2:0.7、4:0.2:0.8, 4:0.2:0.9, 4:0.2:1, 4:0.2:2, 4:0.2:3, 4:0.2:4, 4:0.2:5, 4:0.3:0.6, 4:0.3:0.7, 4:0.3:0.8, 4:0.3:0.9, 4:0.3:1, 4:0.3:2, 4:0.3:3, 4:0.3:4, 4:0.3:5, 4:0.4:0.6, 4:0.4:0.7, 4:0.4:0.8, 4:0.4:0.9, 4 :0.4:1、4:0.4:2、4:0.4:3、4:0.4:4、4:0.4:5、4:0.5:0.6、4:0.5:0.7、4:0.5:0.8、4:0.5:0.9、4:0.5:1、4:0.5:2、4:0.5:3、4:0.5:4、4:0.5:5、5:0.1:0.6、5:0.1:0.7、5:0.1:0.8、5:0.1:0.9、5:0.1:1、5:0.1: 2, 5:0.1:3, 5:0.1:4, 5:0.1:5, 5:0.2:0.6, 5:0.2:0.7, 5:0.2:0.8, 5:0.2:0.9, 5:0.2:1, 5:0.2:2, 5:0.2:3, 5:0.2:4, 5:0.2:5, 5:0.3:0.6, 5:0.3:0.7, 5:0.3:0.8, 5:0.3:0.9, 5:0.3:1, 5:0.3:2, 5:0.3:3, 5:0 .3:4, 5:0.3:5, 5:0.4:0.6, 5:0.4:0.7, 5:0.4:0.8, 5:0.4:0.9, 5:0.4:1, 5:0.4:2, 5:0.4:3, 5:0.4:4, 5:0.4:5, 5:0.5:0.6, 5:0.5:0.7, 5:0.5:0.8, 5:0.5:0.9, 5:0.5:1, 5:0.5:2, 5:0.5:3, 5:0.5:4 or 5:0.5:5. .

[0109] A second aspect of the present disclosure provides a dressing comprising: a substrate and the aforementioned composition.

[0110] In a specific embodiment of the present disclosure, the substrate serves as a carrier of the dressing.

[0111] In a specific embodiment of the present disclosure, the substrate is or consists of absorbent fibers.

[0112] In a specific embodiment of the present disclosure, the substrate has the characteristics of soft adhesion, porous air permeability, and high liquid carrying capacity. It can be a hydrophilic fiber membrane, or it can be one or more of non-woven fabrics, gauze, fruit fiber membranes, silk membranes, Tencel membranes, bacterial cellulose membranes, trehalose membranes, chitosan membranes, and binchotan membranes.

[0113] The third aspect of the present disclosure provides a method for preparing the aforementioned composition or the aforementioned dressing, which comprises the following steps:

[0114] (1) dissolving colanate in water and pretreating the water to obtain a solution A;

[0115] (2) fully dissolving the coagulant in water to obtain solution B;

[0116] (3) mixing the dispersant and the optional preservative and fully dissolving them in water to obtain a solution C;

[0117] (4) Pour solution C into solution B and stir to obtain solution D, and evenly disperse solution A in solution D;

[0118] (5) optionally adding a pH adjuster to adjust the pH to about 5 to about 7;

[0119] (6) Vacuum degassing;

[0120] (7) Packaging, sealing, and steam sterilization;

[0121] (8) Optionally, the resulting solution is loaded onto a carrier.

[0122] In a specific embodiment of the present disclosure, the pretreatment in step (1) is steam sterilization.

[0123] In a specific embodiment of the present disclosure, the temperature of the steam sterilization treatment in step (1) and / or step (7) is about 100-130°C.

[0124] In a specific embodiment of the present disclosure, the time for the steam sterilization treatment in step (1) and / or step (7) is about 10-60 minutes.

[0125] In a specific embodiment of the present disclosure, the colanate salt is sodium colanate. In some preferred embodiments, the number average molecular weight of sodium colanate is 400 kDa-8000 kDa.

[0126] In a specific embodiment of the present disclosure, the coagulant is selected from one or more of carbomer, kaolin and phospholipids.

[0127] According to some preferred embodiments of the present disclosure, the coagulant is carbomer.

[0128] In a specific embodiment of the present disclosure, the dispersant is one or more selected from methanol, ethanol, n-propanol, isopropanol, ethyl acetate, n-hexane and polyethylene glycol.

[0129] According to some preferred embodiments of the present disclosure, the dispersant is polyethylene glycol.

[0130] In a specific embodiment of the present disclosure, the pH adjuster is one or more selected from citric acid, tartaric acid, citric acid, malic acid, chlorogenic acid, palmitic acid, glacial acetic acid, triethanolamine, sodium hydroxide, potassium hydroxide and tromethamine.

[0131] According to some preferred embodiments of the present disclosure, the pH adjuster is tromethamine.

[0132] In a specific embodiment of the present disclosure, the preservative is one or more selected from sodium benzoate, potassium sorbate, sorbic acid and methylparaben.

[0133] According to some preferred embodiments of the present disclosure, the preservative is methylparaben.

[0134] In a specific embodiment of the present disclosure, the composition or dressing prepared by the method comprises: water, sodium colanate, carbomer, polyethylene glycol 400, tromethamine and methylparaben.

[0135] In a specific embodiment of the present disclosure, the composition or dressing prepared by the method comprises: water, sodium colanate, carbomer, glycerin, polyethylene glycol 400, xylitol, tromethamine and methylparaben.

[0136] In a specific embodiment of the present disclosure, the content of the colanate is about 0.5 wt % to about 5.0 wt %, in some preferred embodiments, in some preferred embodiments, the content of the colanate is about 0.6 wt % to about 2.5 wt %, in some more preferred embodiments, the content of the colanate is about 0.8 wt % to about 2.0 wt %, in some more preferred embodiments, the content of the colanate is about 1.0 wt % to about 2.0 wt %, in some more preferred embodiments, the content of the colanate is about 1.0 wt % to about 1.5 wt %. For example, the content of the colanate may be about 0.5 wt%, 0.6 wt%, 0.7 wt%, 0.8 wt%, 0.9 wt%, 1.0 wt%, 1.1 wt%, 1.2 wt%, 1.3 wt%, 1.4 wt%, 1.5 wt%, 1.6 wt%, 1.7 wt%, 1.8 wt%, 1.9 wt%, 2.0 wt%, 2.1 wt%, 2.2 wt%, 2.3 wt%, 2.4 wt%, 2.5 wt%, 2.6 wt%. %, 2.7wt%, 2.8wt%, 2.9wt%, 3.0wt%, 3.1wt%, 3.2wt%, 3.3wt%, 3.4wt%, 3.5wt%, 3.6wt%, 3.7wt%, 3.8wt%, 3.9wt%, 4.0wt%, 4.1wt%, 4.2wt%, 4.3wt%, 4.4wt%, 4.5wt%, 4.6wt%, 4.7wt%, 4.8wt%, 4.9wt% or 5.0wt%.

[0137] In a specific embodiment of the present disclosure, the content of the coagulant is about 0.1wt% to about 0.5wt%. In some preferred embodiments, the content of the coagulant is about 0.1wt% to about 0.3wt% or about 0.3wt% to about 0.5wt%. For example, the content of the carbomer can be about 0.1wt%, 0.11wt%, 0.12wt%, 0.13wt%, 0.14wt%, 0.15wt%, 0.16wt%, 0.17wt%, 0.18wt%, 0.19wt%, 0.2wt%, 0.21wt%, 0.22wt%, 0.23wt%, 0.24wt%, 0.25wt%, 0.26wt%, 0.27wt%, 0.28wt%, 0.29wt%, 0.30wt%, 0.31wt%, 0.32wt%, 0.33wt%, 0.34wt%, 0.35wt%, 0.36wt%, 0.37wt%, 0.38wt%, 0.39wt%, 0.40wt%, 0.41wt%, 0.42wt%, 0.43wt%, 0.44wt%, 0.45wt%, 0.46wt%, 0.47wt%, 0.48wt%, 0.49wt%, 0.50wt%, 0.51wt%, 0.52wt%, 0.53wt%, 0.54wt%, 0.55wt%, 0.56wt%, 0.57wt%, 0.58wt%, 0.59wt%, 0.60wt%, 0.61wt%, 0.62wt%, 0.63wt%, 0.64wt%, 0.65wt%, 0.66wt%, 0.67wt%, 0.68wt%, 0.69wt%, 0 wt%, 0.3wt%, 0.31wt%, 0.32wt%, 0.33wt%, 0.34wt%, 0.35wt%, 0.36wt%, 0.37wt%, 0.38wt%, 0.39wt%, 0 .4wt%, 0.41wt%, 0.42wt%, 0.43wt%, 0.44wt%, 0.45wt%, 0.46wt%, 0.47wt%, 0.48wt%, 0.49wt% or 0.5wt%.

[0138] In a specific embodiment of the present disclosure, the content of the dispersant is about 1.0wt% to about 5.0wt%. In some preferred embodiments, the content of the dispersant is about 1wt% to about 3wt% or about 3wt% to about 5wt%. For example, the content of the polyethylene glycol can be about 1.0wt%, 1.1wt%, 1.2wt%, 1.3wt%, 1.4wt%, 1.5wt%, 1.6wt%, 1.7wt%, 1.8wt%, 1.9wt%, 2.0wt%, 2.1wt%, 2.2wt%, 2.3wt%, 2.4wt%, 2.5wt%, 2.6wt%, 2.7wt%, 2.8wt%, 2.9wt%, 3.0wt%, 3.1wt%, 3.2wt%, 3.3wt%, 3.4wt%, 3.5wt%, 3.6wt%, 3.7wt%, 3.8wt%, 3.9wt%, 4.1wt%, 4.2wt%, 4.3wt%, 4.4wt%, 4.5wt%, 4.6wt%, 4.7wt%, 4.8wt%, 4.9wt%, 4.1wt%, 4. 9wt%, 3.0wt%, 3.1wt%, 3.2wt%, 3.3wt%, 3.4wt%, 3.5wt%, 3.6wt%, 3.7wt%, 3.8wt%, 3.9wt%, 4.0wt%, 4.1wt%, 4.2wt%, 4.3wt%, 4.4wt%, 4.5wt%, 4.6wt%, 4.7wt%, 4.8wt%, 4.9wt% or 5.0wt%.

[0139] In a specific embodiment of the present disclosure, the content of the pH adjuster is about 0.1wt% to about 0.5wt%, in some preferred embodiments, the content of the pH adjuster is about 0.1wt% to about 0.4wt%, and in some more preferred embodiments, the content of the pH adjuster is about 0.2wt% to about 0.3wt%. For example, the content of tromethamine can be about 0.1wt%, 0.11wt%, 0.12wt%, 0.13wt%, 0.14wt%, 0.15wt%, 0.16wt%, 0.17wt%, 0.18wt%, 0.19wt%, 0.2wt%, 0.21wt%, 0.22wt%, 0.23wt%, 0.24wt%, 0.25wt%, 0.26wt%, 0.27wt%, 0.28wt%, 0.29wt%, 0.30wt%, 0.31wt%, 0.32wt%, 0.33wt%, 0.34wt%, 0.35wt%, 0.36wt%, 0.37wt%, 0.38wt%, 0.39wt%, 0.40wt%, 0.41wt%, 0.42wt%, 0.43wt%, 0.44wt%, 0.45wt%, 0.46wt%, 0.47wt%, 0.48wt%, 0.49wt%, 0.50wt%, 0.51wt%, 0.52wt%, 0.53wt%, 0.54wt%, 0.55wt%, 0.56wt%, 0.57wt%, 0.58wt%, 0.59wt%, 0.60wt%, 0.61wt%, 0.62wt%, 0.63wt%, 0.64wt%, 0.65wt%, 0.66wt%, 0.67wt%, 0.6 9wt%, 0.3wt%, 0.31wt%, 0.32wt%, 0.33wt%, 0.34wt%, 0.35wt%, 0.36wt%, 0.37wt%, 0.38wt%, 0.39wt%, 0.4wt%, 0.41wt%, 0.42wt%, 0.43wt%, 0.44wt%, 0.45wt%, 0.46wt%, 0.47wt%, 0.48wt%, 0.49wt% or 0.5wt%.

