Waste liquid treatment method in guanine preparation process

Abstract

The invention belongs to the field of industrial waste liquid treatment, and particularly relates to a waste liquid treatment method in a guanine preparation process. Sulfuric acid and alcohol substances are added into a closed-loop reaction liquid generated in the process of producing the guanine step by step, the conversion between sodium formate and formic acid in the closed-loop reaction liquid is realized, the formate and salt substances obtained after conversion are recycled, so that the economic value of the wastewater in the production process of the guanine is effectively improved, and the pollution to the environment is reduced.

Description

technical field

[0001] The invention belongs to the field of industrial waste liquid treatment, in particular to a waste liquid treatment method in the guanine preparation process. Background technique

[0002] Guanine is an important substance for the synthesis of antivirals, such as antiviral drugs acyclovir and gaga-acyclovir. Its chemical name is: 2-aminopurine, and its molecular formula is: C 5 h 5 N 5 O. Due to the poor water solubility and ester solubility of guanine, in order to ensure the yield of guanine and the purity of prepared guanine, in the prior art, direct or indirect methods are used to obtain 2,4-diamino-6- Hydroxy-5-nitrosopyrimidine (DAHNP) or 2,4,5-triamino-6-hydroxypyrimidine sulfate reacts with formic acid under the action of a catalyst, and the obtained product is washed with formic acid or inorganic acid to obtain a finished product.

[0003] The specific reaction principle is:

[0004] .

[0005] In this process, the application of formic...

Examples

Embodiment 1

[0035] Waste liquid treatment method in the guanine preparation process, comprises the steps:

[0036] Put 561.2g (10.363mol) of formic acid (85%) into a 1500ml three-necked flask, add 249.6g (3.597mol) of sodium formate (98%) under stirring to dissolve it, then add 320g (1.338mol) of triamine, and stir to raise the temperature To reflux reaction for 32 hours. During the reaction, 1.31 mol of formic acid was consumed, and the total amount of residual formic acid was 12.65 mol.

[0037] Collect the closed-loop reaction solution 1130.8g containing formic acid and sodium formate produced in the production process of guanine; Add 179.96g of 98% concentrated sulfuric acid dropwise to the closed-loop reaction solution to convert the sodium formate in the closed-loop reaction solution into formic acid and sodium sulfate; Continue to add 8.82g of 98% concentrated sulfuric acid (0.025 times the amount of sodium formate) as a catalyst, then add 425.57g of methanol (1.05 times the amoun...

Embodiment 2

[0039] Waste liquid treatment method in the guanine preparation process, comprises the steps:

[0040] Put 561.2g (10.363mol) of formic acid (85%) into a 1500ml three-necked flask, add 249.6g (3.597mol) of sodium formate (98%) under stirring to dissolve it, then add 320g (1.338mol) of triamine, and stir to raise the temperature To reflux reaction for 32 hours. During the reaction, 1.31 mol of formic acid was consumed, and the total amount of residual formic acid was 12.65 mol.

[0041] Collect the closed-loop reaction solution 1130.8g containing formic acid and sodium formate produced in the production process of guanine; Add 179.96g of 98% concentrated sulfuric acid dropwise to the closed-loop reaction solution to convert the sodium formate in the closed-loop reaction solution into formic acid and sodium sulfate; Continue to add 176.4g of 98% concentrated sulfuric acid (0.5 times the amount of sodium formate) as a catalyst, then add 506.65g of methanol (1.25 times the amount o...

Embodiment 3

[0043] Waste liquid treatment method in the guanine preparation process, comprises the steps:

[0044] Put 561.2g (10.363mol) of formic acid (85%) into a 1500ml three-necked flask, add 249.6g (3.597mol) of sodium formate (98%) under stirring to dissolve it, then add 320g (1.338mol) of triamine, and stir to raise the temperature To reflux reaction for 32 hours. During the reaction, 1.31 mol of formic acid was consumed, and the total amount of residual formic acid was 12.65 mol.

