Febuxostat tablet preparation process and preparation equipment

Abstract

The invention provides a febuxostat tablet preparation process and preparation equipment, and belongs to the technical field of tablet preparation. Comprising the following steps: step 1, weighing and sieving raw materials: firstly, weighing febuxostat, lactose and pregelatinized starch, and sieving the weighed raw materials through a sieving machine to ensure that the raw materials are powdery; by arranging the fixing frame, the abutting plate and the elastic piece, after the bracket is opened, the elastic piece can enable the abutting plate to extrude the bracket through the elastic force of the elastic piece, so that part of the structure of the bracket is ejected out of the vacuum drying box, and then the bracket continues to be pulled out until a tray containing raw materials has a large enough operation space; when dried raw materials on the bracket are collected, hands do not need to stretch into the vacuum drying box, pollution to the interior of the sealing door in the raw material collecting process is avoided, cleanliness of the raw materials is guaranteed, then the quality of febuxostat tablets prepared subsequently is guaranteed, and operation is easy.

Description

Technical Field

[0001] The present invention relates to the technical field of tablet preparation, and in particular to a preparation process and equipment for a febuxostat tablet. Background Art

[0002] Febuxostat tablets are a long-term treatment for hyperuricemia in gout patients. The preparation process requires a series of steps. Febuxostat, fillers, disintegrants, binders and other raw materials need to be mixed evenly and granulated. After granulation, they are compressed and coated to finally form tablets that can be taken by patients. In the granulation process, if wet granulation is used, the powder and granule raw materials will contain more water after granulation, which is not convenient for subsequent tableting processing. Therefore, special drying equipment is required for drying before tableting.

[0003] A commonly used drying equipment is a vacuum drying oven. When in use, the granular tablet raw materials need to be placed in a tray, and then placed on a bracket in the drying oven for drying. After removing a certain amount of moisture, they can be taken out before subsequent tableting processing can be carried out to ensure the working effect of the tablet press. During the operation, the staff needs to put their hands into the drying oven to take and place the tablet raw materials, but the space in the drying oven is limited. When the tray holding the tablet raw materials is large, it is inconvenient to take it. Even if some drying ovens can take out the tray together by pulling out the bracket, it is still necessary to put your hands into the drying oven for operation, which is easy to cause pollution to the internal space of the drying oven, affecting the efficiency of the Febuxostat tablet preparation process and the quality of the prepared Febuxostat tablets. Therefore, the present application provides a Febuxostat tablet preparation process and preparation equipment to meet the needs. Summary of the invention

[0004] The technical problem to be solved by the present invention is to provide a febuxostat tablet preparation process and preparation equipment to solve the problem that the existing drying equipment is inconvenient to operate when collecting febuxostat tablet raw materials, and is easy to pollute the space in the drying equipment, thereby affecting the quality of the febuxostat tablet product.

[0005] In order to solve the above technical problems, the present invention provides the following technical solutions:

[0006] A process for preparing a febuxostat tablet, comprising:

[0007] Step 1: weighing and sieving raw materials. First, weigh febuxostat, lactose, and pregelatinized starch. After weighing, sieve the raw materials through a powder sifter to ensure that the raw materials are in powder form.

[0008] Step 2, mixing and wet granulation, putting the sieved febuxostat, lactose and pregelatinized starch into a mixer, mixing them through the mixer, and putting the mixed raw materials into a granulator for wet granulation;

[0009] Step 3: Drying and granulation: the wet granules after granulation are placed in a tray for storage, and the wet raw material granules in the tray are evenly distributed, the tray is placed in a drying device, and the drying device is used for drying, and then the dried raw material granules are placed in a fast granulation machine for granulation;

[0010] Step 4: Mix the dried granulated material with cross-linked sodium carboxymethyl cellulose and magnesium stearate, and put them into a rotary tablet press together, and then use the rotary tablet press to compress the tablets to form febuxostat tablets;

[0011] Step 5, testing the compressed febuxostat tablets to check the compression effect of the tablets and whether the tablets are damaged on the outside to ensure that the tablets meet the standards, putting the tested febuxostat tablets into a coating machine, and then adding coating powder to coat the tablets through the coating machine to finally obtain febuxostat tablets;

[0012] The drying equipment is used for drying the febuxostat tablets after wet granulation, and assists in the preparation of the febuxostat tablets.

