Composite fungal polysaccharide nutritious food with effects of strengthening spleen and stomach, resisting cancer and enhancing immunity and application of composite fungal polysaccharide nutritious food

Abstract

The invention relates to a composite fungal polysaccharide nutritious food with the effects of strengthening the spleen and stomach, resisting cancer and enhancing immunity and application of the composite fungal polysaccharide nutritious food. The staple food grain in the product contains 15-50% of millet and 10-30% of oat; the spleen and stomach strengthening food and medicine contains 20-30% of Chinese yam, 10-20% of poria cocos, 10-15% of scutellaria baicalensis, 5-10% of codonopsis pilosula, 5-10% of angelica sinensis, 5-10% of bighead atractylodes rhizome, 5-10% of radix rehmanniae preparata, 5-10% The polysaccharide is mainly prepared from the following raw materials in percentage by weight: 10%-20% of chestnut polysaccharide, 5%-20% of grifola frondosa polysaccharide, 10%-20% of jujube polysaccharide, 10%-20% of lentinan, 10%-20% of hericium erinaceus polysaccharide, 5%-20% of ganoderma lucidum polysaccharide, 5%-20% of agaricus blazei murill polysaccharide, 5%-15% of oyster mushroom polysaccharide and 5%-10% of cordyceps militaris polysaccharide. The composite fungal polysaccharide has the characteristics that fungi rich in active polysaccharides are taken as main materials, the components of the improved traditional Chinese medicine ten-component tonic prescription are reasonably combined, the millet and the oat are matched for combined action, the immunity of the organism is enhanced through multiple ways, and the composite fungal polysaccharide has a good effect on cancer recovery; the traditional Chinese medicine composition has the effects of strengthening the spleen and stomach, has an obvious effect of enhancing immunity, and has a good health-care effect on common people.

Description

Technical Field

[0001] The composite fungal polysaccharide of the present invention is characterized in that it is mainly made of active polysaccharides rich in fungi, and is prepared by rationally combining the ingredients of improved food and medicine tonic prescriptions and cooperating with millet and oats. The composite fungal polysaccharide nutritious food of the present invention and its application. Background Art

[0002] Polysaccharides are a type of active polysaccharides isolated from fungal fruiting bodies, mycelium, and fermentation broth that can control cell division and differentiation, regulate cell growth and aging. They are generally high-molecular polymers composed of more than ten monosaccharide molecules connected by glycosidic bonds. Fungal polysaccharide monomers are largely linked by β (1-3) and β (1-6) glycosidic bonds to form chain molecules with a helical stereo configuration. Scientific experiments have shown that fungal polysaccharides have very strong anti-tumor activity and have a strong inhibitory effect on cancer cells. They also play an important role in immune regulation, lowering blood pressure, lowering blood lipids, anti-thrombosis, stomach and liver protection, etc. Fungal polysaccharides are now widely used in the clinical treatment of immunodeficiency diseases, autoimmune diseases, tumors and other diseases, and are therefore called an important biological effect regulator. Summary of the invention

[0003] The composite fungal polysaccharide of the present invention is characterized in that the main ingredient is fungi rich in active polysaccharides, and the ingredients of the improved traditional Chinese medicine Shiquan Dabu prescription are reasonably combined, and the joint action of millet and oats is used to enhance the body's immunity through multiple pathways, and has a good effect on cancer recovery; the present invention has the effects of strengthening the spleen and stomach, has a significant effect on enhancing immunity, and has a good health care effect on the general population.

[0004] When the product is made into granules, it is prepared from the following raw materials in weight proportions: the staple food contains 15%-50% millet and 10%-30% oats; the spleen and stomach invigorating food contains 20%-30% yam, 10%-20% poria, 10%-15% scutellaria, 5%-10% codonopsis, 5%-10% angelica, 5%-10% atractylodes, 5%-10% tangerine peel, 5%-10% rehmannia, 5%-10% roasted liquorice, and 10%-20% coix seed; chestnut polysaccharide 10%-20%, maitake polysaccharide 5%-20%, jujube polysaccharide 5%-15%, shiitake polysaccharide 10%-20%, hericium erinaceus polysaccharide 10%-20%, ganoderma lucidum polysaccharide 5%-20%, Agaricus blazei polysaccharide 5%-20%, and Cordyceps militaris polysaccharide 5%-10%.

