Cell sorting device

Abstract

The utility model discloses a cell sorting device which comprises a sorting mechanism, a placing part used for placing a sorting container and a magnetic attraction mechanism used for changing the magnetic field intensity of the sorting container, the sorting mechanism comprises a sorting frame and a swing frame arranged on the sorting frame in a swinging mode, and the placing part is arranged on the swing frame. A magnetic attraction plane used for being attached to the magnetic attraction mechanism is arranged on one side of the sorting container, a mounting base capable of horizontally moving is arranged on the swing frame, the magnetic attraction mechanism is arranged on the mounting base, and the mounting base horizontally moves to enable the magnetic attraction mechanism to be away from or close to the containing part. The cell sorting device has the advantages of simple structure, small occupied space, good magnetic attraction effect and the like.

Description

Technical Field

[0001] The utility model relates to the technical field of food and medicine packaging machinery and equipment, in particular to a cell sorting device. Background Art

[0002] The existing application number is 202320887449.9, which is a cell sorting device and a sorting container. The device includes a main frame, a swing mechanism arranged on the main frame, and a placement slot arranged on the swing mechanism for placing the sorting container. A magnetic attraction mechanism for changing the magnetic field strength of the sorting container is arranged below the placement slot. The two opposite sides of the placement slot are arranged at an angle. The magnetic attraction mechanism includes a magnet assembly that can be lifted and translated relative to the placement slot. An adapter slot that matches the shape of the placement slot is arranged on the top of the magnet assembly. The magnetic attraction mechanism also includes a translation seat arranged on the swing mechanism and a lifting frame arranged on the translation seat. A translation drive assembly for driving the translation seat to translate is provided on the swing mechanism, and a lifting drive assembly for driving the lifting frame to lift is provided on the translation seat. The magnet assembly is arranged on the lifting frame. The cell sorting device has the following shortcomings: 1) The magnet assembly is arranged below the placement slot and is lifted and lowered by a lifting frame, which has a complex structure and occupies a large space; 2) The magnetic suction mechanism is difficult to directly fit with the sorting container, and the magnetic suction effect is poor; 3) There is no device for fixing the sorting container in the placement slot, and the stability of the sorting container is poor. Utility Model Content

[0003] The technical problem to be solved by the utility model is to overcome the deficiencies of the prior art and provide a cell sorting device with a simple structure, small occupied space and good magnetic attraction effect.

[0004] In order to solve the above technical problems, the utility model adopts the following technical solutions:

[0005] A cell sorting device comprises a sorting mechanism, a placement portion for placing a sorting container, and a magnetic attraction mechanism for changing the magnetic field strength of the sorting container, the sorting mechanism comprises a sorting frame and a swing frame swingably arranged on the sorting frame, the placement portion is arranged on the swing frame, one side of the sorting container is provided with a magnetic attraction plane for fitting with the magnetic attraction mechanism, the swing frame is provided with a horizontally movable mounting seat, the magnetic attraction mechanism is arranged on the mounting seat and is located on one side of the placement portion, and the horizontal movement of the mounting seat is used to move the magnetic attraction mechanism away from or close to the placement portion.

[0006] As a further improvement of the above technical solution:

[0007] The magnetic attraction mechanism comprises a box body and a magnet arranged in the box body. The box body is detachably arranged on the sorting mechanism. An opening is arranged on one side of the box body facing the placement portion.

[0008] The placement portion is provided with a notch on one side facing the magnetic attraction mechanism, and a flexible pressing component for pressing against the sorting container is provided on the side of the placement portion opposite to the notch.

[0009] The swing frame is provided with a driving component for driving the mounting seat to move.

[0010] The moving stroke of the mounting seat is 500 mm to 600 mm.

[0011] The swing angle of the swing frame is ±75°.

[0012] The sorting rack is provided with a swing detection mechanism for detecting the swing rack; and / or the placement portion is provided with a container detection mechanism for detecting the sorting container; and / or the sorting rack is provided with a bubble sensor for detecting the presence of liquid in the pipeline.

