Dihydrotestosterone composition as spray

Abstract

The purpose of the present invention is to provide a dihydrotestosterone composition as a spray dosage form, and the application of the dihydrotestosterone composition in the preparation of penis growth preparations before micropenis surgery. The dihydrotestosterone composition as a spray is composed of 0.05% to 0.5% dihydrotestosterone by mass percentage in every 30ml dihydrotestosterone combination, 11-35% volume percentage of penetration enhancer and the balance is 50-70% by volume. % of ethanol water solvent composition. The penetration enhancer is composed of 1-10% menthol and 10-20% propylene glycol, or 1-5% laurocapram, 1-10% menthol and 10-20% propylene glycol by volume percentage. The spray is simple to make, low in cost, non-irritating to the skin, and contains less medicine. It is mainly used for hypospadias surgery or other operations that need to increase the penis in a short time before the operation.

Description

technical field

[0001] The invention relates to a dihydrotestosterone spray for treating micropenis, which is mainly used for short-term growth of micropenis before hypospadias operation or other operations. Background technique

[0002] Causes of micropenis: Micropenis refers to a person with a normal appearance but a penis extension length that is less than 2.5 standard deviations from the average penis length of people of the same age or normal development of the same sex. The development of the penis mainly depends on the secretion of testosterone (T) by Leydig cells, which is converted into dihydrotestosterone (DHT) under the action of 5a-reductase 2, and then acts on the androgen receptor to make the penis grow. Human chorionic gonadotropin (HCG) secreted by the placenta in the first 15 weeks of pregnancy stimulates Leydig cells to differentiate and secrete T. After 15 weeks, the fetal hypothalamus and pituitary develop maturely, and then the gonadotropin-releasing ho...

Examples

Embodiment 1

[0016] Embodiment 1: Observation of the clinical efficacy of 0.2% dihydrotestosterone spray and human chorionic gonadotropin HCG in the treatment of micropenis

[0017] (1) Cases and methods

[0018] 30 cases of micropenis children with poor development in infancy, prepuberty and puberty.

[0019] Judgment of micropenis: In children with short penis as the main complaint, first exclude cases such as hypospadias, cryptorchidism, webbed penis, hidden penis, buried penis, hermaphroditism and obesity that may affect penis development and size determination. , and then measure the penis length of each case by using the Feldman method [Feldman KW, et al. J Pediatr, 1975; 6(3): 395-398], which is more common at present, and compare it with the commonly used normal penis length reference standard, Those who were less than 2.5 standard deviations from the mean of the same age were included in this study.

[0020] 30 children with micropenis were randomly divided into two groups, 15...

Embodiment 2

[0027] Example 2: Observation on the clinical curative effect of preoperative use of 0.2% dihydrotestosterone spray and 1% testosterone propionate emulsion in children with hypospadias

[0028] (1) Cases and methods

[0029] From May 2009 to April 2010, a total of 28 children with hypospadias were scheduled for elective surgery. For 14 cases in the control group, testosterone propionate emulsion was used before operation (the preparation method of testosterone propionate emulsion is: add 400 mg of testosterone propionate injection for intramuscular injection into 40 g cream base and stir before use), apply locally, 1 time each morning and evening. The 14 cases in the treatment group were treated with dihydrotestosterone spray (preparation method is the same as that in Example 1) before operation, sprayed locally, once a day; after 1 week of withdrawal in each group, the penis length of each case was measured by Feldman method.

[0030] After treatment, if the penis growth ...

technical field

[0001] The invention relates to a dihydrotestosterone spray for treating micropenis, which is mainly used for short-term growth of micropenis before hypospadias operation or other operations. Background technique

[0002] Causes of micropenis: Micropenis refers to a person with a normal appearance but a penis extension length that is less than 2.5 standard deviations from the average penis length of people of the same age or normal development of the same sex. The development of the penis mainly depends on the secretion of testosterone (T) by Leydig cells, which is converted into dihydrotestosterone (DHT) under the action of 5a-reductase 2, and then acts on the androgen receptor to make the penis grow. Human chorionic gonadotropin (HCG) secreted by the placenta in the first 15 weeks of pregnancy stimulates Leydig cells to differentiate and secrete T. After 15 weeks, the fetal hypothalamus and pituitary develop maturely, and then the gonadotropin-releasing ho...

Examples

Embodiment 1

[0016] Embodiment 1: Observation of the clinical efficacy of 0.2% dihydrotestosterone spray and human chorionic gonadotropin HCG in the treatment of micropenis

[0017] (1) Cases and methods

[0018] 30 cases of micropenis children with poor development in infancy, prepuberty and puberty.

[0019] Judgment of micropenis: In children with short penis as the main complaint, first exclude cases such as hypospadias, cryptorchidism, webbed penis, hidden penis, buried penis, hermaphroditism and obesity that may affect penis development and size determination. , and then measure the penis length of each case by using the Feldman method [Feldman KW, et al. J Pediatr, 1975; 6(3): 395-398], which is more common at present, and compare it with the commonly used normal penis length reference standard, Those who were less than 2.5 standard deviations from the mean of the same age were included in this study.

[0020] 30 children with micropenis were randomly divided into two groups, 15...

Embodiment 2

[0027] Example 2: Observation on the clinical curative effect of preoperative use of 0.2% dihydrotestosterone spray and 1% testosterone propionate emulsion in children with hypospadias

[0028] (1) Cases and methods

[0029] From May 2009 to April 2010, a total of 28 children with hypospadias were scheduled for elective surgery. For 14 cases in the control group, testosterone propionate emulsion was used before operation (the preparation method of testosterone propionate emulsion is: add 400 mg of testosterone propionate injection for intramuscular injection into 40 g cream base and stir before use), apply locally, 1 time each morning and evening. The 14 cases in the treatment group were treated with dihydrotestosterone spray (preparation method is the same as that in Example 1) before operation, sprayed locally, once a day; after 1 week of withdrawal in each group, the penis length of each case was measured by Feldman method.

[0030] After treatment, if the penis growth ...