Composition capable of strengthening body, preventing cancer, conditioning hypertension, hyperglycemia and hyperlipidemia and resisting aging and application of composition

Abstract

The invention belongs to the technical field of medicinal and edible traditional Chinese medicine compositions, and particularly relates to a body-strengthening, cancer-preventing, three-high-regulating and anti-aging composition and application thereof. The body-strengthening, cancer-preventing, three-high-conditioning and anti-aging composition is prepared from the following raw materials in parts by mass: 20 to 40 parts of rhizoma dioscoreae, 15 to 35 parts of fructus ligustri lucidi, 15 to 35 parts of fructus corni, 10 to 25 parts of fructus lycii, 10 to 20 parts of liquorice root, 10 to 20 parts of cortex eucommiae, 8 to 16 parts of rhizoma atractylodis macrocephalae, 5 to 15 parts of fructus crataegi and 3 to 12 parts of poria cocos. The Chinese yam, the glossy privet fruit and the dogwood are used as monarch drugs; liquorice, eucommia ulmoides and fructus lycii are used as ministerial drugs; rhizoma atractylodis macrocephalae and hawthorn are used as adjuvant drugs, and poria cocos is used as a conductant drug; the traditional Chinese medicine composition has the effects of strengthening spleen and stomach, reinforcing qi, nourishing blood, regulating liver and kidney, reinforcing and reducing, strengthening body, preventing cancer, regulating hypertension, hyperglycemia and hyperlipidemia and resisting aging.

Description

Technical Field

[0001] The present invention belongs to the technical field of Chinese medicine compositions that are both medicinal and edible, and specifically relates to a composition for strengthening the body, preventing cancer, regulating three highs and resisting aging and an application thereof. Background Art

[0002] "Medicine and food have the same origin" is an important concept in traditional Chinese medicine, which means that some natural substances can be eaten as food and used as medicine. These substances usually have mild pharmacological effects, and long-term consumption is beneficial to human health. In recent years, with people's pursuit of a healthy lifestyle and preference for natural products, the application of Chinese herbal medicine compositions with the same origin of medicine and food in strengthening the body and preventing cancer, regulating the three highs (high blood pressure, high blood sugar, and high blood lipids), and anti-aging has received widespread attention.

[0003] The three highs are not only the main risk factors for cardiovascular disease, high blood pressure will increase the burden on the heart, high blood sugar and high blood lipids will lead to vascular sclerosis and plaque formation, increasing the risk of heart disease, stroke, etc., but can also cause a variety of complications, such as retinopathy, nephropathy, neuropathy, etc.; high blood lipids can lead to atherosclerosis, increasing the risk of myocardial infarction and stroke.

[0004] Although Western medicine has also achieved remarkable results in the field of reducing the three highs, its clinical application is often accompanied by some side effects, and it is easy to relapse after stopping the medication. Traditional Chinese medicine, which is both medicine and food, usually contains multiple active ingredients, which can play a synergistic role through different pathways and mechanisms to achieve a comprehensive conditioning effect. Therefore, it has potential advantages in the field of reducing the three highs.

[0005] The Chinese patent with the prior art publication number CN118078920A discloses a preparation for promoting blood circulation, removing blood stasis, dissolving blood clots and lowering three highs, which is made of the following raw materials: Gastrodia elata, Chuanxiong, Salvia miltiorrhiza, earthworm protein peptide, Pueraria root, Eucommia ulmoides leaf, hawthorn, Chinese yam, red yeast rice, Prunella vulgaris, Cassia seed, Lycium barbarum, natto powder, golden willow, grape seed powder, Astragalus extract, Siegesbeckia scabra, and shallot. The Chinese medicine composition of this technical scheme is composed of raw materials that are both medicinal and edible. Through the mutual coordination and synergistic effect of each component, it has the effects of lowering blood lipids, lowering blood pressure, and unblocking blood, and can treat and prevent hypertension and blood vessel blockage. However, this technical scheme contains 18 Chinese medicinal materials, and the prescription is relatively complicated.