[0013] The sorting frame is provided with a magnetic bead removal component.

[0014] The sorting rack is provided with a refrigerator and a preheating component, the placement portion is provided with a heating mechanism; and / or the placement portion is provided with a cover.

[0015] The sorting rack is provided with an air supply component for ventilating the sorting container.

[0016] Compared with the prior art, the advantages of the utility model are:

[0017] The cell sorting device of the utility model, firstly, the magnetic attraction mechanism is arranged on one side of the placement part, and the magnetic attraction effect is formed on the sorting container in the placement part by the side of the placement part, and it is relatively arranged below the placement part, which reduces the setting of the lifting frame, has a simple structure and occupies a small space. Secondly, the magnetic attraction mechanism is directly attached to the magnetic attraction plane of the sorting container, and the magnetic attraction effect is good. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] Figure 1 It is a schematic diagram of the three-dimensional structure of the first embodiment of the cell sorting device of the present utility model.

[0019] Figure 2 The internal structure of the swing frame of the first embodiment of the cell sorting device of the utility model is shown in FIG. Figure 1 .

[0020] Figure 3 The internal structure of the swing frame of the first embodiment of the cell sorting device of the utility model is shown in FIG. Figure 2 .

[0021] Figure 4 It is a schematic diagram of the partial structure of the first embodiment of the cell sorting device of the present utility model.

[0022] Figure 5 for Figure 4Schematic diagram of the enlarged structure at point A in the middle.

[0023] Figure 6 This is a schematic diagram of the structure of the box body of the first embodiment of the cell sorting device of the present utility model.

[0024] Figure 7 This is an exploded view of the box body of the first embodiment of the cell sorting device of the present invention.

[0025] Figure 8 It is a schematic diagram of the three-dimensional structure of the second embodiment of the cell sorting device of the present utility model.

[0026] Fig. 9 The internal structure of the swing frame of the second embodiment of the cell sorting device of the utility model is shown in FIG. Figure 1 .

[0027] Fig.10 The internal structure of the swing frame of the first embodiment of the cell sorting device of the utility model is shown in FIG. Figure 2 .

[0028] Fig.11 for Fig.10 Schematic diagram of the enlarged structure at point B in the middle.

[0029] The symbols in the figure represent:

[0030] 1. Sorting mechanism; 11. Sorting rack; 12. Swing rack; 121. Driving assembly; 13. Refrigerator; 14. Preheating assembly; 15. Swing detection mechanism; 16. Bubble sensor; 17. Magnetic bead removal member; 2. Placement portion; 21. Notch; 22. Heating mechanism; 221. Heating plate; 222. Elastic seat; 23. Cover body; 24. Heating assembly; 25. Heating block; 3. Sorting container; 4. Magnetic attraction mechanism; 41. Box body; 411. Iron trough; 412. End cover; 42. Magnet; 5. Open mouth; 6. Screw; 7. Mounting seat; 71. Mounting slot; 8. Guide rail; 9. Flexible tightening assembly. DETAILED DESCRIPTION

[0031] The present invention will be further described in detail below in conjunction with the accompanying drawings and specific embodiments.

[0032] In the description of the present invention, it should be understood that the terms "length", "width", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", etc., indicating the orientation or position relationship, are based on the orientation or position relationship shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on the present invention.

[0033] In addition, the terms "first" and "second" are used for descriptive purposes only and should not be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Therefore, the features defined as "first" and "second" may explicitly or implicitly include one or more of the features. In the description of the present utility model, the meaning of "plurality" is two or more, unless otherwise clearly and specifically defined.

