Application of DMXAA in preparation of medicine for accelerating orthodontic tooth movement
By injecting DMXAA drugs locally under the periosteum around the periodontal, the inflammatory microenvironment is induced and the movement of teeth is accelerated, and the complications of alveolar corticotomy during orthodontics are solved, achieving safe and efficient orthodontic effects.
Patent Information
- Application Number
- CN202411353522.X
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-09-26
- Publication Date
- 2024-12-27
AI Technical Summary
In the prior art, although alveolar cortex can accelerate teeth movement during orthodontics, there is a risk of complications such as pain, swelling, and blood stasis. It is not suitable for all cases and has a high cost. Find a A safe and effective way to accelerate the need for tooth movement.
By injecting DMXAA drugs locally under the periosteum around the periodontal periosteum, the inflammatory microenvironment is induced, thereby accelerating tooth movement, avoiding the invasiveness and postoperative risks of surgery, simple operation and no negative impact.
DMXAA significantly promotes tooth movement, increases tooth movement distance, significantly shortens orthodontic time, avoids surgery-related complications, and improves the safety and efficiency of treatment.
Smart Images
Figure CN119185320A_ABST
Abstract
Description
Technical Field
[0001] The present invention relates to the technical field of drug application, and in particular to application of DMXAA in preparing a drug for accelerating orthodontic tooth movement. Background Art
[0002] Oral orthodontic treatment usually lasts 18-36 months, or even longer. However, the longer the orthodontic treatment, the greater the probability of caries, periodontal disease and root resorption, and the worse the patient's cooperation. This is also one of the reasons why some patients are unwilling to undergo correction. During orthodontic treatment, the methods for achieving rapid tooth movement can currently be roughly divided into three categories: drug therapy, physical therapy and surgical therapy. A large number of experiments and clinical case studies have confirmed the feasibility of alveolar cortical incision to accelerate orthodontic tooth movement in clinical applications, making the use of cortical incision more extensive. However, there are some problems with cortical incision as follows: it is not suitable for all cases, and there is still the possibility of postoperative complications such as pain, swelling, and bruising. There is a risk of proximal bone loss, attachment loss, and even bone defects. The surgery requires additional fees. A large number of studies have shown that during orthodontic tooth movement, the generation and maintenance of an inflammatory microenvironment can help accelerate orthodontic tooth movement, thereby shortening the treatment process.
[0003] DMXAA (2,5-hexanotheobromine, trade name valdemethoxazole) is an anticancer drug jointly developed by the Cancer Research Institute of Oaklin University in New Zealand and Antisoma in the UK. During tumor treatment, the drug can promote the production of inflammatory factors in the tumor microenvironment, thereby recruiting immune cells such as macrophages to kill tumors. However, it is currently unclear whether DMXAA can induce an inflammatory microenvironment during orthodontic tooth movement and be used to accelerate orthodontic tooth movement.
[0004] Therefore, in view of the unclear issue of whether DMXAA can induce an inflammatory microenvironment during orthodontic tooth movement and be used to accelerate orthodontic tooth movement, an experimental study on accelerating orthodontic tooth movement was conducted to provide a basis for its application in accelerating orthodontic tooth movement. Summary of the invention
[0005] In order to overcome the problem that it is not clear whether DMXAA can induce an inflammatory microenvironment during orthodontic tooth movement and be used to accelerate orthodontic tooth movement.
[0006] The technical solution of the present invention is: application of DMXAA in preparing a drug for accelerating orthodontic tooth movement.
[0007] Preferably, the types of orthodontic teeth include molars, premolars, canines, and incisors.
[0008] Beneficial effects of the present invention:
[0009] 1. The application of DMXAA in the preparation of a drug for accelerating orthodontic tooth movement can significantly promote orthodontic tooth movement and avoid the disadvantages associated with cortical bone incision, such as invasive surgery, postoperative bleeding and other postoperative risks. The application is simple to operate and has no negative effects, thereby enhancing the practicality of the present invention.
