Degradation detection device for fibroin biological material
By designing a device for fixing components of magnetic stirring power and flow reduction material, it simulates blood circulation in the body, and realizes slow ablation detection of biological materials, solves the complexity and accuracy of biomaterial degradation detection in the prior art, and improves detection Efficiency and accurate quantities.
Patent Information
- Application Number
- CN202323467798.4
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2023-12-19
- Publication Date
- 2024-12-17
- Estimated Expiration
- 2033-12-19
AI Technical Summary
In the prior art, the in vivo degradation detection of biological materials involves complex animal experiments, which are cumbersome and expensive to operate, and the in vitro detection methods have poor accuracy and cannot accurately determine the quantity.
A wire biomaterial degradation detection device including magnetic stirring power supply, magnetic stirring assembly, liquid flow reduction material fixing assembly and flow rate detection temperature control assembly was designed. The liquid is rotated through the magnetic stirring assembly, and the liquid flow reduction material fixing assembly is finely adjusted. Flow velocity, flow velocity detection and temperature control components simulate blood circulation in the body and realize slow ablation detection of biological materials.
It provides an efficient and simple operating platform, which improves the accuracy and reliability of biomaterial degradation detection, simplifies the detection process, reduces costs, and improves the work efficiency of scientific researchers.
Smart Images
Figure CN222189281U_ABST
Abstract
Description
Technical Field
[0001] The utility model relates to the technical field of degradation detection, in particular to a degradation detection device for silk fibroin biomaterial. Background Art
[0002] Silk medical materials will show different degradation differences depending on the concentration of silk protein, water and other compounds they contain, which directly determines the biocompatibility, tissue plasticity and other properties of the material.
[0003] In the prior art, in vivo degradation detection of biomaterials not only involves complex animal experiments, but also is cumbersome and expensive. In vitro detection methods and means have the disadvantages of poor precision and inability to accurately quantify. Utility Model Content
[0004] The purpose of the utility model is to provide a degradation detection device for silk fibroin biomaterials, which solves the problem that the in vivo degradation detection of biomaterials in the prior art not only involves complex animal experiments, but also is cumbersome and expensive to operate, while the in vitro detection methods and means have the disadvantages of poor precision and inability to accurately quantify.
[0005] To achieve the above-mentioned purpose, the utility model provides a degradation detection device for silk biomaterials, comprising a magnetic stirring power supply, a magnetic stirring component, a liquid flow deceleration material fixing component, a flow velocity detection temperature control component and a silk material to be tested, wherein the magnetic stirring component is arranged above the magnetic stirring power supply, the liquid flow deceleration material fixing component is arranged inside the magnetic stirring component, the flow velocity detection temperature control component is installed above the magnetic stirring power supply and is located on one side of the magnetic stirring component, and the silk material to be tested is arranged on the flow velocity detection temperature control component.
[0006] The magnetic stirring assembly comprises a transparent volumetric cup, a sealing cover and a magnetic stirring bar. The transparent volumetric cup is placed above the magnetic stirring power supply, the sealing cover is covered on the transparent volumetric cup, and the magnetic stirring bar is arranged on the inner bottom wall of the transparent volumetric cup.
[0007] Among them, the flow rate detection temperature control component includes a support column, a temperature detector and a flow rate detector. The support column is fixedly connected to the magnetic stirring power supply and is located above the magnetic stirring power supply. One end of the temperature detector and the flow rate detector are sequentially arranged on the support column, and the other ends of the temperature detector and the flow rate detector are both located inside the transparent capacity cup.
[0008] The liquid flow deceleration material fixing assembly comprises a material fixing unit and a plurality of liquid flow deceleration baffles, and the plurality of liquid flow deceleration baffles are sequentially arranged inside the material fixing unit.
[0009] Among them, the material fixing unit includes a ring body and a fixed cover plate, and the multiple liquid flow deceleration baffles are rotatably connected to the ring body and are distributed in sequence inside the ring body. The ring body has a placement groove, and the silk material to be tested is placed inside the placement groove, and the fixed cover plate covers the placement groove.
