High biosafety risk workshop liquid leakage alarm method and device

Abstract

The invention relates to the technical field of risk early warning, and discloses a high biosafety risk workshop liquid leakage alarm method and device, and the method comprises the steps: arranging a plurality of detection wires in a cofferdam, and enabling the detection wires to cover and exceed the orthographic projection area of a virus bioreactor, so as to monitor the possible virus liquid leakage condition; when virus liquid leakage is detected by the detection lead, liquid leakage signals are collected, processed and analyzed; a sound-light alarm is triggered to inform field operators and operators on duty in a central monitoring room to respond to potential safety risks in time; the sound-light alarm information is transmitted to a server of a central monitoring room, and the server is used for displaying the equipment state and storing and analyzing leakage alarm records. The system comprises a detection lead, a PLC controller, a sound-light alarm module and a central monitoring room. According to the invention, efficient monitoring and response of virus liquid leakage are realized, and the safety and scientificity of workshop management are improved. And a perfect monitoring and response mechanism is formed.

Description

Technical Field

[0001] The present invention relates to the technical field of risk early warning, and in particular to a method and device for alarming liquid leakage in a high biosafety risk workshop. Background Art

[0002] A high biosafety risk workshop refers to a workshop that produces vaccines using highly pathogenic microorganisms or specific bacterial (virus) strains. In the biosafety management of high biosafety risk workshops, the leakage of virus liquid is a very serious biosafety incident. If the leakage is not discovered in time, it will not only cause great harm to personnel and the environment, but also cause huge economic losses. Therefore, it is very important to design an efficient, accurate and stable leakage alarm device to monitor the leakage in real time for the operation of high biosafety risk workshops.

[0003] Prior art 1, Chinese patent, application number: 202410261486.8 discloses a filling device for preventing leakage of ethanol disinfectant filling, including a working side platform and an electric telescopic rod, the electric telescopic rod is installed on the top lower surface of the working side platform, and the bottom end of the electric telescopic rod is provided with an anti-drip component for preventing dripping during ethanol disinfectant filling; the anti-drip component includes a special-shaped bearing top platform, and the special-shaped bearing top platform is fixedly connected to the bottom telescopic shaft of the electric telescopic rod; by lifting the rubber sleeve, the ethanol disinfectant droplets remaining in the inner cavity of the filling nozzle are cut off by the rubber sleeve to flow to the outside, and at the same time, due to the action of the rubber sleeve, the bottom bearing block and the bottom of the rubber sleeve are kept dry during the filling process of the ethanol disinfectant, and then the communication channel between the inner cavity of the filling nozzle and the outside is blocked at this time, so that the residual ethanol disinfectant droplets in the inner cavity of the filling nozzle cannot drip. Although it ensures the economical use of ethanol disinfectant liquid, its structure is relatively simple and lacks relevant functional structures that can warn of leakage, which reduces the intelligence level of leakage detection to a certain extent.

[0004] Prior art 2, Chinese patent, application number: 202210105104.3 discloses a packaging process and inactivation method of infectious virus liquid, including the following steps: (1) taking a cryopreservation tube, the cryopreservation tube includes an end cap and a tube body that are screwed together, and the end cap is provided with two through holes, and the infectious virus liquid is injected into the cryopreservation tube through one of the through holes, and the gas is discharged through the other through hole, so that the residual gas in the cryopreservation tube is ≤1vol%; (2) wiping the overflowed infectious virus liquid and standing until the end surface of the end cap is dry; (3) taking dental resin powder and denture base resin liquid, mixing, stirring, and obtaining a resin mixture; (4) filling the resin mixture into the two through holes on the cryopreservation tube, standing for 10 to 30 minutes, and obtaining a sealed cryopreservation tube; wherein the weight ratio of the dental resin powder to the denture base resin liquid is 1.95 to 2.3:1. Although the packaging process of infectious virus liquid can keep the cryopreservation tube at a low leakage rate under the action of ultra-high pressure. However, the lack of facilities that can predict leakage makes the technical means of leakage detection incomplete.

[0005] Prior art three, Chinese patent, application number: 201810708329.1 discloses a method for concentrating a virus liquid, placing a biofilm in a vessel, and then adding 18-25 ml of the virus liquid according to the weight of 1 g of the biofilm to the vessel, adsorbing at 2-8 ° C for 1-3 hours and then freeze-drying, and then re-dissolving with MEM culture medium containing 1-3 wt% fetal bovine serum, cutting the biofilm into pieces and homogenizing, and then removing the biofilm fragments by centrifugation, and filtering the supernatant to obtain the concentrated virus liquid. The concentration method of the present invention is simple and easy, although the concentrated virus liquid improves the virus titer (not less than 107.0TCID50 / 0.1ml) while maintaining the virus infection ability, and the separated virus liquid can be obtained, which has a wide range of application prospects in virus removal / inactivation verification. However, the process steps do not involve leakage detection, nor do they involve early warning, resulting in poor safety in the production process.

[0006] At present, the leakage detection facilities in the prior art 1, prior art 2 and prior art 3 have the problem that the accuracy is poor and the stability needs to be further improved. Therefore, the present invention provides a leakage alarm method and device for a high biosafety risk workshop, which can detect the accidental leakage of virus liquid at the first time, and promptly activate the emergency plan for the high biosafety risk workshop, reduce biosafety risks and reduce losses. Summary of the invention

[0007] The main purpose of the present invention is to provide a method and device for liquid leakage alarm in a high biosafety risk workshop, so as to solve the problem that the liquid leakage detection facilities in the prior art have poor accuracy and stability that needs to be further improved.

[0008] To achieve the above object, the present invention provides the following technical solutions:

[0009] A method for alarming liquid leakage in a high biosafety risk workshop, the method comprising:

[0010] Arrange multiple detection wires in the cofferdam, the detection wires cover and exceed the positive projection area of ​​the virus bioreactor, so as to monitor possible leakage of virus liquid;

[0011] The detection wire detects the leakage of virus liquid, collects the leakage signal, and processes and analyzes it; it triggers the sound and light alarm to notify the on-site operators and the on-duty personnel in the central monitoring room to respond to potential safety risks in a timely manner;

[0012] The sound and light alarm information is transmitted to the server in the central monitoring room to display the equipment status and store and analyze the leakage alarm records.