[0045] Collect the closed-loop reaction solution 1130.8g containing formic acid and sodium formate produced in the production process of guanine; Add 179.96g of 98% concentrated sulfuric acid dropwise to the closed-loop reaction solution to convert the sodium formate in the closed-loop reaction solution into formic acid and sodium sulfate; Continue to add 92.60g of 98% concentrated sulfuric acid (0.2625 times the amount of sodium formate) as a catalyst, then add 466.10g of methanol (1.15 times the amo...

technical field

[0001] The invention belongs to the field of industrial waste liquid treatment, in particular to a waste liquid treatment method in the guanine preparation process. Background technique

[0002] Guanine is an important substance for the synthesis of antivirals, such as antiviral drugs acyclovir and gaga-acyclovir. Its chemical name is: 2-aminopurine, and its molecular formula is: C 5 h 5 N 5 O. Due to the poor water solubility and ester solubility of guanine, in order to ensure the yield of guanine and the purity of prepared guanine, in the prior art, direct or indirect methods are used to obtain 2,4-diamino-6- Hydroxy-5-nitrosopyrimidine (DAHNP) or 2,4,5-triamino-6-hydroxypyrimidine sulfate reacts with formic acid under the action of a catalyst, and the obtained product is washed with formic acid or inorganic acid to obtain a finished product.

[0003] The specific reaction principle is:

[0004] .

[0005] In this process, the application of formic...

Examples

Embodiment 1

[0035] Waste liquid treatment method in the guanine preparation process, comprises the steps:

[0036] Put 561.2g (10.363mol) of formic acid (85%) into a 1500ml three-necked flask, add 249.6g (3.597mol) of sodium formate (98%) under stirring to dissolve it, then add 320g (1.338mol) of triamine, and stir to raise the temperature To reflux reaction for 32 hours. During the reaction, 1.31 mol of formic acid was consumed, and the total amount of residual formic acid was 12.65 mol.

[0037] Collect the closed-loop reaction solution 1130.8g containing formic acid and sodium formate produced in the production process of guanine; Add 179.96g of 98% concentrated sulfuric acid dropwise to the closed-loop reaction solution to convert the sodium formate in the closed-loop reaction solution into formic acid and sodium sulfate; Continue to add 8.82g of 98% concentrated sulfuric acid (0.025 times the amount of sodium formate) as a catalyst, then add 425.57g of methanol (1.05 times the amoun...

Embodiment 2

[0039] Waste liquid treatment method in the guanine preparation process, comprises the steps:

[0040] Put 561.2g (10.363mol) of formic acid (85%) into a 1500ml three-necked flask, add 249.6g (3.597mol) of sodium formate (98%) under stirring to dissolve it, then add 320g (1.338mol) of triamine, and stir to raise the temperature To reflux reaction for 32 hours. During the reaction, 1.31 mol of formic acid was consumed, and the total amount of residual formic acid was 12.65 mol.

[0041] Collect the closed-loop reaction solution 1130.8g containing formic acid and sodium formate produced in the production process of guanine; Add 179.96g of 98% concentrated sulfuric acid dropwise to the closed-loop reaction solution to convert the sodium formate in the closed-loop reaction solution into formic acid and sodium sulfate; Continue to add 176.4g of 98% concentrated sulfuric acid (0.5 times the amount of sodium formate) as a catalyst, then add 506.65g of methanol (1.25 times the amount o...

Embodiment 3

[0043] Waste liquid treatment method in the guanine preparation process, comprises the steps:

[0044] Put 561.2g (10.363mol) of formic acid (85%) into a 1500ml three-necked flask, add 249.6g (3.597mol) of sodium formate (98%) under stirring to dissolve it, then add 320g (1.338mol) of triamine, and stir to raise the temperature To reflux reaction for 32 hours. During the reaction, 1.31 mol of formic acid was consumed, and the total amount of residual formic acid was 12.65 mol.

[0045] Collect the closed-loop reaction solution 1130.8g containing formic acid and sodium formate produced in the production process of guanine; Add 179.96g of 98% concentrated sulfuric acid dropwise to the closed-loop reaction solution to convert the sodium formate in the closed-loop reaction solution into formic acid and sodium sulfate; Continue to add 92.60g of 98% concentrated sulfuric acid (0.2625 times the amount of sodium formate) as a catalyst, then add 466.10g of methanol (1.15 times the amo...