[0013] A Febuxostat tablet preparation device, as a drying device in the Febuxostat tablet preparation process, comprises a vacuum drying oven, the outside of the vacuum drying oven is movably connected with a sealed door, and the inside of the vacuum drying oven is fixedly connected with uniformly distributed guide rails, a bracket is sleeved between the guide rails, a metal mesh is arranged in the middle of the bracket, the inside of the vacuum drying oven is fixedly connected with a fixed frame located between two groups of the guide rails, and both ends of the fixed frame are fixedly connected with a pressure plate through an elastic sheet; a limiting component is used for fixing the relative position between the pressure plate and the fixed frame, and the limiting component is respectively connected to the fixed frame and the pressure plate; a first connecting component is used for the associated connection between the pressure plate and the bracket, and the first connecting component is respectively connected to the bracket and the pressure plate; a second connecting component is used for the associated connection between the bracket and the sealed door, and the second connecting component is respectively connected to the sealed door and the bracket.

[0014] Optionally, guide bars are fixedly connected to both sides of the bracket, a first guide groove matching the shape of the guide bar is provided in the guide rail, a guide block is fixedly connected to the bottom of the guide bar, and a second guide groove matching the shape of the guide block is provided in the guide rail.

[0015] Optionally, the guide block is located on one end of the guide bar close to the fixed frame, and a movable groove is provided on one end of the guide rail away from the fixed frame, and the length of the movable groove is greater than the length of the guide block.

[0016] Optionally, the limiting assembly includes a first connecting plate fixedly connected to the outside of the pressure plate and a slot opened on the outside of the fixing frame, the first connecting plate is located on a surface of the pressure plate close to the fixing frame, and the first connecting plate and the pressure plate are perpendicular to each other, and the outside of the fixing frame is fixedly connected with symmetrically distributed guide plates, and the distance between the guide plates is the same as the width of the first connecting plate.

[0017] Optionally, a second weakening groove is provided on the outside of the first connecting plate, and a clip strip matching the shape of the clip slot is fixedly connected to a surface of the first connecting plate close to the fixing frame, the elastic sheet is wavy, and a third weakening groove is provided at the bend of the elastic sheet.

[0018] Optionally, the first connecting assembly includes a second connecting plate fixedly connected to the outside of the pressure plate and a connecting groove opened on the outside of the bracket, the second connecting plate is L-shaped, and the shape of the second connecting plate is adapted to the shape of the connecting groove.

[0019] Optionally, a fourth weakened groove is provided at the bend of the second connecting plate, and a slope is provided on a surface of the end of the second connecting plate close to the bracket, and the opening size of the connecting groove is adapted to the size of the end of the second connecting plate.

[0020] Optionally, the second connecting assembly includes a first hook plate fixedly connected to the outside of the bracket and a second hook plate fixedly connected to the sealing door, the first hook plate and the second hook plate are both L-shaped, a second connecting head is provided at the end of the second hook plate, and a first connecting head is provided at the end of the first hook plate.

[0021] Optionally, a first weakened groove is provided at the bending part of the second connector, guide slopes are provided on the outside of the second connector and the first connector, a protrusion is provided on the outside of the second connector, and a recess matching the shape of the protrusion is provided on the first connector.

[0022] Compared with the prior art, the present invention has at least the following beneficial effects:

[0023] In the above scheme, by providing a fixing frame, a pressure plate and an elastic sheet, after the bracket is opened, the elastic sheet can use its own elastic force to cause the pressure plate to squeeze the bracket, thereby pushing part of the structure of the bracket out of the vacuum drying oven, and then the bracket is further pulled out until the tray containing the raw materials has a large enough operating space. When collecting the dried raw materials on the bracket, there is no need to put your hand into the vacuum drying oven, which avoids contamination of the inside of the sealed door during the process of collecting the raw materials, ensures the cleanliness of the raw materials, and then ensures the quality of the febuxostat tablets prepared subsequently, and is easy to operate.

[0024] By setting a limiting component, when the raw materials are placed in the vacuum drying oven, the pressure plate can be squeezed by the bracket, and then the relative positions of the fixing frame and the pressure plate are fixed by the limiting component, and then the contraction state of the elastic sheet is maintained, so that the bracket containing the raw materials of febuxostat tablets can be completely stored in the vacuum drying oven, avoiding the bracket from hindering the closing of the sealing door under the action of the elastic sheet and the pressure plate, making it easier for the staff to close the sealing door later, making the use of the equipment more convenient.

[0025] By setting the first connecting component, when the sealing door is closed, a connection relationship is formed between the pressure plate and the bracket through the first connecting component, and then when the bracket moves, the pressure plate can be pulled to move through the first connecting component, so as to release the limiting effect of the limiting component on the fixed frame and the pressure plate, release the lock on the elastic sheet, and allow the elastic sheet to pop out the bracket in time after the sealing door is opened, thereby achieving the automatic pop-up effect of the bracket when the sealing door is opened, and at the same time, the first connecting component forms a limit on the bracket, controls the pop-up range of the bracket, and avoids excessive pop-up of the bracket to cause spillage of raw materials.