[0006] The Chinese patent application number CN112336815A applied for by this application in 2021 is a "three highs" anti-aging composition for strengthening the body, preventing cancer and conditioning, and its application. The raw materials for its preparation include component A and component B, wherein the weight ratio of component A to component B is (1:2)-(2:1); A includes smilax china and / or Poria cocos, ginseng, schisandra chinensis and / or ganoderma lucidum; the component B includes kudzu root, corn silk, licorice and polygonatum. The "three highs" anti-aging composition for strengthening the body, preventing cancer and conditioning in the present invention has excellent effects of lowering blood pressure, blood sugar and blood lipids, helps to improve human blood circulation, improves physical condition, enhances immunity, resists pathogenic microorganisms, resists viruses, and can dispel wind and dampness, detoxify and disinfect. However, the ginseng and ganoderma lucidum in this technical solution are expensive, and there are many medicinal materials, so the cost is high. Summary of the invention

[0007] In view of the above problems, the present invention provides a composition for strengthening the body, preventing cancer, regulating the three highs and anti-aging and its application. The present invention uses yam, glossy privet fruit and cornus officinalis as main medicines; liquorice, eucommia bark and wolfberry as assistant medicines; atractylodes macrocephala and hawthorn as adjuvants, and poria as a guiding medicine; the whole formula is used together to strengthen the spleen and stomach, invigorate qi and nourish blood, regulate the liver and kidneys, and combine tonification and purgation, so as to achieve the effects of strengthening the body, preventing cancer, regulating the three highs and anti-aging.

[0008] To achieve the above purpose, the technical solution adopted by the present invention is as follows:

[0009] The first aspect of the present invention provides a body strengthening, cancer prevention, conditioning, three highs and anti-aging composition. The raw materials include, by weight: 20-40 parts of yam, 15-35 parts of Ligustrum lucidum, 15-35 parts of Cornus officinalis, 10-25 parts of wolfberry, 10-20 parts of licorice, 10-20 parts of Eucommia ulmoides, 8-16 parts of Atractylodes macrocephala, 5-15 parts of hawthorn, and 3-12 parts of Poria.

[0010] In some preferred embodiments, the composition for strengthening the body, preventing cancer, regulating the three highs and anti-aging, comprises, by weight, 25-35 parts of yam, 20-30 parts of Ligustrum lucidum, 20-30 parts of Cornus officinalis, 15-20 parts of wolfberry, 10-15 parts of licorice, 10-15 parts of Eucommia ulmoides, 10-14 parts of Atractylodes macrocephala, 8-12 parts of hawthorn, and 5-10 parts of Poria.

[0011] As a preferred embodiment, the said body strengthening, cancer prevention, conditioning, three-high and anti-aging composition, calculated by mass, comprises the following raw materials: 30 parts of yam, 25 parts of Ligustrum lucidum, 25 parts of Cornus officinalis, 18 parts of wolfberry, 13 parts of licorice, 13 parts of Eucommia ulmoides, 12 parts of Atractylodes macrocephala, 10 parts of Crataegus pinnatifida, and 8 parts of Poria cocos.

[0012] As a preferred embodiment, the wolfberry is red wolfberry.

[0013] As another preferred embodiment, the wolfberry is a combination of black wolfberry and red wolfberry, and the mass ratio of the black wolfberry to the red wolfberry is 1:3-6.

[0014] The black wolfberry and the red wolfberry described in the present invention both belong to the Solanaceae wolfberry, and the biggest difference between the two is not only the color, but also the different effects of each. From the appearance, the black wolfberry is wild, small in size, with a fruit stalk, and low in sugar content. It has only a slight sweet taste when chewed directly, while the red wolfberry is a flat and long red fruit without a fruit stalk, high in sugar content, and has a sweet taste when chewed directly. The black wolfberry mainly has the effect of clearing away heat, while the red wolfberry mainly has the effect of nourishing the liver and kidney and improving the eyesight.

[0015] The pharmacological effects of the present invention are as follows:

[0016] Chinese Yam: sweet, neutral; enters the lung meridian, spleen meridian, and kidney meridian; nourishes the spleen and stomach, promotes the production of body fluids and benefits the lungs, nourishes the kidneys and astringes semen. Used for spleen deficiency, poor appetite, chronic diarrhea, asthma and cough due to lung deficiency, spermatorrhea due to kidney deficiency, excessive leucorrhea, frequent urination, and thirst due to deficiency heat.

[0017] Fructus Ligustri Lucidi: sweet, bitter, cool in nature; enters the liver and kidney meridians; nourishes the liver and kidneys, strengthens the waist and knees, brightens the eyes and darkens the hair. Treats yin deficiency and internal heat, dizziness, tinnitus, soreness of the waist and knees, and premature graying of hair.

