Digestive tract sampling capsule

Abstract

A digestive tract sampling capsule includes a capsule shell and a sampling chamber disposed in the capsule shell, wherein the capsule shell is provided with a sampling port, and the sampling chamber is provided with an injection port, wherein the injection port and the sampling port can be selectively aligned or misaligned, and further includes a driving component disposed in the capsule shell, wherein the injection port is blocked by a dissolving material, and the driving component drives the injection port or the sampling port to transform between two states relative to the sampling chamber, wherein in a first state, the sampling port is misaligned with the injection port; in a second state, the sampling port is aligned with the injection port, and the dissolving material contacts the sample and dissolves under the action of the sample to open the injection port for sampling. The digestive tract sampling capsule of the present invention adopts a mode combining active and passive trigger sampling, which can achieve accurate sampling and improve the success rate of sampling.

Description

Technical Field

[0001] The present invention relates to the technical field of medical devices, and in particular to a digestive tract sampling capsule. Background Art

[0002] Due to its high reliability and high safety, the digestive tract sampling capsule has become an effective device for diagnosing digestive tract diseases and has been highly recognized in the international medical device field. The digestive tract sampling capsule has a camera unit, a data processing unit, and a wireless transmission unit. When swallowed by the subject, it can take pictures of organs such as the stomach or intestines during the digestive tract system, and send the photographed information to an external receiving device via wireless transmission. The information is received by the external receiving device and then displayed on the display device. In the painless and non-traumatic state of human gastrointestinal peristalsis, medical staff can diagnose gastrointestinal diseases of the subject based on the images displayed on the display device.

[0003] In addition, the digestive tract sampling capsule can also collect liquid samples from organs such as the stomach or intestines for subsequent testing, thereby diagnosing gastrointestinal diseases in the subject. At present, some digestive tract sampling capsules use some special materials to plug the sampling cavity in the capsule. In specific digestive fluids, these plugs degrade, thereby sucking foreign substances into the sampling cavity. This design uses degradable materials as sampling triggers, and its disadvantages are: first, passive trigger sampling, and poor controllability of sampling timing. Taking small intestine collection as an example, when the capsule enters the small intestine, the plug begins to gradually dissolve and the sampling action begins. Therefore, it can only collect samples at the front end of the small intestine, and cannot collect samples from the middle and rear sections of the small intestine. Although the sampling can be delayed by thickening the plug, it is still difficult to estimate the sampling time and cannot be actively controlled; second, the sampling hole cannot be closed again after opening, and the sample is easy to leak or be contaminated by downstream substances in the digestive tract.

[0004] In view of this, it is necessary to provide an improved digestive tract sampling capsule to solve the above technical problems. Summary of the invention

[0005] The object of the present invention is to provide a digestive tract sampling capsule, which can accurately control the sampling timing and improve the sampling effectiveness.

[0006] To achieve the above-mentioned purpose of the invention, the present invention provides a digestive tract sampling capsule, comprising a capsule shell and a sampling chamber arranged in the capsule shell, the capsule shell is provided with a sampling port, the sampling chamber is provided with an injection port, the injection port and the sampling port can be selectively aligned or misaligned, and also includes a driving component arranged in the capsule shell, the injection port is blocked by a dissolving material, the driving component drives the injection port or the sampling port to transform between two states relative to the sampling chamber, in a first state, the sampling port is misaligned with the injection port; in a second state, the sampling port is aligned with the injection port, the dissolving material contacts the sample and dissolves under the action of the sample to open the injection port for sampling.

[0007] As a further improvement of an embodiment of the present invention, the sampling chamber is constructed as a vacuum chamber.

[0008] As a further improvement of one embodiment of the present invention, the capsule shell includes a main shell and an outer shell arranged outside the main shell, the sampling port is arranged on the outer shell, and the driving assembly drives the outer shell to move so that the sampling port is aligned or misaligned with the injection port.

[0009] As a further improvement of an embodiment of the present invention, the housing is constructed as a magnetic housing, the driving assembly includes a magnetic part and a power unit that drives the magnetic part to move, and the housing moves under the magnetic effect of the magnetic part.