[0140] In a specific embodiment of the present disclosure, the content of the preservative is about 0.01wt% to about 0.1wt%, and in some preferred embodiments, the content of the preservative is about 0.01wt% to 0.02wt%. For example, the content of the preservative is about 0.01wt%, 0.02wt%, 0.03wt%, 0.04wt%, 0.05wt%, 0.06wt%, 0.07wt%, 0.08wt%, 0.09wt% or 0.1wt%.

[0141] In a specific embodiment of the present disclosure, the composition or dressing prepared by the method further comprises an auxiliary agent. In some preferred embodiments, the auxiliary agent is selected from one or more of glycerol and xylitol.

[0142] In a specific embodiment of the present disclosure, the content of the auxiliary agent is about 0.5wt% to about 15wt%, in some preferred embodiments, the content of the auxiliary agent is about 0.5wt% to about 5wt%, and in some more preferred embodiments, the content of the auxiliary agent is about 0.5wt% to about 8wt%. For example, the content of the auxiliary agent is about 0.5wt%, 0.6wt%, 0.6wt%, 0.7wt%, 0.8wt%, 0.9wt%, 1wt%, 2wt%, 3wt%, 4wt%, 5wt%, 6wt%, 7wt%, 8wt%, 9wt%, 10wt%, 11wt%, 12wt%, 13wt%, 14wt% or 15wt%.

[0143] In a specific embodiment of the present disclosure, the content ratio of the colanate, coagulant and dispersant is about 0.5-5:0.1-0.5:1-5. In some preferred embodiments, the content ratio of the colanate, coagulant and dispersant is about 0.6-2:0.1-0.5:1-5. In some more preferred embodiments, the content ratio of the colanate, coagulant and dispersant is about 1-2:0.1-0.5:1-5. For example, the content ratio of the colanate, the coagulant and the dispersant may be about 0.5:0.1:0.6, 0.5:0.1:0.7, 0.5:0.1:0.8, 0.5:0.1:0.9, 0.5:0.1:1, 0.5:0.1:2, 0.5:0.1:3, 0.5:0.1:4, 0.5:0.1:5, 0.5:0.2:0.6, 0.5:0.2:0.7, 0.5:0.2:0.8, 0.5:0.2:0.9, 0.5:0.2:1, 0.5:0.2:2, 0.5:0.1:3, 0.5:0.1:4, 0.5:0.1:5, 0.5:0.2:0.6, 0.5:0.2:0.7, 0.5:0.2:0.8, 0.5:0.2:0.9, 0.5:0.2:1, 0.5:0.2:2, 0.5:0.2:3, 0.5:0.1:4, 0.5:0.1:5. .5:0.2:5、0.5:0.3:0.6、0.5:0.3:0.7、0.5:0.3:0.8、0.5:0.3:0.9、0.5:0.3:1、0.5:0.3:2、0.5:0.3:3、0.5:0.3:4、0.5:0.3:5、0.5:0.4:0.6、0.5:0.4:0.7、0.5:0.4:0.8、0.5:0.4:0.9、0.5:0.4:1、0.5:0.4:2、0.5:0.4:3、0.5:0.4:4、0.5:0.4:5、0.5:0.5: 0.6、0.5:0.5:0.7、0.5:0.5:0.8、0.5:0.5:0.9、0.5:0.5:1、0.5:0.5:2、0.5:0.5:3、0.5:0.5:4、0.5:0.5:5、0.6:0.1:0.6、0.6:0.1:0.7、0.6:0.1:0.8、0.6:0.1:0.9、0.6:0.1:1、0.6:0.1:2、0.6:0.1:3、0.6:0.1:4、0.6:0.1:5、0.6:0.2:0.6、0.6:0.2:0.7、0 .6:0.2:0.8, 0.6:0.2:0.9, 0.6:0.2:1, 0.6:0.2:2, 0.6:0.2:3, 0.6:0.2:4, 0.6:0.2:5, 0.6:0.3:0.6, 0.6:0.3:0.7, 0.6:0.3:0.8, 0.6:0.3:0.9, 0.6:0.3:1, 0.6:0.3:2, 0.6:0.3:3, 0.6:0.3:4, 0.6:0.3:5, 0.6:0.4:0.6, 0.6:0.4:0.7, 0.6:0.4:0.8, 0.6:0.4:0.9、0.6:0.4:1、0.6:0.4:2、0.6:0.4:3、0.6:0.4:4、0.6:0.4:5、0.6:0.5:0.6、0.6:0.5:0.7、0.6:0.5:0.8、0.6:0.5:0.9、0.6:0.5:1、0.6:0.5:2、0.6:0.5:3、0.6:0.5:4、0.6:0.5:5、0.7:0.1:0.6、0.7:0.1:0.7、0.7:0.1:0.8、0.7:0.1:0.9、0.7:0.1:1、0.7:0.1:2、0.7:0.1:3、0.7:0.1:4、0.7:0.1:5、0.7:0.2:0.6、0.7:0.2:0.7、0.7:0.2:0.8、0.7:0.2:0.9、0.7:0.2:1、0.7:0.2:2、0.7:0.2:3、0.7:0.2:4、0.7:0.2:5、0.7:0.3:0.6、0.7:0.3:0.7、0.7:0.3:0.8、0.7:0.3:0.9、0.7:0.3:1、0.7:0.3:2、0.7:0.3:3、0.7:0.3:4、0.7:0.3:5、0.7:0.4:0.6、0.7:0.4:0.7、0.7:0.4:0.8、0.7:0.4:0.9、0.7:0.4:1、0.7:0.4:2、0.7:0.4:3、0.7:0.4:4、0.7:0.4:5、0.7:0.5:0.6、0.7:0.5:0.7、0.7:0.5:0.8、0.7:0.5:0.9、0.7:0.5:1、0.7:0.5:2、0.7:0.5:3、0.7:0.5:4、0.7:0.5:5、0.8:0.1:0.6、0.8:0.1:0.7、0.8:0.1:0.8、0.8:0.1:0.9、0.8:0.1:1、0.8:0.1:2、0.8:0.1:3、0.8:0.1:4、0.8:0.1:5、0.8:0.2:0.6、0.8:0.2:0.7、0.8:0.2:0.8、0.8:0.2:0.9、0.8:0.2:1、0.8:0.2:2、0.8:0.2:3、0.8:0.2:4、0.8:0.2:5、0.8:0.3:0.6、0.8:0.3:0.7、0.8:0.3:0.8、0.8:0.3:0.9、0.8:0.3:1、0.8:0.3:2、0.8:0.3:3、0.8:0.3:4、0.8:0.3:5、0.8:0.4:0.6、0.8:0.4:0.7、0.8:0.4:0.8、0.8:0.4:0.9、0.8:0.4:1、0.8:0.4:2、0.8:0.4:3、0.8:0.4:4、0.8:0.4:5、0.8:0.5:0.6、0.8:0.5:0.7、0.8:0.5:0.8、0.8:0.5:0.9、0.8:0.5:1、0.8:0.5:2、0.8:0.5:3、0.8:0.5:4、0.8:0.5:5、0.9:0.1:0.6、0.9:0.1:0.7、0.9:0.1:0.8、0.9:0.1:0.9、0.9:0.1:1、0.9:0.1:2、0.9:0.1:3、0.9:0.1:4、0.9:0.1:5、0.9:0.2:0.6、0.9:0.2:0.7、0.9:0.2:0.8、0.9:0.2:0.9、0.9:0.2:1、0.9:0.2:2、0.9:0.2:3、0.9:0.2:4、0.9:0.2:5、0.9:0.3:0.6、0.9:0.3:0.7、0.9:0.3:0.8、0.9:0.3:0.9、0.9:0.3:1、0.9:0.3:2、0.9:0.3:3、0.9:0.3:4、0.9:0.3:5、0.9:0.4:0.6、0.9:0.4:0.7、0.9:0.4:0.8、0.9:0.4:0.9、0.9:0.4:1、0.9:0.4:2、0.9:0.4:3、0.9:0.4:4、0.9:0.4:5、0.9:0.5:0.6、0.9:0.5:0.7、0.9:0.5:0.8、0.9:0.5:0.9、0.9:0.5:1、0.9:0.5:2、0.9:0.5:3、0.9:0.5:4、0.9:0.5:5、1:0.1:0.6、1:0.1:0.7、1:0.1:0.8、1:0.1:0.9、1:0.1:1、1:0.1:2、1:0.1:3、1:0.1:4、1:0.1:5、1:0.2:0.6、1:0.2:0.7、1:0.2:0.8、1:0.2:0.9、1:0.2:1、1:0.2:2、1:0.2:3、1:0.2:4、1:0.2:5、1:0.3:0.6、1:0.3:0.7、1:0.3:0.8、1:0.3:0.9、1:0.3:1、1:0.3:2、1:0.3:3、1:0.3:4、1:0.3:5、1:0.4:0.6、1:0.4:0.7、1:0.4:0.8、1:0.4:0.9、1:0.4:1、1:0.4:2、1:0.4:3、1:0.4:4、1:0.4:5、1:0.5:0.6、1:0.5:0.7、1:0.5:0.8、1:0.5:0.9、1:0.5:1、1:0.5:2、1:0.5:3、1:0.5:4、1:0.5:5、2:0.1:0.6、2:0.1:0.7、2:0.1:0.8、2:0.1:0.9、2:0.1:1、2:0.1:2、2:0.1:3、2:0.1:4、2:0.1:5、2:0.2:0.6、2:0.2:0.7、2:0.2:0.8、2:0.2:0.9、2:0.2:1、2:0.2:2、2:0.2:3、2:0.2:4、2:0.2:5、2:0.3:0.6、2:0.3:0.7、2:0.3:0.8、2:0.3:0.9、2:0.3:1、2:0.3:2、2:0.3:3、2:0.3:4、2:0.3:5、2:0.4:0.6、2:0.4:0.7、2:0.4:0.8、2:0.4:0.9、2:0.4:1、2:0.4:2、2:0.4:3、2:0.4:4、2:0.4:5、2:0.5:0.6、2:0.5:0.7、2:0.5:0.8、2:0.5:0.9、2:0.5:1、2:0.5:2、2:0.5:3、2:0.5:4、2:0.5:5、3:0.1:0.6、3:0.1:0.7、3:0.1:0.8、3:0.1:0.9、3:0.1:1、3:0.1:2、3:0.1:3、3:0.1:4、3:0.1:5、3:0.2:0.6、3:0.2:0.7、3:0.2:0.8、3:0.2:0.9、3:0.2:1、3:0.2:2、3:0.2:3、3:0.2:4、3:0.2:5、3:0.3:0.6、3:0.3:0.7、3:0.3:0.8、3:0.3:0.9、3:0.3:1、3:0.3:2、3:0.3:3、3:0.3:4、3:0.3:5、3:0.4:0.6、3:0.4:0.7、3:0.4:0.8、3:0.4:0.9、3:0.4:1、3:0.4:2、3:0.4:3、3:0.4:4、3:0.4:5、3:0.5:0.6、3:0.5:0.7、3:0.5:0.8、3:0.5:0.9、3:0.5:1、3:0.5:2、3:0.5:3、3:0.5:4、3:0.5:5、4:0.1:0.6、4:0.1:0.7、4:0.1:0.8、4:0.1:0.9、4:0.1:1、4:0.1:2、4:0.1:3、4:0.1:4、4:0.1:5、4:0.2:0.6、4:0.2:0.7、4:0.2:0.8、4:0.2:0.9、4:0.2:1、4:0.2:2、4:0.2:3、4:0.2:4、4:0.2:5、4:0.3:0.6, 4:0.3:0.7, 4:0.3:0.8, 4:0.3:0.9, 4:0.3:1, 4:0.3:2, 4:0.3:3, 4:0.3:4, 4:0.3:5, 4:0.4:0.6, 4:0.4:0.7, 4:0.4:0.8, 4:0.4:0.9, 4:0.4:1, 4:0.4:2, 4:0.4:3, 4:0.4:4, 4:0.4:5, 4:0.5: 0.6, 4:0.5:0.7, 4:0.5:0.8, 4:0.5:0.9, 4:0.5:1, 4:0.5:2, 4:0.5:3, 4:0.5:4, 4:0.5:5, 5:0.1:0.6, 5:0.1:0.7, 5:0.1:0.8, 5:0.1:0.9, 5:0.1:1, 5:0.1:2, 5:0.1:3, 5:0.1:4, 5:0.1:5, 5:0. 2:0.6、5:0.2:0.7、5:0.2:0.8、5:0.2:0.9、5:0.2:1、5:0.2:2、5:0.2:3、5:0.2:4、5:0.2:5、5:0.3:0.6、5:0.3:0.7、5:0.3:0.8、5:0.3:0.9、5:0.3:1、5:0.3:2、5:0.3:3、5:0.3:4、5:0.3:5、5: 0.4:0.6, 5:0.4:0.7, 5:0.4:0.8, 5:0.4:0.9, 5:0.4:1, 5:0.4:2, 5:0.4:3, 5:0.4:4, 5:0.4:5, 5:0.5:0.6, 5:0.5:0.7, 5:0.5:0.8, 5:0.5:0.9, 5:0.5:1, 5:0.5:2, 5:0.5:3, 5:0.5:4 or 5:0.5:5. .

