Application of BAP18 in resistance to endocrine therapy of breast cancer

1. The technology of BAP18 and breast cancer, applied in the field of biomedicine, can solve the problems that other functions of BAP18 have not been reported.

CN111973745AActive Publication Date: 2020-11-24中国医科大学
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
Publication Date
2020-11-24

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Abstract

The present invention belongs to the technical field of biomedicine, and particularly relates to an application of BAP18 in resistance to endocrine therapy of breast cancer and an application of the targeted inhibitor BAP18 in preparation of drugs for treating breast cancer. The targeted sequence of the inhibitor is shown in SEQ ID No.1. Experiments show that the BAP18 can promote resistance to endocrine drugs for breast cancer and also participate in process of tumor resistance in a tamoxifen mouse model. The BAP18 has potential of drug resistance in the endocrine drugs for breast cancer, theBAP18 small molecule inhibitor is prepared, siRNA may be found to inhibit transcription of the BAP18 to produce miRNA to achieve functions of treating clinical breast cancer and alleviating the resistance of the endocrine therapy of the breast cancer. The BAP18 only plays a role in promoting cancer progression during the occurrence and development of the cancer, besides, the expression of the BAP18 is up-regulated in tissues of most patients with breast cancer, inhibiting the expression of the BAP18 can effectively reduce side effects of other drugs, and a combined inhibitor therapy can effectively increase a clinical treatment effect.
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Description

technical field

[0001] The invention belongs to the technical field of biomedicine, and in particular relates to the application of BAP18 in endocrine therapy resistance of breast cancer. Background technique

[0002] BAP18 (BPTF associated protein 18KDa) is one of the members of the MLL1 / MOF complex and is also found in the NURF complex. It is an important chromatin reader (Histone readers, HRs) that can bind to the H3K4me3 position on the chromatin interact to perform their functions. Currently, BAP18 is reported to be an important co-regulator of androgen receptor (AR), which can upregulate AR-mediated gene transcription and play an important role in prostate cancer and castrated prostate cancer, but other functions of BAP18 It has not been reported, especially the function of BAP18 as a chromatin reader needs to be further explored.

[0003] Female breast cancer is one of the most common malignant tumors in women. Clinical diagnosis data show that more than three-quart...

Examples

Embodiment Construction

[0028] The present invention will be described in further detail below in conjunction with the accompanying drawings and embodiments. The experimental method that does not indicate specific condition in the embodiment, usually according to conventional conditions, such as the conditions described in textbooks and experimental guides, or according to the conditions suggested by the manufacturer, is well known or easy to know by those of ordinary skill in the art, the following implementation Examples are only preferred embodiments of the present invention, and do not limit the present invention. For those skilled in the art, the present invention can have various modifications and changes, and within the spirit and principles of the present invention, any modifications made , equivalent replacements, improvements, etc., should all be included within the protection scope of the present invention.

[0029] Example.

[0030] 1. Preparation of inhibitors.

[0031] According to th...