[0010] As a further improvement of one embodiment of the present invention, the sampling chamber is formed at one end of the main shell, the containing chamber is formed at the other end of the main shell, the driving assembly is arranged in the containing chamber, and the outer shell is arranged on the outside of the main shell and is located between the sampling chamber and the containing chamber.

[0011] As a further improvement of an embodiment of the present invention, a limiting groove is provided on the outside of the main shell, and the shell is installed in the limiting groove and moves along the axial direction of the main shell within the range defined by the limiting groove.

[0012] As a further improvement of an embodiment of the present invention, a limiting groove is provided on the outside of the main shell, and the outer shell is installed in the limiting groove and rotates around the axial direction of the main shell.

[0013] As a further improvement of one embodiment of the present invention, the sampling chamber is connected to a sampling channel, the sampling channel is constructed as a conducting tube, the outlet of the conducting tube is in fluid communication with the sampling chamber, and the inlet of the conducting tube is constructed as the sample inlet.

[0014] As a further improvement of an embodiment of the present invention, the driving assembly drives the conducting tube to move so that the sampling port and the injection port are aligned or misaligned.

[0015] As a further improvement of one embodiment of the present invention, the gastrointestinal sampling capsule also includes a sealing member arranged in the capsule shell and fixed relatively to the conducting tube. The driving component blocks the sampling port through the sealing member or drives the conducting tube to align the injection port with the sampling port.

[0016] As a further improvement of an embodiment of the present invention, the dissolving material is configured as a soluble plug, and the soluble plug is disposed at the injection port.

[0017] As a further improvement of an embodiment of the present invention, the sampling chamber is provided with a sealing cover, and the outlet of the conducting tube passes through the sealing cover and communicates with the sampling chamber.

[0018] As a further improvement of an embodiment of the present invention, the conducting pipe moves relative to the sealing cover along the axial direction of the main shell.

[0019] As a further improvement of an embodiment of the present invention, the conducting tube rotates relative to the sealing cover around the axial direction of the main shell.

[0020] As a further improvement of one embodiment of the present invention, the driving component includes a micromotor and a transmission device, a magnetic spring component and an external triggering magnetic field, a shape memory element and a heating element for heating the shape memory element, an electromagnetic coil and a permanent magnet that moves under the action of the electromagnetic coil.

[0021] Compared with the prior art, the beneficial effects of the present invention are as follows: the digestive tract sampling capsule of the present invention adopts a mode combining active and passive trigger sampling. The first-level gating for opening or closing the sampling port is controlled by the user or triggered by the program. The timing is precisely controllable, and with the positioning capability of the sensor, accurate sampling can be achieved. The passive gating from the sampling port to the sampling chamber uses special materials and is triggered according to the biochemical environment of the digestive tract. It avoids the absorption of a large amount of air during sampling in a passive way, thereby improving the success rate of sampling. After sampling, the sampling chamber can be actively controlled to be closed again to prevent sample leakage and contamination. The dissolving material can be selected from gastric-soluble or enteric-soluble materials as needed; a vacuum container is used as the sampling pool and power source, and the container is independent, which is convenient for disinfection, sampling and other processing, and the structure is simple and space-saving; the system drive component has many alternatives and a flexible design. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] Figure 1 is a cross-sectional view of a digestive tract sampling capsule according to a preferred first embodiment of the present invention, in which the sampling port is in a closed state;

[0023] Figure 2 yes Figure 1 A schematic diagram showing that the sampling port of the digestive tract sampling capsule is in an open state;

[0024] Figure 3is a cross-sectional view of a driving component of a digestive tract sampling capsule according to a preferred first embodiment of the present invention;

[0025] Figure 4 yes Figure 3 Schematic diagram of the working principle of the drive component in;

[0026] Figure 5 is a cross-sectional view of a digestive tract sampling capsule according to a preferred second embodiment of the present invention, in which the sampling port is in a closed state;

[0027] Figure 6 yes Figure 5 A schematic cross-sectional view along line AA;

[0028] Figure 7 It is a cross-sectional view of a digestive tract sampling capsule according to a third preferred embodiment of the present invention. DETAILED DESCRIPTION

[0029] The present invention will be described in detail below in conjunction with the specific embodiments shown in the accompanying drawings. However, these embodiments do not limit the present invention, and any structural, methodological, or functional changes made by a person skilled in the art based on these embodiments are all within the scope of protection of the present invention.