[0144] In a specific embodiment of the present disclosure, the composition or dressing prepared by the method comprises: water, sodium colanate, carbomer, polyethylene glycol 400, tromethamine and methylparaben. The weight average molecular weight of the sodium colanate is 400 kDa-8000 kDa, and the content of the sodium colanate is about 0.5 wt% to about 5.0 wt%. In some preferred embodiments, the content of the sodium colanate is about 0.6 wt% to about 2.5 wt%. In some more preferred embodiments, the content of the sodium colanate is about 0.8 wt% to about 2.0 wt%. In some more preferred embodiments, the content of the sodium colanate is about 1.0 wt% to about 2.0 wt%. In some more preferred embodiments, the content of the sodium colanate is about 1.0 wt% to about 1.5 wt%. For example, the content of the sodium colanate can be about 0.5 wt%, 0.6 wt%, 0.7 wt%, 0.8 wt%, 0.9 wt%, 1.0 wt%, 1.1 wt%. %, 1.2wt%, 1.3wt%, 1.4wt%, 1.5wt%, 1.6wt%, 1.7wt%, 1.8wt%, 1.9wt%, 2.0wt%, 2.1wt%, 2.2wt%, 2.3wt%, 2.4wt%, 2.5wt%, 2.6wt%, 2.7wt%, 2.8wt%, 2.9wt%, 3.0wt%, 3.1wt%, 3.2wt%, 3.3wt%, 3.4wt%, 3.5wt%, 3.6wt%, 3.7wt%, 3.8wt%, 3.9wt%, 4.0wt%, 4.1wt%, 4.2wt%, 4.3wt%, 4.4wt%, 4.5wt%, 4.6wt%, 4.7wt%, 4.8wt%, 4.9wt% or 5.0wt%.The content of the carbomer is about 0.1wt% to about 0.5wt%. In some preferred embodiments, the content of the carbomer is about 0.1wt% to about 0.3wt% or about 0.3wt% to about 0.5wt%. For example, the content of the carbomer can be about 0.1wt%, 0.11wt%, 0.12wt%, 0.13wt%, 0.14wt%, 0.15wt%, 0.16wt%, 0.17wt%, 0.18wt%, 0.19wt%, 0.2wt%, 0.21wt%, 0.22wt%, 0.23wt%, 0.24wt%, wt%, 0.25wt%, 0.26wt%, 0.27wt%, 0.28wt%, 0.29wt%, 0.3wt%, 0.31wt%, 0.32wt%, 0.33wt%, 0.34wt%, 0.35wt%, 0.36wt%, 0.37w t%, 0.38wt%, 0.39wt%, 0.4wt%, 0.41wt%, 0.42wt%, 0.43wt%, 0.44wt%, 0.45wt%, 0.46wt%, 0.47wt%, 0.48wt%, 0.49wt% or 0.5wt%. The content of the polyethylene glycol is about 1 wt % to about 5 wt %. In some preferred embodiments, the content of the polyethylene glycol is about 1 wt % to about 3 wt % or about 3 wt % to about 5 wt %; for example, the content of the polyethylene glycol can be about 1.0 wt %, 1.1 wt %, 1.2 wt %, 1.3 wt %, 1.4 wt %, 1.5 wt %, 1.6 wt %, 1.7 wt %, 1.8 wt %, 1.9 wt %, 2.0 wt %, 2.1 wt %, 2.2 wt %, 2.3 wt %, 2.4 wt%, 2.5wt%, 2.6wt%, 2.7wt%, 2.8wt%, 2.9wt%, 3.0wt%, 3.1wt%, 3.2wt%, 3.3wt%, 3.4wt%, 3.5wt%, 3.6wt%, 3.7wt %, 3.8wt%, 3.9wt%, 4.0wt%, 4.1wt%, 4.2wt%, 4.3wt%, 4.4wt%, 4.5wt%, 4.6wt%, 4.7wt%, 4.8wt%, 4.9wt% or 5.0wt%.The content of the tromethamine is about 0.1wt% to about 0.5wt%, in some preferred embodiments, the content of the tromethamine is about 0.1wt% to about 0.4wt%, in some more preferred embodiments, the content of the tromethamine is about 0.2wt% to about 0.3wt%; for example, the content of the tromethamine can be about 0.1wt%, 0.11wt%, 0.12wt%, 0.13wt%, 0.14wt%, 0.15wt%, 0.16wt%, 0.17wt%, 0.18wt%, 0.19wt%, 0.2wt%, 0.21wt%, 0.22wt%, 0.23wt%, 0.24wt%, 0.25wt%, 0.26wt%, 0.27wt%, 0.28wt%, 0.29wt%, 0.3wt%, 0.31wt%, 0.32wt%, 0.33wt%, 0.34wt%, 0.35wt%, 0.36wt%, 0.37wt%, 0.38wt%, 0.39wt%, 0.4wt%, 0.41wt%, 0.42wt%, 0.43wt%, 0.44wt%, 0.45wt%, 0.46wt%, 0.47wt%, 0.48wt%, 0.49wt% or 0.5wt%. The content of the methylparaben is about 0.01wt% to about 0.1wt%. In some preferred embodiments, the content of the methylparaben is about 0.01wt% to 0.02wt%; for example, the content of the methylparaben is about 0.01wt%, 0.02wt%, 0.03wt%, 0.04wt%, 0.05wt%, 0.06wt%, 0.07wt%, 0.08wt%, 0.09wt% or 0.1wt%.

[0145] In a specific embodiment of the present disclosure, the composition or dressing prepared by the method comprises: water, sodium colanate, carbomer, glycerol, polyethylene glycol 400, xylitol, tromethamine and methylparaben. Wherein, the weight average molecular weight of the sodium colanate is 400kDa-8000kDa, and the content of the sodium colanate is about 0.5wt% to about 5.0wt%. In some preferred embodiments, the content of the sodium colanate is about 0.6wt% to about 2.5wt%. In some more preferred embodiments, the content of the sodium colanate is about 0.8wt% to about 2.0wt%. In some more preferred embodiments, the content of the sodium colanate is about 1.0wt% to about 2.0wt%. In some more preferred embodiments, the content of the sodium colanate is about 1.0wt% to about 1.5wt%. For example, the content of the sodium colanate can be about 0.5wt%, 0.6wt%, 0.7wt%, 0.8wt%, 0.9wt%, 1.0wt%, 1.1wt%, 1.2wt%, 1.3wt%, 1.4wt%, 1.6wt%, 1.7wt%, 1.8wt%, 1.9wt%, 2.0wt%, 2.1wt%, 2.2wt%, 2.3wt%, 2.4wt%, 2.5wt%, 2.6wt%, 2.7wt%, 2.8wt%, 2.9wt%, 2.1wt%, 2.2wt%, 2.4wt%, 2.6wt%, 2.7wt%, 2.8wt%, 2.9wt%, 2. %, 1.2wt%, 1.3wt%, 1.4wt%, 1.5wt%, 1.6wt%, 1.7wt%, 1.8wt%, 1.9wt%, 2.0wt%, 2.1wt%, 2.2wt%, 2.3wt%, 2.4wt%, 2.5wt%, 2.6wt%, 2.7wt%, 2.8wt%, 2.9wt%, 3.0wt%, 3.1wt%, 3.2wt%, 3.3wt%, 3.4wt%, 3.5wt%, 3.6wt%, 3.7wt%, 3.8wt%, 3.9wt%, 4.0wt%, 4.1wt%, 4.2wt%, 4.3wt%, 4.4wt%, 4.5wt%, 4.6wt%, 4.7wt%, 4.8wt%, 4.9wt% or 5.0wt%.The content of the carbomer is about 0.1wt% to about 0.5wt%. In some preferred embodiments, the content of the carbomer is about 0.1wt% to about 0.3wt% or about 0.3wt% to about 0.5wt%. For example, the content of the carbomer can be about 0.1wt%, 0.11wt%, 0.12wt%, 0.13wt%, 0.14wt%, 0.15wt%, 0.16wt%, 0.17wt%, 0.18wt%, 0.19wt%, 0.2wt%, 0.21wt%, 0.22wt%, 0.23wt%, 0.24wt%, wt%, 0.25wt%, 0.26wt%, 0.27wt%, 0.28wt%, 0.29wt%, 0.3wt%, 0.31wt%, 0.32wt%, 0.33wt%, 0.34wt%, 0.35wt%, 0.36wt%, 0.37w t%, 0.38wt%, 0.39wt%, 0.4wt%, 0.41wt%, 0.42wt%, 0.43wt%, 0.44wt%, 0.45wt%, 0.46wt%, 0.47wt%, 0.48wt%, 0.49wt% or 0.5wt%. The content of the polyethylene glycol is about 1 wt % to about 5 wt %. In some preferred embodiments, the content of the polyethylene glycol is about 1 wt % to about 3 wt % or about 3 wt % to about 5 wt %; for example, the content of the polyethylene glycol can be about 1.0 wt %, 1.1 wt %, 1.2 wt %, 1.3 wt %, 1.4 wt %, 1.5 wt %, 1.6 wt %, 1.7 wt %, 1.8 wt %, 1.9 wt %, 2.0 wt %, 2.1 wt %, 2.2 wt %, 2.3 wt %, 2.4 wt%, 2.5wt%, 2.6wt%, 2.7wt%, 2.8wt%, 2.9wt%, 3.0wt%, 3.1wt%, 3.2wt%, 3.3wt%, 3.4wt%, 3.5wt%, 3.6wt%, 3.7wt %, 3.8wt%, 3.9wt%, 4.0wt%, 4.1wt%, 4.2wt%, 4.3wt%, 4.4wt%, 4.5wt%, 4.6wt%, 4.7wt%, 4.8wt%, 4.9wt% or 5.0wt%.The content of the tromethamine is about 0.1wt% to about 0.5wt%, in some preferred embodiments, the content of the tromethamine is about 0.1wt% to about 0.4wt%, in some more preferred embodiments, the content of the tromethamine is about 0.2wt% to about 0.3wt%; for example, the content of the tromethamine can be about 0.1wt%, 0.11wt%, 0.12wt%, 0.13wt%, 0.14wt%, 0.15wt%, 0.16wt%, 0.17wt%, 0.18wt%, 0.19wt%, 0.2wt%, 0.21wt%, 0.22wt%, 0.23wt%, 0.24wt%, 0.25wt%, 0.26wt%, 0.27wt%, 0.28wt%, 0.29wt%, 0.3wt%, 0.31wt%, 0.32wt%, 0.33wt%, 0.34wt%, 0.35wt%, 0.36wt%, 0.37wt%, 0.38wt%, 0.39wt%, 0.4wt%, 0.41wt%, 0.42wt%, 0.43wt%, 0.44wt%, 0.45wt%, 0.46wt%, 0.47wt%, 0.48wt%, 0.49wt% or 0.5wt%. The content of the methylparaben is about 0.01wt% to about 0.1wt%. In some preferred embodiments, the content of the methylparaben is about 0.01wt% to 0.02wt%; for example, the content of the methylparaben is about 0.01wt%, 0.02wt%, 0.03wt%, 0.04wt%, 0.05wt%, 0.06wt%, 0.07wt%, 0.08wt%, 0.09wt% or 0.1wt%.

