A kind of nicotinamide production method

A production method, the technology of nicotinamide, which is applied in the field of nicotinamide production, can solve problems such as the difficulty of solvent recycling, the increase of equipment production load, and the azeotropy of alcohol and water, so as to reduce the probability of agglomeration or agglomeration and reduce the emission rate , The effect of reducing the amount of waste liquid discharge

CN106045904BInactive Publication Date: 2019-04-09GUIZHOU RES INST OF CHEM IND
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Publication Date
2019-04-09
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to the technical field of fine chemical engineering, in particular to a nicotinamide production method. The method comprises the steps that in the hydrolytic process, water is adopted as a solvent, manganese dioxide is adopted as a catalyst, 3-cyanopyridine is subjected to heating and hydrolysis reaction, in the hydrolysis reaction process, alcohol is not needed to serve as a solvent, the production cost of nicotinamide is reduced, the yield of nicotinamide is high and can reach 85% or above, the purity of the product is determined through a high performance liquid chromatography method, the purity can reach 99.93% or above, the cost of recycling the solvent and the catalyst manganese dioxide is effectively reduced, the waste rate of the raw materials is decreased, and the emission rate of liquid waste is decreased.
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Description

technical field

[0001] The invention relates to the technical field of fine chemicals, in particular to a method for producing nicotinamide. Background technique

[0002] The common name of nicotinamide is VB3, and its chemical name is 3-pyridinecarboxamide. It is a white needle-like crystal or powder with a melting point of 129-131°C and is soluble in ethanol and glycerin. Niacinamide is a component of coenzyme I and coenzyme II. When lacking, it can affect the normal respiration and metabolism of cells and cause pellagra. Therefore, nicotinamide is widely used in food and feed additives, pharmaceuticals and raw materials, biochemical agents, color development agents, electroplating brighteners and other fields.

[0003] The production of nicotinamide is mainly based on the main synthesis method of 3-cyanopyridine through microbial hydrolysis or metal oxide catalyzed hydrolysis. At present, the yield of nicotinamide produced in China is relatively high, which can reach mo...

Examples

Embodiment 1

[0021] A production method of nicotinamide, which is prepared by using water, 3-cyanopyridine, and manganese dioxide in a weight ratio of 50:40:2, putting them into a reaction tank, controlling the temperature at 95°C, and stirring for 8 hours. Therefore, the stirring speed is to control the solution so that bumping does not occur.

Embodiment 2

[0023] A method for producing nicotinamide, which uses water, 3-cyanopyridine, and manganese dioxide in a weight ratio of 60:50:5, puts them into a reaction tank, controls the temperature at 95-110°C, and stirs the hydrolysis reaction After 10 hours, it is obtained through the steps of hot filtration, decolorization, concentration, filtration, recrystallization, refiltration, dissolution, granulation, and drying. During the stirring process, it is advisable to control the solution from bumping.

Embodiment 3

[0025] A method for producing nicotinamide, which uses water, 3-cyanopyridine, and manganese dioxide in a weight ratio of 55:45:3, puts them into a reaction tank, controls the temperature at 95-110°C, and stirs and hydrolyzes for 9 hours , and then obtained through the steps of hot filtration, decolorization, concentration, filtration, recrystallization, refiltration, dissolution, granulation, and drying. During the stirring process, it is advisable to control the solution from bumping. The hot filtration is to filter it immediately after the hydrolysis reaction is completed, and adopt two suction filtration treatments, and return the solid to the hydrolysis step; the decolorization is to pass the filtrate after the hot filtration through the decolorization treatment in the activated carbon decolorizer ; The concentration is to distill 20 parts by weight of water from the decolorized material, and then it is cooled and crystallized until the amount of crystals no longer increas...