[0026] By providing the second connecting component, when the sealing door is closed, a connection relationship is formed between the sealing door and the bracket through the second connecting component, so that when the sealing door is opened, the bracket can be pulled to move through the second connecting component, and then the bracket is subjected to a pulling force toward the outside of the vacuum drying oven as soon as the sealing door is opened, thereby releasing the limit of the limit component on the pressure plate, allowing the elastic sheet to reset, and popping the bracket out of the vacuum drying oven, so that the limit component, the first connecting component and the second connecting component are matched, the structure is simple and ingenious, and the respective functions complement each other to form a complete technical solution.

[0027] By providing guide rails, guide strips, guide blocks and movable grooves, the assembly, connection and disassembly operations between the bracket and the guide rails are simple and convenient, reducing the workload of workers when disassembling and assembling the bracket. At the same time, the connection relationship between the installed bracket and the guide rail is stable and reliable, which can provide a good supporting storage environment for the tray containing the Febuxostat tablets and ensure the stability of the bracket during operation. BRIEF DESCRIPTION OF THE DRAWINGS

[0028] The accompanying drawings, which are incorporated herein and constitute a part of the specification, illustrate embodiments of the invention and, together with the description, further serve to explain the principles of the invention and to enable those skilled in the relevant art to make and use the invention.

[0029] Figure 1 This is a schematic diagram of the three-dimensional structure of the equipment for preparing febuxostat tablets;

[0030] Figure 2 It is a schematic diagram of the internal structure of the vacuum drying oven;

[0031] Figure 3 for Figure 2 The enlarged structural diagram at A in the middle;

[0032] Figure 4 It is a schematic diagram of the matching structure of the bracket, the guide rail and the fixing frame;

[0033] Figure 5 It is a schematic diagram of the matching structure of the sealing door, bracket and guide rail;

[0034] Figure 6 for Figure 5 The enlarged structural diagram at B in the middle;

[0035] Figure 7 for Figure 5 The enlarged structural diagram at C in the middle;

[0036] Figure 8 The schematic diagram of the partial cross-section structure is shown as a guide;

[0037] Fig. 9 is a schematic diagram of the three-dimensional structure of the bracket;

[0038] Fig.10 It is a schematic diagram of a partial cross-sectional structure of a fixing frame;

[0039] Fig.11 for Fig.10 The enlarged structural diagram at D in the middle;

[0040] Fig.12 for Fig.10 Enlarged structural diagram at E in the middle.

[0041] Reference numerals:

[0042] 1. Vacuum drying oven; 2. Sealing door; 3. Bracket; 4. Guide rail; 5. Fixed frame; 6. Pressure plate; 7. Guide strip; 8. Movable groove; 9. First hook plate; 10. Second hook plate; 11. Second connector; 12. First connector; 13. First weakened groove; 14. Elastic sheet; 15. Guide plate; 16. First connecting plate; 17. Second weakened groove; 18. First guide groove; 19. Second guide groove; 20. Guide block; 21. Connecting groove; 22. Third weakened groove; 23. Clip strip; 24. Clip groove; 25. Second connecting plate; 26. Fourth weakened groove; 27. Metal mesh; 28. Bump; 29. ​​Notch; 30. Guide slope.

[0043] As shown in the figure, in order to clearly implement the structure of the embodiment of the present invention, specific structures and devices are marked in the figure, but this is only for illustrative purposes and is not intended to limit the present invention to the specific structure, device and environment. According to specific needs, ordinary technicians in this field can adjust or modify these devices and environments. DETAILED DESCRIPTION

[0044] The following is a detailed description of a febuxostat tablet preparation process and a preparation device provided by the present invention in conjunction with the accompanying drawings and specific embodiments. At the same time, it is explained here that in order to make the embodiments more detailed, the following embodiments are the best and preferred embodiments, and those skilled in the art may also adopt other alternatives to implement some known technologies; and the accompanying drawings are only for a more specific description of the embodiments, and are not intended to specifically limit the present invention.

[0045] It should be noted that the references to "one embodiment", "an embodiment", "an exemplary embodiment", "some embodiments" and the like in the specification indicate that the embodiments described may include specific features, structures or characteristics, but not every embodiment may include the specific features, structures or characteristics. In addition, when a specific feature, structure or characteristic is described in conjunction with an embodiment, it should be within the knowledge of a person skilled in the art to implement such feature, structure or characteristic in conjunction with other embodiments (whether or not explicitly described).