[0005] When the product is made into oral liquid, it is prepared from the following raw materials in weight proportion: the staple food contains 10%-20% millet and 10%-15% oats; the spleen and stomach invigorating food contains 10%-20% yam, 15%-20% poria, 10%-15% scutellaria, 5%-10% codonopsis, 5%-10% angelica, 5%-10% atractylodes, 5%-10% tangerine peel, 5%-10% rehmannia, 5%-10% roasted liquorice, and 10% coix seed; 10%-20% chestnut polysaccharide, 5%-20% maitake polysaccharide, 5%-10% jujube polysaccharide, 10%-20% shiitake polysaccharide, 5%-15% hericium erinaceus polysaccharide, 5%-10% ganoderma lucidum polysaccharide, 5%-10% agaricus murill polysaccharide, and 5%-10% cordyceps militaris polysaccharide.

[0006] Millet is a grain crop with high nutritional value. Traditional Chinese medicine believes that millet tastes sweet and salty, and has the effects of clearing away heat, quenching thirst and removing dampness from the stomach. Modern science has confirmed that in addition to preventing and treating symptoms such as indigestion, nausea, and vomiting, millet can also nourish yin and blood. The tryptophan content in millet is the highest among cereals, and tryptophan also has the function of regulating sleep.

[0007] Oats are a plant of the Gramineae family. They are called brome and wild wheat in the Compendium of Materia Medica. They are low-sugar, high-nutrition, and high-energy foods. Oats are sweet and mild in nature. They can nourish the spleen and heart, and restrain sweating. They have high nutritional value. They can be used for patients with spontaneous sweating, night sweats, or tuberculosis. Oats are rich in dietary fiber, can promote gastrointestinal motility, facilitate defecation, and are low in calories. In 1997, the U.S. FDA recognized oats as a functional food that has the effect of lowering cholesterol and stabilizing blood sugar. Oats ranked fifth in the "Top Ten Healthiest Foods in the World" selected by Time magazine, and are the only cereal on the list.

[0008] Lentinan is a typical T cell activator, which can promote the production of cytotoxic T lymphocytes (C cells) in vivo and in vitro, improve the killing activity of CTL, enhance the delayed hypersensitivity (DTH) of normal or immunocompromised mice, and increase the activity of antibody-dependent cytotoxic cells (ADDC). A large number of literatures have proved that Lentinan has strong anti-tumor activity and regulates the body's immune function.

[0009] Chestnut polysaccharides can enhance the body's immunity. They are rich in vitamin D and various B vitamins, can promote calcium absorption and enhance resistance. Chestnut polysaccharides are heteropolysaccharides composed of monosaccharides such as pentose and hexose, among which the monosaccharide composition includes at least one of glucose, arabinose, galactose, ribose, rhamnose, xylose and mannose. Chestnut polysaccharides show strong inhibitory effects on cancerous cell lines of various cancers and can effectively inhibit the proliferation of related cancer cells.

[0010] Cordyceps militaris polysaccharide, also known as Cordyceps sinensis, is considered by Chinese medicine to be the only Chinese medicine that can balance and regulate yin and yang at the same time. Cordyceps militaris contains more cordyceps polysaccharide, cordycepin, cordycepic acid and a variety of amino acids, and has health benefits such as enhancing immunity, anti-cancer, and delaying aging.

[0011] Grifola frondosa polysaccharide, commonly known as "maitake mushroom", is rich in iron, copper, vitamin C, selenium, chromium, calcium, vitamin D and other substances, and has extremely high medical and health functions. In particular, the high content of selenium and β-glucan in Grifola frondosa makes it have strong anti-cancer, anti-tumor, immunity enhancement and anti-aging effects.

[0012] Agaricus blazei polysaccharide, native to Brazil, is rich in polysaccharides, which are 5 times more than those of Ganoderma lucidum. It has a high anti-cancer effect and can effectively enhance the body's immunity. One of the β-D-glucans can directly enhance the activity of phagocytes, macrophages and natural immune cells, and has a unique anti-tumor effect.

[0013] Jujube polysaccharides have multiple pharmacological activities. Jujube polysaccharides are the main active ingredients of jujube for replenishing qi and producing blood. Jujube polysaccharides have antioxidant effects on various active oxygen in the human body, repair liver damage, anti-fatigue effects, immune activity, improve the intestines, inhibit tumor cells and promote calcium absorption.

[0014] Ganoderma lucidum polysaccharide is believed by traditional Chinese medicine to replenish qi and strengthen the spleen, calm the mind and soothe the nerves. Modern research shows that it has the effects of enhancing immunity, anti-tumor and assisting in tumor treatment, and is significantly effective in treating insomnia and indigestion.