[0030] Reference Figure 1 and Figure 2 As shown, in the preferred first embodiment of the present invention, the overall length of the digestive tract sampling capsule 100 is within 30 mm, preferably less than or equal to 27 mm, and the diameter is within 12 mm. The digestive tract sampling capsule 100 includes a capsule shell and a sampling chamber 102 disposed in the capsule shell. The sampling chamber 102 can be formed by at least a portion of the capsule shell, or can also be an independent chamber body disposed in the capsule shell. In this embodiment, preferably, the sampling chamber 102 is a vacuum container, that is, the interior of the sampling chamber 102 is a vacuum environment before sampling, or it can be said that the sampling chamber 102 is constructed as a vacuum chamber, and its volume is greater than or equal to 0.3 mL, so that enough samples can be collected. A sealing cover 103 is provided at a position roughly in the middle of the interior of the capsule shell, and the sealing cover 103 is fixed to the capsule shell. The sealing cover 103 divides the internal space of the capsule shell into two parts, wherein the space formed by the sealing cover 103 and one side of the capsule shell is the sampling chamber 102, and the space on the other side can be used to accommodate other components. A fixed sealing cover 103 is provided to maintain the vacuum of the sampling chamber 102.

[0031] Among them, the capsule shell is provided with a sampling port 104, and the sampling chamber 102 has an injection port, and the injection port and the sampling port 104 can be selectively aligned or misaligned. Alignment here refers to the position correspondence between the injection port and the sampling port 104 to allow the sample outside the digestive tract sampling capsule to enter the injection port from the sampling port 104; misalignment refers to the position misalignment between the injection port and the sampling port 104 to restrict the sample outside the digestive tract sampling capsule from entering the injection port from the sampling port 104, that is, allowing or restricting the fluid connection from the sampling port 104 to the injection port. Of course, it is not that the sampling port 104 and the injection port are aligned to achieve the fluid connection from the sampling port 104 to the sampling chamber 102. The injection port is blocked by a dissolving material, that is, when the injection port and the sampling port 104 are aligned, the sample outside the digestive tract sampling capsule is allowed to enter from the sampling port 104, so that the dissolving material contacts the sample and dissolves under the action of the sample, and then the injection port is turned on, and sampling is performed under the vacuum suction of the sampling chamber 102.

[0032] Furthermore, the digestive tract sampling capsule also includes a driving component disposed in the capsule shell, and the alignment or misalignment of the sample inlet and the sampling port 104 is achieved by the driving component. In this embodiment, the driving component drives the sampling port 104 to change between two states relative to the sampling chamber 102. In the first state, the sampling port 104 is misaligned with the sample inlet, that is, the sample outside the digestive tract sampling capsule is restricted from entering the sample inlet from the sampling port 104; in the second state, the sampling port 104 is aligned with the sample inlet, that is, the sample outside the digestive tract sampling capsule is allowed to enter the sample inlet from the sampling port 104, and the dissolved material contacts the sample and dissolves under the action of the sample to conduct the sample inlet for sampling. When sampling is not performed, the sampling port 104 is staggered with the sample inlet, so that the dissolved material does not contact the digestive tract substance, thereby keeping the sampling chamber 102 sealed. In addition, a sampling channel is provided between the sampling chamber 102 and the sampling port 104. The sampling channel is configured as a conducting tube 107. The dissolving material is disposed in the conducting tube 107. The conducting tube 107 passes through the sealing cover 103 to communicate with the sampling chamber 102. The conducting tube 107 also passes through the capsule shell to selectively communicate with the sampling port 104. Therefore, any position in the conducting tube 107 can be configured as an injection port. The dissolving material can be configured as a soluble plug 108. The outlet of the conducting tube 107 faces the sealing cover 103 and passes through the sealing cover 103 to communicate with the sampling chamber 102. The injection port of the conducting tube 107 is blocked by the soluble plug 108 to keep the sampling chamber 102 in a vacuum. The soluble plug 108 is made of a dissolving material and dissolves only in a specific digestive tract environment (pH, enzyme, etc.). For example, when a digestive tract sampling capsule is required for intestinal sampling, the soluble plug is made of an enteric material, such as acrylic resin, HPMCAS, etc. Of course, the conducting tube may not be provided, for example, the sampling chamber may be provided with an injection port, and the position of the injection port matches the sampling port.

