Ultrasonic helmet-medicine composite administration instrument

Abstract

The invention discloses an ultrasonic helmet-medicine composite administration instrument. The device comprises a power supply module, a single-chip microcomputer micro-control unit and an ultrasonic drive circuit power supply, a 7.4 V battery is adopted to be connected with a single-chip microcomputer, and pulse width modulation waves are sent by the micro-control unit module, reach a transducer through a booster circuit and then are fed back to the micro-control module through a sampling circuit. A receptor of the temperature sensor is arranged in the ultrasonic transducer, the main control is carried out on the single chip microcomputer, and when the temperature exceeds 50 DEG C, the power is automatically cut off to protect the skin. The working frequency of the transducer is 3MHz, the working power is 3-6W, the total diameter is 20mm, and the height is 20mm. In order to enable ultrasonic waves to have a better penetrating effect, the surface of the transducer is designed to be a concave surface, and a lead zirconate titanate material is used. The helmet is printed by using thermoplastic polyurethane rubber through a fused deposition 3D printing technology, and the helmet is used for fixing the transducer to the head. The device is small in size, can be worn at any time, is suitable for non-invasive external use, can improve the drug treatment effect, and is good in safety.

Description

Technical Field

[0001] The present invention relates to the field of medicine, and more specifically, to a method for preparing an ultrasonic helmet-drug compound drug delivery device. Background Art

[0002] With the widespread application of ultrasound technology in the medical field, non-invasive treatment methods have gradually become mainstream, especially in terms of drug penetration, tissue repair and analgesia. Existing ultrasound treatment equipment is often large in size, inconvenient to carry, and complicated to operate, and cannot meet the needs of portable and continuous drug delivery. At the same time, there is room for further optimization of the design and working parameters of the ultrasonic transducer to better meet the treatment needs of different patients and improve the drug delivery effect and patient experience. Therefore, it is of great significance to develop a portable, wearable ultrasound treatment device with precise drug delivery function. Summary of the invention

[0003] The present invention designs an ultrasonic helmet-drug compound drug delivery device, which solves the problems of large size and complicated operation of traditional ultrasonic equipment, and at the same time significantly improves the penetration efficiency and therapeutic effect of the drug.

[0004] The ultrasonic helmet of the present invention includes a support structure formed by 3D printing and a concave ultrasonic transducer. The transducer is made of lead zirconate titanate, has an operating frequency of 3MHz, and a power between 3-6W. It can accurately conduct ultrasonic waves and promote deep penetration of drugs. The device controls the pulse width modulation waveform of the ultrasonic transducer through a single-chip microcomputer to achieve precise control. The temperature sensor is used to monitor the internal temperature of the helmet. When the temperature exceeds 50°C, the power supply is automatically cut off to protect the user's skin.

[0005] The core innovation of this invention is that it combines ultrasound and drug delivery technology, and significantly enhances the drug penetration effect by acting on the skin surface through ultrasonic mechanical vibration. The device is suitable for the delivery of different drugs and can be personalized according to the needs of patients.

[0006] The invention provides an ultrasound treatment and drug delivery scheme with good portability and high safety, which is suitable for non-invasive treatment of the head and skin. The device has a simple structure, is easy to operate, and has broad application prospects. BRIEF DESCRIPTION OF THE DRAWINGS

[0007] Figure 1 The module diagram, simulation and output sound wave of the present invention

[0008] Figure 2 Evaluation of drug content, brain structural proteins and skin safety after the drug penetration into the brain was promoted by the present invention

[0009] Figure 3The present invention promotes the relevant index factors and behavioral results after the drug enters the brain DETAILED DESCRIPTION

[0010] The present invention will be further described in detail below in conjunction with the accompanying drawings so that those skilled in the art can implement the invention with reference to the description.

[0011] <Example 1> Design and production of ultrasonic helmet

[0012] A portable ultrasonic helmet was designed and produced. The shell is made of TPU material through 3D printing technology. The transducer is made of lead zirconate titanate (PZT) material and is designed to be concave to enhance the ultrasonic focusing effect (frequency 3MHz, power 3-6W). The mainboard is based on STM32 control, and the three-speed ultrasonic output can be adjusted through Bluetooth. It also integrates a temperature sensor, which automatically cuts off the power when the temperature exceeds 50℃ to ensure safety. Finite element analysis shows that the helmet has no significant deformation under a load of 500N, and steady-state thermal simulation shows that the inner surface temperature of the helmet is always less than 50℃, thus ensuring the stability and safety of the equipment ( Figure 1 ).