[0018] Cornus officinalis: sour, astringent, slightly warm; enters the liver and kidney meridians; nourishes the liver and kidneys, astringes the essence and qi, and consolidates collapse. Treats soreness of waist and knees, dizziness, tinnitus, impotence, spermatorrhea, frequent urination, liver deficiency cold and heat, excessive sweating, and palpitations.

[0019] Red wolfberry: sweet, neutral; enters the liver and kidney meridians; nourishes the liver and kidneys, improves the essence and improves eyesight. Used for asthenia, loss of essence, soreness of waist and knees, dizziness and tinnitus, internal heat and thirst, blood deficiency and sallow complexion, blurred vision.

[0020] Licorice: sweet, neutral; enters the heart, lung, spleen, and stomach meridians; tonifies the spleen and replenishes qi, clears away heat and detoxifies, removes phlegm and relieves cough, relieves pain, and harmonizes various medicines. It is used for spleen and stomach weakness, fatigue, palpitations and shortness of breath, cough with sputum, abdominal and limb cramps and pain, carbuncle, sore and ulcer, and relieves drug toxicity and potency.

[0021] Eucommia: sweet, slightly pungent, warm in nature; enters the liver and kidney meridians; nourishes the liver and kidneys, strengthens the tendons and bones, and stabilizes the fetus. Treats back pain, weakness of the feet and knees, residual urine, itchy genitals, miscarriage, restless fetuses, and high blood pressure.

[0022] Atractylodes macrocephala: bitter, sweet, warm; enters the spleen and stomach meridians; nourishes the spleen, benefits the stomach, dries dampness, harmonizes the middle, and stabilizes the fetus. Treats weak spleen and stomach qi, loss of appetite, fatigue and shortness of breath, bloating, diarrhea, phlegm and fluid, edema, jaundice, dampness, difficulty urinating, dizziness, spontaneous sweating, and restless fetus.

[0023] Hawthorn: sour, sweet, slightly warm; enters the spleen, stomach, and liver meridians; helps digestion and strengthens the stomach, promotes qi and dissipates blood stasis. Used for meat stagnation, stomach distension, diarrhea, abdominal pain, blood stasis, amenorrhea, postpartum blood stasis, heart and abdomen pain, hernia pain, and hyperlipidemia.

[0024] Poria: sweet, light, neutral; enters the heart meridian, spleen meridian, lung meridian, and kidney meridian; dissipates dampness and promotes diuresis, benefits the spleen and stomach, and calms the mind. It is used to treat urinary problems, edema, phlegm and cough, vomiting, diarrhea, spermatorrhea, stranguria, palpitations, and forgetfulness.

[0025] The second aspect of the present invention provides the application of the above-mentioned body strengthening, cancer prevention, conditioning, three-high and anti-aging composition, which is any one of the following:

[0026] A. Application in the preparation of body strengthening products;

[0027] B. Application in the preparation of anti-cancer products;

[0028] C. Application in the preparation of products for regulating the three highs;

[0029] D. Application in the preparation of anti-aging products.

[0030] In some preferred embodiments, the product comprises a powder mixture of the above-mentioned strengthening, anti-cancer, conditioning, three-highs and anti-aging composition or an extract of the strengthening, anti-cancer, conditioning, three-highs and anti-aging composition.

[0031] Preferably, the powder mixture is a superfine powder mixture of various raw material components of the above-mentioned body strengthening, cancer prevention, conditioning, three-high and anti-aging composition.

[0032] Preferably, the method for preparing the powder mixture comprises the following steps: ultrafinely powdering each component of the raw material respectively, and then mixing them according to mass parts.

[0033] Preferably, the extract can be a product obtained by extracting it in any feasible way in the field of traditional Chinese medicine or food, for example, it can be an extract obtained by extracting the body strengthening, cancer prevention, conditioning, three highs and anti-aging composition by decoction, or an extract obtained by extracting the body strengthening, cancer prevention, conditioning, three highs and anti-aging composition by water extraction or alcohol extraction.

[0034] Most preferably, the strengthening body, preventing cancer, conditioning, three highs and anti-aging composition is obtained from the extract of the strengthening body, preventing cancer, conditioning, three highs and anti-aging composition raw material, and the extract is the extract obtained by extracting the strengthening body, preventing cancer, conditioning, three highs and anti-aging composition by decoction method.