[0146] In a specific embodiment of the present disclosure, the composition or dressing prepared by the method comprises: water, sodium colanate, carbomer, polyethylene glycol 400, tromethamine and methylparaben, wherein the content ratio of sodium colanate, carbomer and polyethylene glycol 400 is about 0.5-5:0.1-0.5:1-5, in some preferred embodiments, the content ratio of sodium colanate, carbomer and polyethylene glycol 400 is about 0.6-2:0.1-0.5:1-5, in some more preferred embodiments, the content ratio of sodium colanate, carbomer and polyethylene glycol 400 is about 1-2:0.1-0.5:1-5. For example, the content ratio of sodium colanate, carbomer and polyethylene glycol 400 can be about 0.5:0.1:0.6, 0.5:0.1:0.7, 0.5:0.1:0.8, 0.5:0.1:0.9, 0.5:0.1:1, 0.5:0.1:2, 0.5:0.1:3, 0.5:0.1:4, 0.5:0.1:5, 0.5:0.2:0.6, 0.5:0.2:0.7, 0.5:0.2:0.8, 0.5:0.2:0.9, 0.5:0.1:1, 0.5:0.1:2, 0.5:0.1:3, 0.5:0.1:4, 0.5:0.1:5, 0.5:0.2:0.6, 0.5:0.2:0.7, 0.5:0.2:0.8, 0.5:0.2:0.9, 0.5:0.2:1, 0.5:0.2:2, 0.5:0.1:3. 5:0.2:3, 0.5:0.2:4, 0.5:0.2:5, 0.5:0.3:0.6, 0.5:0.3:0.7, 0.5:0.3:0.8, 0.5:0.3:0.9, 0.5:0.3:1, 0.5:0.3:2, 0.5:0.3:3, 0.5:0.3:4, 0.5:0.3:5, 0.5:0.4:0.6, 0.5:0.4:0.7, 0.5:0.4:0.8, 0.5:0.4:0.9, 0.5:0.4:1, 0.5:0.4:2, 0.5 :0.4:3、0.5:0.4:4、0.5:0.4:5、0.5:0.5:0.6、0.5:0.5:0.7、0.5:0.5:0.8、0.5:0.5:0.9、0.5:0.5:1、0.5:0.5:2、0.5:0.5:3、0.5:0.5:4、0.5:0.5:5、0.6:0.1:0.6、0.6:0.1:0.7、0.6:0.1:0.8、0.6:0.1:0.9、0.6:0.1:1、0.6:0.1:2、0.6: 0.1:3, 0.6:0.1:4, 0.6:0.1:5, 0.6:0.2:0.6, 0.6:0.2:0.7, 0.6:0.2:0.8, 0.6:0.2:0.9, 0.6:0.2:1, 0.6:0.2:2, 0.6:0.2:3, 0.6:0.2:4, 0.6:0.2:5, 0.6:0.3:0.6, 0.6:0.3:0.7, 0.6:0.3:0.8, 0.6:0.3:0.9, 0.6:0.3:1, 0.6:0.3:2, 0.6:0.3:3、0.6:0.3:4、0.6:0.3:5、0.6:0.4:0.6、0.6:0.4:0.7、0.6:0.4:0.8、0.6:0.4:0.9、0.6:0.4:1、0.6:0.4:2、0.6:0.4:3、0.6:0.4:4、0.6:0.4:5、0.6:0.5:0.6、0.6:0.5:0.7、0.6:0.5:0.8、0.6:0.5:0.9、0.6:0.5:1、0.6:0.5:2、0.6:0.5:3、0.6:0.5:4、0.6:0.5:5、0.7:0.1:0.6、0.7:0.1:0.7、0.7:0.1:0.8、0.7:0.1:0.9、0.7:0.1:1、0.7:0.1:2、0.7:0.1:3、0.7:0.1:4、0.7:0.1:5、0.7:0.2:0.6、0.7:0.2:0.7、0.7:0.2:0.8、0.7:0.2:0.9、0.7:0.2:1、0.7:0.2:2、0.7:0.2:3、0.7:0.2:4、0.7:0.2:5、0.7:0.3:0.6、0.7:0.3:0.7、0.7:0.3:0.8、0.7:0.3:0.9、0.7:0.3:1、0.7:0.3:2、0.7:0.3:3、0.7:0.3:4、0.7:0.3:5、0.7:0.4:0.6、0.7:0.4:0.7、0.7:0.4:0.8、0.7:0.4:0.9、0.7:0.4:1、0.7:0.4:2、0.7:0.4:3、0.7:0.4:4、0.7:0.4:5、0.7:0.5:0.6、0.7:0.5:0.7、0.7:0.5:0.8、0.7:0.5:0.9、0.7:0.5:1、0.7:0.5:2、0.7:0.5:3、0.7:0.5:4、0.7:0.5:5、0.8:0.1:0.6、0.8:0.1:0.7、0.8:0.1:0.8、0.8:0.1:0.9、0.8:0.1:1、0.8:0.1:2、0.8:0.1:3、0.8:0.1:4、0.8:0.1:5、0.8:0.2:0.6、0.8:0.2:0.7、0.8:0.2:0.8、0.8:0.2:0.9、0.8:0.2:1、0.8:0.2:2、0.8:0.2:3、0.8:0.2:4、0.8:0.2:5、0.8:0.3:0.6、0.8:0.3:0.7、0.8:0.3:0.8、0.8:0.3:0.9、0.8:0.3:1、0.8:0.3:2、0.8:0.3:3、0.8:0.3:4、0.8:0.3:5、0.8:0.4:0.6、0.8:0.4:0.7、0.8:0.4:0.8、0.8:0.4:0.9、0.8:0.4:1、0.8:0.4:2、0.8:0.4:3、0.8:0.4:4、0.8:0.4:5、0.8:0.5:0.6、0.8:0.5:0.7、0.8:0.5:0.8、0.8:0.5:0.9、0.8:0.5:1、0.8:0.5:2、0.8:0.5:3、0.8:0.5:4、0.8:0.5:5、0.9:0.1:0.6、0.9:0.1:0.7、0.9:0.1:0.8、0.9:0.1:0.9、0.9:0.1:1、0.9:0.1:2、0.9:0.1:3、0.9:0.1:4、0.9:0.1:5、0.9:0.2:0.6、0.9:0.2:0.7、0.9:0.2:0.8、0.9:0.2:0.9、0.9:0.2:1、0.9:0.2:2、0.9:0.2:3、0.9:0.2:4、0.9:0.2:5、0.9:0.3:0.6、0.9:0.3:0.7、0.9:0.3:0.8、0.9:0.3:0.9、0.9:0.3:1、0.9:0.3:2、0.9:0.3:3、0.9:0.3:4、0.9:0.3:5、0.9:0.4:0.6、0.9:0.4:0.7、0.9:0.4:0.8、0.9:0.4:0.9、0.9:0.4:1、0.9:0.4:2、0.9:0.4:3、0.9:0.4:4、0.9:0.4:5、0.9:0.5:0.6、0.9:0.5:0.7、0.9:0.5:0.8、0.9:0.5:0.9、0.9:0.5:1、0.9:0.5:2、0.9:0.5:3、0.9:0.5:4、0.9:0.5:5、1:0.1:0.6、1:0.1:0.7、1:0.1:0.8、1:0.1:0.9、1:0.1:1、1:0.1:2、1:0.1:3、1:0.1:4、1:0.1:5、1:0.2:0.6、1:0.2:0.7、1:0.2:0.8、1:0.2:0.9、1:0.2:1、1:0.2:2、1:0.2:3、1:0.2:4、1:0.2:5、1:0.3:0.6、1:0.3:0.7、1:0.3:0.8、1:0.3:0.9、1:0.3:1、1:0.3:2、1:0.3:3、1:0.3:4、1:0.3:5、1:0.4:0.6、1:0.4:0.7、1:0.4:0.8、1:0.4:0.9、1:0.4:1、1:0.4:2、1:0.4:3、1:0.4:4、1:0.4:5、1:0.5:0.6、1:0.5:0.7、1:0.5:0.8、1:0.5:0.9、1:0.5:1、1:0.5:2、1:0.5:3、1:0.5:4、1:0.5:5、2:0.1:0.6、2:0.1:0.7、2:0.1:0.8、2:0.1:0.9、2:0.1:1、2:0.1:2、2:0.1:3、2:0.1:4、2:0.1:5、2:0.2:0.6、2:0.2:0.7、2:0.2:0.8、2:0.2:0.9、2:0.2:1、2:0.2:2、2:0.2:3、2:0.2:4、2:0.2:5、2:0.3:0.6、2:0.3:0.7、2:0.3:0.8、2:0.3:0.9、2:0.3:1、2:0.3:2、2:0.3:3、2:0.3:4、2:0.3:5、2:0.4:0.6、2:0.4:0.7、2:0.4:0.8、2:0.4:0.9、2:0.4:1、2:0.4:2、2:0.4:3、2:0.4:4、2:0.4:5、2:0.5:0.6、2:0.5:0.7、2:0.5:0.8、2:0.5:0.9、2:0.5:1、2:0.5:2、2:0.5:3、2:0.5:4、2:0.5:5、3:0.1:0.6、3:0.1:0.7、3:0.1:0.8、3:0.1:0.9、3:0.1:1、3:0.1:2、3:0.1:3、3:0.1:4、3:0.1:5、3:0.2:0.6、3:0.2:0.7、3:0.2:0.8、3:0.2:0.9、3:0.2:1、3:0.2:2、3:0.2:3、3:0.2:4、3:0.2:5、3:0.3:0.6、3:0.3:0.7、3:0.3:0.8、3:0.3:0.9、3:0.3:1、3:0.3:2、3:0.3:3、3:0.3:4、3:0.3:5、3:0.4:0.6、3:0.4:0.7、3:0.4:0.8、3:0.4:0.9、3:0.4:1、3:0.4:2、3:0.4:3、3:0.4:4、3:0.4:5、3:0.5:0.6、3:0.5:0.7、3:0.5:0.8、3:0.5:0.9、3:0.5:1、3:0.5:2、3:0.5:3、3:0.5:4、3:0.5:5、4:0.1:0.6、4:0.1:0.7、4:0.1:0.8、4:0.1:0.9、4:0.1:1、4:0.1:2、4:0.1:3、4:0.1:4、4:0.1:5、4:0.2:0.6、4:0.2:0.7、4:0.2:0.8, 4:0.2:0.9, 4:0.2:1, 4:0.2:2, 4:0.2:3, 4:0.2:4, 4:0.2:5, 4:0.3:0.6, 4:0.3:0.7, 4:0.3:0.8, 4:0.3:0.9, 4:0.3:1, 4:0.3:2, 4:0.3:3, 4:0.3:4, 4:0.3:5, 4:0.4:0.6, 4:0.4:0.7, 4:0.4:0.8, 4:0.4:0.9, 4 :0.4:1、4:0.4:2、4:0.4:3、4:0.4:4、4:0.4:5、4:0.5:0.6、4:0.5:0.7、4:0.5:0.8、4:0.5:0.9、4:0.5:1、4:0.5:2、4:0.5:3、4:0.5:4、4:0.5:5、5:0.1:0.6、5:0.1:0.7、5:0.1:0.8、5:0.1:0.9、5:0.1:1、5:0.1: 2, 5:0.1:3, 5:0.1:4, 5:0.1:5, 5:0.2:0.6, 5:0.2:0.7, 5:0.2:0.8, 5:0.2:0.9, 5:0.2:1, 5:0.2:2, 5:0.2:3, 5:0.2:4, 5:0.2:5, 5:0.3:0.6, 5:0.3:0.7, 5:0.3:0.8, 5:0.3:0.9, 5:0.3:1, 5:0.3:2, 5:0.3:3, 5:0 .3:4, 5:0.3:5, 5:0.4:0.6, 5:0.4:0.7, 5:0.4:0.8, 5:0.4:0.9, 5:0.4:1, 5:0.4:2, 5:0.4:3, 5:0.4:4, 5:0.4:5, 5:0.5:0.6, 5:0.5:0.7, 5:0.5:0.8, 5:0.5:0.9, 5:0.5:1, 5:0.5:2, 5:0.5:3, 5:0.5:4 or 5:0.5:5. .

