Whole blood mixing device

Abstract

The present invention discloses a whole blood mixing device, including a bracket, a connecting rod, a test tube clamping assembly for clamping a test tube, and a motor installed on the bracket and having an output shaft connected to the test tube clamping assembly through the connecting rod to drive the test tube clamping assembly to swing. The test tube clamping assembly is provided with a slot for the bottom of the test tube to be clamped and positioned, the bracket is penetrated in a first direction and is provided with a first penetration hole for the test tube to be penetrated and limited, the output shaft of the motor extends along a second direction, the first direction and the second direction have an angle α, and α is an acute angle. The whole blood mixing device disclosed in the present invention has the advantages that the whole blood in the test tube can obtain a better mixing effect, improves the reliability and stability of the whole blood mixing, and the test tube does not need to be covered with a lid, which is convenient for subsequent equipment to extract samples from the test tube, and reduces the risk of cross contamination caused by the need to extract samples by puncture when the lid is covered.

Description

Technical Field

[0001] The present invention relates to the field of medical devices, and in particular to a whole blood mixing device. Background Art

[0002] Medical devices, especially automated medical devices, such as enzyme-linked immunosorbent analyzers, chemiluminescence analyzers, biochemical analyzers, etc., in the field of in vitro diagnosis, the types of test samples are mainly human or animal body fluids, mainly blood (plasma, serum, whole blood). For fully automatic and large-scale in vitro diagnostic equipment, the samples, especially whole blood samples, are concentrated. In the process of waiting for the sample to be sucked, it is very easy to produce sedimentation of the whole blood sample, resulting in uneven sample composition in the experiment, inaccurate test results, or even wrong results. This requires us to keep the whole blood sample uniform and without sedimentation, and without coagulation and hemolysis in the experiment, especially before sucking the whole blood sample. At present, the mechanism devices that realize similar functions on the market mostly use stepper motors with eccentric wheel mechanisms or left and right swing mechanisms, clamping the test tube and rotating and shaking to achieve, which has the problem of unsatisfactory mixing effect and hemolysis. It also requires that the test tube cover cannot be opened, which limits the subsequent sampling method and requires additional puncture of the test tube cover for sampling or opening the cover. At the same time, the mechanism has problems such as high failure rate, short life, and inconvenient maintenance.

[0003] At present, a stepper motor is used to drive the eccentric wheel mechanism, so that the test tube performs eccentric, forward and reverse motion under the movement of the eccentric wheel. In this design, the eccentric wheel can easily produce a centrifugal effect during the forward and reverse mixing process, causing hemolysis of blood cells in the whole blood, affecting the quality and effectiveness of the test sample.

[0004] At present, a stepper motor is used to drive the whole blood sample to shake left and right or vibrate the whole blood test tube. This design has two main disadvantages. First, the mixing effect of this type of mixing method is generally uncontrollable and the effect is not very ideal. If the shaking amplitude is too large, the whole blood sample in the test tube may be thrown out. If the shaking amplitude is too small, the mixing effect cannot be achieved. Second, the use of this mixing method generally requires the test tube to have a lid, which limits the subsequent sample suction method. Only a permanent sampling needle with a puncture can be used, which increases the risk of cross-contamination, or requires manual opening of the lid, otherwise an opening device needs to be added to achieve automation, which increases technical risks and costs. Summary of the invention

[0005] In order to overcome the deficiencies of the prior art, the present invention discloses a whole blood mixing device, which is used to solve the problem that the existing whole blood mixing device has a poor whole blood mixing effect.

[0006] The present invention is implemented by the following technical solutions:

[0007] A whole blood mixing device comprises a bracket, a connecting rod, a test tube clamping assembly for clamping a test tube, and a motor installed on the bracket and having an output shaft connected to the test tube clamping assembly through the connecting rod to drive the test tube clamping assembly to swing, wherein the test tube clamping assembly is provided with a slot for the bottom of the test tube to be clamped and positioned, the bracket is penetrated in a first direction and is provided with a first penetration hole for the test tube to be passed through and limited, the output shaft of the motor extends along a second direction, and there is an angle α between the first direction and the second direction, and α is an acute angle.