[0033] Specifically, in this embodiment, the capsule shell includes a main shell 106 and a shell 105 disposed outside the main shell 106, the sampling port 104 is disposed on the shell 105, and the driving assembly drives the shell 105 to move relative to the main shell 106 so that the sampling port 104 is aligned or misaligned with the injection port. In this way, the load of the driving assembly is small and the power requirement is low, so that the digestive tract sampling capsule can be more miniaturized. Preferably, the shell 105 is constructed as a magnetic shell, the driving assembly includes a magnetic member 109 and a power unit 110 that drives the magnetic member 109 to move, and the shell 105 moves under the magnetic action of the magnetic member 109. Among them, the shell 105 can be directly composed of a material containing magnetism, or a magnetic element can be embedded in the shell, so that the shell can be attracted by the magnetic member 109. One end of the main shell 106 forms a sampling chamber 102, and the other end of the main shell 106 forms a containing chamber, the driving assembly is arranged in the containing chamber, and the shell 105 is sleeved on the outside of the main shell 106 and is located between the sampling chamber 102 and the containing chamber. Preferably, a limiting groove 114 is provided on the outside of the main shell 106, and the shell 105 is installed in the limiting groove 114, that is, the shell 105 is sleeved in the limiting groove 114, so that the shell 105 matches the overall shape of the main shell 106, so that the capsule shell has a smooth outer surface. The shell 105 and the main shell 106 can be closely matched to play a sealing role, but the shell 105 can slide axially along the main shell 106. The magnetic member 109 is connected to the power unit 110, and the power unit 110 can drive the magnetic member 109 to move along the axial straight line of the digestive tract sampling capsule, thereby driving the shell 105 to slide back and forth. By setting the shell 105 to have a magnetic mode, the drive assembly can drive the smaller shell 105 to move, which plays the role of the first-level gating of opening and closing the sampling port 104, and there is no need for a mechanical connection between the shell 105 and the magnetic member 109 to avoid the risk of water leakage.

[0034] In addition, a circuit assembly 111 and a sensor 112 connected to the circuit assembly 111 are also provided in the storage compartment 102 of the digestive tract sampling capsule. The circuit assembly 111 may include a battery, a processor, a wireless communication module, etc. The sensor 112 is used to monitor the digestive tract environment and can play a role in positioning. The specific sensor may be a camera, a pH sensor, a pressure sensor, an ultrasonic probe, etc.

[0035] like Figure 2As shown, a schematic diagram of the state of the digestive tract sampling capsule during sampling is shown. When the power unit 110 drives the magnetic member 109 to move rightward along the axis, the magnetic member 109 attracts the magnetic shell 105 to slide to the right, so that the sampling port 104 is aligned with the inlet of the guide tube 107, that is, the injection port, so that the soluble plug 108 is in contact with the digestive tract environment. At this time, if the soluble plug 108 is immersed in the liquid sample of the digestive tract, the soluble plug 108 will gradually dissolve, and the sample material such as the digestive fluid will be sucked into the sampling chamber 102 under the vacuum suction of the sampling chamber 102. If the soluble plug 108 is exposed to the air, the soluble plug 108 will not dissolve, and a large amount of air absorption can be avoided. After the sampling is completed, the power unit 110 drives the magnetic member 109 to move to the left, thereby driving the magnetic shell 105 to slide to the left, and the sampling port 104 is staggered with the injection port to achieve closure.