[0147] In a specific embodiment of the present disclosure, the composition or dressing prepared by the method comprises: water, sodium colanate, carbomer, glycerol, polyethylene glycol 400, xylitol, tromethamine and methylparaben, wherein the content ratio of sodium colanate, carbomer and polyethylene glycol 400 is about 0.5-5:0.1-0.5:1-5, in some preferred embodiments, the content ratio of sodium colanate, carbomer and polyethylene glycol 400 is about 0.6-2:0.1-0.5:1-5, in some more preferred embodiments, the content ratio of sodium colanate, carbomer and polyethylene glycol 400 is about 1-2:0.1-0.5:1-5. For example, the content ratio of sodium colanate, carbomer and polyethylene glycol 400 can be about 0.5:0.1:0.6, 0.5:0.1:0.7, 0.5:0.1:0.8, 0.5:0.1:0.9, 0.5:0.1:1, 0.5:0.1:2, 0.5:0.1:3, 0.5:0.1:4, 0.5:0.1:5, 0.5:0.2:0.6, 0.5:0.2:0.7, 0.5:0.2:0.8, 0.5:0.2:0.9, 0.5:0.1:1, 0.5:0.1:2, 0.5:0.1:3, 0.5:0.1:4, 0.5:0.1:5, 0.5:0.2:0.6, 0.5:0.2:0.7, 0.5:0.2:0.8, 0.5:0.2:0.9, 0.5:0.2:1, 0.5:0.2:2. 、0.5:0.2:3、0.5:0.2:4、0.5:0.2:5、0.5:0.3:0.6、0.5:0.3:0.7、0.5:0.3:0.8、0.5:0.3:0.9、0.5:0.3:1、0.5:0.3:2、0.5:0.3:3、0.5:0.3:4、0.5:0.3:5、0.5:0.4:0.6、0.5:0.4:0.7、0.5:0.4:0.8、0.5:0.4:0.9、0.5:0.4:1、0.5:0.4: 2. 0.5:0.4:3. 0.5:0.4:4. 0.5:0.4:5. 0.5:0.5:0.6. 0.5:0.5:0.7. 0.5:0.5:0.8. 0.5:0.5:0.9. 0.5:0.5:1. 0.5:0.5:2. 0.5:0.5:3. 0.5:0.5:4. 0.5:0.5:5. 0.6:0.1:0.6. 0.6:0.1:0.7. 0.6:0.1:0.8. 0.6:0.1:0.9. 0.6:0.1:1. 0.6:0.1 :2, 0.6:0.1:3, 0.6:0.1:4, 0.6:0.1:5, 0.6:0.2:0.6, 0.6:0.2:0.7, 0.6:0.2:0.8, 0.6:0.2:0.9, 0.6:0.2:1, 0.6:0.2:2, 0.6:0.2:3, 0.6:0.2:4, 0.6:0.2:5, 0.6:0.3:0.6, 0.6:0.3:0.7, 0.6:0.3:0.8, 0.6:0.3:0.9, 0.6:0.3:1, 0.6:0.3:2、0.6:0.3:3、0.6:0.3:4、0.6:0.3:5、0.6:0.4:0.6、0.6:0.4:0.7、0.6:0.4:0.8、0.6:0.4:0.9、0.6:0.4:1、0.6:0.4:2、0.6:0.4:3、0.6:0.4:4、0.6:0.4:5、0.6:0.5:0.6、0.6:0.5:0.7、0.6:0.5:0.8、0.6:0.5:0.9、0.6:0.5:1、0.6:0.5:2、0.6:0.5:3、0.6:0.5:4、0.6:0.5:5、0.7:0.1:0.6、0.7:0.1:0.7、0.7:0.1:0.8、0.7:0.1:0.9、0.7:0.1:1、0.7:0.1:2、0.7:0.1:3、0.7:0.1:4、0.7:0.1:5、0.7:0.2:0.6、0.7:0.2:0.7、0.7:0.2:0.8、0.7:0.2:0.9、0.7:0.2:1、0.7:0.2:2、0.7:0.2:3、0.7:0.2:4、0.7:0.2:5、0.7:0.3:0.6、0.7:0.3:0.7、0.7:0.3:0.8、0.7:0.3:0.9、0.7:0.3:1、0.7:0.3:2、0.7:0.3:3、0.7:0.3:4、0.7:0.3:5、0.7:0.4:0.6、0.7:0.4:0.7、0.7:0.4:0.8、0.7:0.4:0.9、0.7:0.4:1、0.7:0.4:2、0.7:0.4:3、0.7:0.4:4、0.7:0.4:5、0.7:0.5:0.6、0.7:0.5:0.7、0.7:0.5:0.8、0.7:0.5:0.9、0.7:0.5:1、0.7:0.5:2、0.7:0.5:3、0.7:0.5:4、0.7:0.5:5、0.8:0.1:0.6、0.8:0.1:0.7、0.8:0.1:0.8、0.8:0.1:0.9、0.8:0.1:1、0.8:0.1:2、0.8:0.1:3、0.8:0.1:4、0.8:0.1:5、0.8:0.2:0.6、0.8:0.2:0.7、0.8:0.2:0.8、0.8:0.2:0.9、0.8:0.2:1、0.8:0.2:2、0.8:0.2:3、0.8:0.2:4、0.8:0.2:5、0.8:0.3:0.6、0.8:0.3:0.7、0.8:0.3:0.8、0.8:0.3:0.9、0.8:0.3:1、0.8:0.3:2、0.8:0.3:3、0.8:0.3:4、0.8:0.3:5、0.8:0.4:0.6、0.8:0.4:0.7、0.8:0.4:0.8、0.8:0.4:0.9、0.8:0.4:1、0.8:0.4:2、0.8:0.4:3、0.8:0.4:4、0.8:0.4:5、0.8:0.5:0.6、0.8:0.5:0.7、0.8:0.5:0.8、0.8:0.5:0.9、0.8:0.5:1、0.8:0.5:2、0.8:0.5:3、0.8:0.5:4、0.8:0.5:5、0.9:0.1:0.6、0.9:0.1:0.7、0.9:0.1:0.8、0.9:0.1:0.9、0.9:0.1:1、0.9:0.1:2、0.9:0.1:3、0.9:0.1:4、0.9:0.1:5、0.9:0.2:0.6、0.9:0.2:0.7、0.9:0.2:0.8、0.9:0.2:0.9、0.9:0.2:1、0.9:0.2:2、0.9:0.2:3、0.9:0.2:4、0.9:0.2:5、0.9:0.3:0.6、0.9:0.3:0.7、0.9:0.3:0.8、0.9:0.3:0.9、0.9:0.3:1、0.9:0.3:2、0.9:0.3:3、0.9:0.3:4、0.9:0.3:5、0.9:0.4:0.6、0.9:0.4:0.7、0.9:0.4:0.8、0.9:0.4:0.9、0.9:0.4:1、0.9:0.4:2、0.9:0.4:3、0.9:0.4:4、0.9:0.4:5、0.9:0.5:0.6、0.9:0.5:0.7、0.9:0.5:0.8、0.9:0.5:0.9、0.9:0.5:1、0.9:0.5:2、0.9:0.5:3、0.9:0.5:4、0.9:0.5:5、1:0.1:0.6、1:0.1:0.7、1:0.1:0.8、1:0.1:0.9、1:0.1:1、1:0.1:2、1:0.1:3、1:0.1:4、1:0.1:5、1:0.2:0.6、1:0.2:0.7、1:0.2:0.8、1:0.2:0.9、1:0.2:1、1:0.2:2、1:0.2:3、1:0.2:4、1:0.2:5、1:0.3:0.6、1:0.3:0.7、1:0.3:0.8、1:0.3:0.9、1:0.3:1、1:0.3:2、1:0.3:3、1:0.3:4、1:0.3:5、1:0.4:0.6、1:0.4:0.7、1:0.4:0.8、1:0.4:0.9、1:0.4:1、1:0.4:2、1:0.4:3、1:0.4:4、1:0.4:5、1:0.5:0.6、1:0.5:0.7、1:0.5:0.8、1:0.5:0.9、1:0.5:1、1:0.5:2、1:0.5:3、1:0.5:4、1:0.5:5、2:0.1:0.6、2:0.1:0.7、2:0.1:0.8、2:0.1:0.9、2:0.1:1、2:0.1:2、2:0.1:3、2:0.1:4、2:0.1:5、2:0.2:0.6、2:0.2:0.7、2:0.2:0.8、2:0.2:0.9、2:0.2:1、2:0.2:2、2:0.2:3、2:0.2:4、2:0.2:5、2:0.3:0.6、2:0.3:0.7、2:0.3:0.8、2:0.3:0.9、2:0.3:1、2:0.3:2、2:0.3:3、2:0.3:4、2:0.3:5、2:0.4:0.6、2:0.4:0.7、2:0.4:0.8、2:0.4:0.9、2:0.4:1、2:0.4:2、2:0.4:3、2:0.4:4、2:0.4:5、2:0.5:0.6、2:0.5:0.7、2:0.5:0.8、2:0.5:0.9、2:0.5:1、2:0.5:2、2:0.5:3、2:0.5:4、2:0.5:5、3:0.1:0.6、3:0.1:0.7、3:0.1:0.8、3:0.1:0.9、3:0.1:1、3:0.1:2、3:0.1:3、3:0.1:4、3:0.1:5、3:0.2:0.6、3:0.2:0.7、3:0.2:0.8、3:0.2:0.9、3:0.2:1、3:0.2:2、3:0.2:3、3:0.2:4、3:0.2:5、3:0.3:0.6、3:0.3:0.7、3:0.3:0.8、3:0.3:0.9、3:0.3:1、3:0.3:2、3:0.3:3、3:0.3:4、3:0.3:5、3:0.4:0.6、3:0.4:0.7、3:0.4:0.8、3:0.4:0.9、3:0.4:1、3:0.4:2、3:0.4:3、3:0.4:4、3:0.4:5、3:0.5:0.6、3:0.5:0.7、3:0.5:0.8、3:0.5:0.9、3:0.5:1、3:0.5:2、3:0.5:3、3:0.5:4、3:0.5:5、4:0.1:0.6、4:0.1:0.7、4:0.1:0.8、4:0.1:0.9、4:0.1:1、4:0.1:2、4:0.1:3、4:0.1:4、4:0.1:5、4:0.2:0.6、4:0.2:0.7, 4:0.2:0.8, 4:0.2:0.9, 4:0.2:1, 4:0.2:2, 4:0.2:3, 4:0.2:4, 4:0.2:5, 4:0.3:0.6, 4:0.3:0.7, 4:0.3:0.8, 4:0.3:0.9, 4:0.3:1, 4:0.3:2, 4:0.3:3, 4:0.3:4, 4:0.3:5, 4:0.4:0.6, 4:0.4:0.7, 4:0.4:0.8, 4:0 .4:0.9, 4:0.4:1, 4:0.4:2, 4:0.4:3, 4:0.4:4, 4:0.4:5, 4:0.5:0.6, 4:0.5:0.7, 4:0.5:0.8, 4:0.5:0.9, 4:0.5:1, 4:0.5:2, 4:0.5:3, 4:0.5:4, 4:0.5:5, 5:0.1:0.6, 5:0.1:0.7, 5:0.1:0.8, 5:0.1:0.9, 5:0.1:1, 5 :0.1:2、5:0.1:3、5:0.1:4、5:0.1:5、5:0.2:0.6、5:0.2:0.7、5:0.2:0.8、5:0.2:0.9、5:0.2:1、5:0.2:2、5:0.2:3、5:0.2:4、5:0.2:5、5:0.3:0.6、5:0.3:0.7、5:0.3:0.8、5:0.3:0.9、5:0.3:1、5:0.3:2、5:0.3:3、 5:0.3:4, 5:0.3:5, 5:0.4:0.6, 5:0.4:0.7, 5:0.4:0.8, 5:0.4:0.9, 5:0.4:1, 5:0.4:2, 5:0.4:3, 5:0.4:4, 5:0.4:5, 5:0.5:0.6, 5:0.5:0.7, 5:0.5:0.8, 5:0.5:0.9, 5:0.5:1, 5:0.5:2, 5:0.5:3, 5:0.5:4 or 5:0.5:5. .

