Temperature control integrated assembled protection seat for marmoset experiment

Abstract

The invention discloses a temperature control integrated assembly type protective seat for marmoset experiments, which comprises a seat main body structure comprising a detachable horizontal back plate, a semi-cylinder which forms an accommodating cavity with the horizontal back plate and is used for supporting the body of a marmoset, and a circular seat plate which is arranged in the semi-cylinder and is used for adjusting the relative position of the marmoset in the semi-cylinder, a supporting panel for fixing the head of a marmoset and a neck restraining plate are arranged at the top of the semi-cylinder; the head fixing protector comprises an arc fixing part which is vertically mounted on the supporting panel and is used for protecting the rear head and neck of the marmoset, and an arc chin supporting plate which slides up and down along the arc fixing part and is used for supporting the chin of the marmoset; the damping material is arranged in the seat main body structure and the head fixing protector at the contact part with the marmoset; the temperature control adjusting system comprises an air cooling adjusting module and a water cooling adjusting module, the air cooling adjusting module controls the fan to achieve air cooling temperature adjustment, the water cooling adjusting module controls the water cooling pipe to achieve water cooling temperature adjustment, and the seat can provide a stable and comfortable experiment environment for marmosets.

Description

Technical Field

[0001] The invention belongs to the technical field of fixed experimental devices in special environments for primates, and in particular relates to a temperature-controlled integrated assemblable protective seat for marmoset experiments. Background Art

[0002] Primates are one of the species that are most closely related to humans and are highly genetically similar. Therefore, in research in fields such as neuroscience, non-human primates are often used as the main experimental subjects. Among non-human primates, marmosets are a type commonly used in laboratories. The body length of marmosets is about 15-25 cm, and they have a tail that is about 25-30 cm long. Marmosets are small in size, reproduce quickly, have a docile temperament, are safe and easy to operate, and have increasingly mature transgenic models. They are very suitable for non-human primate experiments and are receiving increasing attention from the academic community.

[0003] In experiments and tests on marmosets (such as CT and MRI examinations), the chair used to fix and restrain the posture of the marmoset is very important, affecting the accuracy of the experiment and test results. Most of the existing monkey chair technologies are for large monkeys such as macaques, while there are relatively few chairs suitable for marmosets.

[0004] First, the existing marmoset seats disclosed in application numbers CN201711278763.2 and CN201520075969.5 only consider the fixation of marmosets in fixed experimental scenarios, do not have a protective function, and cannot be used in extreme experimental environments such as transportation, vibration, acceleration, etc.

[0005] Secondly, the suitable environmental temperature for marmosets is 24-30℃. Long-term immobilization and unstable external factors (noise, vibration) will cause tension in marmosets. In addition, the closed and stuffy environment will cause the marmosets' body temperature to rise, seriously affecting their life safety. Existing marmoset experiments or tests in complex environments usually use anesthesia, which poses risks and affects some experimental results.

[0006] Therefore, considering the fixation and protection of marmosets in a waking state in a complex environment, especially the control of ambient temperature, it is of great significance to invent a temperature-controlled integrated protective seat for marmoset experiments. Summary of the invention

[0007] In view of the above, an object of the present invention is to provide a temperature-controlled integrated assemblable protective seat for marmoset experiments, which can provide a stable and comfortable experimental environment for marmosets.

[0008] To achieve the above-mentioned purpose of the invention, the embodiment provides a temperature-controlled integrated assemblable protective seat for marmoset experiments, comprising a seat main body structure, a head fixing protective gear, a shock-absorbing material, and a temperature control adjustment system;

[0009] The main structure of the seat includes a detachable horizontal back plate, a semi-cylinder that forms a receiving cavity with the horizontal back plate and supports the body of the marmoset, a circular seat plate that is arranged in the semi-cylinder and is used to adjust the relative position of the marmoset in the semi-cylinder, and a support panel and a neck restraint plate that are used to fix the head of the marmoset are arranged on the top of the semi-cylinder;

[0010] The head fixing protective gear comprises an arc fixing piece vertically mounted on the support panel and used to protect the back of the head and neck of the marmoset, and an arc-shaped chin support plate sliding up and down along the arc fixing piece and used to support the chin of the marmoset;

[0011] The shock-absorbing material is provided at the contact part between the main structure of the seat and the head fixing protector and the marmoset;

[0012] The temperature control and regulation system includes an air cooling regulation module and a water cooling regulation module. The air cooling regulation module controls a fan to achieve air cooling and temperature regulation, and the water cooling regulation module controls a water cooling pipe to achieve water cooling and temperature regulation.