[0035] Preferably, the decoction method comprises the following steps: placing the raw materials (yam, Ligustrum lucidum, Cornus officinalis, wolfberry, liquorice, Eucommia ulmoides, Atractylodes macrocephala, Crataegus pinnatifida and Poria cocos) in a container, soaking and decocting the extracts 2-3 times with water, combining the extracts, concentrating under reduced pressure to a thick paste with a relative density of 1.2-1.3 at 65°C, drying, crushing and passing through a 100-mesh sieve.

[0036] Preferably, the material-liquid ratio of the raw material to water is 1:8-12.

[0037] The term "feed-to-liquid ratio" used in the technical solution of the present invention refers to the volume ratio (mg / mL) of the amount of raw material, i.e., "material", to the extraction solution, i.e., "liquid". For example, a feed-to-liquid ratio of 1:10 means that 10 times the amount of extraction solvent is added to 1 g of raw material.

[0038] In some preferred embodiments, the product is a medicine, a health product, a beverage or a food.

[0039] In some preferred embodiments, the dosage form of the product is one of granules, capsules, pills, tablets, oral liquids, health teas, solid beverages, and candy tablets.

[0040] In some preferred embodiments, the product may further include auxiliary materials or other meridian-guiding drugs.

[0041] In some preferred embodiments, the meridian-guiding drugs include but are not limited to cassia twig, cinnamon bark, Achyranthes bidentata, kudzu root, yellow wine, etc.

[0042] In some preferred embodiments, the excipients include but are not limited to pharmaceutically acceptable excipients and food acceptable excipients.

[0043] The pharmaceutically acceptable excipients include but are not limited to fillers, binders, glidants, disintegrants and lubricants; the fillers include but are not limited to lactose, anhydrous lactose, microcrystalline cellulose, mannitol and starch; binders include but are not limited to hydroxypropyl methylcellulose, hydroxypropyl cellulose, povidone, hydroxyethyl cellulose, sodium carboxymethyl cellulose and polyvinyl alcohol; glidants include but are not limited to colloidal silicon dioxide, talc and micro-powdered silica; disintegrants include but are not limited to low-substituted hydroxypropyl cellulose, cross-linked sodium carboxymethyl cellulose, sodium carboxymethyl starch and cross-linked povidone; lubricants include but are not limited to magnesium stearate, calcium stearate and sodium stearyl fumarate.

[0044] The acceptable excipients for food include but are not limited to cereals, sweeteners, acidity regulators, pigments, nutritional enhancers, etc.; the cereals include but are not limited to wheat flour, corn flour, oat flour, buckwheat flour, barley flour, quinoa flour, sesame flour, soybean flour, flaxseed flour, etc.; the sweeteners include but are not limited to sucrose, glucose, fructose, aspartame, cyclamate, sucralose, steviol glycosides, etc.; the acidity regulators include but are not limited to citric acid, malic acid, tartaric acid, etc.; the pigments include but are not limited to carotene, anthocyanins, chlorophyll, carmine sunset yellow, etc.; the nutritional enhancers include but are not limited to vitamins, minerals (calcium, iron, zinc, etc.), amino acids, etc.

[0045] Compared with the prior art, the present invention has the following beneficial effects:

[0046] 1. The body strengthening, cancer prevention, conditioning, three highs and anti-aging composition provided by the present invention is demonstrated with the liver, kidney and spleen, follows the medication principle of "monarch, minister, assistant and envoy" of traditional Chinese medicine, and takes yam, Ligustrum lucidum and Cornus officinalis as monarch medicines. Yam nourishes the spleen and stomach, promotes fluid and benefits the lungs. Ligustrum lucidum nourishes the liver and kidneys, strengthens the waist and knees. Cornus officinalis nourishes the liver and kidneys, astringes the essence and qi, and consolidates collapse; takes liquorice, Eucommia ulmoides and wolfberry as minister medicines. Licorice nourishes the spleen and replenishes qi, clears away heat and detoxifies. Wolfberry and Eucommia ulmoides nourish the liver and kidneys, and can help the monarch medicine strengthen the effect of nourishing the liver, kidney and spleen; takes Atractylodes macrocephala and Crataegus pinnatifida as adjuvant medicines. Atractylodes macrocephala nourishes the spleen, benefits the stomach, and dries dampness. Crataegus pinnatifida helps digestion and strengthens the stomach, promotes qi and disperses blood stasis; takes Poria cocos as the envoy medicine. Poria cocos penetrates dampness and promotes diuresis, benefits the spleen and stomach, and harmonizes various medicines; the whole formula is used together to strengthen the spleen and stomach, replenish qi and nourish blood, regulate the liver and kidney, and combine tonification and purgation, so as to achieve excellent effects of regulating the three highs.