[0015] Hericium erinaceus polysaccharide is an edible fungus polysaccharide that enhances immunity, protects the gastric mucosa, and improves the adverse reactions of tumor chemotherapy, such as lack of appetite, vomiting, nausea, and leukopenia.

[0016] Yam nourishes the spleen and stomach, promotes the production of body fluids and benefits the lungs, and nourishes the kidneys and astringes the essence. Yam is rich in nutrients, such as protein, carbohydrates, multiple vitamins, and multiple enzymes, which help to strengthen the spleen and stomach functions, moisten the lungs and relieve coughs, and nourish the kidneys and consolidate essence.

[0017] Poria cocos is diuretic and can invigorate the spleen and calm the mind. It has a significant effect on treating symptoms such as spleen and stomach weakness, edema, palpitations, and insomnia. It can also enhance immunity and has anti-cancer and anti-tumor effects.

[0018] Scutellaria baicalensis has the functions of clearing away heat and dampness, purging fire and detoxifying, stopping bleeding and calming the fetus. Scutellaria baicalensis is mainly used to treat damp-heat diseases, such as fever due to dampness and heat, chest tightness, jaundice, etc. It also has antibacterial and antiviral effects, and has inhibitory effects on a variety of pathogens.

[0019] Codonopsis pilosula replenishes qi, strengthens the spleen and lungs, nourishes blood and produces body fluid. Codonopsis pilosula is a commonly used qi-tonifying medicine, and has a good effect on treating symptoms such as spleen and lung qi deficiency, lack of appetite, fatigue, palpitations and shortness of breath. It can also enhance immune function and improve gastrointestinal function.

[0020] Tangerine peel, also known as orange peel, is used as medicine after being dried. It has the effects of regulating qi and strengthening the spleen, drying dampness and resolving phlegm. Tangerine peel is widely used to treat symptoms such as spleen and stomach qi stagnation, abdominal distension, loss of appetite, vomiting and diarrhea. Its unique aroma and taste can also help digestion and relieve stomach discomfort. In addition, the volatile oil components in tangerine peel also have antibacterial and anti-inflammatory effects, which have multiple benefits for human health.

[0021] Licorice root, as the "old man" in traditional Chinese medicine, has the effects of tonifying the spleen and replenishing qi, clearing away heat and detoxifying, removing phlegm and relieving cough, relieving pain, and harmonizing various medicines. Licorice root is effective in treating symptoms such as spleen and stomach weakness, fatigue, palpitations and shortness of breath. At the same time, licorice root can also detoxify and has a certain relieving effect on drug and food poisoning. In addition, glycyrrhizic acid and other ingredients in licorice root also have multiple pharmacological effects such as anti-inflammatory, anti-allergic, and antiviral.

[0022] Angelica sinensis nourishes blood, invigorates blood circulation, regulates menstruation and relieves pain, and moistens the intestines and promotes bowel movements. Angelica sinensis is a commonly used gynecological medicine, mainly used to treat symptoms such as blood deficiency, sallow complexion, dizziness, palpitations, and irregular menstruation. It can also enhance immunity and has anti-aging effects.

[0023] Atractylodes macrocephala can invigorate the spleen and replenish qi, dry dampness and promote diuresis, stop sweating and stabilize pregnancy. Atractylodes macrocephala has a significant effect on treating symptoms such as spleen and stomach weakness, loss of appetite, abdominal distension, and diarrhea. It can also promote water metabolism and has a diuretic effect.

[0024] Rehmannia glutinosa nourishes blood and yin, replenishes essence and fills marrow. Rehmannia glutinosa is mainly used to treat symptoms such as blood deficiency, sallow complexion, dizziness, palpitations, and irregular menstruation. It can also enhance immunity and has anti-aging effects.

[0025] Job's tears can invigorate water and eliminate dampness, strengthen the spleen and stop diarrhea, and remove numbness and discharge pus. Job's tears have significant effects on treating edema, athlete's foot, spleen deficiency diarrhea and other symptoms. It can also lower blood sugar and blood lipids, and has the effect of beautifying and nourishing the skin.

[0026] Specific implementation methods: The following are some specific embodiments to illustrate the present invention. It is necessary to point out that the following specific embodiments are only used to further illustrate the present invention and do not limit the protection scope of the present invention. Some non-essential modifications and adjustments made by others based on the present invention still fall within the protection scope of the present invention.