[0013] Preferably, the semi-cylinder of the seat body structure is divided into a seat front part, a seat middle part and a seat rear part, wherein:

[0014] The front part of the seat is a short semi-cylindrical door with shock-absorbing material embedded inside. Under the protection of the shock-absorbing material, it comes into contact with the back of the marmoset to provide support. Ventilation holes are also drilled for ventilation.

[0015] The middle of the seat is a long semi-cylindrical door, which is embedded with a slide track for the circular seat plate to slide up and down to adjust the relative position, and also provides the function of protecting and fixing the marmoset's tail;

[0016] At the rear of the seat is a long semi-cylindrical door that protects the temperature control system supported within it.

[0017] Preferably, the circular seat plate is provided with a circular hole to expose the marmoset tail, and a long hole is provided for ventilation. The circular seat plate is connected to the slide rail through a connector and slides on the slide rail, and can be removed from the slide rail when not in use.

[0018] Preferably, the support panel has a semicircular through hole that allows the marmoset's head to extend from the hole; the neck restraint plate has an arc-shaped groove that can cooperate with the support panel to fix and protect the marmoset's head; the neck restraint plate and the support panel are connected, slid and fixed by slots and screws.

[0019] Preferably, the horizontal backplane is divided into two types, one of which is provided with a groove in which the water cooling pipe of the water cooling adjustment module is embedded, and the other of which is provided with a fan for heat dissipation of the air cooling adjustment module.

[0020] Preferably, a water reservoir for storing and transmitting hot water or cold water is also provided at the bottom of the semi-cylinder, and the water in the water reservoir is heated by an electric heating wire and cooled by a radiator.

[0021] Preferably, the temperature control and adjustment system also includes three temperature sensors arranged in the main structure of the seat, which monitor the temperature of the marmoset's chest, abdomen, and back in real time, and use a central control adjustment module to negatively feedback control the operation of the air cooling adjustment module and the water cooling adjustment module based on the average temperature of the three sensors.

[0022] Preferably, the temperatures collected by the three temperature sensors are also transmitted to the user's mobile phone via Bluetooth, the temperature adjustment range is set by the user's mobile phone, and the central control adjustment module performs negative feedback adjustment based on the temperature adjustment range.

[0023] Compared with the prior art, the present invention has the following beneficial effects:

[0024] 1. The temperature of the seat can be regulated by the fan, water cooling pipe and storage device in the temperature control system, which can make the marmoset more comfortable and adapt to environmental conditions of different temperatures.

[0025] 2. The overall seat is comfortable. The shock-absorbing material can wrap the marmoset tightly in the monkey chair. The shock-absorbing material is soft and shock-resistant, which can enable the marmoset to adapt to extreme environments such as vibration and acceleration. It will not cause discomfort to the marmoset and can restrain the marmoset for a long time, providing time for behavioral research on the marmoset.

[0026] 3. The seat is designed as an independent unit, which is easy to fix and move. It can be placed in different environments for different marmoset behavioral paradigms. The back panel design is also convenient for fixing the seat.

[0027] 4. The seat is designed to be assembled, and the detachable bottom plate can adapt to different environmental requirements and cool down the inside of the seat.

[0028] 5. The head fixing protective gear can wrap the entire head of the marmoset, so that the seat can be used in various extreme environments without affecting the safety of the marmoset. The shock-absorbing material inside the protective gear can be suitable for different marmosets and ensure the comfort of the marmoset's head.

[0029] 6. The seat is designed to be prone and lying. The seat can be fixed to different planes through the horizontal backboard, changing the marmoset's different prone and lying postures to meet different experimental needs. BRIEF DESCRIPTION OF THE DRAWINGS

[0030] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without creative work.