[0013] As a further improvement of the present invention, the calculation of the positive projection area of ​​the virus bioreactor includes:

[0014] Gather geometry information from blueprints of the viral bioreactor; add a mesh to estimate the size and proportions of the shapes;

[0015] Create a virtual transparent plane, add an infinite plane to simulate the virus bioreactor projection from above, and set the color of the virus bioreactor body to transparent; extract the contour in the projection plane, and convert the extracted contour data into coordinate form;

[0016] Based on the shape of the contour, the extracted area is divided into rectangular, triangular or polygonal basic shapes. Depending on the type of contour, the area is calculated from the point coordinates of the contour using a mathematical formula. A dynamic simulation is created to load the virtual liquid from a certain part of the virus bioreactor model and obtain the diffusion on the orthographic projection plane. The arrangement of the wires is adjusted according to the simulation results.

[0017] As a further improvement of the present invention, geometric information, including height, diameter and curvature, creates the basic shape of the reactor.

[0018] As a further improvement of the present invention, the leakage signal is processed and analyzed, including:

[0019] When there is no liquid, the detection wire is in a normally open state. When encountering liquid, the detection wire changes from a normally open state to a normally closed state because the liquid has a certain electrical conductivity. Therefore, when the detection wire senses changes in the presence of liquid in the surrounding environment, the detection wire changes from a disconnected state to a closed loop, converting the change information of the presence of liquid into an electrical signal, which is then input into the relevant control module for processing and analysis.

[0020] According to the analysis results, if liquid leakage occurs, the alarm mechanism will be triggered and the alarm will be sounded in the form of sound and light signals; at the same time, the alarm information will be transmitted to the central monitoring room via TCP / IP communication, and the alarm triggering time, location, duration and alarm type will be automatically recorded.

[0021] As a further improvement of the present invention, triggering the alarm mechanism includes:

[0022] The analysis results are identified, leakage is defined as binary 1, and no leakage is defined as binary 0. Binary 1 is combined with the alarm program. The alarm program content is: when there is leakage, the red light is on and the buzzer sounds, and the green light is off; when there is no leakage, the red light is off and the buzzer does not sound, and the green light is on;

[0023] Creating a first alarm rule according to the content of the alarm procedure;

[0024] Based on the recognition of the analysis results, the specific content of the binary is obtained, and the first alarm rule is matched with the specific content. If the specific content meets the alarm condition, an alarm operation corresponding to the first alarm rule is generated and displayed on the traffic light and buzzer.

[0025] As a further improvement of the present invention, the first alarm rule includes multiple items of traffic light rules and buzzer rules, the traffic light rules include turning on and off the red light and green light, and the buzzer includes sounding and not sounding; the first alarm rule also includes multiple second alarm rules that meet the content of the alarm procedure, the content of which is to detect that the wire is in a continuous closed state within a preset time, and increase the working frequency of the red light and the buzzer.

[0026] As a further improvement of the present invention, the sound and light alarm information is transmitted to the server in the central monitoring room, including:

[0027] When receiving a data packet of alarm information, the server reads the data length field in the data packet; reads valid information according to the length information, calculates the checksum, and compares the calculated value with the checksum in the data packet; if the checksum passes, the integrity of the data packet is confirmed; if it does not match, the data packet is discarded and an error log is recorded;

[0028] Parse the valid information and extract each alarm information, including alarm type, trigger device ID, and occurrence time; save the parsed data into the database through object-relational mapping, and record the context information of related events;

[0029] Create a history panel to display past alarm records in table or timeline format.

[0030] As a further improvement of the present invention, the following are listed: alarm time, alarm device ID, alarm type and processing status.

[0031] To achieve the above object, the present invention also provides the following technical solutions:

[0032] A liquid leakage alarm device for a high biosafety risk workshop, which is applied to the liquid leakage alarm method for a high biosafety risk workshop, and the liquid leakage alarm device for a high biosafety risk workshop comprises: a workshop site and a central monitoring room;

[0033] Among them, the workshop is equipped with a cofferdam, a tank, a detection wire, a PLC controller, and a first sound and light alarm device; the central monitoring room is equipped with a server, a second sound and light alarm device, and a display.

[0034] As a further improvement of the present invention, the cofferdam is used to control the leakage of the virus liquid within a certain range, a tank body and a detection wire are arranged inside the cofferdam, the tank body is used to contain the virus liquid, the detection wire is used to detect the leakage of the virus liquid, and the detection wire covers the tank body; the PLC controller is connected to the detection wire and the first sound and light alarm device, and the first sound and light alarm device is used to perform sound and light alarm at the workshop site;

[0035] The server inside the central monitoring room is connected to the PLC controller through a network switch, and the PLC controller is connected to the second sound and light alarm device and the display. The PLC controller is used to collect leakage signals, process and analyze the signals, trigger the sound and light alarm devices in the workshop and the central monitoring room, and transmit the alarm signal to the server in the central monitoring room; the server displays the equipment status on the display, stores and records the analysis of leakage alarms; the function of the second sound and light alarm device is to let the on-site operators and the on-duty personnel in the central control room know that a leakage has occurred; a power module is also provided in the central monitoring room to provide power support for the entire system.

[0036] The present invention arranges detection wires, and by arranging multiple detection wires in the cofferdam so that they cover and exceed the positive projection area of ​​the virus bioreactor, it can ensure comprehensive monitoring of potential leakage areas; the detection wires can continuously monitor the environment, and once liquid leakage occurs, it can be discovered in time. The significance achieved: ensure that any possible leakage can be detected quickly to reduce biosafety risks; provide effective preventive measures to reduce the possibility of accidents and protect the safety of workers and the environment. Signal processing and alarm, once the wire detects the leakage of virus liquid, it can quickly collect and analyze the signal to ensure a fast and accurate response; send out an audible and visual alarm to promptly notify the on-site operators and the on-duty personnel in the central monitoring room so that they can immediately take countermeasures. The significance achieved: ensure that potential dangers can be handled in time and reduce the harm caused by virus leakage; through the rapid alarm mechanism, improve the response efficiency of on-site and central monitoring room personnel, and enhance the overall safety management level. Information transmission and record preservation, the audible and visual alarm information is transmitted to the server in the central monitoring room, so that the equipment status can be monitored in real time and displayed accordingly; store and analyze the leakage alarm records to provide data support for subsequent safety assessment and management. Significance achieved: Through systematic information recording and analysis, it helps relevant managers better understand leakage incidents and optimize safety management measures; it provides support for future risk assessment and decision-making, making biosafety management more scientific and effective. BRIEF DESCRIPTION OF THE DRAWINGS