[0034] In the present invention, unless otherwise clearly specified and limited, the terms "assemble", "connect", "connect", "fix" and the like should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium, it can be the internal connection of two elements or the interaction relationship between two elements. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0035] Embodiment 1:

[0036] Figures 1 to 7 An embodiment of the cell sorting device of the utility model is shown. The cell sorting device of this embodiment includes a sorting mechanism 1, a placement portion 2 arranged on the sorting mechanism 1 for placing a sorting container 3, and a magnetic attraction mechanism 4 for changing the magnetic field strength of the sorting container 3. The sorting mechanism 1 includes a sorting frame 11 and a swing frame 12 swingably arranged on the sorting frame 11, the placement portion 2 is arranged on the swing frame 12, a magnetic attraction plane for fitting with the magnetic attraction mechanism 4 is arranged on one side of the sorting container 3, a horizontally movable mounting seat 7 is arranged on the mounting seat 7 and is located on one side of the placement portion 2, and the mounting seat 7 is horizontally moved to make the magnetic attraction mechanism 4 move away from or close to the placement portion 2.

[0037] First, the magnetic attraction mechanism 4 is arranged on one side of the placement part 2, and forms a magnetic attraction effect on the sorting container 3 in the placement part 2 at the side of the placement part 2. It is relatively arranged below the placement part 2, which reduces the setting of the lifting frame, has a simple structure and occupies a small space. Secondly, the magnetic attraction mechanism 4 is directly attached to the magnetic attraction plane of the sorting container 3, and the magnetic attraction effect is good.

[0038] Furthermore, in this embodiment, the magnetic attraction mechanism 4 includes a box body 41 and a magnet 42 arranged in the box body 41. The magnet 42 is a neodymium iron boron magnet, and can also be other magnets, or an electromagnet. The box body 41 is detachably arranged on the sorting mechanism 1 and is located on one side of the placement portion 2. The box body 41 is provided with an open mouth 5 on the side facing the placement portion 2, and at least one side wall of the box body 41 is detachably arranged. The box body 41 is provided with an open mouth 5 on the side facing the placement portion 2. The magnetic field of the magnet 42 has a magnetic attraction effect on the sorting container 3 in the placement portion 2 through the open mouth 5, and the magnetic attraction effect is good. At least one side wall of the box body 41 is detachably arranged, which is convenient for disassembling and assembling the magnet 42 through the side wall, rather than disassembling and assembling the magnet 42 through the open mouth 5, so as to prevent the magnet 42 from colliding with the placement portion 2 and being damaged.

[0039] Furthermore, in this embodiment, if Figure 6 and Figure 7 As shown, the box body 41 includes an iron groove 411 and two end covers 412. The magnet 42 is arranged in the iron groove 411. The opening 5 is formed at the opening of the iron groove 411. The two end covers 412 are detachably mounted on the sorting mechanism 1, and the iron groove 411 is clamped between the two end covers 412. By removing any end cover 412, the magnet 42 can be replaced. The structure is simple and the disassembly and assembly are convenient.

[0040] Furthermore, in this embodiment, the end cover 412 is mounted on the sorting mechanism 1 by means of screws 6 .

[0041] Furthermore, in this embodiment, a notch 21 is provided on the side of the placement portion 2 facing the magnetic attraction mechanism 4. The notch 21 allows the magnetic attraction mechanism 4 to directly fit with the sorting container 3, thereby improving the magnetic field effect and further improving the sorting effect.

[0042] Furthermore, in this embodiment, the iron trough 411 is U-shaped, which is suitable for placing a square sorting container 3 .

[0043] Furthermore, a flexible pressing component 9 for pressing against the sorting container 3 is provided on one side of the placement portion 2 opposite to the notch 21 . The flexible pressing component 9 is used for pressing against the sorting container 3 , thereby improving the stability of the sorting container 3 in the placement portion 2 .

[0044] Furthermore, in this embodiment, if Figures 1 to 5 As shown, the sorting mechanism 1 includes a sorting frame 11 and a swing frame 12 swingably arranged on the sorting frame 11, and the placement part 2 is arranged on the swing frame 12. In this way, the magnet 42 and the sorting container 3 can swing with the sorting frame 11, and perform magnetic attraction while swinging.