[0013] <Example 2> Ultrasound-assisted drug penetration into the brain

[0014] In this experiment, a portable ultrasound helmet was used to promote the penetration of the poorly water-soluble drug topiramate (0.01M) and the water-soluble drug cytarabine (0.01M) through the blood-brain barrier. 2 The optimized waveform output significantly enhanced the permeability of the blood-brain barrier. Brain tissue was obtained within 20 minutes after treatment and analyzed using a Waters C8 column (0.1% formic acid aqueous solution and acetonitrile as mobile phase) HPLC-MS / MS, which showed that the brain concentrations of topiramate and cytarabine increased by 48.7% and 55.3%, respectively, confirming the significant effect of the ultrasound helmet in enhancing the efficiency of drugs crossing the blood-brain barrier ( Figure 2 ).

[0015] <Example 3> Temperature Control and Safety Test

[0016] The ultrasonic helmet has been tested for long-term use, and the results show that the temperature control system can stably control the temperature below 50°C. 2 The effect on the mouse scalp was observed by HE staining. The skin tissue structure was not significantly damaged, and the expression of brain structural proteins Occludin and ZO-1 remained normal. This result verifies the temperature control stability of the ultrasonic helmet under continuous working conditions and its safety to skin and brain tissue ( Figure 2 ).

[0017] <Example 4> Ultrasonic helmet enhances drug treatment effect

[0018] A mouse model of radiation brain injury was established. The mice were irradiated with a Co source at a dose of 15 Gy for 15 min. The drug group was injected with dexamethasone (DXMS, 1 mg / kg / d) and pregabalin (PGB, 30 mg / kg / d), and the ultrasound-assisted group was treated with an ultrasound helmet (3 W / cm 2 , 10min) adjuvant therapy. ELISA detected its pathological indicators. The malondialdehyde (MDA) content in the brain tissue of mice in the drug-combined drug delivery device group decreased by 35%, and the levels of brain-derived neurotrophic factor (BDNF) and c-Jun amino-terminal kinase (JNK) increased by 40% and 45%, respectively. These indicators reflect the improvement of oxidative stress, neuroprotection and cell repair mechanisms, respectively; behavioral tests included open field tests and new object recognition experiments. The results showed that the activity and cognition of mice in the ultrasound group were significantly better than those in the drug group, verifying the potential of ultrasound helmets in enhancing the therapeutic effect of brain injury drugs ( Figure 3 ).

[0019] Although the embodiments of the present invention have been disclosed as above, they are not limited to the applications listed in the specification and the implementation modes, and they can be fully applied to various fields suitable for the present invention. For those familiar with the art, additional modifications can be easily implemented. Therefore, without departing from the general concept defined by the claims and the scope of equivalents, the present invention is not limited to the specific details and the illustrations shown and described herein.

Claims

1. An ultrasonic helmet-drug compound drug delivery device, characterized in that: include: A power module, a single-chip microcontroller unit, and an ultrasonic drive circuit; the ultrasonic drive circuit is connected to the single-chip microcomputer via a 7.4V battery, the single-chip microcomputer controls the ultrasonic transducer via a pulse width modulation wave, and the ultrasonic transducer is arranged in the helmet to emit ultrasonic waves to promote the penetration of drugs into the head tissue.

2. The ultrasonic helmet-drug compound drug delivery device according to claim 1, characterized in that: The transducer surface is a concave structure and is made of lead zirconate titanate to enhance the penetration effect of ultrasound.

3. The ultrasonic helmet-drug compound drug delivery device according to claim 1, characterized in that: It also includes a temperature sensor, which is arranged in the ultrasonic transducer and is used to detect the temperature of the transducer when it is working; when the temperature exceeds 50°C, the single-chip microcomputer automatically cuts off the power to protect the user's skin.

4. The ultrasonic helmet-drug compound drug delivery device according to claim 1, characterized in that: The operating frequency of the transducer is 3 MHz, and the operating power is 3-6 W.

5. The ultrasonic helmet-drug compound drug delivery device according to claim 1, characterized in that: The helmet is made of thermoplastic polyurethane rubber using 3D printing technology and is used to fix the ultrasonic transducer on the user's head to ensure stability during treatment.

6. The ultrasonic helmet-drug compound drug delivery device according to claim 1, characterized in that: It also includes a feedback sampling circuit, which feeds back the working state of the transducer to the single-chip microcomputer for real-time adjustment of the ultrasonic output parameters.

7. The ultrasonic helmet-drug compound drug delivery device according to claim 1, characterized in that: The device is portable, small in size, convenient to wear at any time and suitable for non-invasive treatment.

8. The ultrasonic helmet-drug compound drug delivery device according to claim 1, characterized in that: The device has high safety and the function of promoting the entry of drugs into the brain, and can effectively improve the therapeutic effect of drugs.

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