[0037] Figure 1 A schematic flow chart of the steps of an embodiment of a method for alarming a liquid leakage in a high biosafety risk workshop of the present invention;

[0038] Figure 2 A schematic flow chart of the steps of calculating the orthographic projection area of ​​a virus bioreactor in one embodiment of a method for alarming a liquid leakage in a high biosafety risk workshop of the present invention;

[0039] Figure 3 A schematic flow chart of the steps of processing and analyzing a leakage signal in an embodiment of a method for alarming a leakage in a workshop with high biological safety risk according to the present invention;

[0040] Figure 4 A schematic flow chart of the steps of transmitting the sound and light alarm information to the server in the central monitoring room in one embodiment of the method for alarming liquid leakage in a high biosafety risk workshop of the present invention;

[0041] Figure 5 This is a functional module diagram of an embodiment of a liquid leakage alarm device for a high biosafety risk workshop of the present invention;

[0042] Figure 6 This is a schematic diagram of the working principle of an embodiment of a liquid leakage alarm device for a high biosafety risk workshop of the present invention;

[0043] Figure 7 It is a structural schematic diagram of an embodiment of an electronic device of the present invention;

[0044] Figure 8 A schematic diagram of the structure of a storage medium according to an embodiment of the present invention;

[0045] Fig. 9 It is a control logic diagram of the programmable logic controller (PLC) of the present invention. DETAILED DESCRIPTION

[0046] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0047] The terms "first", "second" and "third" in the present invention are only used for descriptive purposes and cannot be understood as indicating or implying relative importance or implicitly indicating the number of indicated technical features. Therefore, the features defined as "first", "second" and "third" can explicitly or implicitly include at least one of the features. In the description of the present invention, the meaning of "multiple" is at least two, such as two, three, etc., unless otherwise clearly and specifically defined. All directional indications (such as up, down, left, right, front, back...) in the embodiments of the present invention are only used to explain the relative position relationship, movement, etc. between the components under a certain specific posture (as shown in the accompanying drawings). If the specific posture changes, the directional indication also changes accordingly. In addition, the terms "including" and "having" and any of their variations are intended to cover non-exclusive inclusions. For example, a process, method, system, product or device that includes a series of steps or units is not limited to the listed steps or units, but optionally also includes steps or units that are not listed, or optionally also includes other steps or units inherent to these processes, methods, products or devices.

[0048] Reference to an "embodiment" herein means that a particular feature, structure, or characteristic described in conjunction with the embodiment may be included in at least one embodiment of the present invention. The appearance of the phrase in various places in the specification does not necessarily refer to the same embodiment, nor is it an independent or alternative embodiment that is mutually exclusive with other embodiments. It is explicitly and implicitly understood by those skilled in the art that the embodiments described herein may be combined with other embodiments.

[0049] like Figure 1 As shown, this embodiment provides an embodiment of a method for alarming liquid leakage in a high biosafety risk workshop. In this embodiment, the method for alarming liquid leakage in a high biosafety risk workshop specifically includes the following steps:

[0050] Step S1: Arrange a plurality of detection wires in the cofferdam, wherein the detection wires cover and exceed the positive projection area of ​​the virus bioreactor to monitor possible leakage of the virus liquid;

[0051] Step S2: The detection wire detects the leakage of virus liquid, collects the leakage signal, and processes and analyzes it; triggers the sound and light alarm to notify the on-site operator and the on-duty personnel in the central monitoring room to respond to potential safety risks in a timely manner;

[0052] Step S3: Transmit the sound and light alarm information to the server in the central monitoring room for displaying the equipment status and storing and analyzing the leakage alarm records.

[0053] Preferably, in step S1 of this embodiment, the detection wire is arranged. By arranging multiple detection wires in the cofferdam so that they cover and exceed the positive projection area of ​​the virus bioreactor, comprehensive monitoring of the potential leakage area can be ensured; the detection wire can continuously monitor the environment and can be discovered in time once a liquid leak occurs. The significance achieved: ensure that any possible leakage can be detected quickly to reduce biosafety risks; provide effective preventive measures to reduce the possibility of accidents and protect the safety of workers and the environment. Step S2 signal processing and alarm, once the wire detects a virus liquid leak, it can quickly collect and analyze the signal to ensure a fast and accurate response; send out an audible and visual alarm to promptly notify the on-site operator and the on-duty personnel in the central monitoring room so that they can take countermeasures immediately. The significance achieved: ensure that potential dangers can be handled in a timely manner and reduce the harm caused by virus leakage; through the rapid alarm mechanism, improve the response efficiency of the on-site and central monitoring room personnel, and enhance the overall safety management level. Step S3 information transmission and record preservation, transmit the audible and visual alarm information to the server in the central monitoring room, so that the equipment status can be monitored in real time and displayed accordingly; store and analyze the leakage alarm records to provide data support for subsequent safety assessment and management. Significance achieved: Through systematic information recording and analysis, it helps relevant managers better understand leakage incidents and optimize safety management measures; it provides support for future risk assessment and decision-making, making biosafety management more scientific and effective.

[0054] In summary, the entire liquid leakage alarm method of this embodiment not only realizes efficient monitoring and response of virus liquid leakage, but also improves the safety and scientificity of workshop management. Each step cooperates with each other to form a complete monitoring and response mechanism, which helps to protect the safety of staff and prevent the expansion of biological risks.