[0046] In general, a term can be understood, at least in part, from its use in context. For example, depending, at least in part, on the context, the term "one or more" as used herein can be used to describe any feature, structure, or characteristic in the singular sense, or can be used to describe a combination of features, structures, or characteristics in the plural sense. Additionally, the term "based on" can be understood as not necessarily intended to convey an exclusive set of factors, but can instead, depending, at least in part, on the context, allow for the presence of other factors that are not necessarily explicitly described.

[0047] It will be understood that the meanings of “on,” “over,” and “above” in the present invention should be interpreted in the broadest manner, so that “on” not only means “directly on” something, but also includes the meaning of being “on” something with intervening features or layers therebetween, and “on” or “over” not only means “on” or “above” something, but also includes the meaning of being “on” or “above” something with no intervening features or layers therebetween.

[0048] Additionally, spatially relative terms such as "under," "beneath," "lower," "above," "upper," and the like may be used herein for descriptive convenience to describe the relationship of one element or feature to another element or features, as shown in the accompanying drawings. Spatially relative terms are intended to encompass different orientations of the device in use or operation in addition to the orientation depicted in the accompanying drawings. The device may be oriented in other ways, and the spatially relative descriptors used herein may be similarly interpreted accordingly.

[0049] An embodiment of the present invention provides a process for preparing a febuxostat tablet, and the process for preparing a febuxostat tablet comprises:

[0050] Step 1: weighing and sieving raw materials. First, weigh febuxostat, lactose, and pregelatinized starch. After weighing, sieve the raw materials through a powder sifter to ensure that the raw materials are in powder form.

[0051] Step 2, mixing and wet granulation, putting the sieved febuxostat, lactose and pregelatinized starch into a mixer, mixing them through the mixer, and putting the mixed raw materials into a granulator for wet granulation;

[0052] Step 3: Drying and granulation: the wet granules after granulation are placed in a tray for storage, and the wet raw material granules in the tray are evenly distributed, the tray is placed in a drying device, and the drying device is used for drying, and then the dried raw material granules are placed in a fast granulation machine for granulation;

[0053] Step 4: Mix the dried granulated material with cross-linked sodium carboxymethyl cellulose and magnesium stearate, and put them into a rotary tablet press together, and then use the rotary tablet press to compress the tablets to form febuxostat tablets;

[0054] Step 5, testing the compressed febuxostat tablets to check the compression effect of the tablets and whether the tablets are damaged on the outside to ensure that the tablets meet the standards, putting the tested febuxostat tablets into a coating machine, and then adding coating powder to coat the tablets through the coating machine to finally obtain febuxostat tablets;

[0055] The drying equipment is used for drying the febuxostat tablets after wet granulation, and assists in the preparation of the febuxostat tablets.

[0056] like Figures 1 to 12 As shown, an embodiment of the present invention further provides a Febuxostat tablet preparation device, which is used as a drying device in the Febuxostat tablet preparation process, including a vacuum drying oven 1, the outside of the vacuum drying oven 1 is movably connected to a sealed door 2, and the inside of the vacuum drying oven 1 is fixedly connected to evenly distributed guide rails 4. The vacuum drying oven 1 is started after the sealed door 2 is closed to vacuum dry the logistics inside the vacuum drying oven 1, thereby reducing the moisture in the Febuxostat tablet raw material obtained by wet granulation, which is convenient for subsequent tableting processing. The principle and use method of the vacuum drying oven 1 and the sealed door 2 are the same as those in the prior art, and will not be described in detail here. A bracket 3 is sleeved between the guide rails 4, and a metal mesh 27 is provided in the middle of the bracket 3. The metal mesh 27 is made of metal material and can provide a good support effect for the tray placed on the bracket 3. At the same time, the mesh holes on the metal mesh 27 can ensure the airflow circulation effect in the vacuum drying oven 1, ensure that the moisture removed by drying can be extracted from the vacuum drying oven 1, and ensure the drying effect. The guide rail 4 It is used to provide an assembly position for the bracket 3 and enable the bracket 3 to slide between the guide rails 4, so that the bracket 3 can be pulled out of the vacuum drying oven 1, so that the tray containing the febuxostat tablet raw materials placed on the bracket 3 can follow the bracket 3 to move to the outside of the bracket 3, so that the staff has a larger operating space and it is easy for the staff to operate the tray. The interior of the vacuum drying oven 1 is fixedly connected with a fixing frame 5 located between the two sets of guide rails 4, and both ends of the fixing frame 5 are fixedly connected with a pressure plate 6 through an elastic sheet 14. After the sealing door 2 is closed, the bracket 3 is stored in the vacuum drying oven 1, and the pressure plate 6 is squeezed by the bracket 3 to drive the elastic sheet 14 to contract and accumulate elastic potential energy. After the sealing door 2 is opened, the elastic sheet 14 can be reset by its own elastic force, and drive the pressure plate 6 to squeeze the bracket 3, thereby pushing part of the structure of the bracket 3 out of the vacuum drying oven 1 for a distance, so that the staff can operate the bracket 3 outside the vacuum drying oven 1 to avoid contamination of the internal space of the vacuum drying oven 1.