[0031] Figure 1 is a schematic structural diagram of a temperature control integrated assemblable protective seat provided in an embodiment;

[0032] Figure 2 is a closed state diagram of the temperature control integrated assemblable protective seat provided in the embodiment;

[0033] Figure 3 is a diagram of an open state of a temperature-controlled integrated assemblable protective seat provided in an embodiment;

[0034] Figure 4 is a schematic diagram of a horizontal backplane structure provided by an embodiment;

[0035] Figure 5 is a schematic diagram of another horizontal backplane structure provided by an embodiment;

[0036] Figure 6 is a top view of a temperature control integrated assemblable protective seat provided in an embodiment;

[0037] Figure 7 is a flow chart of the use of the temperature control integrated assemblable protective seat provided in the embodiment;

[0038] Among them, 1-horizontal back plate, 2-support panel, 3-neck restraint plate, 4-chin support plate of head fixation guard, 5-arc fixing part of head fixation guard, 6-central control adjustment module, 7-front short semi-cylindrical door, 8-middle long semi-cylindrical door, 9-rear long semi-cylindrical door, 10-water tank, 11-circular seat plate, 12-slide rail, 13-shock-absorbing material, 14-water cooling pipe, 15-fan. DETAILED DESCRIPTION

[0039] To make the purpose, technical solution and advantages of the present invention more clearly understood, the present invention is further described in detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific implementation methods described herein are only used to explain the present invention and do not limit the scope of protection of the present invention.

[0040] like Figure 1-Figure 3 , Figure 6 As shown, an embodiment provides a temperature-controlled integrated assemblable protective seat for marmoset experiments, including a seat main body structure, a head fixing protective gear, and a temperature control adjustment system.

[0041] The main structure of the seat is formed by connecting a semi-cylinder with a detachable horizontal back panel 1, wherein the horizontal back panel 1 and the semi-cylinder form a receiving cavity for accommodating and supporting the body of the marmoset, and the horizontal back panel 1 has six perforations for fixing the body of the marmoset. A support panel 2 for fixing the head of the marmoset is extended from the top of the semi-cylinder, and the support panel 2 also has a semicircular through hole that allows the head of the marmoset to extend out of the hole; the neck restraint plate 3 has an arc-shaped groove that can cooperate with the support panel 2 to fix and protect the head of the marmoset; the neck restraint plate 3 is connected, slid and fixed to the support panel 2 through slots and screws, and specifically, rectangular protrusions extend from both sides of the support panel 2 to fix the movement trajectory of the neck restraint plate 3, and the support panel 2 is also provided with four screw holes for fixing the neck restraint plate 3 and the chin support plate 4 of the head fixing guard.

[0042] The semi-cylindrical part of the main structure of the seat is divided into the front part, the middle part and the back part of the seat. The front part of the seat is a short semi-cylindrical door 7, which is embedded with a shock-absorbing material 13. Under the protection of the shock-absorbing material 13, it contacts the back of the marmoset to achieve support, and is drilled with ventilation holes for ventilation; the middle part of the seat is a long semi-cylindrical door 8, which is embedded with a slide rail 12 for the circular seat plate 11 to slide up and down to adjust the relative position, and provides the function of protecting and fixing the marmoset's tail; the back part of the seat is a long semi-cylindrical door 9, which is used to protect the temperature control system supported therein.

[0043] The shock-absorbing material can be shock-absorbing cotton such as polyvinyl alcohol, polyester fiber material, etc.

[0044] The main structure of the seat also includes a circular seat plate 11, which is arranged in the semi-cylinder and is used to adjust the relative position of the marmoset in the semi-cylinder. Specifically, it is arranged in the long semi-cylindrical door 8. The circular seat plate 11 is connected to the slide rail 12 in the long semi-cylindrical door 8 through a connecting piece, and slides on the slide rail 12 to adjust the relative position. When not in use, it can be removed from the slide rail 12. The circular seat plate 11 has a circular hole to expose the marmoset's tail, and a long strip hole is opened for ventilation.

[0045] The head fixing protective gear comprises an arc fixing piece 5 vertically mounted on the supporting panel 2 and used to protect the back of the head and neck of the marmoset, and an arc-shaped chin support plate 4 sliding up and down along the arc fixing piece 5 and used to support the chin of the marmoset.

