Methods of using and compositions comprising selective cytokine inhibitory drugs for the treatment and management of disorders of the central nervous system

A central nervous system, cytokine technology, applied in nervous system diseases, drug combinations, pharmaceutical formulations, etc., can solve problems such as side effects, memory loss, cognitive impairment, etc.

Inactive Publication Date: 2007-04-25
CELGENE CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the side effects and unfavorable dosage requirements of these drugs, new methods and compounds capable of treating AD and its symptoms are highly desired
[0016] 2.3 Mild cognitive impairment
[0024] 2.5 Long-term memory loss

Method used

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  • Methods of using and compositions comprising selective cytokine inhibitory drugs for the treatment and management of disorders of the central nervous system
  • Methods of using and compositions comprising selective cytokine inhibitory drugs for the treatment and management of disorders of the central nervous system
  • Methods of using and compositions comprising selective cytokine inhibitory drugs for the treatment and management of disorders of the central nervous system

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Embodiment Construction

[0035] The first embodiment of the present invention includes a method of treating or preventing central nervous system diseases, which method comprises administering to a patient in need of such treatment or prevention a therapeutically or preventively effective amount of a selective cytokine inhibitor, or a pharmacologically Acceptable salts, solvates, hydrates, stereoisomers, clathrates or prodrugs. Central nervous system diseases include but are not limited to Parkinson's disease, bradykinesia, muscle rigidity, Parkinson's tremor, Parkinson's gait, motor freezing, depression, long-term memory loss, Rubmstein-Taybi syndrome (RTS), dementia, sleep Disorders, postural instability, hypokinesia disorder, inflammation, synuclein disorder, multiple system atrophy, striatal substantia nigra degeneration, olive pontine cerebellar atrophy, Shy-Drager syndrome, motor neuron disease characteristic of Parkinson's disease , Lewy body dementia, τ (Tau) pathological disorder, progressive supr...

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Abstract

Methods of treating, preventing and / or managing central nervous system disorders, such as Parkinson disease, Alzheimer disease, mild cognitive impairment, Huntington disease, Amytophic Lateral Sclerosis, depression and defective long-term memory, and related syndromes are disclosed. Specific methods encompass the administration of a selective cytokine inhibitory drug, or a pharmaceutically acceptable salt, solvate, hydrate, stereoisomer, clathrate, or prodrug thereof, alone or in combination with a second active ingredient. Pharmaceutical compositions, single unit dosage forms, and kits suitable for use in methods of the invention are also disclosed.

Description

1. Field of Invention [0001] The present invention relates in part to methods of treating, preventing and / or controlling central nervous system diseases, including but not limited to Parkinson’s disease, Alzheimer’s disease, mild cognitive impairment, Huntington’s disease, Amyotrophic lateral sclerosis, depression, long-term memory loss and related diseases, the method includes administering selective cytokine inhibitors or their pharmaceutically acceptable salts, solvates, hydrates, stereoisomers, and Compound or prodrug. 2. Background of the invention [0002] Central nervous system diseases affect a large number of people to varying degrees. Generally speaking, one of the main characteristics of this type of disease includes obvious cognitive or memory impairment, which is manifested as a significant deterioration of the original level of function. For example, dementia is characterized by several cognitive impairments, including obvious memory deficiency, and it can exist alo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4035A61K31/553A61K31/554A61K45/06
CPCA61K31/4035A61K31/554A61K31/553A61K45/06A61P25/00A61P25/08A61P25/14A61P25/16A61P25/20A61P25/24A61P25/28A61P43/00A61K2300/00
Inventor 杰罗米·B·杰奥迪斯彼得·H·谢弗
Owner CELGENE CORP
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