[0027] The present invention relates to a functional health food used as an auxiliary food granule. Embodiment 1 of the present invention comprises 15%-50% of millet and 10%-30% of oat; the spleen and stomach strengthening food comprises 20%-30% of yam, 10%-20% of poria, 10%-15% of scutellaria, 5%-10% of codonopsis, 5%-10% of angelica, 5%-10% of atractylodes, 5%-10% of tangerine peel, 5%-10% of prepared rehmannia, 5%-10% of roasted liquorice, 10%-20% of coix seed; 10%-20% of chestnut polysaccharide, 5%-20% of maitake polysaccharide, 5%-15% of jujube polysaccharide, 10%-20% of shiitake polysaccharide, 10%-20% of hericium erinaceus polysaccharide, 5%-20% of ganoderma lucidum polysaccharide, 5%-20% of Agaricus blazei polysaccharide and 5%-10% of cordyceps militaris polysaccharide.

[0028] Embodiment 2 of the present invention contains millet 20%-30%, oat 10%-40%; spleen and stomach invigorating food contains yam 10%-30%, Poria 10%-15%, Scutellaria 10%-15%, Codonopsis pilosula 5%-10%, Angelica 5%-10%, Atractylodes macrocephala 5%-10%, Tangerine peel 5%-10%, Rehmannia glutinosa 5%-10%, Radix Glycyrrhizae uralensis 5%-10%, Coix seeds 10%-15%; Chestnut polysaccharide 5%-10%, Grifola frondosa polysaccharide 5%-10%, jujube polysaccharide 5%-10%, Lentinan polysaccharide 5%-10%, Hericium erinaceus polysaccharide 5%-10%, Ganoderma lucidum polysaccharide 5%-10%, Agaricus blazei polysaccharide 5%-10%, Cordyceps militaris polysaccharide 5%-10%.

[0029] The present invention relates to a functional health food used as an auxiliary food granule, which comprises the following steps: preparing oat flakes: taking cleaned and enzyme-killed oat grains, steaming and ripening them for 2 hours in four stages with hot steam, wherein the first stage is 105-100°C, the second stage is 100-95°C, the third stage is 95-90°C, and the fourth stage is 95-105°C, and the time for each stage is 25-35 minutes; and then tableting, drying and cooling are performed to obtain oat flakes.

[0030] Millet machine selection and magnetic separation: adjust the machine to working state, remove stones and impurities from the selected millet, put them into the magnetic separator respectively, and wash them.

[0031] Coarse grinding: Put the clean oats and millet into the grinder and grind them to a precision of 100 mesh for later use.

[0032] Select 10-30 parts of yam, 8-20 parts of licorice, 10-20 parts of codonopsis, 10-20 parts of coix seeds, 15-30 parts of poria, 10-20 parts of angelica, 10-20 parts of coix seeds, 10-20 parts of atractylodes, 5-10 parts of tangerine peel, and 8-30 parts of rehmannia prepared, mix and then grind into ultrafine powder to process it into ultrafine powder of 80 to 120 mesh, so as to remove the crude fiber in these materials which can be used as both medicine and food.

[0033] Then add water of the same volume as the total of the above components, the water temperature is 85 degrees, and reflux extraction is performed for 2 hours. Then filter it and keep the filtrate. Add the same amount of water to the residue again, reflux extraction for 2 times as above, each time for 1.5 hours, filter it and keep the filtrate for later use.

[0034] Put the crushed millet and oats into the above filtrate at a ratio of 20 parts to 15 parts, soak for 24 hours, and then grind them three times on a colloid mill. The raw materials are fully mixed and dissolved, and sterilized with a sterilizer for 4 to 6 seconds at a humidity of 135 to 145°C. Then, the sterilized mixture is concentrated with a vacuum concentrator. The temperature in the vacuum concentrator is 58 to 60°C, and the vacuum degree is 620 to 700 mmHg. The concentrated slurry is required to reach a Baume degree of more than 13 degrees. Use a pressure spray tower to spray-dry the concentrated slurry to form fine dry powder. The inlet air temperature of the spray tower is between 145 and 160°C, and the temperature in the tower is 80 to 90°C. The obtained dry powder is tested according to quality standards for use.

[0035] Various polysaccharide extraction methods include: Soxhlet extraction, hot water extraction, acid-base extraction, pressurized solvent extraction, enzyme-assisted extraction, microwave extraction, ultrasonic extraction, supercritical extraction, etc. Preferably, the solvent extraction method is a pressurized solvent extraction method, which includes: mixing powdered chestnuts, ganoderma lucidum and various fungal raw materials with diatomaceous earth and placing them in an extraction container, using water as an extraction solvent, and extracting for 4 to 20 minutes at 50 to 70°C and 3 to 15 MPa. Further, the decolorization treatment includes: mixing the deproteinized chestnuts, ganoderma lucidum and various real raw material crude extracts with 15 to 25% H2O2, decolorizing at 40 to 55°C for 1.5 to 2.5 hours, adjusting the pH value of the chestnuts, ganoderma lucidum and various real raw material crude extracts to 6 to 7, and then concentrating under reduced pressure and drying to obtain polysaccharide extracts.