[0047] 2. The ultrafine powder mixture of each component of the raw materials of the strengthening, anti-cancer, conditioning, three-high and anti-aging composition provided by the present invention or the extract obtained by extracting the strengthening, anti-cancer, conditioning, three-high and anti-aging composition by decocting method has good effects of lowering blood lipids, blood pressure and blood sugar, especially the extract has better effect.

[0048] 3. The ingredients of the body strengthening, cancer prevention, conditioning, three-high and anti-aging composition provided by the present invention are all medicinal and edible ingredients. The medicinal and edible ingredients have no side effects. Long-term use will not cause damage to important organs such as the liver and kidneys. Since they are natural ingredients, they will not produce drug resistance, so they can be eaten for a long time. At the same time, the medicinal and edible ingredients of the present invention have a large content of biologically active substances, including polysaccharides, polyphenols, and flavonoids. Polysaccharides can enhance the body's immune function, so they can enhance immunity. Polyphenols and flavonoids have powerful antioxidant effects, scavenge free radicals, and protect cells from oxidative damage, so they can resist aging. In addition, some ingredients in wolfberry and eucommia have anti-tumor effects, so they can prevent cancer. DETAILED DESCRIPTION

[0049] Various exemplary embodiments of the present invention will now be described in detail. This detailed description should not be considered as limiting the present invention, but should be understood as a more detailed description of certain aspects, features, and embodiments of the present invention.

[0050] It should be understood that the terms described in the present invention are only for describing special embodiments and are not intended to limit the present invention. In addition, for the numerical range in the present invention, it should be understood that each intermediate value between the upper and lower limits of the scope is also specifically disclosed. Each smaller range between the intermediate value in any stated value or stated range and any other stated value or intermediate value in the described range is also included in the present invention. The upper and lower limits of these smaller ranges can be independently included or excluded in the scope.

[0051] Unless otherwise indicated, all technical and scientific terms used herein have the same meanings as those generally understood by those skilled in the art. Although the present invention describes only preferred methods and materials, any methods and materials similar or equivalent to those described herein may also be used in the implementation or testing of the present invention. All documents mentioned in this specification are incorporated by reference to disclose and describe the methods and / or materials associated with the documents. In the event of a conflict with any incorporated document, the content of this specification shall prevail.

[0052] It will be apparent to those skilled in the art that various modifications and variations may be made to the specific embodiments of the present invention description without departing from the scope or spirit of the present invention. Other embodiments derived from the present invention description will be apparent to those skilled in the art. The present invention description and examples are exemplary only.

[0053] The words “include,” “including,” “have,” “contain,” etc. used in this document are open-ended terms, meaning including but not limited to.

[0054] In the following examples, unless otherwise specified, all raw materials used were commercially available or prepared by conventional methods in the art.

[0055] Example

[0056] The body strengthening, cancer prevention, conditioning, three-high and anti-aging compositions of Examples 1 to 6 are composed of raw materials according to the formula in Table 1, calculated by mass.

[0057] Table 1

[0058] Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 Yam 20 servings 40 servings 30 servings 25 servings 35 servings 30 servings Ligustrum lucidum 15 servings 35 servings 25 servings 20 servings 30 servings 25 servings Dogwood 15 servings 35 servings 25 servings 20 servings 30 servings 25 servings Red wolfberry 10 servings 25 servings 18 servings 15 servings 20 servings 15 servings Black wolfberry / / / / / 3 servings Licorice 10 servings 20 servings 13 servings 10 servings 15 servings 13 servings Eucommia 10 servings 20 servings 13 servings 10 servings 15 servings 13 servings Atractylodes macrocephala 8 servings 16 servings 12 servings 10 servings 14 servings 12 servings hawthorn 5 servings 15 servings 10 servings 8 servings 12 servings 10 servings Poria 3 servings 12 servings 8 servings 5 servings 10 servings 8 servings

[0059] The preparation method of the three-high anti-aging composition for strengthening the body, preventing cancer and conditioning of Examples 1 to 6 comprises the following steps: placing the raw materials (Chinese yam, Ligustrum lucidum, Cornus officinalis, Lycium barbarum, Licorice, Eucommia ulmoides, Atractylodes macrocephala, Crataegus pinnatifida and Poria cocos) in a container, adding water (the solid-liquid ratio of the raw materials to water is 1:10), soaking, decocting and extracting for 3 times, combining the extracts, concentrating under reduced pressure to a thick paste with a relative density of 1.3 at 65°C, drying, crushing, and passing through a 100-mesh sieve.