[0010] The utility model discloses a degradation detection device for silk biomaterials. The magnetic stirring power source is turned on, and the liquid in the container is rotated and flowed through the magnetic stirring component, and the liquid flow speed is fine-tuned through the liquid flow deceleration material fixing component. The flow speed detection temperature control component can monitor and regulate the circulating liquid speed to simulate the blood circulation in the body. Then, the biomaterial to be tested is placed in the fixing component to make it slowly dissolve over time, thereby achieving the effect of measuring the degradation of the material. This provides an efficient and simple operation platform for detecting the degradation of biological and medical materials such as silk, and improves the work efficiency of scientific researchers. BRIEF DESCRIPTION OF THE DRAWINGS
[0011] In order to more clearly illustrate the embodiments of the present application or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art are briefly introduced below.
[0012] Figure 1 It is an overall structural schematic diagram of the utility model.
[0013] Figure 2 It is a sectional view of the whole of the utility model.
[0014] 1-magnetic stirring power supply, 2-silk material to be tested, 3-transparent capacity cup, 4-sealing cover, 5-magnetic stirring bar, 6-support column, 7-temperature detector, 8-flow velocity detector, 9-material fixing unit, 10-liquid flow deceleration baffle, 11-ring body, 12-fixed cover plate, 13-placement tank. DETAILED DESCRIPTION
[0015] Embodiments of the present invention are described in detail below, and examples of the embodiments are shown in the accompanying drawings. The embodiments described below with reference to the accompanying drawings are exemplary and are intended to be used to explain the present invention, but should not be understood as limiting the present invention.
[0016] See also Figure 1 and Figure 2The utility model provides a degradation detection device for silk biomaterials, comprising a magnetic stirring power supply 1, a magnetic stirring component, a liquid flow deceleration material fixing component, a flow velocity detection temperature control component and a silk material 2 to be tested, wherein the magnetic stirring component is arranged above the magnetic stirring power supply 1, the liquid flow deceleration material fixing component is arranged inside the magnetic stirring component, the flow velocity detection temperature control component is installed above the magnetic stirring power supply 1 and is located on one side of the magnetic stirring component, and the silk material 2 to be tested is arranged on the flow velocity detection temperature control component.
[0017] In this embodiment, the magnetic stirring power supply 1 is turned on, the liquid in the container is rotated and flowed through the magnetic stirring component, and the liquid flow velocity is fine-tuned through the liquid flow deceleration material fixing component. The flow velocity detection temperature control component can monitor and regulate the circulating liquid velocity to simulate blood circulation in the body, and then the biological material to be tested is placed in the fixing component to make it slowly ablate over time, thereby achieving the effect of measuring material degradation.
[0018] Furthermore, the magnetic stirring assembly includes a transparent volumetric cup 3, a sealing cover 4 and a magnetic stirring bar 5, the transparent volumetric cup 3 is placed above the magnetic stirring power supply 1, the sealing cover 4 covers the transparent volumetric cup 3, and the magnetic stirring bar 5 is arranged on the inner bottom wall of the transparent volumetric cup 3.
[0019] In this embodiment, liquid is stored in the transparent volumetric cup 3, and the sealing cover 4 is covered for sealing. The magnetic stirring power supply 1 is turned on to make the liquid rotate and flow in the transparent volumetric cup 3. The instantaneous flow velocity is detected by the liquid flow deceleration material fixing component. If the liquid flow is too large, the liquid flow velocity can be reduced by reducing the rotation speed of the magnetic stirrer 5, and the baffle angle of the flow velocity detection temperature control component is further adjusted to fine-tune the liquid flow until the instantaneous flow velocity meets the experimental requirements.
[0020] Furthermore, the flow velocity detection temperature control component includes a support column 6, a temperature detector 7 and a flow velocity detector 8, the support column 6 is fixedly connected to the magnetic stirring power supply 1 and is located above the magnetic stirring power supply 1, one end of the temperature detector 7 and the flow velocity detector 8 are sequentially arranged on the support column 6, and the other ends of the temperature detector 7 and the flow velocity detector 8 are both located inside the transparent capacity cup 3.
[0021] In this embodiment, the support column 6 supports the temperature detector 7 and the flow rate detector 8, the temperature detector 7 detects the real-time temperature of the liquid, and the flow rate detector 8 detects the real-time flow rate of the liquid.
[0022] Furthermore, the liquid flow deceleration material fixing assembly includes a material fixing unit 9 and a plurality of liquid flow deceleration baffles 10 , and the plurality of liquid flow deceleration baffles 10 are sequentially arranged inside the material fixing unit 9 .