[0055] Furthermore, if Figure 2 As shown, the calculation process of the orthographic projection area of ​​the virus bioreactor in step S1 specifically includes the following steps:

[0056] Step S11: Collect geometric information from the design drawings of the virus bioreactor, including height, diameter, and curvature, etc., to create the basic shape of the reactor; add a grid to estimate the size and proportion of the shape;

[0057] Step S12: creating a virtual transparent plane, adding an infinite plane to simulate the virus bioreactor projection from above, setting the color of the virus bioreactor body to transparent; extracting the contour within the projection plane, and converting the extracted contour data into coordinate form;

[0058] Step S13: according to the shape of the contour, the extracted area is divided into basic shapes such as rectangle, triangle or polygon, and according to the type of contour, the area is calculated according to the point coordinates of the contour using a mathematical formula; a dynamic simulation is created to load the virtual liquid from a certain part of the virus bioreactor model and obtain the diffusion on the orthographic projection plane, and the arrangement of the wire is adjusted according to the simulation results;

[0059] Among them, it is assumed that the geometry of the reactor can be combined with multiple parameterized equations;

[0060]

[0061] Where: R0 represents the base radius, A n and B n is the amplitude adjustment coefficient, ω n ,φ n , γ n and θ n are the frequency and phase shifts; R(z) represents the radius of the reactor at a given height z; n represents the number of parameters; N represents the total number of parameters;

[0062] Introducing a spatial mapping function Represent the reactor shape by parameterizing a high-dimensional surface:

[0063] G(x,y,z)=[X(x,y,z)+C sin(λz),Y(x,y,z)+D cos(μz)]

[0064] Where x and y are mapping parameters defined by the z dimension; C and D introduce distortions to the shape, improving the nonlinear behavior of the mapping, λ and μ are new tuning frequencies; Y is not in a one-dimensional or two-dimensional curve or spatial coordinate, representing the vertical axis or the second coordinate component, and Z represents the vertical coordinate axis. In spatial mapping, z represents the height or depth of the reactor and is used to define the three-dimensional characteristics of the geometric shape;

[0065] Parameterization of contour curve: Use parameter t to express the contour curve as: x(t), y(t), z(t))t∈[t0, t1] and apply polynomial curve fitting to accurately construct the contour;

[0066] Calculate contour length and local area: Use the curve length L formula:

[0067]

[0068] Each small part of the curve can be subdivided into small areas A j Processing; κ(t) represents the local curvature, which enhances the geometric understanding of the contour;

[0069] Area calculation and topological analysis of complex regions;

[0070] Area A calculation: For each small area A j , using a more complex method for calculating the contour area of ​​arbitrary shapes:

[0071]

[0072] Calculate the area of ​​the closed region through line integral; A j It is a regional subdivision, f(x,y) represents the local area expression within the region, which may contain variable adjustments; m is used for counting, indicating the number of regions considered in a certain context, and j is used as an index variable to refer to a specific small region for looping or summing;

[0073] For complex topological structures, the homology groups are calculated to capture the characteristics within the region:

[0074]

[0075] Here, X represents the area of ​​the contour, and H k It represents the homology group of order k, and its characteristics differ in the complexity of its topological structure;

[0076] Dynamic simulation and feedback optimization

[0077] Fluid dynamics model: Use the nonlinear equations of fluid dynamics to model the flow patterns inside the reactor:

[0078]

[0079] Where ∈ is the disturbance intensity, (u) is the nonlinear correction of the flow field using an optimization algorithm to automatically adjust the internal structure to maximize the reaction efficiency; p represents the pressure in the fluid dynamics equation, and v represents the dynamic viscosity (or kinematic viscosity), which describes the flow characteristics of the fluid;

[0080] maximizef(θ)subject tog i (θ)=0,h j (θ)≤0

[0081] where maximizef(θ) is the design parameter, g i is the boundary condition; h j (θ) is a constraint that allows optimization under boundary conditions and material limitations; i is used for counting, indicating the specific area currently being processed;

[0082] Through the above complex process, the final orthographic projection area calculation can be expressed as:

[0083]

[0084] Where: C i represents the cyclic integral of the split edge, D is the projection area, It can be used to describe the divergence of the flow field and help optimize the design. f The adjustment amount introduced by the feedback mechanism, Ω(θ,u) represents the dynamic adjustment amount in the flow field and the correction effect of the convolution calculation on the efficiency.

[0085] Preferably, in step S11 of this embodiment, geometric information collection and grid addition are performed to collect geometric information (height, diameter, radian, etc.) of the reactor to lay the foundation for subsequent modeling, so that the model has accurate size and shape; adding grids helps visualize the various spatial dimensions of the reactor, which is convenient for intuitive estimation of shape and proportion. Significance achieved: Accurate geometric parameters are the basis for subsequent projection and area calculation, ensuring that all subsequent operations have reliable data support; in the design and safety assessment process, clear spatial considerations can effectively support the requirements for risk analysis and safety monitoring of the reactor. Step S12 transparent plane creation and contour extraction simulates the appearance of observing the reactor from above, and intuitively displays the contour of the reactor through a transparent plane, which is convenient for subsequent data extraction; contour data is extracted through software functions and converted into coordinate form, laying the foundation for subsequent calculations. Significance achieved: Through this visual method, the positive projection effect of the reactor can be very intuitively understood, and potential leaks and safety hazards can be identified in advance; contour extraction ensures a comprehensive understanding of the shape and reduces the errors that may be caused by manual calculations. Step S13: Region classification and area calculation: the extracted contours are divided into different basic shapes, so as to select the corresponding mathematical formula for accurate calculation. During the calculation process, the virtual liquid is loaded by dynamic simulation and its diffusion is observed to enhance the realism and practical application value of the model. The significance achieved: Calculating the area according to different shapes can improve the accuracy of the calculation, which is extremely important for the subsequent leakage monitoring system. The simulation results can be used to optimize the layout of the wires to enhance their ability to detect potential leaks and ensure that biosafety and risk control are strengthened.

[0086] In summary, this embodiment not only ensures the accuracy of the calculation of the positive projection area of ​​the virus bioreactor by utilizing modern digital modeling and data processing technology, but also provides an operational solution in reactor design and safety monitoring. Through the organic combination of various steps, the whole process is more systematic and efficient, providing a basis and guarantee for the actual safety management of the bioreactor, and ensuring the safety and health of the operators.