[0046] The temperature control system includes an air cooling adjustment module and a water cooling adjustment module. The air cooling adjustment module controls the fan to achieve air cooling and temperature adjustment, and the water cooling adjustment module controls the water cooling pipe to achieve water cooling and temperature adjustment. Specifically, the horizontal backplane 11 is divided into two types, such as Figure 4 As shown, a horizontal back plate 11 is embedded with a groove, and a water cooling pipe 14 of a water cooling adjustment module is embedded in the groove. Figure 5As shown, another horizontal back panel 11 is provided with a fan 15 for heat dissipation of the air-cooling adjustment module. A water reservoir 10 for storing and transmitting hot or cold water is also provided at the bottom of the semi-cylinder, and the water in the water reservoir 10 is heated by an electric heating wire and cooled by a radiator. The temperature control system also includes three temperature sensors arranged in the main structure of the seat, which monitor the temperature of the chest, abdomen, and back of the marmoset in real time, and use the central control adjustment module 6 to negatively feedback control the operation of the air-cooling adjustment module and the water-cooling adjustment module based on the average temperature of the three sensors. When controlling the operation of the water-cooling adjustment module, the water reservoir 10 is driven to inject cold water or hot water through the cold water pipe based on the monitored temperature to reduce or increase the internal temperature of the seat.

[0047] The central control and adjustment module 6 obtains the temperature data of the three temperature sensors in real time. Considering that there is a certain physical distance between the central control and adjustment module 6 and the temperature sensor, the RS485 bus is used for communication. The central control system is also responsible for powering and communicating the three temperature sensors. The temperature range controlled by the three temperature sensors is set to 24 to 30 degrees Celsius by default, and the detected temperature information is transmitted to the user via Bluetooth. At the same time, the user can set the temperature adjustment range through the mobile phone software. When the detected temperature is higher than the set temperature range, the central control and adjustment module 6 controls the speed of the water flow in the conduit through a water pump to achieve the purpose of heat dissipation; when the detected temperature is lower than the set temperature range, the central control and adjustment module 6 starts the heating wire to increase the water temperature, and introduces the warm water into the conduit through the water pump to achieve the purpose of heating. In order to prevent scalding, the heating water temperature is set at about 60°C, and the horizontal back plate 1 with a fan can be started under the control of the central control and adjustment module 6 to dissipate heat inside the monkey chair. The central control and adjustment module 6 is not limited to single-chip microcomputers, MCUs, CPUs, FPGAs, etc. In this embodiment, the central control and adjustment module 6 uses an MCU chip with a Bluetooth module, and the extended antenna achieves the purpose of Bluetooth transceiver. The temperature sensor, water pump and electric heating wire are controlled by serial port and PWM at the same time. The system can be powered by lithium battery or power adapter.

[0048] like Figure 7 As shown, when using the seat of the present invention to conduct marmoset experiments, there are two steps, namely, preliminary preparation and animal placement. When using the above-mentioned seat to conduct behavioral experiments such as marmoset fixation and transportation, it is first necessary to place it on the loading platform, select a suitable horizontal backboard 1, install the horizontal backboard 1 on the semi-cylinder, and place the horizontal backboard 1 flat in contact with the loading platform. The two semi-cylindrical doors 8 and 9 in the middle and rear of the seat are opened, and the semi-cylindrical door 7 in the front of the seat is closed. The circular seat plate 11 is slid down to the tail of the seat through the slide rail 12, the neck restraint plate 3 is removed, the chin support plate 4 is lowered, and the arc fixing part 5 is opened to complete the preliminary preparation work.

[0049] During the animal placement stage, the marmoset used as the experimental model is taken out and placed prone in the middle part of the main structure of the seat. The experimenter pushes the marmoset to the front of the seat. When the marmoset passes through this part and its head is exposed, the neck restraint plate 3 is used to fix the head of the marmoset. The rectangular grooves on both sides of the neck restraint plate 3 are engaged with the rectangular protrusions of the support panel 2, so that the neck restraint plate 3 slides up and down until the head of the marmoset can be fixed so that the marmoset cannot retract its head. The position of the neck restraint plate is fixed with screws and screw holes on the support panel 2. The next step is to move and adjust the circular seat plate 11 so that the marmoset can contact the circular seat plate 11, and the marmoset's tail is stuck in the tail notch of the circular seat plate 11. After confirming the position, the position is fixed using the screws of the circular seat plate 11 and the circular holes of the slide rail 12. The semi-cylindrical door 8 in the middle part is closed and sealed with a cable tie. Next, adjust the chin support plate 4 of the head fixing protective gear, move the chin support plate 4 upward so that the support plate can hold the marmoset's chin, and after confirming the position, use the screws and the screw holes on the support panel 2 to fix the chin support plate 4, and fix the arc component 5 with a cable tie so that the entire head protective gear wraps the marmoset's head. Finally, close the rear semi-cylindrical door 9 and fix the central control adjustment system 6.