[0008] Preferably, the angle α between the first direction and the second direction is 10° to 30°; and / or,

[0009] The first direction is a vertical direction.

[0010] Preferably, the connecting rod is rotatably connected to the bottom of the test tube clamping assembly.

[0011] Preferably, the whole blood mixing device also includes a bearing and an axial limiter, an extension rod is provided at the bottom of the test tube clamping assembly, one end of the connecting rod is penetrated by a mounting hole, the bearing is installed in the mounting hole, and one end of the extension rod passes through the bearing and is limited by the axial limiter.

[0012] Preferably, the test tube clamping assembly includes a clamping member for clamping the test tube and an adapter connected to the clamping member by snapping, the adapter includes a connecting plate and the extension rod with one end connected to the surface of the connecting plate, and the connecting plate is clamped at the bottom of the clamping member.

[0013] Preferably, the clamping member includes a base plate, at least three claws and at least three undercuts, the claws are arranged at intervals along the circumferential direction on the outer edge of one side of the base plate, the undercuts are arranged at intervals along the circumferential direction on the outer edge of the other side of the base plate, each of the claws and the base plate encloses the slot, each of the claws includes a rod-shaped portion and a protrusion arranged at one end of the rod-shaped portion away from the base plate and protruding toward one side of the slot, and the connecting plate is clamped at the bottom of the clamping member through the undercuts.

[0014] Preferably, the connecting rod includes a block-shaped portion for connecting to the output shaft and a handle-shaped portion extending obliquely from one side of the block-shaped portion and connected to the test tube clamping assembly, the block-shaped portion is penetrated by a second through hole for the output shaft to pass through, the axis of the second through hole is parallel to the second direction, the angle between the extension direction of the handle-shaped portion and the axis of the second through hole is β, β=90°-α, and the mounting hole is opened on the handle-shaped portion.

[0015] Preferably, the whole blood mixing device further comprises a buffer pad embedded in the first penetration hole, the buffer pad comprising an annular portion having a through hole and a plurality of spacer rings arranged on the edge of the through hole and extending toward the same side of the annular portion for pressing the pressing piece of the test tube.

[0016] Preferably, the whole blood mixing device further comprises a first sensor, which is mounted on the support and used to detect the mixing degree of the blood inside the test tube; and / or,

[0017] The whole blood mixing device also includes a second sensor arranged on the bracket and a baffle arranged on the connecting rod. The second sensor includes a transmitter and a receiver arranged at intervals. The running track of the baffle passes between the transmitter and the receiver.

[0018] Preferably, the bracket includes a base, a fixing base and a motor base, the fixing base includes a first plate body and a second plate body one end of which is vertically connected to the first plate body, the other end of the second plate body is connected to the top edge of the base, the motor base includes a third plate body and a fourth plate body arranged at an angle to the third plate body, the third plate body is connected to the top of the base, the fourth plate body extends obliquely toward the side where the first plate body is located, the first through hole is opened on the first plate body, and the motor is installed on the fourth plate body.

[0019] Compared with the prior art, the present invention has the following beneficial effects:

[0020] The whole blood mixing device provided by the present invention is arranged to form an angle between the extension direction of the output shaft of the motor and the extension direction of the first penetration hole. In this way, when the output shaft of the motor rotates, the output shaft drives the test tube clamping assembly through the connecting rod, that is, drives the test tube to swing in a conical trajectory, and the whole blood in the test tube can obtain a better mixing effect, thereby improving the reliability and stability of the whole blood mixing; in addition, compared with the left-right swinging method, the swinging method of the circular trajectory has a smaller shaking amplitude of the test tube, and the whole blood sample will not be thrown out of the test tube, that is, the test tube does not need to be covered with a lid, which is convenient for subsequent equipment to extract samples from the test tube, and reduces the risk of cross contamination caused by the puncture method required to extract samples when covering the lid; further, the whole blood mixing device has a simple structure, no intermediate transmission, a compact and small structure, high transmission efficiency, extended service life of the motor and improved transmission reliability. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] Figure 1 A schematic diagram of the structure of a whole blood mixing device provided in an embodiment of the present invention;