[0010] 2. DMXAA can induce an inflammatory microenvironment during orthodontic tooth movement and can be used to accelerate orthodontic tooth movement. Statistical comparison of data shows that local injection of DMXAA drugs under the periosteum can increase the distance of orthodontic tooth movement and has a significant accelerating effect on orthodontic tooth movement. BRIEF DESCRIPTION OF THE DRAWINGS
[0011] Figure 1 is a schematic diagram of establishing a mouse orthodontic tooth movement model in an embodiment of the present invention;
[0012] Figure 2 The diagram is a schematic diagram of the marking and measurement of the tooth movement distance of mice in the orthodontic + DMSO group on the 14th day of the experiment, wherein (a) is a schematic diagram of the marking of the tooth movement distance of mice, and (b) is a schematic diagram of the measurement of the tooth movement distance of mice;
[0013] Figure 3 Schematic diagram of CT scan of mouse maxillary bone sample using DMXAA in preparing a drug for accelerating orthodontic tooth movement in the embodiment;
[0014] Figure 4 This is a schematic diagram of the application of DMXAA in the preparation of a drug for accelerating orthodontic tooth movement in the example, and the change in the orthodontic tooth movement distance of mice over time. DETAILED DESCRIPTION
[0015] The present invention will be further described below in conjunction with the accompanying drawings and embodiments.
[0016] Example 1
[0017] By selecting and establishing different animal experimental groups, a mouse orthodontic tooth movement model was constructed. After sampling, the samples were scanned by Micro-CT technology, and then the tooth movement distance was measured, providing a basis for the application of DMXAA (5,6-dimethylxanthone-4-acetic acid, trade name vardimesen) in accelerating orthodontic tooth movement.
[0018] Twelve 8-week-old male C57BL / 6 mice weighing 25-30 g were used in this experiment.
[0019] like Figure 1, an orthodontic tooth movement model was established in mice. After the mice were anesthetized, a 0.20 mm ligature was used to ligate the left first molar, and a nickel-titanium tension spring was used to apply a force of 30 ± 0.1 g. The two maxillary central incisors of the mice were ligated as support, and the ligature was bonded to the central incisor to pull the first molar to move mesially. The appliance was fixed, the mice were fed with soft food, and the tooth movement appliance was checked every day.
[0020] The mice with established models were randomly divided into two groups. One group was a DMSO control group, which was injected with local injection under the periosteum around the mobile teeth once every 3 days, with 10ul for each mouse each time. The other group was a DMXAA drug treatment group, which was injected with local injection under the periosteum around the mobile teeth once every 3 days, with 25ug / 10ul for each mouse each time.
[0021] On the 0th, 3rd, 7th and 14th day of the experiment, the mice were euthanized, the maxilla of the mice was separated, the soft tissue was removed, and the orthodontic appliance was removed. All fresh maxillary bone samples were scanned using the same Micro-CT under the same conditions. Figure 3 .
[0022] Randomly rename the scanned CT data, import the Dicom format file into the CT data processing software, and mark and measure the tooth movement distance of mice. The tooth movement distance marking and measurement of mice in the orthodontic + DMSO group on the 14th day of the experiment are used as an example. Figure 2 (a) Mark the contour high point of the distal surface of the first molar (point B) and the contour high point of the mesial surface of the second molar (point A), and measure the distance between the two points as the orthodontic tooth movement distance of the mouse, as shown in Figure 2 (b) and perform three-dimensional reconstruction.
[0023] according to Figure 3 and Figure 4 It can be seen that the DMXAA injection group was able to significantly promote orthodontic tooth movement on the 7th and 14th days, and the difference was statistically significant (*p < 0.05; application of DMXAA in the preparation of drugs for accelerating orthodontic tooth movement p < 0.01).
[0024] The embodiments of the present invention are described in detail above with reference to the accompanying drawings, but the present invention is not limited to the above embodiments, and various changes can be made within the knowledge scope of those skilled in the art without departing from the spirit of the present invention.
Claims
1. Application of DMXAA in the preparation of drugs for accelerating orthodontic tooth movement.
2. The use of DMXAA according to claim 1 in preparing a drug for accelerating orthodontic tooth movement, characterized in that: Types of orthodontic teeth include molars, premolars, canines, and incisors.