[0060] Example 7

[0061] The difference from Example 3 is that the preparation method of the said strengthening, anti-cancer, conditioning, three-high and anti-aging composition comprises the following steps: ultrafine powdering each component of the raw materials separately, and then mixing them according to mass parts; the rest are the same.

[0062] Comparative Example

[0063] The three-highs, conditioning and anti-aging compositions of Comparative Examples 1 to 5 are composed of raw materials according to the formula in Table 2, calculated by mass.

[0064] Table 2

[0065]

[0066]

[0067] The preparation methods of the body strengthening, cancer prevention, conditioning, three-high and anti-aging compositions of Comparative Examples 1 to 5 are the same as that of Example 3.

[0068] Comparative Example 6

[0069] The Chinese patent with the previous application publication number CN112336815A, the technical solution of its best embodiment 1:

[0070] The invention comprises a component A and a component B, wherein the weight ratio of the component A to the component B is 1:1; the raw materials for preparing the component A, in parts by weight, comprise: 45 parts of smilax china, 35 parts of ginseng, and 38 parts of astragalus; the raw materials for preparing the component B, in parts by weight, comprise: 40 parts of kudzu root, 35 parts of corn silk, 38 parts of liquorice, 30 parts of polygonatum, 28 parts of yam, and 25 parts of gardenia.

[0071] The preparation method is the same as Example 3 of the present application.

[0072] Experimental Example 1: Blood lipid lowering effect experiment

[0073] SPF SD male rats weighing 200 ± 20 g were selected. After one week of adaptive feeding, the SD male rats were divided into a blank group (fed with a basic feed and given 50 mg / kg / day of normal saline by gavage), a model group (fed with a high-fat feed formula and given 50 mg / kg / day of normal saline by gavage), Example 1-7 groups (fed with a high-fat feed formula, and given the composition provided by Examples 1-7 by gavage, respectively, dissolved in an appropriate amount of normal saline, and the dosage was 50 mg / kg / day), and Comparative Example 1-6 groups (fed with a high-fat feed formula, and given the composition provided by Comparative Example 1-6 by gavage, respectively, dissolved in an appropriate amount of normal saline, and the dosage was 50 mg / kg / day), 10 rats in each group, each group was given once a day by gavage, and after 14 consecutive days of administration, fasting within 12 hours without water, the levels of total cholesterol, triglycerides, high-density lipoprotein and low-density lipoprotein in rat serum were measured, and all data were statistically analyzed using SPSS22.0 statistical software, and the statistical value was used. The comparison among the groups was performed by one-way analysis of variance, and P < 0.05 was considered statistically significant.

[0074] The high-fat feed formula consists of 68% basic feed, 10% egg yolk powder, 10% lard, and 12% cholesterol.

[0075] Table 3 Results of the lipid-lowering efficacy experiment

[0076]

[0077]

[0078] As can be seen from Table 3, the levels of total cholesterol, triglycerides, and low-density lipoprotein in the serum of the rats in the model group were significantly higher than those in the blank group (P<0.01), and the level of high-density lipoprotein was significantly reduced (P<0.01), indicating that the hyperlipidemia model was successfully established in rats.

[0079] After drug administration, compared with the model group, the total cholesterol, triglyceride, and low-density lipoprotein levels in the serum of the rats in the Example 1-6 groups were significantly reduced (P<0.05 or P<0.01), and the high-density lipoprotein level was significantly increased ((P<0.05 or P<0.01), indicating that the composition of Examples 1-6 has a good lipid-lowering effect;

[0080] The total cholesterol and low-density lipoprotein levels in the Example 7 group were significantly reduced (P<0.05), the high-density lipoprotein level was significantly increased ((P<0.05), and the triglyceride level had no significant difference, but was lower than that in the model group, indicating that the lipid-lowering effect of the combination of Example 7 was reduced relative to that of Examples 1-6.

[0081] Compared with Comparative Example 6, there are no significant differences in total cholesterol, triglycerides, low-density lipoprotein levels, and high-density lipoprotein levels in the serum of rats in Examples 1-6 groups, indicating that the lipid-lowering effect of the composition of Examples 1-6 is equivalent to the technical solution of the best embodiment 1 of the Chinese patent with publication number CN112336815A; the triglyceride level of the Example 7 group is significantly different from that of Comparative Example 6 (P<0.05), indicating that the lipid-lowering effect of the composition of Example 7 is slightly worse than that of Comparative Example 6.