[0022] Figure 2 An exploded schematic diagram of a whole blood mixing device provided in an embodiment of the present invention;

[0023] Figure 3 for Figure 2 The structural schematic diagram of the connecting rod shown in;

[0024] Figure 4 for Figure 2 A schematic diagram of the structure of the clamping member and the adapter shown in ;

[0025] Figure 5 for Figure 2 The structural schematic diagram of the fixing seat shown in ;

[0026] Figure 6 for Figure 2 The structural schematic diagram of the motor base is shown in FIG. DETAILED DESCRIPTION

[0027] The present invention is further described below in conjunction with the accompanying drawings and specific implementation methods. It should be noted that, under the premise of no conflict, the various embodiments or technical features described below can be arbitrarily combined to form a new embodiment.

[0028] See also Figures 1 to 6 The embodiment of the present invention provides a whole blood mixing device 10, including a bracket 11, a connecting rod 12, a test tube clamping assembly 13 for clamping a test tube 100, and a motor 14 installed on the bracket 11 and having an output shaft connected to the test tube clamping assembly 13 through the connecting rod 12 for driving the test tube clamping assembly 13 to swing. The test tube clamping assembly 13 is provided with a card slot 131 for the bottom of the test tube to be clamped and positioned. The bracket 11 is penetrated in a first direction and is provided with a first penetration hole 111 for the test tube 100 to be penetrated and limited. The output shaft of the motor extends along a second direction. There is an angle α between the first direction and the second direction, and α is an acute angle.

[0029] With this design, the extension direction of the output shaft of the motor 14 and the extension direction of the first hole 111 are set at an angle. In this way, when the output shaft of the motor 14 rotates, the output shaft 14 drives the test tube clamping assembly 13 through the connecting rod 12, that is, drives the test tube 100 to swing in a conical trajectory, and the whole blood in the test tube 100 can obtain a better mixing effect, thereby improving the reliability and stability of the whole blood mixing; in addition, compared with the left-right swinging method, the swinging method of the circular trajectory has a smaller shaking amplitude of the test tube 100, and the whole blood sample will not be thrown out of the test tube 100, that is, the test tube 100 does not need to be covered with a lid, which is convenient for subsequent equipment to extract samples from the test tube 100, and reduces the risk of cross contamination caused by the puncture method required to extract samples due to the cover; further, the whole blood mixing device 10 has a simple structure, no intermediate transmission, a compact structure, high transmission efficiency, and a prolonged service life of the motor and improved transmission reliability.

[0030] Specifically, by setting the diameter of the first penetration hole 111 to be slightly larger than the diameter of the test tube, the test tube 100 can pass through the first penetration hole 111, and when the test tube 100 swings, the first penetration hole 111 can limit the test tube 100, so that the test tube 100 can only swing in a conical trajectory. Specifically, the mixing effect can be adjusted by setting the mixing speed, that is, by setting the speed of the motor 14; or by setting the mixing time.

[0031] Preferably, the first direction is a vertical direction.

[0032] Preferably, the angle α between the first direction and the second direction is 10° to 30°.

[0033] Preferably, the connecting rod 12 is rotatably connected to the bottom of the test tube clamping assembly 13. Preferably, the whole blood mixing device 10 also includes a bearing 15 and an axial stopper 16. An extension rod 132 is provided at the bottom of the test tube clamping assembly 13. One end of the connecting rod 12 is penetrated with a mounting hole 123. The bearing 15 is installed in the mounting hole 123. One end of the extension rod 132 passes through the bearing 15 and is limited by the axial stopper 16. In this design, by setting the test tube clamping assembly 13 to be rotatably connected to the connecting rod 12, in this way, when the motor 14 drives the test tube to swing through the connecting rod 12, the self-rotation of the test tube 100 can be reduced, and the hemolysis of blood cells in the whole blood caused by the centrifugal effect of the self-rotation of the test tube 100 can be reduced, which affects the quality and effectiveness of the test sample.

[0034] Preferably, the test tube clamping assembly 13 includes a clamping member 133 for clamping the test tube 100 and an adapter 134 snap-connected to the clamping member 133, the adapter 134 includes a connecting plate 1341 and the extension rod 132 having one end connected to the surface of the connecting plate 1341, and the connecting plate 1341 is snap-connected to the bottom of the clamping member 133. It is understandable that the extension rod 132 can be directly connected to the bottom of the clamping member 133.