[0045] Furthermore, in this embodiment, a mounting seat 7 is provided on the swing frame 12 which can be moved closer to and away from the placing part 2, a mounting groove 71 is provided on the mounting seat 7, the box body 41 is disposed in the mounting groove 71, a driving component 121 for driving the mounting seat 7 to move is provided on the swing frame 12, a guide rail 8 is provided on the swing frame 12, and the mounting seat 7 is slidably disposed on the guide rail 8.

[0046] The swing frame 12 is provided with a mounting seat 7 that can move closer to and away from the placement portion 2, the box body 41 is provided on the mounting seat 7, and the swing frame 12 is provided with a driving component 121 for driving the mounting seat 7 to move. The driving component 121 drives the mounting seat 7 to move closer to the placement portion 2, strengthens the magnetic field strength of the sorting container 3 in the placement portion 2, and performs a magnetic attraction on the sorting container 3. On the contrary, the driving component 121 drives the mounting seat 7 to move away from the placement portion 2, reduces the magnetic field strength of the sorting container 3 in the placement portion 2, and even releases the magnetic attraction on the sorting container 3. The mounting seat 7 is slidably arranged on the guide rail 8, slides along the guide rail 8, and moves stably. The moving stroke of the mounting seat 7 is 500mm~600mm. In other embodiments, the moving stroke of the mounting seat 7 is 900mm~1000mm, and 500mm~600mm is the preferred moving stroke. The moving stroke indicates the distance that the mounting seat 7 can move the magnet away from the placement portion 2, and the moving speed is 20mm / s.

[0047] The swing angle of the swing frame 12 is ±75°, or can be ±90°, and the swing speed is 50° / second or 75° / second. In other embodiments, the sorting frame 11 is provided with a swing detection mechanism 15 for detecting the swing frame 12, and the sorting frame 11 is provided with a bubble sensor 16 for detecting the presence of liquid in the pipeline, and the bubble sensor is arranged on the outlet pipeline of the sorting container 3.

[0048] The placement portion 2 is provided with a container detection mechanism for detecting the sorting container 3, which is not shown in the figure. The container detection mechanism includes a camera and a light source that can collect information in the sorting container 3. The camera and the light source are both arranged in the placement portion 2. In other embodiments, the camera and the light source are both arranged in the heating plate 221.

[0049] Embodiment 2:

[0050] Figures 8 to 10An embodiment of the cell sorting device of the utility model is shown. The cell sorting device of this embodiment is basically the same as that of the first embodiment, and the only difference is that a refrigerator 13 and a preheating component 14 are provided on the sorting rack 11, and a heating mechanism 22 is provided on the placement portion 2. The buffer or culture fluid required by the sorting container 3 can be stored in the refrigerator 13. When in use, it is heated to a preset temperature by the preheating component 14 and then injected into the sorting container 3. The requirements for refrigeration and rapid heating of the buffer or culture fluid are met. In addition, a heating mechanism 22 is provided on the placement portion 2, which can heat the sorting container 3 to a temperature suitable for cell growth, thereby improving the cell culture effect.

[0051] Furthermore, in this embodiment, if Fig.10 and Fig.11 As shown, the heating mechanism 22 includes a heating plate 221 and an elastic seat 222. The heating plate 221 is arranged on the swing frame 12 through the elastic seat 222. The heating plate 221 is arranged on the side of the placement portion 2 opposite to the notch 21. An elastic member is provided between the elastic seat 222 and the swing frame 12. When the sorting container 3 is placed in the placement portion 2, the elastic member applies an elastic force to the elastic seat 222, so that the heating plate 221 is pressed against the sorting container 3.

[0052] Furthermore, in this embodiment, a cover 23 is provided on the placement portion 2. The opening of the placement portion 2 is sealed by the cover 23 to prevent the sorting container 3 from falling out during the swinging process. Fig. 9 As shown, the heating mechanism 22 includes a heating block 25 disposed on the cover 23 , or a heating cover 24 disposed in the swing frame 12 .