[0148] A fourth aspect of the present disclosure provides use of the aforementioned composition or the aforementioned dressing in preparing a product for aftercare of light medical aesthetics.

[0149] In a specific embodiment of the present disclosure, the product is a cosmetic or a medical dressing.

[0150] In a specific embodiment of the present disclosure, the aforementioned composition or dressing is used after a patient undergoes aesthetic medical treatment.

[0151] Example

[0152] The following examples are illustrative only and are not intended to limit the scope or content of the present invention in any way.

[0153] Example 1

[0154] This embodiment provides a sodium colanate repair dressing. Sodium colanate 1.0wt%, carbomer 0.1wt%, polyethylene glycol 400 3.0wt%, tromethamine 0.3wt%, methylparaben 0.01wt%, and the balance is water. The content ratio of sodium colanate: carbomer: polyethylene glycol 400 is 1:0.1:3. The weight-average molecular weight of sodium colanate is 400kDa. The preparation steps are: weigh sodium colanate, dissolve it in purified water, place it in a steam sterilizer for pretreatment to remove endotoxins, 121°C, 30min, to obtain solution 1. Weigh carbomer and add it to a vacuum stirring tank, add purified water, heat at 80°C for 10min, stir mechanically until fully dissolved, and stir at a speed of 300rpm to obtain solution 2. Weigh polyethylene glycol 400 and methylparaben, add purified water, stir mechanically at room temperature until fully dissolved, and stir at a speed of 300rpm to obtain solution 3. Pour solution 3 into solution 2, stir evenly in a vacuum stirring tank, and then slowly add solution 1. Then gradually add tromethamine, adjust the pH to 7, and vacuum degassing to obtain sodium colanate repair dressing. Package and seal the sodium colanate repair dressing, and then steam sterilize (121°C, 30 minutes).

[0155] Example 2

[0156] This embodiment provides a sodium colanate repair dressing. Sodium colanate 1.0wt%, carbomer 0.3wt%, polyethylene glycol 400 3.0wt%, tromethamine 0.3wt%, methylparaben 0.01wt%, and the balance is water. The content ratio of sodium colanate: carbomer: polyethylene glycol 400 is 1:0.3:3. The weight-average molecular weight of sodium colanate is 400kDa. The preparation steps are: weigh sodium colanate, dissolve it in purified water, place it in a steam sterilizer for pretreatment to remove endotoxins, 121°C, 30min, to obtain solution 1. Weigh carbomer and add it to a vacuum stirring tank, add purified water, heat at 80°C for 10min, stir mechanically until fully dissolved, and stir at a speed of 300rpm to obtain solution 2. Weigh polyethylene glycol 400 and methylparaben, add purified water, stir mechanically at room temperature until fully dissolved, and stir at a speed of 300rpm to obtain solution 3. Pour solution 3 into solution 2, stir evenly in a vacuum stirring tank, and then slowly add solution 1. Then gradually add tromethamine, adjust the pH to 7, and obtain sodium colanate repair dressing after vacuum degassing. The sodium colanate repair dressing is packaged, sealed, and then steam sterilized (121° C., 30 min). The difference between Example 2 and Example 1 is that the carbomer ratio is adjusted to 0.3wt%, and the other components and preparation methods are the same.

[0157] Example 3

[0158] This embodiment provides a sodium colanate repair dressing. Sodium colanate 1.0wt%, carbomer 0.5wt%, polyethylene glycol 400 3.0wt%, tromethamine 0.3wt%, methylparaben 0.01wt%, and the balance is water. The content ratio of sodium colanate: carbomer: polyethylene glycol 400 is 1:0.5:3. The weight-average molecular weight of sodium colanate is 400kDa. The preparation steps are: weigh sodium colanate, dissolve it in purified water, place it in a steam sterilizer for pretreatment to remove endotoxins, 121°C, 30min, to obtain solution 1. Weigh carbomer and add it to a vacuum stirring tank, add purified water, heat at 80°C for 10 minutes, stir mechanically until fully dissolved, and stir at a speed of 300rpm to obtain solution 2. Weigh polyethylene glycol 400 and methylparaben, add purified water, stir mechanically at room temperature until fully dissolved, and stir at a speed of 300rpm to obtain solution 3. Solution 3 is poured into solution 2, mechanically stirred in a vacuum stirring tank, and then solution 1 is slowly added. Tromethamine is then added gradually, the pH is adjusted to 7, and sodium colanate repair dressing is obtained after vacuum degassing. The sodium colanate repair dressing is packaged, sealed, and then steam sterilized (121° C., 30 min). The difference between Example 3 and Example 1 is that the proportion of carbomer is adjusted to 0.5wt%, and the other components and preparation methods are the same.

[0159] Example 4

[0160] This embodiment provides a sodium colanate repair dressing. Sodium colanate 1.0wt%, carbomer 0.1wt%, polyethylene glycol 400 1.0wt%, tromethamine 0.3wt%, methylparaben 0.01wt%, and the balance is water. The content ratio of sodium colanate: carbomer: polyethylene glycol 400 is 1:0.1:1. The weight-average molecular weight of sodium colanate is 400kDa. The preparation steps are: weigh sodium colanate, dissolve it in purified water, place it in a steam sterilizer for pretreatment to remove endotoxins, 121°C, 30min, to obtain solution 1. Weigh carbomer and add it to a vacuum stirring tank, add purified water, heat at 80°C for 10min, stir mechanically until fully dissolved, and stir at a speed of 300rpm to obtain solution 2. Weigh polyethylene glycol 400 and methylparaben, add purified water, stir mechanically at room temperature until fully dissolved, and stir at a speed of 300rpm to obtain solution 3. Solution 3 is poured into solution 2, mechanically stirred evenly in a vacuum stirring tank, and then solution 1 is slowly added. Tromethamine is then added gradually, the pH is adjusted to 7, and sodium colanate repair dressing is obtained after vacuum degassing. The sodium colanate repair dressing is packaged, sealed, and then steam sterilized (121° C., 30 min). The difference between Example 4 and Example 1 is that the proportion of polyethylene glycol 400 is adjusted to 1.0wt%, and the other components and preparation methods are the same.

[0161] Example 5

[0162] This embodiment provides a sodium colanate repair dressing. Sodium colanate 1.0wt%, carbomer 0.1wt%, polyethylene glycol 400 5.0wt%, tromethamine 0.3wt%, methylparaben 0.01wt%, and the balance is water. The content ratio of sodium colanate: carbomer: polyethylene glycol 400 is 1:0.1:5. The weight-average molecular weight of sodium colanate is 400kDa. The preparation steps are: weigh sodium colanate, dissolve it in purified water, place it in a steam sterilizer for pretreatment to remove endotoxins, 121°C, 30min, to obtain solution 1. Weigh carbomer and add it to a vacuum stirring tank, add purified water, heat at 80°C for 10min, stir mechanically until fully dissolved, and stir at a speed of 300rpm to obtain solution 2. Weigh polyethylene glycol 400 and methylparaben, add purified water, stir mechanically at room temperature until fully dissolved, and stir at a speed of 300rpm to obtain solution 3. Solution 3 is poured into solution 2, mechanically stirred evenly in a vacuum stirring tank, and then solution 1 is slowly added. Tromethamine is then added gradually, the pH is adjusted to 7, and sodium colanate repair dressing is obtained after vacuum degassing. The sodium colanate repair dressing is packaged, sealed, and then steam sterilized (121° C., 30 min). The difference between Example 5 and Example 1 is that the proportion of carbomer is increased to 5.0wt%, and the other components and preparation methods are the same.

[0163] Example 6

[0164] This embodiment provides a sodium colanate repair dressing. Sodium colanate 1.0wt%, carbomer 0.1wt%, polyethylene glycol 400 3.0wt%, tromethamine 0.3wt%, methylparaben 0.01wt%, and the balance is water. The content ratio of sodium colanate: carbomer: polyethylene glycol 400 is 1:0.1:3. The weight-average molecular weight of sodium colanate is 8000kDa. The preparation steps are: weigh sodium colanate, dissolve it in purified water, place it in a steam sterilizer for pretreatment to remove endotoxins, 121°C, 30min, to obtain solution 1. Weigh carbomer and add it to a vacuum stirring tank, add purified water, heat at 80°C for 10min, stir mechanically until fully dissolved, and stir at a speed of 300rpm to obtain solution 2. Weigh polyethylene glycol 400 and methylparaben, add purified water, stir mechanically at room temperature until fully dissolved, and stir at a speed of 300rpm to obtain solution 3. Solution 3 is poured into solution 2, mechanically stirred evenly in a vacuum stirring tank, and then solution 1 is slowly added. Tromethamine is then added gradually, the pH is adjusted to 7, and the sodium colanate repair dressing is obtained after vacuum degassing. The sodium colanate repair dressing is packaged, sealed, and then steam sterilized (121° C., 30 min). The difference between Example 6 and Example 1 is that the molecular weight of sodium colanate is 8000 kDa, and the other components and preparation methods are the same.