[0035] Preferably, the clamping member 133 includes a base plate 1331, at least three claws 1332 and at least three undercuts 1333, the claws 1332 are arranged at intervals along the circumferential direction on the outer edge of one side of the base plate 1331, the undercuts 1333 are arranged at intervals along the circumferential direction on the outer edge of the other side of the base plate 1331, each claw 1332 and the base plate 1331 enclose the slot 131, each claw 1332 includes a rod-shaped portion 13321 and a protrusion 13322 arranged at one end of the rod-shaped portion 13321 away from the base plate 1331 and protruding toward one side of the slot 131, and the connecting plate 1341 is clamped at the bottom of the clamping member 133 through the undercuts 1333. Preferably, the clamping member 133 is made of plastic material.

[0036] Preferably, the connecting rod 12 includes a block portion 121 for connecting with the output shaft and a handle portion 122 extending obliquely from one side of the block portion 121 and connected with the test tube clamping assembly. The block portion 121 is provided with a second through hole 1211 for the output shaft to pass through. The axis of the second through hole 1211 is parallel to the second direction. The angle between the extending direction of the handle portion 122 and the axis of the second through hole 1211 is β, β=90°-α. The mounting hole 123 is provided on the handle portion 122. In this design, when the second through hole 1211 runs to the bottom of the first through hole 131, the handle portion 122 is in a horizontal state, so that the test tube is in an upright state, which is convenient for subsequent equipment to take samples from the test tube 100.

[0037] Preferably, the whole blood mixing device 10 further includes a buffer pad 17 embedded in the first penetration hole 111, and the buffer pad 17 includes an annular portion 171 having a through hole and a plurality of spacer rings arranged at the edge of the through hole and extending toward the same side of the annular portion to press the test tube. Preferably, the buffer pad 17 is made of plastic material. In this design, the test tube can be further compressed by providing the pressing sheet 172, thereby reducing the self-rotation of the test tube 100 during the swinging process.

[0038] Preferably, the whole blood mixing device 10 further comprises a pressing plate 21 , which is mounted on the bracket 11 to press the buffer pad 17 into the first penetration hole 111 .

[0039] Preferably, the whole blood mixing device 10 also includes a first sensor 18, which is installed on the bracket to detect the mixing degree of the blood inside the test tube 100. Preferably, the first sensor 18 is a photoelectric sensor, which determines the mixing effect by detecting the reflective ability of the whole blood in the test tube 100 to light. In this design, by setting the first sensor 18, it is possible to more accurately judge whether the mixing effect of the whole blood in the test tube 100 reaches the expected effect of the experiment, prevent insufficient mixing and excessive mixing, and avoid accidents caused by putting a new test tube before the previous test tube 100 is removed. Specifically, the detection data of the first sensor 18 can be calculated and displayed by setting a controller and a display screen connected to the first sensor 18.

[0040] Preferably, the whole blood mixing device 10 further comprises a second sensor 19 arranged on the bracket 11 and a baffle 20 arranged on the connecting rod 12. The second sensor 19 comprises a transmitter 191 and a receiver 192 arranged at intervals, and the running track of the baffle 20 passes between the transmitter 191 and the receiver 192. On the one hand, the second sensor 19 is used to count the number of swings of the test tube 100. Specifically, the baffle 20 rotates with the connecting rod 12, and counts once each time it passes between the transmitter 191 and the receiver 192. On the other hand, the second sensor 19 is also used to position the test tube 100. Specifically, when the whole blood in the test tube 100 is mixed evenly, the baffle 20 rotates again to between the transmitter 191 and the receiver 192, and the second sensor 19 generates a trigger signal to control the motor 14 to stop rotating, thereby positioning the test tube 100. Preferably, the second sensor 19 is arranged below the first penetration hole 111, and the end of the baffle 20 is located on the extension line of the extension rod 132. In this way, when the second sensor 19 detects the baffle 20 and controls the motor 14 to stop rotating, the test tube is just in an upright state, which is convenient for subsequent equipment to take samples from the test tube 100.

