Application of sinomenine or pharmaceutically acceptable salt thereof as medicament for preventing and treating pulmonary interstitial fibrosis

A technology of pulmonary interstitial fibrosis and sinomenine, applied in the field of alkaloids, can solve problems such as organ or tissue damage, achieve the effects of preventing occurrence and development, clarifying the chemical structure, and eliminating adverse effects

CN102579445AActive Publication Date: 2012-07-18李蕴麟
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Publication Date
2012-07-18

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Abstract

The invention relates to application of sinomenine as a medicament for preventing and treating pulmonary interstitial fibrosis. The medicament is prepared by sinomenine or pharmaceutically acceptable salt thereof and other adjuvants, wherein sinomenine or pharmaceutically acceptable salt thereof serves as an activating agent. The routes of administration of the medicament include intravenous drip, intramuscular injection, oral administration, transdermal absorption, atomization inhalation and bronchoalveolar lavage. Experiments show that sinomenine does not have obvious difference with the dexamethasone control group in the effect on inhibiting formation of bleomycin-induced pulmonary fibrosis in mice and prove that sinomenine can alleviate pulmonary alveolitis and fibrosis degrees of themice with bleomycin-induced pulmonary fibrosis and the mechanisms are probably realized by inhibiting expressions of TGF (transforming growth factor)-beta1 and alpha-SMA (smooth muscle actin) and thecontent of HYP (hydroxyproline).
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Description

technical field

[0001] The present invention relates to an alkaloid used for preventing and treating pulmonary interstitial fibrosis, in particular to sinomenine or its pharmaceutically acceptable salt for preventing and treating pulmonary interstitial fibrosis caused by various chronic inflammatory pathological mechanisms change. Background technique

[0002] 1. Pharmacological effects of sinomenine

[0003] Sinomenine (sinomenine) is one of the alkaloids extracted from the stem and root of Sinomenium acutum (Thunb.) R.etWils., which is a known medicinal substance. Modern pharmacological studies have shown that sinomenine has a variety of pharmacological effects. In a nutshell, the main pharmacological effects of sinomenine known so far are as follows: anti-inflammatory, immunosuppressive, antihypertensive, central inhibitory, antiarrhythmic, etc.

[0004] Sinomenine hydrochloride has the following pharmacological effects:

[0005] 1. Anti-inflammatory effect: can inhib...

Examples

experiment example

[0116] Experimental example: Effect of sinomenine on bleomycin-induced pulmonary fibrosis in mice and its mechanism

[0117] Pulmonary fibrosis is a common pathological change of various heterogeneous interstitial lung diseases represented by idiopathic pulmonary fibrosis (IPF), and it is the main cause of respiratory failure and death caused by the irreversible development of such diseases. The pathogenesis remains unclear. Traditional corticosteroids and immunosuppressants in the treatment of diffuse pulmonary interstitial fibrosis are not only ineffective but also have many adverse reactions. Currently, there is no effective treatment other than lung transplantation. Sinomenine is an alkaloid monomer extracted from the traditional Chinese medicinal plant S. chinensis. Studies have found that it has anti-inflammatory, anti-oxidation, immunosuppressive, and analgesic effects. It is used in the treatment of rheumatic diseases such as rheumatoid arthritis. widely used in (Zho...