[0087] Furthermore, if Figure 3 As shown, the process of processing and analyzing the leakage signal in step S2 specifically includes the following steps:

[0088] Step S21: detecting changes in the presence of liquid in the surrounding environment sensed inside the wire, checking that the wire forms a closed loop from a disconnected state, and inputting corresponding electrical signals to the corresponding module;

[0089] Step S22: After the input module receives the corresponding electrical signal, it is fed back to the CPU for logic analysis, the corresponding point of the output module has a voltage output, and the relevant relay operates to output;

[0090] Step S23: According to the analysis results, if liquid leakage occurs, the alarm mechanism is triggered and an alarm is issued in the form of sound and light signals; at the same time, the alarm information is transmitted to the central monitoring room, and the triggering time, location, duration and alarm type of the alarm are automatically recorded.

[0091] Preferably, in step S21 of this embodiment, the detection wire induction and electrical signal conversion are performed, and the detection wire monitors whether there is liquid in the environment in real time. If the inspection wire is closed, it indicates that there may be liquid in the surrounding environment; the information of the presence of liquid is converted into an electrical signal for subsequent processing. This is the key first step, which ensures that the input signal source of the entire monitoring system is reliable. The significance achieved: real-time monitoring enables any potential liquid leakage to be detected quickly, thereby improving on-site safety, enhancing the accuracy of monitoring, and laying the foundation for subsequent analysis. Step S22 When the detection wire detects liquid, the input module receives the corresponding electrical signal and feeds it back to the CPU for logical analysis, the corresponding point of the output module has a voltage output, and the relevant relay outputs. Step S23 triggers alarm and information recording. When liquid leakage is confirmed, the system starts the sound and light alarm mechanism, so that the on-site operator can immediately notice the potential risk situation; at the same time, the alarm information is transmitted to the central monitoring room, and the alarm trigger time, location, duration and alarm type and other important information are recorded, which provides necessary data support for subsequent response and analysis. Significance achieved: Sound and light alarms can effectively alert on-site personnel at the first time, allowing them to respond in time and take emergency measures quickly; automatic recording of alarm information is helpful for subsequent accident analysis, summarizing lessons learned, further optimizing safety management measures, and providing a data basis for future risk assessment and monitoring system improvements.

[0092] In summary, this embodiment together constitutes an effective liquid leakage monitoring system, which ensures that liquid leakage can be monitored in a high biosafety risk workshop in a timely and accurate manner, quickly responds to potential risks, and avoids or reduces possible losses and hazards. Through the coordinated work of sensor induction, electrical signal processing, filtering and alarm mechanisms, a safety monitoring system with a reasonable structure, clear logic and efficient operation is formed.

[0093] Furthermore, the process of triggering the alarm mechanism in step S23 specifically includes the following steps:

[0094] Step S231: Identify the analysis results, define leakage as binary 1, and define no leakage as binary 0. Binary 1 is combined with an alarm program. The alarm program is as follows: when leakage occurs, the red light is on and the buzzer sounds, and the green light is off; when no leakage occurs, the red light is off and the buzzer does not sound, and the green light is on.

[0095] Step S232: creating a first alarm rule according to the content of the alarm program, the first alarm rule including multiple items of the traffic light rule and the buzzer rule, the traffic light rule including the on and off of the red light and the green light, and the buzzer including the sounding and not sounding; the first alarm rule also includes multiple second alarm rules that meet the content of the alarm program, the content of which is to increase the working frequency of the red light and the buzzer when the detection wire is in a continuous closed state;

[0096] Step S233: Based on the recognition of the analysis results, the specific content of the binary is obtained, and the first alarm rule is matched with the specific content. If the specific content meets the alarm condition, an alarm operation corresponding to the first alarm rule is generated and displayed on the traffic light and buzzer; if the detection wire is in a continuously closed state, the second alarm rule is activated.

[0097] Preferably, step S231 of this embodiment identifies the analysis results and defines the status, and provides a clear status identification system by defining leakage and non-leakage as binary 1 (leakage) and 0 (non-leakage) respectively, which is convenient for subsequent processing; the logic of the alarm program is simplified by using binary status, so that the program can quickly judge and execute the corresponding alarm operation. The significance achieved: the liquid leakage status is simplified into binary form, so that the system can respond quickly and improve the speed of emergency treatment; clear alarm signals (red light, green light, buzzer) are defined, which are easy for on-site staff to quickly identify and understand the alarm status, which is helpful for real-time response. Step S232 creates a first alarm rule, integrates the traffic light rule and the buzzer rule into a first alarm rule, and improves the effectiveness of the alarm system through multiple specific rules; preliminarily sets the basic alarm conditions, and can create multiple second alarm rules for complex situations, and activate higher frequency alarms under preset conditions. The significance achieved: through the setting of multiple rules, the system can adjust the alarm mode according to different leakage situations (such as degree, duration, etc.), which increases the flexibility of the system; avoids missed detection, ensures timely alarm in any possible leakage situation, and strengthens the safety management of equipment and environment. In step S233, rule matching and alarm operation generation, the system can match and judge the first alarm rule according to the identified binary state, and generate the corresponding alarm operation; if the detection wire is continuously closed, the second alarm rule can be automatically activated to increase the alarm frequency and strengthen the warning effect of leakage. Significance achieved: Through the alarm operation generation function, a rapid response to leakage events is achieved to ensure on-site safety and processing efficiency; by dynamically adjusting the frequency and intensity of the alarm, a step-by-step warning mechanism is created, so that the staff can better respond to the severity of the leakage and the treatment measures.

[0098] In summary, this embodiment constitutes an efficient, flexible and highly adaptable alarm mechanism, which makes the detection and response of liquid leakage have good operability and reliability in the processing flow by simplifying the state definition, creating multi-layer alarm rules and implementing precise matching. It not only improves the early warning capability of potential safety risks, but also improves the management efficiency and the sense of security of on-site workers in actual operation, thereby effectively maintaining the safety of equipment and the stability of the environment.

[0099] Furthermore, if Figure 4 As shown, the process of transmitting the sound and light alarm information to the server in the central monitoring room in step S3 specifically includes the following steps:

[0100] Step S31: When receiving a data packet of alarm information, the server reads the data length field in the data packet; reads valid information according to the length information, calculates the checksum, and compares the calculated value with the checksum in the data packet; if the checksum passes, the integrity of the data packet is confirmed; if it does not match, the data packet is discarded and an error log is recorded;

[0101] Step S32: parse the valid information part and extract various alarm information, including alarm type, trigger device ID, and occurrence time; the parsed data is saved in the database through object relational mapping, and the context information of related events is recorded;

[0102] Step S33: Create a history record panel to display past alarm records in a table or timeline format, listing: alarm time, alarm device ID, alarm type and processing status.