[0023] Furthermore, the material fixing unit 9 includes a ring body 11 and a fixed cover plate 12, and the plurality of liquid flow deceleration baffles 10 are rotatably connected to the ring body 11 and are sequentially distributed inside the ring body 11, the ring body 11 has a placement groove 13, the silk fibroin material 2 to be tested is placed inside the placement groove 13, and the fixed cover plate 12 covers the placement groove 13.
[0024] In this embodiment, after the silk material 2 to be tested is placed in the placement groove 13, the fixing cover plate 12 is covered to complete the fixing of the silk material 2 to be tested. If the liquid flow is too large, the liquid flow speed can be reduced by reducing the rotation speed of the magnetic stirrer 5, and the angle of the liquid flow deceleration baffle 10 of the flow rate detection temperature control component is further adjusted to fine-tune the liquid flow until the instantaneous flow rate reaches the experimental requirements.
[0025] First, the digestion liquid is prepared according to the requirements of different experiments, and the liquid is placed in the transparent volumetric cup 3 so that the liquid submerges the liquid flow deceleration material fixing assembly, and the liquid flow deceleration material fixing assembly is placed in the transparent volumetric cup 3, and the magnetic stirring power supply 1 is turned on to make the liquid rotate and flow in the transparent volumetric cup 3, and the instantaneous flow rate is detected by the flow rate detector 8; if the liquid flow is too large, the liquid flow rate can be reduced by reducing the rotation speed of the magnetic stirring bar 5, and then the angle of the liquid flow deceleration baffle 10 in the ring body 11 is rotated to fine-tune the liquid flow until the instantaneous flow rate reaches the experimental requirements, and the instantaneous temperature of the liquid is detected by the temperature detector 7, and the weight and volume of the silk biomaterial to be detected are accurately weighed by an electronic balance, and then the material is placed in the material fixing assembly, and the sealing cover 4 is tightly covered to prevent excessive evaporation of the liquid, and the time is set to test. When the test time is over (for example: 3 days, 7 days, 14 days, 21 days), the material is taken out, freeze-dried or oven-dried, and then measured by an electronic balance to obtain indicators such as the mass and volume of the digested material.
[0026] Finally, it should be noted that the above embodiments are only used to illustrate the technical solution of the utility model rather than to limit it. Although the utility model has been described in detail with reference to the preferred embodiments, ordinary technicians in the field should understand that the technical solution of the utility model can be modified or replaced by equivalents without departing from the purpose and scope of the technical solution, which should be included in the scope of the claims of the utility model.
Claims
1. A degradation detection device for silk fibroin biomaterial, characterized in that: It includes a magnetic stirring power supply, a magnetic stirring component, a liquid flow deceleration material fixing component, a flow velocity detection temperature control component and a silk material to be tested, wherein the magnetic stirring component is arranged above the magnetic stirring power supply, the liquid flow deceleration material fixing component is arranged inside the magnetic stirring component, the flow velocity detection temperature control component is installed above the magnetic stirring power supply and located on one side of the magnetic stirring component, and the silk material to be tested is arranged on the flow velocity detection temperature control component.
2. The degradation detection device for silk fibroin biomaterial according to claim 1, characterized in that: The magnetic stirring assembly comprises a transparent capacity cup, a sealing cover and a magnetic stirring bar. The transparent capacity cup is placed above the magnetic stirring power supply, the sealing cover is covered on the transparent capacity cup, and the magnetic stirring bar is arranged on the inner bottom wall of the transparent capacity cup.
3. The degradation detection device for silk fibroin biomaterial according to claim 2, characterized in that: The flow rate detection temperature control component includes a support column, a temperature detector and a flow rate detector. The support column is fixedly connected to the magnetic stirring power supply and is located above the magnetic stirring power supply. One end of the temperature detector and the flow rate detector are sequentially arranged on the support column, and the other ends of the temperature detector and the flow rate detector are both located inside the transparent capacity cup.
4. The degradation detection device for silk fibroin biomaterial according to claim 3, characterized in that: The liquid flow deceleration material fixing assembly includes a material fixing unit and a plurality of liquid flow deceleration baffles, and the plurality of liquid flow deceleration baffles are sequentially arranged inside the material fixing unit.
5. The degradation detection device for silk fibroin biomaterial according to claim 4, characterized in that: The material fixing unit includes a ring body and a fixed cover plate. The plurality of liquid flow deceleration baffles are rotatably connected to the ring body and are sequentially distributed inside the ring body. The ring body has a placement groove. The silk fibroin material to be tested is placed inside the placement groove, and the fixed cover plate covers the placement groove.