[0057] The limiting component is used to fix the relative position between the pressure plate 6 and the fixed frame 5. The limiting components are respectively connected to the fixed frame 5 and the pressure plate 6. Before the sealing door 2 is closed, the bracket 3 loaded with the raw material of Febuxostat tablets is pushed into the vacuum drying oven 1, which will drive the limiting component to move, and the limiting fixation of the pressure plate 6 is formed by the moving component, and the contraction state of the elastic sheet 14 is maintained, so as to prevent the bracket 3 from being extended from the vacuum drying oven 1 under the action of the elastic sheet 14 and the pressure plate 6. The closing of the sealing door 2 is facilitated by the staff; the first connecting component is used for the associated connection between the pressure plate 6 and the bracket 3. The first connecting component is respectively connected to the bracket 3 and the pressure plate 6. The first connecting component is closed when the sealing door 2 is closed In the state, an associated connection can be formed between the bracket 3 and the pressure plate 6, and then the movement of the bracket 3 can drive the pressure plate 6 to move, so that the movement of the bracket 3 can control the working state of the limit assembly, so that the limit assembly and the first connecting assembly are coordinated; the second connecting assembly is used for the associated connection between the bracket 3 and the sealing door 2, and the second connecting assembly is respectively connected to the sealing door 2 and the bracket 3. The second connecting assembly can form an associated connection between the sealing door 2 and the bracket 3 when the sealing door 2 is closed, so that the sealing door 2 can pull the bracket 3 during the opening process, so that the bracket 3 is subjected to force and applies force to the pressure plate 6 through the first connecting assembly, and finally drives the limit assembly to release the limit on the pressure plate 6, and finally presents an automatic pop-up effect of the bracket 3 after the sealing door 2 is opened.

[0058] In this embodiment, if Figures 1 to 3 as well as Figure 8 and Fig. 9As shown, guide bars 7 are fixedly connected to both sides of the bracket 3, a first guide groove 18 matching the shape of the guide bar 7 is provided in the guide rail 4, the bracket 3 and the guide rail 4 are connected via the guide bar 7 and the first guide groove 18, the outer portion of the guide bar 7 is T-shaped, the shape of the first guide groove 18 matches the guide bar 7, when the bracket 3 slides in the vacuum drying oven 1, the guide bar 7 synchronously slides in the first guide groove 18 to guide and limit the bracket 3, a guide block 20 is fixedly connected to the bottom of the guide bar 7, and a second guide groove 19 matching the shape of the guide block 20 is provided in the guide rail 4. The guide block 20 is located at one end of the guide bar 7 close to the fixed frame 5, and a movable groove 8 is provided at one end of the guide rail 4 away from the fixed frame 5. The length of the movable groove 8 is greater than the length of the guide block 20. When the bracket 3 needs to be disassembled and maintained, it is only necessary to pull the bracket 3 out of the vacuum drying oven 1 to the maximum value. At this time, the guide block 20 on the guide bar 7 follows the bracket 3 to move to the movable groove 8 in the guide rail 4. At this time, the bracket 3 has a larger range of movement. The guide block 20 can be disengaged from the first guide groove 18 by lifting it parallel to the guide bar 7, so that the bracket 3 can be disassembled, making the removal operation of the bracket 3 simple and convenient. When installing the bracket 3, the guide block 20 The area on the guide bar 7 where the guide block 20 is provided is put into the movable groove 8, and the bracket 3 is kept parallel to the bottom of the vacuum drying box 1. Then, the bracket 3 is put down so that the guide block 20 on the guide bar 7 can be embedded in the second guide groove 19, and the guide bar 7 is also embedded in the first guide groove 18, forming a connection relationship between the bracket 3 and the guide rail 4. Without applying external force to the bracket 3, even if the guide block 20 is driven to move to the movable groove 8, the bracket 3 cannot be in a parallel state due to the influence of its own gravity, so that the guide block 20 cannot be separated from the second guide groove 19, thereby ensuring the stability of the connection between the bracket 3 and the guide rail 4.

