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Devices capable of fluid sample concentration for extended sensing of analytes

a technology of fluid sample and extended sensing, which is applied in the field of wearable devices capable of extending sensing analytes with fluid sample concentration, can solve the problems of difficult implementation of many laboratory techniques, and the technical challenges of achieving continuous monitoring are considerabl

Inactive Publication Date: 2018-11-08
ECCRINE SYST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0005]The disclosed invention provides a fluid sensing device capable of collecting a fluid sample, concentrating the sample with respect to a target analyte, and measuring the target analyte in the concentrated sample. The invention is also capable of determining the change in molarity of the fluid sample with respect to the target analyte, as the sample is concentrated by the device.

Problems solved by technology

While bio-monitoring fluids offer their greatest potential when used a source of continuous information about the body, the technological challenges of accomplishing such continuous monitoring are considerable.
For example, many techniques that work well in a laboratory are difficult to implement in a wearable device.

Method used

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  • Devices capable of fluid sample concentration for extended sensing of analytes
  • Devices capable of fluid sample concentration for extended sensing of analytes
  • Devices capable of fluid sample concentration for extended sensing of analytes

Examples

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example 1

[0085]This example provides additional examples of membranes suitable for the disclosed invention, including calculations of criteria related to membrane operation in the invention. Membranes of this and previous embodiments may utilize any material or filtration technique known by those skilled in the art of sample concentration or microfiltration. Solutes or analytes may be small ions, ions, small molecules, proteins, DNA, RNA, micro RNA or DNA, peptides, lipids, or any other solute or analyte of interest in sweat. Commercially available ultrafiltration and filtration membranes are most effective for larger solutes found in sweat, like proteins or peptides. Smaller molecules, including hormones and nucleotides, however, present a challenge, as they will typically pass through such membranes. Furthermore, if a membrane is used to block small molecules, but pass only water, then the concentration of salts, lactic acid, and other sweat-abundant analytes could fall out of solution or ...

example 2

[0091]This example provides additional examples of membranes suitable for the disclosed invention, including in some cases calculations of criteria related to their operation in the invention. More specifically, this example teaches an exemplary case for a determined amount of concentration as taught for FIG. 10. Assume a hydrophilic channel that is 7 μm tall, and 500 μm wide and which has a wicking pressure of ˜20,000 N / m2. Assume a membrane that as biologically inert and ultra-pure, such as Biotech Cellulose Ester (CE) membranes, which offer a large range of concise molecular weight cut-offs (100 to 1,000,000 Da) and that tolerates weak or dilute acids & bases, as well as mild alcohols. For example, choose a molecular weight cut-off of ˜500 Da. Assume a concentrator pump with a draw material that is 7 mM of polyethylenimine in water and / or other suitable solvent with a molecular weight of ˜10,000 Da, and the draw solution may also contain other solutes found in natural sweat (pH, ...

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Abstract

The disclosed invention provides a fluid sensing device and method capable of collecting a fluid sample, concentrating the sample with respect to one or more target analytes, and measuring the target analyte(s) in the concentrated sample. The invention is also capable of determining the change in molarity of the fluid sample with respect to the target analyte(s), as the sample is concentrated by the device. The invention further includes a method for using a fluid sensing device to concentrate a fluid sample with respect to one or more target analytes. The disclosed method further includes the ability to correlate the measured target analyte concentration to a physiological condition of a device wearer, or of a fluid source.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application relates to PCT / US2015 / 032893; U.S. Provisional No. 62 / 245,638, filed Oct. 23, 2015; U.S. Provisional No. 62 / 269,244, filed Dec. 18, 2015, and U.S. Provisional No. 62 / 269,447, filed Dec. 18, 2015, the disclosures of which are hereby incorporated by reference herein in their entirety.BACKGROUND OF THE INVENTION[0002]Non-invasive biosensing technologies have enormous potential for several medical, fitness, and personal well-being applications. The sweat ducts can provide a route of access to many of the same biomarkers, chemicals, or solutes that are carried in blood and can provide significant information enabling one to diagnose ailments, health status, toxins, performance, and other physiological attributes even in advance of any physical sign. Sweat has many of the same analytes and analyte concentrations found in blood and interstitial fluid. Interstitial fluid has even more analytes nearer to blood concentrations than ...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61B5/00A61B10/00A61F13/02A61B5/145G01N33/66
CPCA61B5/4266A61B10/0064A61F13/0246A61B5/14521A61B5/14532G01N33/66A61B5/0002A61B5/14517A61B5/14546A61B5/1468A61B5/6833A61B10/0012A61B2010/0016G01N33/50G01N33/5308G01N33/5438A61B5/0004
Inventor HEIKENFELD, JASONBERTRAND, JACOB A.BROTHERS, MICHAELJAJACK, ANDREW
Owner ECCRINE SYST