[0050] In summary, the temperature-controlled integrated assemblable protective seat for marmoset experiments provided by the present invention can restrain marmosets for a long time and conduct experiments such as transportation, behavior, and temperature control.

[0051] The specific implementation methods described above provide a detailed description of the technical solutions and beneficial effects of the present invention. It should be understood that the above is only the most preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, supplements and equivalent substitutions made within the scope of the principles of the present invention should be included in the protection scope of the present invention.

Claims

1. A temperature-controlled integrated assemblable protective seat for marmoset experiments, characterized in that: Including the main structure of the seat, head fixing protector, shock absorbing material and temperature control system; The main structure of the seat includes a detachable horizontal back plate, a semi-cylinder that forms a receiving cavity with the horizontal back plate and supports the body of the marmoset, a circular seat plate that is arranged in the semi-cylinder and is used to adjust the relative position of the marmoset in the semi-cylinder, and a support panel and a neck restraint plate that are used to fix the head of the marmoset are arranged on the top of the semi-cylinder; The head fixing protective gear comprises an arc fixing piece vertically mounted on the support panel and used to protect the back of the head and neck of the marmoset, and an arc-shaped chin support plate sliding up and down along the arc fixing piece and used to support the chin of the marmoset; The shock-absorbing material is provided at the contact part between the main structure of the seat and the head fixing protector and the marmoset; The temperature control and regulation system includes an air cooling regulation module and a water cooling regulation module. The air cooling regulation module controls a fan to achieve air cooling and temperature regulation, and the water cooling regulation module controls a water cooling pipe to achieve water cooling and temperature regulation.

2. The temperature-controlled integrated assemblable protective seat for marmoset experiments according to claim 1, characterized in that: The semi-cylinder of the seat main structure is divided into a seat front part, a seat middle part and a seat rear part, wherein: The front part of the seat is a short semi-cylindrical door with shock-absorbing material embedded inside. Under the protection of the shock-absorbing material, it comes into contact with the back of the marmoset to provide support. Ventilation holes are also drilled for ventilation. The middle of the seat is a long semi-cylindrical door, which is embedded with a slide track for the circular seat plate to slide up and down to adjust the relative position, and also provides the function of protecting and fixing the marmoset's tail; At the rear of the seat is a long semi-cylindrical door that protects the temperature control system supported within it.

3. The temperature-controlled integrated assemblable protective seat for marmoset experiments according to claim 2, characterized in that: The circular seat plate is provided with a circular hole to expose the marmoset tail, and a long hole is provided for ventilation. The circular seat plate is connected to the slide rail through a connecting piece and slides on the slide rail, and can be removed from the slide rail when not in use.

4. The temperature-controlled integrated assemblable protective seat for marmoset experiments according to claim 1, characterized in that: The support panel has a semicircular through hole that allows the marmoset's head to extend out of the hole; the neck restraint plate has an arc-shaped groove that can cooperate with the support panel to fix and protect the marmoset's head; the neck restraint plate and the support panel are connected, slid and fixed through slots and screws.

5. The temperature-controlled integrated assemblable protective seat for marmoset experiments according to claim 1, characterized in that: There are two types of horizontal backplanes. One type of horizontal backplane is embedded with grooves, and water cooling pipes of a water cooling adjustment module are embedded in the grooves. The other type of horizontal backplane is provided with a fan for heat dissipation of an air cooling adjustment module.

6. The temperature-controlled integrated assemblable protective seat for marmoset experiments according to claim 1, characterized in that: A water reservoir for storing and transmitting hot water or cold water is also provided at the bottom of the semi-cylinder, and the water in the water reservoir is heated by an electric heating wire and cooled by a radiator.

7. The temperature-controlled integrated assemblable protective seat for marmoset experiments according to claim 1, characterized in that: The temperature control system also includes three temperature sensors arranged in the main structure of the seat, which monitor the temperature of the marmoset's chest, abdomen, and back in real time, and use a central control adjustment module to negatively feedback control the operation of the air cooling adjustment module and the water cooling adjustment module based on the average temperature of the three sensors.

8. The temperature-controlled integrated assemblable protective seat for marmoset experiments according to claim 7, characterized in that: The temperatures collected by the three temperature sensors are also transmitted to the user's mobile phone via Bluetooth. The temperature adjustment range is set by the user's mobile phone, and the central control adjustment module performs negative feedback adjustment based on the temperature adjustment range.

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