[0059] In this embodiment, if Figure 4 and Figure 7 as well as Fig.10 and Fig.11As shown, the limiting assembly includes a first connecting plate 16 fixedly connected to the outside of the pressure plate 6 and a card slot 24 opened on the outside of the fixing frame 5. The first connecting plate 16 is located on the side of the pressure plate 6 close to the fixing frame 5, and the first connecting plate 16 and the pressure plate 6 are perpendicular to each other. The outside of the fixing frame 5 is fixedly connected with symmetrically distributed guide plates 15. The distance between the guide plates 15 is the same as the width of the first connecting plate 16. The pressure plate 6 will drive the first connecting plate 16 to move during its displacement. The first connecting plate 16 will be inserted between the two guide plates 15 during its approach to the fixing frame 5. During this process, the side edge of the first connecting plate 16 will contact the inner side wall of the guide plate 15, so that the guide plate 15 forms a guiding limit for the first connecting plate 16, and indirectly forms a guiding limit for the first connecting plate 16, thereby ensuring the moving trajectory of the pressure plate 6 and avoiding misalignment during the compression and movement of the pressure plate 6. A second weakening groove 17 is provided on the outside of the first connecting plate 16, and a card strip 23 adapted to the shape of the card slot 24 is fixedly connected to the first connecting plate 16 on a surface close to the fixing frame 5. The elastic sheet 14 is wavy, and a third weakening groove 22 is provided at the bending part of the elastic sheet 14. The second weakening groove 17 provided on the first connecting plate 16 and the third weakening groove 22 at the bending part of the elastic sheet 14 make the thickness of the first connecting plate 16 at the second weakening groove 17 and the elastic sheet 14 at the third weakening groove 22 thinner and weaker, and more easily deformed after being acted upon by external force. During the process of pushing the bracket 3 into the vacuum drying oven 1, the bracket 3 will come into contact with the pressing plate 6. As the bracket 3 is pushed in, the pressing plate 6 will continue to approach the fixing frame 5, driving the elastic sheet 14 to contract, thereby making the first connecting plate 16 thinner and weaker in strength. After the plate 16 drives the card strip 23 to approach the card slot 24 and the card strip 23 contacts the outside of the fixing frame 5, the first connecting plate 16 can bend and deform at the second weakened groove 17, and then drive the card strip 23 to avoid the outside of the fixing frame 5, until the first connecting plate 16 drives the card strip 23 to move to the card slot 24, and the first connecting plate 16 is reset under the action of its own elastic force, driving the card strip 23 to form a card connection relationship with the card slot 24. After the card strip 23 is carded with the card slot 24, it forms a limit fixation on the pressure plate 6 through the conduction of the first connecting plate 16, maintaining the contracted state of the elastic sheet 14, so that after the bracket 3 is pushed into the vacuum drying box 1, it can be stored in the vacuum drying box 1, and will not pop out immediately again under the action of the elastic sheet 14 and the pressure plate 6, which is convenient for the staff to close the sealing door 2.

[0060] In this embodiment, if Figures 9 to 12As shown, the first connecting component includes a second connecting plate 25 fixedly connected to the outside of the pressure plate 6 and a connecting groove 21 opened on the outside of the bracket 3, the second connecting plate 25 is L-shaped, and the shape of the second connecting plate 25 is adapted to the shape of the connecting groove 21, a fourth weakening groove 26 is opened at the bending part of the second connecting plate 25, and an inclined surface is provided on the surface of the end of the second connecting plate 25 close to the bracket 3, the opening size of the connecting groove 21 is adapted to the size of the end of the second connecting plate 25, and during the process of pushing the bracket 3 into the vacuum drying oven 1, when the back side of the bracket 3 contacts the pressure plate 6, the position of the connecting groove 21 corresponds to the position of the second connecting plate 25 on the pressure plate 6, and as the bracket 3 continues to squeeze the second connecting plate 25, the second connecting plate 25 will bend and deform at the fourth weakening groove 26 until the second connecting plate 25 can pass through the connecting groove The opening of 21 enters the connecting groove 21. After entering the connecting groove 21, the second connecting plate 25 recovers under the action of its own elastic force, and forms a hook connection with the connecting groove 21 through its own L-shaped structure, thereby forming an associated connection between the bracket 3 and the pressure plate 6. When the bracket 3 is subjected to a force toward the outside of the vacuum drying oven 1, the hooking relationship between the second connecting plate 25 and the connecting groove 21 can drive the pressure plate 6 to move with the bracket 3, thereby enabling the pressure plate 6 to drive the limit assembly to unlock, so that the elastic sheet 14 can pop out the bracket 3 through its own elastic force. At the same time, the hooking relationship between the second connecting plate 25 and the connecting groove 21 can also limit the maximum range of the bracket 3 being ejected, thereby preventing the bracket 3 from being ejected excessively from the vacuum drying oven 1, causing the tray containing the raw materials of Febuxostat tablets placed on the bracket 3 to be unstable, resulting in spillage of the raw materials.