[0036] Mixing: Add 10-20% by mass fraction of the millet and oatmeal mixed powder obtained in step

[00034] to the chestnut and fungal polysaccharide obtained in step

[00035] , and stir for 12-15 minutes to make a powder of 80-100 mesh, dry it at 70°C, and then pack it at 50 g / bag.

[0037] The present invention relates to a nutritious food of composite fungal polysaccharide having the effects of strengthening spleen and stomach, anti-cancer and enhancing immunity, which comprises the following steps when used as an oral liquid:

[0038] Millet machine selection and magnetic separation: adjust the machine to working state, remove stones and impurities from the selected millet, put them into the magnetic separator respectively, and wash them.

[0039] Coarse grinding: Put clean oats, millet and yam 10%-30%, Poria 10%-15%, Scutellaria 10%-15%, Codonopsis pilosula 5%-10%, Angelica 5%-10%, Atractylodes 5%-10%, Tangerine peel 5%-10%, Rehmannia glutinosa 5%-10%, Roasted Licorice 5%-10%, Coix seeds 10%-15% into a grinder and grind to a precision of 100 mesh for use.

[0040] Then add water of the same volume as the total of the above components at 85 degrees, perform reflux extraction for 2 hours, filter it, retain the filtrate, and add twice the amount of water to the residue again, perform reflux extraction twice as above, each time for 1.5 hours. The raw materials are fully mixed and dissolved, filtered, sterilized with a sterilization device for 4 to 6 seconds, and set aside.

[0041] The finished polysaccharide products are hydrolyzed according to the following weight percentages: chestnut polysaccharide 5%-15%, maitake polysaccharide 5%-20%, jujube polysaccharide 5%-15%, shiitake polysaccharide 5%-20%, hericium erinaceus polysaccharide 5%-20%, ganoderma lucidum polysaccharide 5%-20%, Agaricus blazei polysaccharide 5%-20%, oyster mushroom polysaccharide 5%-15%, Cordyceps militaris polysaccharide 5%-10%, filter them, and keep the filtrate for later use.

[0042] Mix

[00040] and

[00041] in a ratio of 1:1.5, filter and sterilize using a sterilizer for 4 to 6 seconds, pack into 50 ml bottles, and drink one bottle per day.

[0043] Eating the composite fungal polysaccharide nutritious food or oral liquid for half a month can strengthen the spleen and stomach, and at the same time has the dietary health care effect of strengthening physical fitness and immunity; it has a strong inhibitory effect on cancer cells, and plays an important role in immune regulation, lowering blood pressure, lowering blood lipids, anti-thrombosis, strengthening the stomach and protecting the liver, and increasing white blood cells for cancer patients undergoing chemotherapy and radiotherapy. Fungal polysaccharides are now widely used in the clinical treatment of diseases such as immunodeficiency diseases, autoimmune diseases and tumors.

Claims

1. A nutritious food of composite fungal polysaccharide with the effects of strengthening spleen and stomach, anti-cancer and enhancing immunity and its application, characterized in that: It is prepared from the following raw materials in the following weight proportions: Xiaomi 20%-70% Oats 15%-30% Job's tears 10%-20% Yam 15%-30% Poria 10%-20% Scutellaria baicalensis 5%-15% Codonopsis pilosula 5%-10% Angelica 5%-10% Tangerine peel 5%-10% Atractylodes macrocephala 5%-10% Rehmannia glutinosa 5%-10% Roasted Licorice 5%-10% Cordyceps militaris polysaccharide (powder) 0.5%-5% Hericium erinaceus polysaccharide (powder) 0.5%-3% Lentinan (powder) 0.5%-2% Chestnut polysaccharide (powder) 0.5%-2% Grifola frondosa polysaccharide (powder) 0.2% - 2% Agaricus blazei polysaccharide (powder) 0.2%-2% Jujube polysaccharide (powder) 0.2%-2% Ganoderma lucidum polysaccharide (powder) 0.2%-2% 2. According to claim 1, the nutritious food containing composite fungal polysaccharides having the effects of strengthening the spleen and stomach, anti-cancer and enhancing immunity can be packaged into small packages as supplementary food powders, granules, granules, tablets, capsules, oral liquids, etc.