[0103] Preferably, step S31 of this embodiment is to check and confirm the integrity of the data packet, by reading the data length field and subsequent data in the data packet, to ensure that the information density is correct, thereby preventing accidental data loss or redundancy; calculate the checksum and compare it with the received checksum to ensure that the data has not been tampered with during transmission. If the check fails, the data packet will be discarded and an error log will be recorded. This provides a basis for subsequent troubleshooting. The significance achieved: the guaranteed integrity allows the system to receive alarm data in a timely and accurate manner, reduce the possibility of false alarms, and improve the stability of the system; prevent malicious tampering of data or false alarms, and protect the safety and data accuracy of the biosafety area; by recording error logs, the system can be audited and monitored, which is convenient for later troubleshooting and system maintenance. Step S32 data parsing and storage, after parsing the valid information, the necessary alarm information, such as alarm type, trigger device ID and occurrence time, can be extracted; through object-relational mapping (ORM), the parsed data is structured and stored in the database to record relevant event context information. Significance achieved: Data is stored in a structured manner for easy retrieval and analysis in the future, and the flexibility and convenience of data processing are enhanced; alarm information is quickly extracted and organized so that on-site operators and managers can obtain the required information immediately to facilitate rapid action; data silos are avoided, and through the recording of contextual information, the system can provide comprehensive information support for event analysis, including alarm frequency, equipment failure trend, etc. Step S33: Creation of a historical record panel, creating a graphical historical record panel in the form of a table or timeline to display past alarm records and related information; providing filtering, sorting and other functions so that users can easily find alarm records for specific times or specific equipment. Significance achieved: Through intuitive interface design, users can more easily understand and use the system and respond quickly; by analyzing historical records, management can identify potential risks, seasonal changes in equipment failures and their corresponding response strategies, thereby gradually optimizing the safety management process; recorded alarm data can be used for audits and compliance checks to ensure that operations comply with relevant laws and regulations, and provide guarantees for the long-term stable operation of the enterprise.

[0104] In summary, steps S31, S32 and S33 of this embodiment not only improve the emergency response and processing efficiency of high biosafety risk workshops through data integrity confirmation, information analysis and storage, and the creation of historical records, but also provide strong support for system maintenance and risk management. The steps together constitute an efficient, safe and reliable alarm monitoring mechanism to ensure the safety and rationality of operations.

[0105] like Figure 5As shown, this embodiment also provides an embodiment of a liquid leakage alarm device for a high biosafety risk workshop. In this embodiment, the liquid leakage alarm device for a high biosafety risk workshop is applied to the liquid leakage alarm method for a high biosafety risk workshop in the above embodiment. The liquid leakage alarm device for a high biosafety risk workshop includes a workshop site 1, a central monitoring room 2, a cofferdam 3, a tank body 4, a detection wire 5, a PLC controller 6, a first sound and light alarm device 7, a server 8, a second sound and light alarm device 9, and a display 10;

[0106] The workshop site 1 is provided with a cofferdam 3, a tank 4, a detection wire 5, a PLC controller 6, and a first sound and light alarm device 7; the central monitoring room 2 is provided with a server 8, a second sound and light alarm device 9, and a display 10;

[0107] The cofferdam 3 is used to control the leakage of the virus liquid within a certain range. A tank body 4 and a detection wire 5 are arranged inside the cofferdam 3. The tank body 4 is used to contain the virus liquid. The detection wire 5 is used to detect the leakage of the virus liquid. The detection wire 5 covers the tank body 4. The PLC controller 6 is connected to the detection wire 5 and the first sound and light alarm device 7. The first sound and light alarm device 7 is used to make a sound and light alarm at the workshop site 1.

[0108] The server 8 inside the central monitoring room 2 is connected to the PLC controller 6 through a network switch, and the PLC controller 6 is connected to the second sound and light alarm device 9 and the display 10. The PLC controller 6 is used to collect leakage signals, process and analyze the signals, trigger the sound and light alarm devices at the workshop site 1 and the central monitoring room 2, and transmit the alarm signal to the server 6 in the central monitoring room 2; the server 6 displays the equipment status on the display 10, stores and records the analysis of leakage alarms; the function of the second sound and light alarm device 9 is to let the on-site operators and the on-duty personnel in the central control room know that a leakage has occurred; a power module is also provided in the central monitoring room 2 to provide power support for the entire system.

[0109] Preferably, the working principle of the present embodiment is as follows: when the system is started and no liquid leakage is detected, the green lights of the first sound and light alarm device 7 and the second sound and light alarm device 9 of the system are on, and the system is in normal operation; when the detection wire 5 detects liquid leakage, the PLC controller 6 collects the corresponding signal, analyzes it, and outputs the corresponding signal to the server 8 and the first sound and light alarm device 7 and the second sound and light alarm device 9. After receiving the signal, the server 8 will record the alarm information and display the relevant alarm information on the display 10. After receiving the signal, the first sound and light alarm device 7 and the second sound and light alarm device 9 will light up the red light and trigger the buzzer to sound; after the liquid is cleared, the detection wire 5 does not detect the liquid, the PLC controller 6 will collect the corresponding signal, analyze it, and output the corresponding signal to the server 8 and the first sound and light alarm device 7 and the second sound and light alarm device 9. After receiving the signal, the server 8 does not display the alarm information on the display 10, the red light of the first sound and light alarm device 7 and the second sound and light alarm device 9 goes out, the buzzer does not sound, the green light is on, and the system returns to normal.