[0061] In this embodiment, if Figures 2 to 6As shown, the second connecting assembly includes a first hook plate 9 fixedly connected to the outside of the bracket 3 and a second hook plate 10 fixedly connected to the sealing door 2. The first hook plate 9 and the second hook plate 10 are both L-shaped. A second connecting head 11 is provided at the end of the second hook plate 10. A first connecting head 12 is provided at the end of the first hook plate 9. A first weakening groove 13 is provided at the bending part of the second connecting head 11. The opening of the first weakening groove 13 makes the structure of the second connecting head 11 at the first weakening groove 13 thinned. The strength of the second connecting head 11 at the first weakening groove 13 is weaker, and it is more likely to deform after being subjected to external force. The second connecting head 11 and the first connecting head 12 are both provided with guide inclined surfaces 3 on the outside. 0, and a protrusion 28 is provided on the outside of the second connecting head 11, and a notch 29 matching the shape of the protrusion 28 is provided on the first connecting head 12. In the process of closing the sealing door 2, the second hook plate 10 follows the deflection of the sealing door 2 to approach the first hook plate 9, and the second connecting head 11 on the second hook plate 10 and the first connecting head 12 on the first hook plate 9 contact each other, and the contact surface is the guide inclined surface 30 on the second connecting head 11 and the first connecting head 12. The extrusion force exerted on the second connecting head 11 and the first connecting head 12 is decomposed by the setting of the guide inclined surface 30, and is decomposed into two groups of forces parallel and perpendicular to the second connecting head 11. The force perpendicular to the second connecting head 11 causes the second connecting head 11 to be in contact with each other. The first weakened groove 13 is bent and deformed to avoid the first connecting head 12 until the sealing door 2 is completely closed, and the second connecting head 11 moves to the inner side of the first connecting head 12. At this time, the protrusion 28 on the second connecting head 11 is engaged with the notch 29 on the first connecting head 12, so that a connection relationship is formed between the first hook plate 9 and the second hook plate 10. When the sealing door 2 is in a closed state, the second hook plate 10 on the sealing door 2 and the first hook plate 9 outside the bracket 3 are in a hooked state. In the process of opening the sealing door 2, the bracket 3 can be driven to move by the transmission of the first hook plate 9 and the second hook plate 10, so that the bracket 3 is subjected to a force toward the outside of the vacuum drying box 1, which promotes the bracket 3 to move. The bracket 3 drives the first connecting component to release the limiting fixation of the limiting component, and after the sealed door 2 is opened to a certain angle, the second hook plate 10 will follow the deflection of the sealed door 2 and form an angle with the bracket 3. At the same time, after the bracket 3 is limited by the first connecting component, the second hook plate 10 and the first hook plate 9 are separated from each other, realizing the automatic pop-up process of the bracket 3. If the space outside the vacuum drying box 1 when the bracket 3 is still unable to meet the operating needs of the staff, the first connecting component can be disconnected by continuing to pull the bracket 3 until the space outside the vacuum drying box 1 when the bracket 3 is able to meet the operating needs of the staff, and the switch of the sealed door 2 is used to switch the state of the limiting component.

[0062] The present invention covers any substitution, modification, equivalent method and scheme made on the essence and scope of the present invention. In order to make the public have a thorough understanding of the present invention, specific details are described in detail in the following preferred embodiments of the present invention, but those skilled in the art can fully understand the present invention without the description of these details. In addition, in order to avoid unnecessary confusion about the essence of the present invention, well-known methods, processes, procedures, components and circuits are not described in detail.