[0036] In addition, see Figure 3 and Figure 4 As shown in FIG. 1 , a specific implementation of the driving component in this embodiment is shown. Figure 3 As shown, the driving assembly is a magnetic spring assembly, and the sampling port 104 is opened and closed by the magnetic spring assembly. This structure does not require a special circuit control to be set inside the capsule, but requires external equipment assistance, that is, the action is completed under the control of the external magnetic field. Specifically, the magnetic spring assembly includes: a first permanent magnet 115 and a second permanent magnet 116 arranged axially, wherein the first permanent magnet 115 and the second permanent magnet 116 are both radially magnetized magnetic rings; a limiting guide rail 125, which cooperates with the first permanent magnet 115 so that the first permanent magnet 115 can only move axially and cannot rotate axially; an axis 120 on which the first permanent magnet 115 and the second permanent magnet 116 are sleeved; a limiter 121 is set on the side of the first permanent magnet 115 close to the conducting tube 107, which is used to limit the axial movement of the first permanent magnet 115 within a preset range; and stoppers 126 are set on both sides of the second permanent magnet 116, which are used to limit the axial movement of the second permanent magnet 116 so that it can only rotate around the axial direction.

[0037] like Figure 4 The figure shows the working principle of the magnetic spring assembly. When an external magnetic field acts, for example, the large permanent magnet 150 gradually approaches, at this time, the second permanent magnet 116 rotates around the axis 120 due to the magnetic field, thereby causing a repulsive force between the first permanent magnet 115 and the second permanent magnet 116. Since the second permanent magnet 116 cannot move axially, it pushes the first permanent magnet 115 to move axially away from the second permanent magnet 116, thereby driving the housing 105 to slide, so that the sampling port 104 is aligned with the injection port, thereby starting sampling. When the external magnetic field is removed, that is, the large permanent magnet 150 gradually moves away, the second permanent magnet 116 rotates around the axis 120 under the action of the magnetic field of the first permanent magnet 115, and the second permanent magnet 116 is restored. Figure 3In the state shown, at this time, an attractive force is generated between the first permanent magnet 115 and the second permanent magnet 116. Since the second permanent magnet 116 cannot move axially, the first permanent magnet 115 is attracted by the second permanent magnet 116 and moves axially, thereby driving the housing 105 to slide, causing the sampling port 104 to be misaligned with the injection port, thereby terminating the sampling.

[0038] The magnetic spring assembly described above is only one design scheme of the drive assembly. There are many other design schemes for the drive assembly to achieve linear motion, such as using shape memory elements (deformed by heating, restored after temperature recovery) and heating elements that heat the shape memory elements, micromotors and transmission systems, voice coil motors (directly generate linear displacement), electromagnetic coils and permanent magnets that move under the action of electromagnetic coils, such as solenoids that use electromagnetic action to generate linear motion. The present application is not limited to a certain implementation method of the drive assembly, and any structure that can achieve linear motion based on external signal control can be applied.

[0039] In this embodiment, the digestive tract sampling capsule uses a push-type method to actively trigger sampling, and uses a soluble plug 108 to achieve passive trigger sampling. This active and passive combination can effectively avoid absorbing a large amount of air while accurately controlling the sampling timing, thereby improving the sampling success rate. Using a vacuum container as the sampling chamber 102, that is, one component (vacuum container) realizes the two functions of sample storage and providing sampling power, which ensures the independence of the sampling chamber, improves the sampling rate, and saves space.

[0040] Reference Figure 5 and Figure 6As shown, in the preferred second embodiment of the present invention, the overall structure of the digestive tract sampling capsule 200 is substantially the same as that of the first embodiment. The digestive tract sampling capsule 200 also includes a main shell 206 and a shell 205 sleeved in a limit groove 214 on the main shell 206. A sampling chamber 202 is arranged in the main shell, and the sampling chamber 202 is sealed by a sealing cover 203. A conducting tube 207 passes through the sealing cover 203 and communicates with the sampling chamber 202. The inlet of the conducting tube 207 is sealed by a soluble plug 208. The driving assembly is arranged in the main shell 206, which includes a power unit 210 and a magnetic member 209 driven by the power unit 210. The shell 205 is also constructed as a magnetic shell, but the difference is that the shell 205 is constructed to rotate around the axial direction of the capsule shell, that is, the sampling port 204 and the injection port are aligned or misaligned by rotating the shell 205 relative to the main shell 206. Specifically, the power unit 210 drives the magnetic member 209 to rotate, thereby driving the magnetic shell 205 to rotate. When the sampling port 204 on the shell 205 is aligned with the inlet on the conducting tube 207, the soluble plug 208 contacts the digestive tract environment and starts sampling after dissolving. In the closed state, i.e., the non-sampling state, the sampling port 204 and the inlet on the conducting tube 207, i.e., the sampling port, are staggered along the circumference of the capsule shell. Similarly, there are several implementation schemes for the drive assembly, such as micro-motors, shape memory elements, magnetic torsion springs, etc.