[0110] The combination of the detection wire 5 and the PLC controller 6 of this embodiment realizes real-time monitoring of the liquid state of the tank body 4; it can quickly identify the leakage and respond in time; when a leakage is detected, the PLC controller 6 immediately analyzes the signal and outputs the result, and triggers the sound and light alarm devices 7 and 9 at the same time, ensuring that an alarm can be issued as soon as the leakage occurs to remind the on-site operator and the on-duty personnel in the central monitoring room; the server 8 is responsible for recording all alarm information and displaying the current equipment status and related alarm information in real time on the display 10; the information management method can trace the alarm history and provide reliable data support for later analysis and troubleshooting; the first sound and light alarm device 7 and the second sound and light alarm device 9 clearly convey the working status of the system to the operator by switching between red and green lights, ensuring that both the staff and the monitoring personnel can quickly understand the system status; a power module is set to ensure that the entire alarm system can obtain a stable power supply and achieve continuity and reliability in data acquisition and processing. Significance achieved: Real-time monitoring of the status of liquids, timely alarms, and reduction of potential threats to the environment and personnel caused by leakage are particularly important for biosafety risk workshops; the rapid response alarm mechanism can significantly shorten the processing time, ensuring that on-site personnel and managers can quickly take effective actions to reduce possible losses; recording and analyzing alarm information provides managers with an important data basis, supports targeted management and improvement measures, and promotes the development of safety management towards dataization and refinement; the intuitive indication of the sound and light alarm device reduces the communication error between people and machines, ensuring that each operator can quickly understand the current status and reduce the risk of decision-making errors; an effective safety early warning system and its recording capabilities help companies meet compliance requirements when implementing safety management, increase the trust of the public and regulators, and thus improve corporate image and market competitiveness.

[0111] like Figure 6 As shown, after the system is started, no leakage is detected, the relay K1 is closed, the green light of the sound and light alarm device is on, and the system is in normal operation; when there is liquid leakage, the wire S is checked to be closed, the digital input DI module has a signal input, the CPU analyzes the collected signal, the digital output DQ module has a signal output, the relays K2 and K3 are closed, K1 is disconnected, the red light of the sound and light alarm device is on, the buzzer sounds, and the green light goes out; at the same time, the server 8 receives and records the corresponding alarm information through the network switch, and displays the relevant alarm information on the display; after the liquid is cleared, the wire S is checked to be disconnected, the digital input DI module has no signal input, the CPU analyzes the collected signal, the digital output DQ module outputs the corresponding signal, the relays K2 and K3 are disconnected, K1 is closed, the red light of the sound and light alarm device is off, the buzzer does not sound, the green light is on, and the system returns to normal.

[0112] In summary, the leakage alarm device for high biosafety risk workshops in this embodiment significantly improves safety and management efficiency through real-time monitoring, rapid response, information recording and feedback, etc. Its design effectively reduces the damage that may be caused by leakage events, promotes enterprises to move towards a refined and intelligent management model, and provides a solid guarantee for the normal operation of enterprises.

[0113] like Figure 7 As shown, this embodiment provides an embodiment of an electronic device. In this embodiment, the electronic device 11 includes a processor 111 and a memory 112 coupled to the processor 111 .

[0114] The memory 112 stores program instructions for implementing the liquid leakage alarm method for a high biosafety risk workshop in any of the above embodiments.

[0115] The processor 111 is used to execute program instructions stored in the memory 112 to generate a liquid leakage alarm for a workshop with high biosafety risk.

[0116] The processor 111 may also be referred to as a CPU (Central Processing Unit). The processor 111 may be an integrated circuit chip having the ability to process signals. The processor 111 may also be a general-purpose processor, a digital signal processor (DSP), an application-specific integrated circuit (ASIC), a field programmable gate array (FPGA) or other programmable logic devices, discrete gate or transistor logic devices, discrete hardware components. The general-purpose processor may be a microprocessor or the processor may also be any conventional processor, etc.

[0117] Further, Figure 8The schematic diagram of the structure of the storage medium of an embodiment of the present application is that the storage medium 12 of the embodiment of the present application stores program instructions 121 capable of implementing all the above methods, wherein the program instructions 121 can be stored in the above storage medium in the form of a software product, including several instructions for enabling a computer device (which can be a personal computer, server, or network device, etc.) or a processor to execute all or part of the steps of the methods described in each embodiment of the present application. The aforementioned storage medium includes: various media that can store program codes, such as a USB flash drive, a mobile hard disk, a read-only memory (ROM), a random access memory (RAM), a magnetic disk or an optical disk, or terminal devices such as a computer, a server, a mobile phone, and a tablet.

[0118] like Fig. 9 As shown in the figure, after the PLC control logic program starts running, the PLC will enter the sampling stage and read the status of the digital input and output module terminals. When there is no liquid, the wire is in a disconnected state, the PLC executes the normal system program, the corresponding terminal of the digital output module has a voltage signal output, and the system green light is on. When there is a liquid leak, the wire is in a closed state, the digital input module has a voltage signal input, the PLC executes the alarm program, the digital output module terminal acts, and outputs or stops outputting the corresponding voltage signal. The system green light goes out, the red light is on, the buzzer sounds, and the system alarms. During the entire program running process, the server host will read the data in the PLC in real time, store and record the alarm status, parse the effective information part, and extract various alarm information, including alarm type, trigger device ID, and occurrence time; the parsed data is saved in the database through object-relational mapping, and the context information of related events is recorded.

[0119] In the several embodiments provided by the present invention, it should be understood that the disclosed systems, devices and methods can be implemented in other ways. For example, the device embodiments described above are only schematic, for example, the division of units is only a logical function division, and there may be other division methods in actual implementation, such as multiple units or components can be combined or integrated into another system, or some features can be ignored or not executed. Another point is that the mutual coupling or direct coupling or communication connection shown or discussed can be an indirect coupling or communication connection through some interfaces, devices or units, which can be electrical, mechanical or other forms.

[0120] In addition, each functional unit in each embodiment of the present invention may be integrated into one processing unit, or each unit may exist physically separately, or two or more units may be integrated into one unit. The above integrated unit may be implemented in the form of hardware or in the form of software functional units. The above is only an implementation mode of the present invention, and does not limit the patent scope of the present invention. Any equivalent structure or equivalent process transformation made by using the contents of the present invention specification and drawings, or directly or indirectly used in other related technical fields, is also included in the patent protection scope of the present invention.

[0121] The specific implementation methods of the invention are described in detail above, but they are only examples, and the invention is not limited to the specific implementation methods described above. For those skilled in the art, any equivalent modification or substitution of the invention is also within the scope of the invention, therefore, the equalization, modification, improvement, etc. made without departing from the spirit and principle of the invention should be included in the scope of the invention.