[0053] The sorting rack 11 is provided with a swing detection mechanism 15 for detecting the swing rack 12. The swing detection mechanism 15 is a camera. In other embodiments, the swing detection mechanism 15 may also be a detection mechanism such as a sensor. The sorting rack 11 is provided with a magnetic bead removal component 17. The magnetic bead removal component 17 is a neodymium iron boron magnet. The magnetic bead removal component 17 is arranged at the outlet of the sorting container 3 to remove the magnetic beads from the harvested cell fluid for the second time to reduce the magnetic beads carried in the cell fluid. The sorting rack 11 is provided with a gas supply component for ventilating the sorting container 3. The gas supply component is not shown in the figure. The gas supply component is used to provide carbon dioxide and other substances to meet the environment of cell culture.

[0054] Although the present invention has been disclosed as a preferred embodiment, it is not intended to limit the present invention. Any technician familiar with the art can use the above disclosed technical content to make many possible changes and modifications to the technical solution of the present invention without departing from the scope of the technical solution of the present invention, or modify it into an equivalent embodiment of equivalent changes. Therefore, any simple modification, equivalent change and modification made to the above embodiments based on the technical essence of the present invention without departing from the content of the technical solution of the present invention should fall within the scope of protection of the technical solution of the present invention.

Claims

1. A cell sorting device, comprising a sorting mechanism (1), a placement portion (2) for placing a sorting container (3), and a magnetic attraction mechanism (4) for changing the magnetic field strength of the sorting container (3), wherein the sorting mechanism (1) comprises a sorting frame (11) and a swing frame (12) swingably arranged on the sorting frame (11), the placement portion (2) being arranged on the swing frame (12), and characterized in that: A magnetic attraction plane for fitting with the magnetic attraction mechanism (4) is provided on one side of the sorting container (3); a horizontally movable mounting seat (7) is provided on the swing frame (12); the magnetic attraction mechanism (4) is arranged on the mounting seat (7) and is located on one side of the placement portion (2); the mounting seat (7) is horizontally movable to move the magnetic attraction mechanism (4) away from or close to the placement portion (2).

2. The cell sorting device according to claim 1, characterized in that: The magnetic attraction mechanism (4) comprises a box body (41) and a magnet (42) arranged in the box body (41); the box body (41) is detachably arranged on the sorting mechanism (1); and an opening (5) is provided on one side of the box body (41) facing the placement portion (2).

3. The cell sorting device according to claim 1, characterized in that: The placement portion (2) is provided with a notch (21) on the side facing the magnetic attraction mechanism (4), and the placement portion (2) is provided with a flexible pressing component (9) for pressing against the sorting container (3) on the side opposite to the notch (21).

4. The cell sorting device according to any one of claims 1 to 3, characterized in that: The swing frame (12) is provided with a driving assembly (121) for driving the mounting seat (7) to move.

5. The cell sorting device according to claim 4, characterized in that: The moving stroke of the mounting seat (7) is 500 mm to 600 mm.

6. The cell sorting device according to claim 4, characterized in that: The swing angle of the swing frame (12) is ±75°.

7. The cell sorting device according to claim 4, characterized in that: The sorting rack (11) is provided with a swing detection mechanism (15) for detecting the swing rack (12); and / or the placement portion (2) is provided with a container detection mechanism for detecting the sorting container (3); and / or the sorting rack (11) is provided with a bubble sensor (16) for detecting the presence or absence of liquid in the pipeline.

8. The cell sorting device according to claim 4, characterized in that: The sorting frame (11) is provided with a magnetic bead removal component (17).

9. The cell sorting device according to claim 4, characterized in that: The sorting rack (11) is provided with a refrigerator (13) and a preheating component (14), the placement portion (2) is provided with a heating mechanism (22); and / or the placement portion (2) is provided with a cover (23).

10. The cell sorting device according to claim 9, characterized in that: The sorting frame (11) is provided with an air supply component for ventilating the sorting container (3).

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