[0041] Reference Figure 7As shown, in a preferred third embodiment of the present invention, the digestive tract sampling capsule 300 includes a capsule shell and a sampling chamber 302 arranged in the capsule shell, the capsule shell includes a main shell 306, the sampling port 304 is arranged on the main shell 306, and the sampling chamber 302 is provided with an injection port, and the injection port and the sampling port 304 can be selectively aligned or misaligned. Among them, the injection port is blocked by a soluble plug 308. A driving component is also arranged in the main shell 306, and the driving component drives the injection port to change between two states relative to the sampling chamber 302. In the first state, the sampling port 304 is misaligned with the injection port; in the second state, the sampling port 304 is aligned with the injection port, and the dissolving material contacts the sample and dissolves under the action of the sample to conduct the injection port for sampling. In this embodiment, a conducting tube 307 passing through the sealing cover 303 is also provided in the main shell 306, and there can be a plurality of sampling ports 304 on the main shell 306, corresponding to the injection port on the conducting tube 307. Wherein, the driving assembly includes a power unit 310 and a blocking member 309 connected to the power unit. The blocking member 309 is connected to the conducting tube 307, so that the power unit 310 drives the blocking member 309 and the conducting tube 307 to move together. The movement of the blocking member 309 can be axial movement or rotation around the axial direction. Wherein, the blocking member 309 and the inner contact surface of the main shell 306 are tightly matched, which plays a sealing role, but does not affect the movement of the blocking member 309 relative to the capsule shell. In this embodiment, the sampling port 304 is fixed relative to the main shell 306, and the power unit 310 drives the blocking member 309, thereby driving the conducting tube 307 to slide or rotate along the axial direction, so that the sampling port 304 is aligned or misaligned with the injection port, so as to achieve the purpose of sampling and sealing. During the movement process, the conducting tube 307 and the contact surface that penetrates the sealing cover 303 are always tightly matched to maintain the seal.

[0042] It should be noted that the capsule shell is not limited to the shape shown in the figure, and can also be in a rugby shape or other shapes. In addition, the number of sampling ports and injection ports can be one or more, and the sampling chamber can also be one or more, that is, one injection port corresponds to one sampling chamber, or multiple injection ports correspond to one sampling chamber. In addition, the drive assembly is used to cooperate with an external control device (not shown), and the external control device can control the drive assembly wirelessly.

[0043] The digestive tract sampling capsule of the present invention adopts a mode combining active and passive trigger sampling. The first-level gating for opening or closing the sampling port is controlled by the user or triggered by the program. The timing is precisely controllable, and combined with the positioning capability of the sensor, accurate sampling can be achieved. The passive gating from the sampling port to the sampling chamber uses special materials and is triggered according to the biochemical environment of the digestive tract. It avoids the absorption of a large amount of air during sampling in a passive way, thereby improving the success rate of sampling. After sampling, the sampling chamber can be actively controlled to be closed again to prevent sample leakage and contamination. The dissolving material can be selected from gastric-soluble or enteric-soluble materials as needed; a vacuum container is used as a sampling pool and power source, and the container is independent, which is convenient for disinfection, sampling and other processing, and has a simple structure and saves space; the system drive component has many alternatives and a flexible design.

[0044] It should be understood that although this specification is described according to implementation modes, not every implementation mode contains only one independent technical solution. This description of the specification is only for the sake of clarity. Those skilled in the art should regard the specification as a whole. The technical solutions in each implementation mode may also be appropriately combined to form other implementation modes that can be understood by those skilled in the art.