[0041] Preferably, the whole blood mixing device 10 further includes a second sensor holder 22 , and the second sensor 19 is fixed on the bracket 11 via the second sensor holder 22 .

[0042] Preferably, the bracket 11 includes a base 112, a fixing base 113 and a motor base 114. The fixing base 113 includes a first plate 1131 and a second plate 1132 having one end vertically connected to the first plate 1131. The other end of the second plate 1132 is connected to the top edge of the base 112. The motor base 114 includes a third plate 1141 and a fourth plate 1142 arranged at an angle to the third plate 1141. The third plate 1141 is connected to the top of the base 112. The fourth plate 1142 extends obliquely toward the side where the first plate 1131 is located. The first through hole 111 is provided on the first plate 1131. The motor 14 is mounted on the fourth plate 1142. Preferably, the angle between the extension direction of the third plate 1141 and the extension direction of the fourth plate 1142 is equal to the size of α.

[0043] The above-mentioned embodiments are only preferred embodiments of the present invention and cannot be used to limit the scope of protection of the present invention. Any non-substantial changes and substitutions made by technicians in this field on the basis of the present invention shall fall within the scope of protection required by the present invention.

Claims

1. A whole blood mixing device, characterized in that: The cam is a device for activating a rotation of the motor and the motor is used to rotate the motor to move the test tube, the motor being used to rotate the motor and the test tube rotating shaft.

2. The whole blood mixing device according to claim 1, characterized in that: An included angle α between the first direction and the second direction is 10° to 30°.

3. The whole blood mixing device according to claim 1, characterized in that: The whole blood mixing device also includes a bearing and an axial limiter. A mounting hole is formed through one end of the connecting rod, and the bearing is mounted in the mounting hole. One end of the extension rod passes through the bearing and is limited by the axial limiter.

4. The whole blood mixing device according to claim 1, characterized in that: The clamping member includes a base plate, at least three claws and at least three undercuts, the claws are arranged at intervals along the circumferential direction on the outer edge of one side of the base plate, the undercuts are arranged at intervals along the circumferential direction on the outer edge of the other side of the base plate, each of the claws and the base plate encloses the slot, each of the claws includes a rod-shaped portion and a protrusion arranged at one end of the rod-shaped portion away from the base plate and protruding toward one side of the slot, and the connecting plate is clamped at the bottom of the clamping member through the undercuts.

5. The whole blood mixing device according to claim 3, characterized in that: The connecting rod includes a block portion for connecting to the output shaft and a handle portion extending obliquely from one side of the block portion and connected to the test tube clamping assembly, the block portion is penetrated by a second through hole for the output shaft to pass through, the axis of the second through hole is parallel to the second direction, the angle between the extension direction of the handle portion and the axis of the second through hole is β, β=90°-α, and the mounting hole is opened on the handle portion.

6. The whole blood mixing device according to any one of claims 1 to 5, characterized in that: The whole blood mixing device also includes a buffer pad embedded in the first penetration hole, and the buffer pad includes an annular portion with a through hole and a plurality of spacer rings arranged at the edge of the through hole and extending toward the same side of the annular portion to press the test tube.

7. The whole blood mixing device according to any one of claims 1 to 5, characterized in that: The whole blood mixing device further comprises a first sensor, which is mounted on the support and used to detect the mixing degree of the blood in the test tube; and / or, The whole blood mixing device also includes a second sensor arranged on the bracket and a baffle arranged on the connecting rod. The second sensor includes a transmitter and a receiver arranged at intervals. The running track of the baffle passes between the transmitter and the receiver.

8. The whole blood mixing device according to any one of claims 1 to 5, characterized in that: The bracket includes a base, a fixing base and a motor base, the fixing base includes a first plate and a second plate at one end vertically connected to the first plate, the other end of the second plate is connected to the top edge of the base, the motor base includes a third plate and a fourth plate arranged at an angle to the third plate, the third plate is connected to the top of the base, the fourth plate extends obliquely toward the side where the first plate is located, the first through hole is opened on the first plate, and the motor is installed on the fourth plate.

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