[0082] The difference between Comparative Example 1 and Example 3 is that yam is replaced with licorice of equal mass, the difference between Comparative Example 2 and Example 3 is that the mass parts of Eucommia ulmoides and Ligustrum lucidum are replaced with each other, the difference between Comparative Example 3 and Example 3 is that red wolfberry is replaced with mulberry of equal mass, the difference between Comparative Example 4 and Example 3 is that hawthorn is replaced with Atractylodes macrocephala of equal mass, and the difference between Comparative Example 5 and Example 3 is that the weight parts of each raw material of the composition are not within the range specified in Weight 1. Due to the change in the formula of Comparative Examples 1-5, the relationship between the monarch, minister, assistant and envoy of the composition is changed, and the obtained composition does not have a significant lipid-lowering effect compared with the model group.

[0083] Experimental Example 2: Experiment on hypoglycemic efficacy

[0084] SPF SD male rats weighing 200±20g were selected. After one week of adaptive feeding, the SD male rats were divided into a blank group (no modeling, intragastric administration of 50 mg / kg / day of normal saline), a model group (modeling, intragastric administration of 50 mg / kg / day of normal saline), Example 1-7 groups (modeling, intragastric administration of the composition provided by Examples 1-7, each at a dosage of 50 mg / kg / day), and Comparative Example 1-6 groups (modeling, intragastric administration of the composition provided by Comparative Example 1-6, each at a dosage of 50 mg / kg / day), 10 rats in each group, each group was intragastrically administered once a day, and after continuous administration for 14 days, fasting but not water within 12 hours, and the fasting blood glucose value of the rats was measured. All data were statistically analyzed using SPSS22.0 statistical software, and the statistical value was used. The comparison among the groups was performed by one-way analysis of variance, and P < 0.05 was considered statistically significant.

[0085] Modeling method: rats were fasted for 24 hours (free drinking water), and 130 mg / kg of alloxan was injected intraperitoneally to establish the model. After 7 days of free diet, the fasting blood glucose level was measured. If the blood glucose level was greater than 11.1 mmol / L, the model was successfully established.

[0086] Table 4 Hypoglycemic efficacy experimental results

[0087]

[0088]

[0089] As can be seen from Table 4, the fasting blood glucose level of rats in the model group was significantly higher than that in the blank group (P<0.01), indicating that the hyperglycemia model was successfully established in rats.

[0090] After drug administration, compared with the model group, the fasting blood glucose levels of the Example 1-7 groups were significantly reduced (P<0.05 or P<0.01), indicating that the composition of Example 1-7 has a good hypoglycemic effect;

[0091] Compared with Comparative Example 6, there was no significant difference in the fasting blood glucose levels of the rats in the Examples 1-7 groups, indicating that the hypoglycemic effect of the compositions of Examples 1-7 is equivalent to the technical solution of the best embodiment 1 of the Chinese patent publication number CN112336815A;

[0092] In comparative examples 1-5, the relationship between the monarch, minister, adjuvant and facilitator of the composition was changed due to the change in the formula, and the obtained composition did not have a significant hypoglycemic effect compared with the model group.

[0093] Experimental Example 3: Blood Pressure Lowering Effect Experiment

[0094] SPF male spontaneously hypertensive rats (SHR) weighing 200±20g were selected. After one week of adaptive feeding, the SPF male spontaneously hypertensive rats were divided into a model group (gavage administration of 50 mg / kg / day of normal saline), Example 1-7 groups (gavage administration of the composition provided in Example 1-7, respectively, at a dosage of 50 mg / kg / day), and Comparative Example 1-6 groups (gavage administration of the composition provided in Comparative Example 1-6, respectively, at a dosage of 50 mg / kg / day), 10 rats in each group, and 10 SPF male Wistar rats weighing 200±20g were taken as a blank group. The blank group was gavaged with 50 mg / kg / day of normal saline. Each group was gavaged once a day. After 14 consecutive days of administration, fasting but not water within 12 hours was allowed. A small animal non-invasive blood pressure measuring instrument tail cuff was placed at the proximal end of the rat's tail to block or relax arterial blood flow. The systolic blood pressure was accurately read according to the tail artery pulsation curve and the pressure transducer dose pressure curve. All data were statistically analyzed using SPSS22.0 statistical software, and the statistical value was used. The comparison among the groups was performed by one-way analysis of variance, and P < 0.05 was considered statistically significant.

