Skin itch-treatment granular traditional Chinese medicine composition and preparation method thereof

Abstract

The invention relates to a skin itch-treatment granular traditional Chinese medicine composition and a preparation method thereof. The skin itch-treatment granular traditional Chinese medicine composition is prepared from cocklebur fruit, broom cypress fruit, ligusticum wallichii, safflower and solanum lyratum thumb. The skin itch-treatment granular traditional Chinese medicine composition has effects of dispelling wind and invigorating the circulation of blood, and removing moisture and relieving itching, and can be mainly used for skin itch and urticaria. Compared with the prior art, the preparation method is more reasonable and substantially improves clinical pharmacodynamics test effects of the skin itch-treatment granular traditional Chinese medicine composition. The skin itch-treatment granular traditional Chinese medicine composition has high bioavailability, good drug stability and no toxic or side effect.

Description

technical field

[0001] The invention relates to a Fuyang granule traditional Chinese medicine composition and a preparation method thereof, belonging to the technical field of pharmacy. technical background

[0002] Skin pruritus and urticaria are common and frequently-occurring diseases in dermatology; the main manifestations are unbearable skin itching, rash, and dermatitis, which seriously affect the daily work and life of patients; in the prior art, there are many Chinese patent medicines for the treatment of skin diseases , Most of them treat the symptoms but not the disease, and the cure rate is relatively poor. The Ministry-issued standard "Chinese Medicine Prescriptions" Volume 6 WS3-B-1160-92 "Fuyang Granules" has achieved certain clinical curative effect, but many problems have been found after years of clinical application: 1. Patients Long-term use will cause nausea, stomach discomfort and other adverse reactions, and they are more serious. 2, curative effect i...

Examples

Embodiment 1

[0091] Formula ratio:

[0092] Xanthium 444g Kochia 444g Chuanxiong 444g

[0093] 444g of safflower and 222g of white flower;

[0094] The preparation method is as follows: add the above five flavors, add water to decoct twice, add 6 times the amount of water to decoct for 2 hours for the first time, add 4 times the amount of water to decoct for 1 hour for the second time, combine the decoction, add ethanol until the alcohol content reaches 70% to stand still for 8 hours, take the supernatant and concentrate it under reduced pressure to 65-75°C and measure the clear paste with a relative density of 1.36; take the clear paste, add appropriate amount of dextrin and stevioside, mix well, and granulate with 75% ethanol , dried at 65-70°C, granulated, made into 1000g, and packed into bags.

Embodiment 2

[0096] Formula ratio:

[0097] Xanthium 444g Kochia 444g Chuanxiong 444g

[0098] 444g of safflower and 222g of white flower;

[0099] The preparation method is as follows: add the above five flavors, add water to decoct twice, add 6 times the amount of water to decoct for 2 hours for the first time, add 4 times the amount of water to decoct for 1 hour for the second time, combine the decoction, add ethanol until the alcohol content reaches 70% and let it stand for 8 hours, take the supernatant and concentrate it under reduced pressure to 65-75°C and measure the clear paste with a relative density of 1.34; take the clear paste, add appropriate amount of dextrin and stevioside, mix well, and granulate with 75% ethanol , dried at 60-70°C, granulated, made into 1000g, and packed into bags.

Embodiment 3

[0101] Formula ratio:

[0102] Xanthium 444g Kochia 444g Chuanxiong 444g

[0103]444g of safflower and 222g of white flower;

[0104] The preparation method is as follows: add the above five flavors, add water to decoct twice, add 6 times the amount of water to decoct for 2 hours for the first time, add 4 times the amount of water to decoct for 1 hour for the second time, combine the decoction, add ethanol until the alcohol content reaches 70% and let it stand for 8 hours, take the supernatant and concentrate it under reduced pressure to 65-75°C and measure the clear paste with a relative density of 1.37; take the clear paste, add appropriate amount of dextrin and stevioside, mix well, and granulate with 75% ethanol , dried at 60-70°C, granulated, made into 1000g, and packed into bags.

technical field

[0001] The invention relates to a Fuyang granule traditional Chinese medicine composition and a preparation method thereof, belonging to the technical field of pharmacy. technical background

[0002] Skin pruritus and urticaria are common and frequently-occurring diseases in dermatology; the main manifestations are unbearable skin itching, rash, and dermatitis, which seriously affect the daily work and life of patients; in the prior art, there are many Chinese patent medicines for the treatment of skin diseases , Most of them treat the symptoms but not the disease, and the cure rate is relatively poor. The Ministry-issued standard "Chinese Medicine Prescriptions" Volume 6 WS3-B-1160-92 "Fuyang Granules" has achieved certain clinical curative effect, but many problems have been found after years of clinical application: 1. Patients Long-term use will cause nausea, stomach discomfort and other adverse reactions, and they are more serious. 2, curative effect i...

Examples

Embodiment 1

[0091] Formula ratio:

[0092] Xanthium 444g Kochia 444g Chuanxiong 444g

[0093] 444g of safflower and 222g of white flower;

[0094] The preparation method is as follows: add the above five flavors, add water to decoct twice, add 6 times the amount of water to decoct for 2 hours for the first time, add 4 times the amount of water to decoct for 1 hour for the second time, combine the decoction, add ethanol until the alcohol content reaches 70% to stand still for 8 hours, take the supernatant and concentrate it under reduced pressure to 65-75°C and measure the clear paste with a relative density of 1.36; take the clear paste, add appropriate amount of dextrin and stevioside, mix well, and granulate with 75% ethanol , dried at 65-70°C, granulated, made into 1000g, and packed into bags.

Embodiment 2

[0096] Formula ratio:

[0097] Xanthium 444g Kochia 444g Chuanxiong 444g

[0098] 444g of safflower and 222g of white flower;

[0099] The preparation method is as follows: add the above five flavors, add water to decoct twice, add 6 times the amount of water to decoct for 2 hours for the first time, add 4 times the amount of water to decoct for 1 hour for the second time, combine the decoction, add ethanol until the alcohol content reaches 70% and let it stand for 8 hours, take the supernatant and concentrate it under reduced pressure to 65-75°C and measure the clear paste with a relative density of 1.34; take the clear paste, add appropriate amount of dextrin and stevioside, mix well, and granulate with 75% ethanol , dried at 60-70°C, granulated, made into 1000g, and packed into bags.

Embodiment 3

[0101] Formula ratio:

[0102] Xanthium 444g Kochia 444g Chuanxiong 444g

[0103]444g of safflower and 222g of white flower;

[0104] The preparation method is as follows: add the above five flavors, add water to decoct twice, add 6 times the amount of water to decoct for 2 hours for the first time, add 4 times the amount of water to decoct for 1 hour for the second time, combine the decoction, add ethanol until the alcohol content reaches 70% and let it stand for 8 hours, take the supernatant and concentrate it under reduced pressure to 65-75°C and measure the clear paste with a relative density of 1.37; take the clear paste, add appropriate amount of dextrin and stevioside, mix well, and granulate with 75% ethanol , dried at 60-70°C, granulated, made into 1000g, and packed into bags.

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