Claims

1. A method for alarming liquid leakage in a high biosafety risk workshop, characterized in that: The liquid leakage alarm method for a high biosafety risk workshop comprises: Arrange multiple detection wires in the cofferdam, the detection wires cover and exceed the positive projection area of ​​the virus bioreactor, so as to monitor possible leakage of virus liquid; The detection wire detects the leakage of virus liquid, collects the leakage signal, and processes and analyzes it; it triggers the sound and light alarm to notify the on-site operators and the on-duty personnel in the central monitoring room to respond to potential safety risks in a timely manner; The sound and light alarm information is transmitted to the server in the central monitoring room to display the equipment status and store and analyze the leakage alarm records.

2. The method for alarming liquid leakage in a high biosafety risk workshop according to claim 1, characterized in that: Calculation of the orthographic projection area of ​​the virus bioreactor, including: Gather geometry information from blueprints of the viral bioreactor; add a mesh to estimate the size and proportions of the shapes; Create a virtual transparent plane, add an infinite plane to simulate the virus bioreactor projection from above, and set the color of the virus bioreactor body to transparent; extract the contour in the projection plane, and convert the extracted contour data into coordinate form; Based on the shape of the contour, the extracted area is divided into rectangular, triangular or polygonal basic shapes. Depending on the type of contour, the area is calculated from the point coordinates of the contour using a mathematical formula. A dynamic simulation is created to load the virtual liquid from a certain part of the virus bioreactor model and obtain the diffusion on the orthographic projection plane. The arrangement of the wires is adjusted according to the simulation results.

3. The method for alarming liquid leakage in a high biosafety risk workshop according to claim 2, characterized in that: Geometry information, including height, diameter, and curvature, creates the basic shape of the reactor.

4. The method for alarming liquid leakage in a high biosafety risk workshop according to claim 2, characterized in that: The leakage signal is processed and analyzed, including: When there is no liquid, the detection wire is in a normally open state. When encountering liquid, the detection wire changes from a normally open state to a normally closed state because the liquid has a certain electrical conductivity. Therefore, when the detection wire senses changes in the presence of liquid in the surrounding environment, the detection wire changes from a disconnected state to a closed loop, converting the change information of the presence of liquid into an electrical signal, which is then input into the relevant control module for processing and analysis. According to the analysis results, if liquid leakage occurs, the alarm mechanism will be triggered and the alarm will be sounded in the form of sound and light signals; at the same time, the alarm information will be transmitted to the central monitoring room via TCP / IP communication, and the alarm triggering time, location, duration and alarm type will be automatically recorded.

5. The method for alarming liquid leakage in a high biosafety risk workshop according to claim 4, characterized in that: Triggering alarm mechanisms, including: The analysis results are identified, leakage is defined as binary 1, and no leakage is defined as binary 0. Binary 1 is combined with the alarm program. The alarm program content is: when there is leakage, the red light is on and the buzzer sounds, and the green light is off; when there is no leakage, the red light is off and the buzzer does not sound, and the green light is on; Creating a first alarm rule according to the content of the alarm procedure; Based on the recognition of the analysis results, the specific content of the binary is obtained, and the first alarm rule is matched with the specific content. If the specific content meets the alarm condition, an alarm operation corresponding to the first alarm rule is generated and displayed on the traffic light and buzzer.

6. The method for alarming liquid leakage in a high biosafety risk workshop according to claim 5, characterized in that: The first alarm rule includes multiple items of traffic light rules and buzzer rules. The traffic light rules include turning on and off the red and green lights, and the buzzer includes sounding and not sounding. The first alarm rule also includes multiple second alarm rules that meet the content of the alarm procedure, which includes detecting that the wire is in a continuous closed state within a preset time and increasing the working frequency of the red light and the buzzer.

7. The method for alarming liquid leakage in a high biosafety risk workshop according to claim 1, characterized in that: The sound and light alarm information is transmitted to the server in the central monitoring room, including: When receiving a data packet of alarm information, the server reads the data length field in the data packet; reads valid information according to the length information, calculates the checksum, and compares the calculated value with the checksum in the data packet; if the checksum passes, the integrity of the data packet is confirmed; if it does not match, the data packet is discarded and an error log is recorded; Parse the valid information and extract each alarm information, including alarm type, trigger device ID, and occurrence time; save the parsed data into the database through object-relational mapping, and record the context information of related events; Create a history panel to display past alarm records in table or timeline format.

8. The method for alarming liquid leakage in a high biosafety risk workshop according to claim 7, characterized in that: List: alarm time, alarm device ID, alarm type and processing status.

9. A liquid leakage alarm device for a high biosafety risk workshop, which is applied to the liquid leakage alarm method for a high biosafety risk workshop as claimed in any one of claims 1 to 8, characterized in that: The liquid leakage alarm device for the high biosafety risk workshop includes: workshop site and central monitoring room; Among them, the workshop is equipped with a cofferdam, a tank, a detection wire, a PLC controller, and a first sound and light alarm device; the central monitoring room is equipped with a server, a second sound and light alarm device, and a display.

10. The liquid leakage alarm device for a high biosafety risk workshop according to claim 9, characterized in that: The cofferdam is used to control the leakage of the virus liquid within a certain range. A tank body and a detection wire are arranged inside the cofferdam. The tank body is used to contain the virus liquid. The detection wire is used to detect the leakage of the virus liquid. The detection wire covers the tank body. The PLC controller is connected to the detection wire and the first sound and light alarm device, and the first sound and light alarm device is used for sound and light alarm at the workshop site; The server inside the central monitoring room is connected to the PLC controller through a network switch, and the PLC controller is connected to the second sound and light alarm device and the display. The PLC controller is used to collect leakage signals, process and analyze the signals, trigger the sound and light alarm devices in the workshop and the central monitoring room, and transmit the alarm signal to the server in the central monitoring room; the server displays the equipment status on the display, stores and records the analysis of leakage alarms; the function of the second sound and light alarm device is to let the on-site operators and the on-duty personnel in the central control room know that a leakage has occurred; a power module is also provided in the central monitoring room to provide power support for the entire system.

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