[0165] Example 7

[0166] This embodiment provides a sodium colanate repair dressing. Sodium colanate 2.0wt%, carbomer 0.1wt%, polyethylene glycol 400 3.0wt%, tromethamine 0.3wt%, methylparaben 0.01wt%, and the remainder is water. The content ratio of sodium colanate: carbomer: polyethylene glycol 400 is 2:0.1:3. The weight-average molecular weight of sodium colanate is 400kDa. The preparation steps are: weigh sodium colanate, dissolve it in purified water, place it in a steam sterilizer for pretreatment to remove endotoxins, 121°C, 30min, to obtain solution 1. Weigh carbomer and add it to a vacuum stirring tank, add purified water, heat at 80°C for 10min, stir mechanically until fully dissolved, and stir at a speed of 300rpm to obtain solution 2. Weigh polyethylene glycol 400 and methylparaben, add purified water, stir mechanically at room temperature until fully dissolved, and stir at a speed of 300rpm to obtain solution 3. Solution 3 is poured into solution 2, mechanically stirred in a vacuum stirring tank, and then solution 1 is slowly added. Tromethamine is then added gradually, the pH is adjusted to 7, and a sodium colanate repair dressing is obtained after vacuum degassing. The sodium colanate repair dressing is packaged, sealed, and then steam sterilized (121° C., 30 min). The difference between Example 7 and Example 1 is that the sodium colanate ratio is adjusted to 2.0wt%, and the other components and preparation methods are the same.

[0167] Example 8

[0168] This embodiment provides a sodium colanate repair dressing. Sodium colanate 1.0wt%, carbomer 0.1wt%, polyethylene glycol 400 3.0wt%, tromethamine 0.2wt%, methylparaben 0.02wt%, and the remainder is water. The content ratio of sodium colanate: carbomer: polyethylene glycol 400 is 1:0.1:3. The weight-average molecular weight of sodium colanate is 400kDa. The preparation steps are: weigh sodium colanate, dissolve it in purified water, place it in a steam sterilizer for pretreatment to remove endotoxins, 121°C, 30min, to obtain solution 1. Weigh carbomer and add it to a vacuum stirring tank, add purified water, heat at 80°C for 10min, stir mechanically until fully dissolved, and stir at a speed of 300rpm to obtain solution 2. Weigh polyethylene glycol 400 and methylparaben, add purified water, stir mechanically at room temperature until fully dissolved, and stir at a speed of 300rpm to obtain solution 3. Pour solution 3 into solution 2, stir evenly in a vacuum stirring tank, and then slowly add solution 1. Then gradually add tromethamine, adjust the pH to 7, and obtain sodium colanate repair dressing after vacuum degassing. The sodium colanate repair dressing is packaged, sealed, and then steam sterilized (121° C., 30 min). The difference between Example 8 and Example 1 is that the ratio of tromethamine and methylparaben is appropriately adjusted, and the other components and preparation methods are the same.

[0169] Comparative Example 1

[0170] This comparative example provides a sodium hyaluronate repair dressing. Sodium hyaluronate 1.0wt%, carbomer 0.1wt%, polyethylene glycol 400 3.0wt%, tromethamine 0.3wt%, methylparaben 0.01wt%, and the balance is water. The content ratio of sodium hyaluronate: carbomer: polyethylene glycol 400 is 1:0.1:3. The weight-average molecular weight of sodium hyaluronate is 100kDa. The preparation steps are: weigh sodium hyaluronate, dissolve it in purified water, place it in a steam sterilizer for pretreatment to remove endotoxins, 121°C, 30min, to obtain solution 1. Weigh carbomer and add it to a vacuum stirring tank, add purified water, heat at 80°C for 10min, stir mechanically until fully dissolved, and stir at a speed of 300rpm to obtain solution 2. Weigh polyethylene glycol 400 and methylparaben, add purified water, stir mechanically at room temperature until fully dissolved, and stir at a speed of 300rpm to obtain solution 3. Solution 3 is poured into solution 2, mechanically stirred evenly in a vacuum stirring tank, and then solution 1 is slowly added. Tromethamine is then added gradually, the pH is adjusted to 7, and a sodium hyaluronate repair dressing is obtained after vacuum degassing. The sodium hyaluronate repair dressing is packaged, sealed, and then steam sterilized. Comparative Example 1 is different from Example 1 in that sodium hyaluronate is used instead of sodium colanate, and the other components and preparation methods are the same. Sodium hyaluronate is an outsourced reagent.

[0171] Comparative Example 2

[0172] This comparative example provides a sodium colanate repair dressing. Sodium colanate 1.0wt%, carbomer 0.1wt%, polyethylene glycol 400 3.0wt%, tromethamine 0.3wt%, methylparaben 0.01wt%, and the balance is water. The content ratio of sodium colanate: carbomer: polyethylene glycol 400 is 1:0.1:3. The weight-average molecular weight of sodium colanate is 400kDa. The preparation steps are: weigh sodium colanate, dissolve it in purified water, place it in a steam sterilizer for pretreatment to remove endotoxins, 121°C, 5min, to obtain solution 1. Weigh carbomer and add it to a vacuum stirring tank, add purified water, heat at 80°C for 10min, stir mechanically until fully dissolved, and stir at a speed of 300rpm to obtain solution 2. Weigh polyethylene glycol 400 and methylparaben, add purified water, stir mechanically at room temperature until fully dissolved, and stir at a speed of 300rpm to obtain solution 3. Solution 3 is poured into solution 2, mechanically stirred evenly in a vacuum stirring tank, and then solution 1 is slowly added. Tromethamine is then added gradually, the pH is adjusted to 7, and sodium colanate repair dressing is obtained after vacuum degassing. The sodium colanate repair dressing is packaged, sealed, and then steam sterilized. The difference between Comparative Example 2 and Example 1 is that the steam pretreatment process time is 5 minutes, and the other components and preparation methods are the same.

[0173] Comparative Example 3

[0174] This comparative example provides a sodium colanate repair dressing. Sodium colanate 1.0wt%, carbomer 0.0wt%, polyethylene glycol 400 3.0wt%, tromethamine 0.3wt%, methylparaben 0.01wt%, and the remainder is water. The content ratio of sodium colanate: carbomer: polyethylene glycol 400 is 1:0:3. The weight-average molecular weight of sodium colanate is 400kDa. The preparation steps are: weigh sodium colanate, dissolve it in purified water, place it in a steam sterilizer for pretreatment to remove endotoxins, 121°C, 30min, to obtain solution 1. Weigh carbomer and add it to a vacuum stirring tank, add purified water, heat at 80°C for 10min, stir mechanically until fully dissolved, and stir at a speed of 300rpm to obtain solution 2. Weigh polyethylene glycol 400 and methylparaben, add purified water, stir mechanically at room temperature until fully dissolved, and stir at a speed of 300rpm to obtain solution 3. Solution 3 is poured into solution 2, mechanically stirred evenly in a vacuum stirring tank, and then solution 1 is slowly added. Tromethamine is then added gradually, the pH is adjusted to 7, and sodium colanate repair dressing is obtained after vacuum degassing. The sodium colanate repair dressing is packaged, sealed, and then steam sterilized. Comparative Example 3 is different from Example 1 in that the carbomer content is 0.0wt%, and the other components and preparation methods are the same.

[0175] Comparative Example 4

[0176] This comparative example provides a sodium colanate repair dressing. Sodium colanate 1.0wt%, carbomer 0.1wt%, polyethylene glycol 400 0.0wt%, tromethamine 0.3wt%, methylparaben 0.01wt%, and the balance is water. The content ratio of sodium colanate: carbomer: polyethylene glycol 400 is 1:0.1:0. The weight-average molecular weight of sodium colanate is 400kDa. The preparation steps are: weigh sodium colanate, dissolve it in purified water, place it in a steam sterilizer for pretreatment to remove endotoxins, 121°C, 30min, to obtain solution 1. Weigh carbomer and add it to a vacuum stirring tank, add purified water, heat at 80°C for 10min, stir mechanically until fully dissolved, and stir at a speed of 300rpm to obtain solution 2. Weigh polyethylene glycol 400 and methylparaben, add purified water, stir mechanically at room temperature until fully dissolved, and stir at a speed of 300rpm to obtain solution 3. Solution 3 is poured into solution 2, mechanically stirred in a vacuum stirring tank, and then solution 1 is slowly added. Tromethamine is then added gradually, the pH is adjusted to 7, and sodium colanate repair dressing is obtained after vacuum degassing. The sodium colanate repair dressing is packaged, sealed, and then steam sterilized. Comparative Example 4 is different from Example 1 in that the content of polyethylene glycol 400 is 0.0wt%, and the other components and preparation methods are the same.

[0177] Comparative Example 5

[0178] This comparative example provides a sodium colanate repair dressing. Sodium colanate 1.0wt%, carbomer 0.1wt%, polyethylene glycol 400 3.0wt%, tromethamine 0.3wt%, methylparaben 0.01wt%, and the balance is water. The content ratio of sodium colanate: carbomer: polyethylene glycol 400 is 1:0.1:3. The weight-average molecular weight of sodium colanate is 4kDa. The preparation steps are: weigh sodium colanate, dissolve it in purified water, place it in a steam sterilizer for pretreatment to remove endotoxins, 121°C, 30min, to obtain solution 1. Weigh carbomer and add it to a vacuum stirring tank, add purified water, heat at 80°C for 10min, stir mechanically until fully dissolved, and stir at a speed of 300rpm to obtain solution 2. Weigh polyethylene glycol 400 and methylparaben, add purified water, stir mechanically at room temperature until fully dissolved, and stir at a speed of 300rpm to obtain solution 3. Solution 3 is poured into solution 2, mechanically stirred evenly in a vacuum stirring tank, and then solution 1 is slowly added. Tromethamine is then added gradually, the pH is adjusted to 7, and sodium colanate repair dressing is obtained after vacuum degassing. The sodium colanate repair dressing is packaged, sealed, and then steam sterilized. Comparative Example 5 is different from Example 1 in that the weight average molecular weight of sodium colanate is 4 kDa, and the other components and preparation methods are the same. Sodium colanate with a molecular weight of 4 kDa is obtained by repeated hydrolysis process.

[0179] Comparative Example 6

[0180] This comparative example provides a repair dressing. 0.0wt% sodium colanate, 0.1wt% carbomer, 3.0wt% polyethylene glycol 400, 0.3wt% tromethamine, 0.01wt% methylparaben, and the remainder is water. The content ratio of sodium colanate: carbomer: polyethylene glycol 400 is 0:0.1:3. The weight-average molecular weight of sodium colanate is 400kDa. The preparation steps are: weigh sodium colanate, dissolve it in purified water, place it in a steam sterilizer for pretreatment to remove endotoxins, 121°C, 30min, to obtain solution 1. Weigh carbomer and add it to a vacuum stirring tank, add purified water, heat at 80°C for 10min, stir mechanically until fully dissolved, and stir at a speed of 300rpm to obtain solution 2. Weigh polyethylene glycol 400 and methylparaben, add purified water, stir mechanically at room temperature until fully dissolved, and stir at a speed of 300rpm to obtain solution 3. Solution 3 is poured into solution 2, mechanically stirred evenly in a vacuum stirring tank, and then solution 1 is slowly added. Tromethamine is then added gradually, the pH is adjusted to 7, and a sodium colanate repair dressing is obtained after vacuum degassing. The sodium colanate repair dressing is packaged, sealed, and then steam sterilized. Comparative Example 6 is different from Example 1 in that the sodium colanate content is 0.0wt%, and the other components and preparation methods are the same.

[0181] Table 1 Summary of Examples and Comparative Examples

[0182]

[0183] In order to verify the influence of the composition ratio of the present invention on the performance, as well as the influence on the efficacy performance and biosafety, a comparative study and analysis of one or more samples in the above-mentioned embodiments and comparative examples was conducted.

[0184] Test Example 1

[0185] The sodium colanate repair dressings prepared in Examples 1, 2, 3 and Comparative Example 3 were subjected to viscosity and macroscopic film-forming effect test tests. The viscosity test method refers to the viscosity determination method of Part IV of the Chinese Pharmacopoeia (2020 edition) 0633. The macroscopic film-forming effect test refers to the document "Performance Test of Recombinant Collagen Liquid Dressing for Class II Medical Devices [J]. 2024" by Wang Xiaochen et al.