[0095] Table 5. Results of the blood pressure lowering efficacy experiment

[0096]

[0097]

[0098] As can be seen from Table 5, the systolic blood pressure level of rats in the model group was significantly higher than that in the blank group (P<0.01), indicating that the rat hypertension model was successful.

[0099] After drug administration, the systolic blood pressure of the Example 1-7 group was significantly reduced compared with the model group (P<0.01), indicating that the composition of Example 1-7 has a good blood pressure lowering effect;

[0100] Compared with Comparative Example 6, there was no significant difference in the fasting blood glucose levels of the rats in the Examples 1-7 groups, indicating that the blood pressure lowering effect of the compositions of Examples 1-7 is equivalent to the technical solution of the best embodiment 1 of the Chinese patent publication number CN112336815A;

[0101] In comparative examples 1-5, due to the change in the formula, the relationship between the monarch, minister, adjuvant and facilitator of the composition was changed, and the obtained composition did not have a significant blood pressure lowering effect compared with the model group.

[0102] Finally, it should be noted that the above content is only used to illustrate the technical solution of the present invention, rather than to limit the scope of protection of the present invention. Simple modifications or equivalent substitutions of the technical solution of the present invention by ordinary technicians in this field do not deviate from the essence and scope of the technical solution of the present invention.

Claims

1. A composition for strengthening the body, preventing cancer, regulating the three highs and anti-aging, characterized in that: By weight, the raw materials include: 20-40 parts of yam, 15-35 parts of Ligustrum lucidum, 15-35 parts of Cornus officinalis, 10-25 parts of wolfberry, 10-20 parts of licorice, 10-20 parts of Eucommia ulmoides, 8-16 parts of Atractylodes macrocephala, 5-15 parts of hawthorn, and 3-12 parts of Poria cocos.

2. The body strengthening, cancer prevention, conditioning, three-high and anti-aging composition according to claim 1, characterized in that: By weight, the raw materials include: 25-35 parts of yam, 20-30 parts of Ligustrum lucidum, 20-30 parts of Cornus officinalis, 15-20 parts of wolfberry, 10-15 parts of licorice, 10-15 parts of Eucommia ulmoides, 10-14 parts of Atractylodes macrocephala, 8-12 parts of hawthorn, and 5-10 parts of Poria.

3. The body strengthening, cancer prevention, conditioning, three-high and anti-aging composition according to claim 2 is characterized in that: By weight, the raw materials include: 30 parts of yam, 25 parts of Ligustrum lucidum, 25 parts of Cornus officinalis, 18 parts of wolfberry, 13 parts of licorice, 13 parts of Eucommia ulmoides, 12 parts of Atractylodes macrocephala, 10 parts of hawthorn, and 8 parts of Poria.

4. The composition for strengthening body, preventing cancer, regulating three highs and anti-aging according to claim 3, characterized in that: The wolfberry is red wolfberry.

5. The body strengthening, cancer prevention, conditioning, three-high and anti-aging composition according to claim 3, characterized in that: The wolfberry is a combination of black wolfberry and red wolfberry, and the mass ratio of the black wolfberry to the red wolfberry is 1:3-6.

6. The use of the body strengthening, cancer prevention, conditioning, three highs and anti-aging composition according to any one of claims 1 to 5, characterized in that: Any of the following: A. Application in the preparation of body strengthening products; B. Application in the preparation of anti-cancer products; C. Application in the preparation of products for regulating the three highs; D. Application in the preparation of anti-aging products.

7. The use according to claim 6, characterized in that: The product comprises a powder mixture of a composition for strengthening the body, preventing cancer, conditioning, three highs and anti-aging, or an extract of a composition for strengthening the body, preventing cancer, conditioning, three highs and anti-aging.

8. The use according to claim 7, characterized in that: The extract is obtained by extracting the body strengthening, cancer prevention, conditioning, three-high and anti-aging composition by a decoction method.

9. The use according to claim 8, characterized in that: The decoction method comprises the following steps: placing each raw material in a container, soaking it in water, decoct and extract it 2-3 times, combining the extracts, concentrating under reduced pressure to a thick paste with a relative density of 1.2-1.3 at 65° C., drying, crushing, and passing through a 100-mesh sieve to obtain the product.

10. The use according to claim 6, characterized in that: The product is a medicine, a health product, a beverage or a food.

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