[0063] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principle of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims

1. A process for preparing febuxostat tablets, characterized in that: The febuxostat tablet preparation process comprises: Step 1: weighing and sieving raw materials. First, weigh febuxostat, lactose, and pregelatinized starch. After weighing, sieve the raw materials through a powder sifter to ensure that the raw materials are in powder form. Step 2, mixing and wet granulation, putting the sieved febuxostat, lactose and pregelatinized starch into a mixer, mixing them through the mixer, and putting the mixed raw materials into a granulator for wet granulation; Step 3: Drying and granulation: the wet granules after granulation are placed in a tray for storage, and the wet raw material granules in the tray are evenly distributed, the tray is placed in a drying device, and the drying device is used for drying, and then the dried raw material granules are placed in a fast granulation machine for granulation; Step 4: Mix the dried granulated material with cross-linked sodium carboxymethyl cellulose and magnesium stearate, and put them into a rotary tablet press together, and then use the rotary tablet press to compress the tablets to form febuxostat tablets; Step 5, testing the compressed febuxostat tablets to check the compression effect of the tablets and whether the tablets are damaged on the outside to ensure that the tablets meet the standards, putting the tested febuxostat tablets into a coating machine, and then adding coating powder to coat the tablets through the coating machine to finally obtain febuxostat tablets; The drying equipment is used for drying the febuxostat tablets after wet granulation, and assists in the preparation of the febuxostat tablets.

2. A Febuxostat tablet preparation device, as a drying device in the Febuxostat tablet preparation process, comprises a vacuum drying oven, characterized in that: The outside of the vacuum drying box is movably connected with a sealed door, and the inside of the vacuum drying box is fixedly connected with evenly distributed guide rails, a bracket is sleeved between the guide rails, a metal mesh is arranged in the middle of the bracket, and the inside of the vacuum drying box is fixedly connected with a fixing frame located between two groups of the guide rails, and both ends of the fixing frame are fixedly connected with a pressure plate through an elastic sheet; A limiting assembly, used for fixing the relative position between the pressing plate and the fixing frame, wherein the limiting assembly is respectively connected to the fixing frame and the pressing plate; A first connecting component, used for the associated connection between the pressure plate and the bracket, wherein the first connecting component is respectively connected to the bracket and the pressure plate; The second connecting component is used for the associated connection between the bracket and the sealing door, and the second connecting component is connected to the sealing door and the bracket respectively.

3. The febuxostat tablet preparation equipment according to claim 2, characterized in that: Guide bars are fixedly connected to both sides of the bracket, a first guide groove matching the shape of the guide bar is provided in the guide rail, a guide block is fixedly connected to the bottom of the guide bar, and a second guide groove matching the shape of the guide block is provided in the guide rail.

4. The febuxostat tablet preparation equipment according to claim 3, characterized in that: The guide block is located at one end of the guide bar close to the fixing frame, and a movable groove is provided at one end of the guide rail away from the fixing frame, and the length of the movable groove is greater than the length of the guide block.

5. The febuxostat tablet preparation equipment according to claim 2, characterized in that: The limiting assembly includes a first connecting plate fixedly connected to the outside of the pressure plate and a slot opened on the outside of the fixing frame, the first connecting plate is located on a surface of the pressure plate close to the fixing frame, and the first connecting plate and the pressure plate are perpendicular to each other, and symmetrically distributed guide plates are fixedly connected to the outside of the fixing frame, and the distance between the guide plates is the same as the width of the first connecting plate.

6. The febuxostat tablet preparation equipment according to claim 5, characterized in that: A second weakening groove is provided on the outside of the first connecting plate, and a clamping strip matching the shape of the clamping groove is fixedly connected to a surface of the first connecting plate close to the fixing frame. The elastic sheet is wavy, and a third weakening groove is provided at the bend of the elastic sheet.

7. The febuxostat tablet preparation equipment according to claim 6, characterized in that: The first connecting assembly includes a second connecting plate fixedly connected to the outside of the pressing plate and a connecting groove opened on the outside of the bracket. The second connecting plate is L-shaped, and the shape of the second connecting plate is adapted to the shape of the connecting groove.

8. The febuxostat tablet preparation equipment according to claim 7, characterized in that: A fourth weakened groove is provided at the bending part of the second connecting plate, and a slope is provided on a surface of the end of the second connecting plate close to the bracket, and the opening size of the connecting groove is adapted to the size of the end of the second connecting plate.

9. The febuxostat tablet preparation equipment according to claim 8, characterized in that: The second connecting assembly includes a first hook plate fixedly connected to the outside of the bracket and a second hook plate fixedly connected to the sealing door, the first hook plate and the second hook plate are both L-shaped, a second connecting head is provided at the end of the second hook plate, and a first connecting head is provided at the end of the first hook plate.

10. The febuxostat tablet preparation equipment according to claim 9, characterized in that: A first weakened groove is provided at the bending part of the second connector, guiding slopes are provided on the outside of the second connector and the first connector, a protrusion is provided on the outside of the second connector, and a recess matching the shape of the protrusion is provided on the first connector.

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