[0186] The results show (Table 2): Carbomer as a coagulant has a certain effect on the viscosity and physical film formation of sodium colanate repair dressings. The lower the carbomer content, the lower the viscosity. When carbomer is not included, the viscosity is too low and it is difficult to form a film.

[0187] Table 2 Effect of carbomer on dressing viscosity and macroscopic film-forming effect

[0188] Example Name Carbomer / wt% Viscosity / mPas Macro film-forming effect Example 1 0.1 1501 Good film formation and thin thickness Example 2 0.3 2674 Good film formation and moderate thickness Example 3 0.5 4159 Good film formation and thicker thickness Comparative Example 3 0.0 235 The viscosity is too low to form a film

[0189] Test Example 2

[0190] The sodium colanate repair dressings prepared in Examples 1, 4, 5 and Comparative Example 4 were subjected to solution uniformity and macroscopic film-forming effect test tests. The uniformity test was observed with the naked eye, and the macroscopic film-forming effect test was the same as that in Test Example 1. The results (Table 3) show that polyethylene glycol 400 has a certain influence on the uniformity of solution dispersion during the preparation of sodium colanate repair dressings. The lower the content of polyethylene glycol 400, the worse the uniformity. When polyethylene glycol 400 is not present, the uniformity of the prepared solution is too low, and it is difficult to form a uniform dressing solution.

[0191] Table 3 Effect of polyethylene glycol 400 on dressing film formation

[0192] Example Name Polyethylene glycol 400 / wt% Solution homogeneity Example 1 3.0 The solution is uniform and has no clumps. Example 4 1.0 The solution is relatively uniform, with very few flocs Example 5 5.0 The solution is uniform and has no clumps. Comparative Example 4 0.0 Uneven, with more clumps

[0193] Test Example 3

[0194] The present invention conducts macroscopic film-forming effect, water vapor permeability and other physical film-forming, moisturizing and breathability tests on the sodium hyaluronate repair dressings prepared in Examples 1, 7 and 6 and the sodium hyaluronate dressing prepared in Comparative Example 1 (see Table 4). Macroscopic film-forming effect detection method general test example 1. Water vapor permeability detection refers to the method of "YY / T 0471.2-2004 Test method for contact wound dressings Part 2: Water vapor permeability of breathable film dressings". The results show that as the content of sodium hyaluronate increases, the film-forming effect and uniformity gradually increase, the water vapor permeability gradually decreases, and the moisturizing effect increases. At the same content, compared with the commonly used sodium hyaluronate dressings on the market, the film-forming effect and water vapor permeability of the sodium hyaluronate dressing are slightly better.

[0195] At the same time, 20 SD rats were selected and divided into 4 groups according to Table 4. Each group used the dressing samples of Example 1, 7, 6, and Comparative Example 1, respectively, to simulate the light medical aesthetic laser treatment of the human body. First, the skin preparation area of ​​the experimental animals was treated with CO 2 The laser device (power of about 60W) made a 4cm×4cm square laser treatment wound model in the center of the back, and the dressing was applied in groups for 30 minutes each time. The wound was observed every day after surgery. The experimental period was 2 weeks. The dressing was changed once a day in the first week; the dressing was changed once every 2 days in the second week. The animal experiment was commissioned by Standkechuang Pharmaceutical Technology (Qingdao) Co., Ltd., and the experimental animals were from Jinan Pengyue Experimental Animal Breeding Co., Ltd. The skin moisture content and transepidermal water loss of the affected skin after surgery, as well as the moisturizing and wound healing effects of wound repair were tested using a skin tester (see Table 5). The results showed that with the increase of sodium hyaluronate content, the skin moisture content increased after laser surgery, and the transepidermal water loss decreased, showing a good moisturizing effect. In addition, the wound healing rate also increased. It can be seen that the increase of sodium hyaluronate helps to accelerate the promotion of wound repair. At the same content, compared with the commonly used sodium hyaluronate dressings on the market, the skin moisture content, transepidermal water loss, and wound repair effects of sodium hyaluronate dressings are comparable.

[0196] Table 4 Effect of sodium colanate content on film-forming effect and water vapor transmission rate

[0197] Table 5 Effect of sodium colanate content on skin moisture content, transepidermal water loss and wound repair in animals after laser treatment

[0198] Test Example 4

[0199] The present invention uses the repair dressings prepared by using sodium colanate with different weight average molecular weights in Example 1, Example 6 and Comparative Example 5 to conduct macroscopic film-forming effect detection tests and raw material cost analysis. The results show (Table 6) that the molecular weight affects the film-forming property of the dressing. When the molecular weight is low, not only is the film-forming property poor, but it is also difficult to form a uniform film; however, when the molecular weight exceeds 8000 kDa, the production capacity may be limited.

[0200] Table 6 Effect of molecular weight of sodium colanate on film-forming effect of dressing

[0201] Example Name Sodium colanate weight average molecular weight / kDa Macro film-forming effect Example 1 400 Good film formation and uniformity Example 6 8000 Good film formation and uniformity, but limited production capacity Comparative Example 5 4 Poor film formation

[0202] Test Example 5

[0203] The present invention performs bacterial endotoxin and antibacterial detection on the sodium colanate repair dressing prepared in Example 1 and Comparative Example 2. In addition, the dressing is tested for pyrogen, cytotoxicity, irritation, intradermal reaction, and acute toxicity-related biocompatibility according to the GB / T 16886 series of standards; bacterial endotoxin detection is performed with reference to the 1143 bacterial endotoxin test method of Part IV of the Chinese Pharmacopoeia (2020 edition); and antibacterial detection is performed with reference to the WS / T 650-2019 antibacterial and antibacterial effect evaluation method. The results show that the parameters of steam treatment directly affect the bacterial endotoxin and pyrogen properties of sodium colanate repair dressings. If the steam pretreatment meets the requirements, the bacterial endotoxin and pyrogen results of the dressing are qualified, meeting the requirements of medical device products (medical devices require that the bacterial endotoxin of wound care equipment is not higher than 20EU / piece, and there should be no pyrogenic reaction); on the contrary, if the steam pretreatment is not in place, the bacterial endotoxin and pyrogen are unqualified. In addition, from the perspective of antibacterial activity, cytotoxicity, irritation, intradermal reaction, and acute toxicity, the results of both groups of samples were qualified, indicating that the sodium colanate repair dressing has good biocompatibility (Table 7).

[0204] Table 7 Effect of steam pretreatment on bacterial endotoxins and biocompatibility

[0205]

[0206] Test Example 6

[0207] Conduct human trial experiment of dressing. Select Example 1 for experiment, select 15 volunteers, use it once every 2 days, and use it continuously for 7 days. The use steps are: first clean the affected area and surrounding skin, unfold the dressing and apply it to the affected area evenly, and apply it for 15-30 minutes. Observe the multi-dimensional evaluation of the initial experience of unpacking, during use, and after use. The results are shown in the attached Figure 1 As shown in the data, there was no adverse feedback during the entire use process, and the overall skin feel was good, which shows that the sodium colanate repair dressing has good applicability, as well as good skin feel and moisturizing effects.

[0208] Incorporated by Reference

[0209] Each patent and scientific article mentioned herein is incorporated by reference in its entirety for all purposes.

[0210] Equivalence

[0211] The present invention may be embodied in other specific ways without departing from its spirit or essential characteristics. Therefore, the above embodiments should be regarded as illustrative in all cases, rather than limiting the invention described herein. Therefore, the scope of the present invention is indicated by the appended claims rather than by the above description, and it is intended that all changes within the equivalent meaning and scope of the claims are included therein.

Claims

1. A composition comprising a colanate, a coagulant, a dispersant, water, and optionally a pH adjuster and optionally a preservative.

2. The composition according to claim 1, wherein the colanate salt is sodium colanate, and preferably, the weight average molecular weight of sodium colanate is 400 kDa-8000 kDa.

3. The composition according to claim 1 or 2, wherein The coagulant is one or more selected from carbomer, kaolin and phospholipids, and / or The dispersant is one or more selected from methanol, ethanol, n-propanol, isopropanol, ethyl acetate, n-hexane and polyethylene glycol, and / or The pH regulator is one or more selected from citric acid, tartaric acid, citric acid, malic acid, chlorogenic acid, palmitic acid, glacial acetic acid, triethanolamine, sodium hydroxide, potassium hydroxide and tromethamine, and / or The preservative is one or more selected from the group consisting of sodium benzoate, potassium sorbate, sorbic acid and methylparaben.

4. The composition according to any one of claims 1 to 3, wherein The solution contains: water, sodium colanate, carbomer, polyethylene glycol 400, tromethamine and methylparaben.

5. The composition according to any one of claims 1 to 4, wherein The content of the colanate is about 0.5 wt % to about 5.0 wt %, preferably about 0.6 wt % to about 2.5 wt %, more preferably about 1 wt % to about 2 wt %.

6. The composition according to any one of claims 1 to 5, wherein The content of the coagulant is about 0.1 wt % to about 0.5 wt %, preferably about 0.1 wt % to about 0.3 wt % or about 0.3 wt % to about 0.5 wt %.

7. The composition according to any one of claims 1 to 6, wherein The dispersant may be present in an amount of about 1.0 wt % to about 5.0 wt %, preferably about 1.0 wt % to about 3.0 wt % or about 3.0 wt % to about 5.0 wt %.

8. The composition according to any one of claims 1 to 7, wherein the content of the pH adjuster is from about 0.1 wt% to about 0.5 wt%, preferably from about 0.1 wt% to about 0.4 wt%, more preferably from about 0.2 wt% to about 0.3 wt%.

9. The composition of any one of claims 1 to 8, wherein the preservative is present in an amount of about 0.01 wt% to about 0.1 wt%, preferably about 0.01 wt% to about 0.02 wt%.

10. The composition according to any one of claims 1 to 9, wherein The content ratio of the colanate, the coagulant and the dispersant is about 0.5-5:0.1-0.5:1-5, preferably about 0.6-2:0.1-0.5:1-5, and more preferably about 1-2:0.1-0.5:1-5.

11. A dressing comprising: a substrate and the composition according to any one of claims 1 to 10, wherein: The substrate serves as a carrier of the dressing.

12. The dressing according to claim 11, wherein The substrate is a hydrophilic fiber membrane.

13. The dressing according to claim 11, wherein The substrate is one or more of non-woven fabric, gauze, fruit fiber membrane, silk membrane, tencel membrane, bacterial cellulose membrane, trehalose membrane, chitosan membrane, and binchotan membrane.

14. A method for preparing the composition according to any one of claims 1 to 10 or the dressing according to any one of claims 11 to 13, comprising the following steps: (1) dissolving colanate in water and pretreating the water to obtain a solution A; (2) fully dissolving the coagulant in water to obtain solution B; (3) mixing the dispersant and the optional preservative and fully dissolving them in water to obtain a solution C; (4) Pour solution C into solution B and stir to obtain solution D, and evenly disperse solution A in solution D; (5) optionally adding a pH adjuster to adjust the pH to about 5 to about 7; (6) Vacuum degassing; (7) Packaging, sealing, and steam sterilization; (8) Optionally, the resulting solution is loaded onto a carrier.

15. The method according to claim 14, wherein: The pretreatment in step (1) is steam sterilization.

16. The method according to claim 14 or 15, wherein: The temperature of the steam sterilization treatment in step (1) and / or step (7) is about 100-130° C., and / or the time is about 10-60 min.

17. Use of the composition according to any one of claims 1 to 10 or the dressing according to any one of claims 11 to 13 in the preparation of a product for aftercare of light medical aesthetics.

18. The use according to claim 17, wherein The light medical beauty includes one or more of laser, radio frequency, ultrasound, fruit acid peel, Thermage, ultrasonic knife, and water light injection treatment.

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