[0045] The series of detailed descriptions listed above are only specific descriptions of feasible implementation methods of the present invention. They are not intended to limit the scope of protection of the present invention. Any equivalent implementation methods or changes that do not deviate from the technical spirit of the present invention should be included in the scope of protection of the present invention.

Claims

1. A digestive tract sampling capsule, comprising a capsule shell and a sampling chamber arranged in the capsule shell, wherein the capsule shell is provided with a sampling port, and the sampling chamber is provided with a sample inlet, wherein the sample inlet and the sampling port can be selectively aligned or misaligned, and characterized in that: It also includes a driving assembly disposed in the capsule shell, the injection port is blocked by a dissolving material, and the driving assembly drives the injection port or the sampling port to transform between two states relative to the sampling chamber. In a first state, the sampling port is misaligned with the injection port; In the second state, the sampling port is aligned with the injection port, and the dissolving material contacts the sample and dissolves under the action of the sample to open the injection port for sampling; The capsule shell comprises a main shell and an outer shell arranged outside the main shell, the sampling port is arranged on the outer shell, and the outer shell is configured as a magnetic shell; The driving assembly is a magnetic spring assembly, and the magnetic spring assembly includes: A first permanent magnet and a second permanent magnet are arranged axially, wherein the first permanent magnet and the second permanent magnet are radially magnetized magnetic rings, and the first permanent magnet can drive the housing to slide; The limiting guide rail cooperates with the first permanent magnet to enable the first permanent magnet to move in the axial direction and limit the first permanent magnet from rotating in the axial direction; A shaft sleeved inside the first permanent magnet and the second permanent magnet; The stoppers arranged on both sides of the second permanent magnet enable the second permanent magnet to rotate around the axial direction and limit the axial movement of the second permanent magnet; Alternatively, the sampling chamber is connected to a sampling channel, the sampling channel is configured as a conducting tube, the outlet of the conducting tube is in fluid communication with the sampling chamber, the inlet of the conducting tube is configured as the injection port, and the driving assembly drives the conducting tube to move so that the sampling port is aligned or misaligned with the injection port; The digestive tract sampling capsule further includes a blocking member disposed in the capsule shell and relatively fixed to the conducting tube, and the driving assembly blocks the sampling port through the blocking member and drives the conducting tube to align the sampling port with the sampling port; The sampling chamber is provided with a sealing cover, and the outlet of the conducting tube passes through the sealing cover and is communicated with the sampling chamber.

2. The digestive tract sampling capsule according to claim 1, characterized in that: The sampling chamber is configured as a vacuum chamber.

3. The digestive tract sampling capsule according to claim 1, characterized in that: The driving assembly is a magnetic spring assembly, one end of the main shell forms the sampling chamber, the other end of the main shell forms the containing chamber, the driving assembly is arranged in the containing chamber, and the outer shell is arranged on the outside of the main shell and is located between the sampling chamber and the containing chamber.

4. The digestive tract sampling capsule according to claim 1, characterized in that: The driving assembly is a magnetic spring assembly. A limiting groove is provided on the outside of the main housing. The housing is installed in the limiting groove and moves along the axial direction of the main housing within the range defined by the limiting groove.

5. The digestive tract sampling capsule according to claim 1, characterized in that: The dissolving material is configured as a soluble plug, and the soluble plug is disposed at the injection port.

6. The digestive tract sampling capsule according to claim 1, characterized in that: The sampling chamber is connected to a sampling channel, and the sampling channel is configured as a conducting tube. The conducting tube moves relative to the sealing cover along the axial direction of the main housing.

7. The digestive tract sampling capsule according to claim 1, characterized in that: The sampling chamber is connected to a sampling channel, and the sampling channel is configured as a conducting tube. The conducting tube rotates relative to the sealing cover around the axial direction of the main housing.

8. The digestive tract sampling capsule according to claim 1, characterized in that: The sampling chamber is connected to a sampling channel, and the sampling channel is constructed as a conducting tube. The driving component includes a micromotor and a transmission device and an external triggering magnetic field, a shape memory element and a heating element for heating the shape memory element, an electromagnetic coil and a permanent magnet moving under the action of the electromagnetic coil.

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