Physiological signal sensor device

Abstract

A physiological signal sensing device includes a base for being set on the skin surface of a biological body, a sensor, a transmitter, and a sealing unit. The sensor includes a fixing seat and a sensing test piece. The fixing seat has a through hole. The sensing test piece is set on the fixing seat and partially penetrates the through hole to be implanted under the skin surface of the biological body to measure physiological signals. The through hole is used for allowing an implantation needle to removably penetrate to guide the sensing test piece to be partially implanted under the skin surface of the biological body. The transmitter is used to receive and output the physiological signal. The sensor has a bottom. The transmitter is covered on the base with the bottom facing the base, and the sensing test piece is coupled to the transmitter. The sealing unit includes a top abutment group. The top abutment group is located between the bottom of the transmitter and the through hole of the fixing seat of the sensor, and seals the through hole of the fixing seat of the sensor to seal the implantation needle path.

Description

Technical Field

[0001] The present invention relates to a sensor device, and in particular to a physiological signal sensor device. Background Art

[0002] In order to control diabetes or reduce its complications, controlling blood sugar is a very important part. Regularly measuring blood sugar and understanding the changing trend of blood sugar concentration can ensure that the blood sugar concentration is at a safe and stable level for a long time. For the measurement of blood sugar concentration, the common practice in the past is that the patient pierces the skin with a puncture device to collect blood, and then uses a test strip in conjunction with a detection machine to measure and calculate the glucose concentration in the collected blood based on the principle of electrochemical analysis. However, repeated blood sampling and testing in a day often cause inconvenience to patients' lives. Therefore, in the past two decades, the development of implantable continuous glucose monitoring (CGM) systems has been the fastest. They are used to monitor the effects of insulin injections or medication, diet, and exercise on blood sugar concentration throughout the day in real time and continuously, thereby providing more effective help in treatment and control.

[0003] The continuous blood glucose monitoring system must be worn by the user for a long time. Therefore, how to prevent sewage from seeping into the system and affecting the internal electronic components during the long-term wearing process, and how to prevent blood stains from the implanted wound from seeping into the system, and how to prevent the implanted wound from being infected, will become important issues for whether the product is reliable and safe. In addition, the basic architecture of the continuous blood glucose monitoring system at least includes a sensor for measuring the physiological signal corresponding to the glucose concentration in the body and a sensor for receiving and transmitting physiological signals. However, related products today have sensors and sensors packaged separately, and users must assemble them by themselves when using them. The sensors and sensors are designed to be detachable, which will greatly increase the difficulty of preventing sewage leakage and wound infection.

[0004] In addition, the existing continuous blood glucose monitoring system has another problem, that is, the existing products all require the user to implant the sensor under the skin using a needle. However, when the needle pierces the skin, blood will instantly spurt out, causing fear in the user. Moreover, if the sensor is immediately installed on the sensor at this time, the blood may also enter the sensor through the sensor and the sensor connection, thereby damaging the electronic components inside the sensor. Summary of the invention

[0005] One of the purposes of the present invention is to provide a physiological signal sensing device that can prevent external liquid from penetrating.

[0006] The physiological signal sensing device of the present invention comprises a base, a sensor, a transmitter, and a sealing unit.

[0007] The base is used to be arranged on the skin surface of a biological body.

[0008] The sensor includes a fixing seat and a sensing test piece. The fixing seat has a through hole that penetrates the top and bottom surfaces of the fixing seat. The sensing test piece is arranged on the fixing seat and partially penetrates the through hole to be implanted under the skin of the organism and measure at least one analytical substance in the organism and transmit a corresponding physiological signal, and the through hole of the fixing seat is used for a needle to be removably penetrated to guide the sensing test piece to be partially implanted under the skin of the organism.

[0009] The transmitter is used to receive and output the physiological signal. The transmitter has a bottom, and the transmitter is covered on the base with the bottom facing the base, so that the fixing base is located between the base and the transmitter, and the sensing test piece is coupled to the transmitter.

[0010] The sealing unit includes a top abutment group. The top abutment group is located between the bottom of the transmitter and the through hole of the fixing seat of the sensor, and the top abutment group seals the through hole of the fixing seat of the sensor to seal the implantation needle path.

[0011] In the physiological signal sensor device of the present invention, the abutment assembly of the sealing unit has a abutment located at the bottom of the transmitter, and the position of the abutment corresponds to the through hole of the fixing seat and is tightly combined with the top of the through hole.

[0012] In the physiological signal sensor device of the present invention, the bottom of the transmitter has a first groove, and the first groove of the transmitter and the base together define an accommodation space to accommodate the fixing seat of the sensor, and the abutment member is arranged on the bottom surface of the first groove.

[0013] In the physiological signal sensor device of the present invention, the abutment component set of the sealing unit further comprises a fourth sealing component disposed on the top of the through hole, and the abutment component is tightly combined with the fourth sealing component to seal the implant needle path.

[0014] In the physiological signal sensor device of the present invention, the abutting piece of the sealing unit is protruding from the bottom of the transmitter, and the top of the fourth sealing piece is in a groove shape for the abutting piece to abut against.

[0015] In the physiological signal sensor device of the present invention, the abutting member of the sealing unit is an upwardly recessed groove-shaped structure, and the fourth sealing member protrudes upwardly and abuts against the abutting member.

[0016] In the physiological signal sensing device of the present invention, the abutment component set of the sealing unit includes a fourth sealing component disposed at the top of the through hole, which is used to seal the needle implantation path.

[0017] In the physiological signal sensor device of the present invention, the fourth sealing member is made of elastic material.

[0018] The physiological signal sensing device of the present invention has a base with a through hole, and the through hole of the fixing base of the sensor and the through hole of the base are used for the sensing test piece to pass through and for the implantation needle to removably penetrate to guide the sensing test piece to be implanted under the skin of a biological body, and the implantation needle path extends from the through hole and the through hole to the place where the sensing test piece is coupled to the transmitter.

[0019] The physiological signal sensing device of the present invention comprises a base including a bottom plate for being set on the skin surface of the biological body, and a groove peripheral wall protruding from the top surface of the bottom plate, wherein the groove peripheral wall and the bottom plate jointly define a setting groove, wherein the fixing seat of the sensor is set in the setting groove, and the sealing unit further comprises a third sealing member, wherein the third sealing member is clamped between the inner wall surface of the groove peripheral wall of the base and the outer peripheral surface of the fixing seat of the sensor to seal the first liquid leakage path.

[0020] The physiological signal sensing device of the present invention has a base with a perforation connected to the setting groove and for the sensing test piece to pass through so as to be implanted under the skin of the biological body. The first liquid leakage path enters from the perforation and passes through the base and the fixing seat of the sensor, and extends toward the place where the sensing test piece is coupled to the transmitter.

[0021] The physiological signal sensing device of the present invention has a base with a through hole, and the through hole of the fixing base of the sensor and the through hole of the base are used for the sensing test piece to pass through and for the implantation needle to removably penetrate to guide the sensing test piece to be implanted under the skin of a biological body, and the implantation needle path extends from the through hole and the through hole to the place where the sensing test piece is coupled to the transmitter.

[0022] Another object of the present invention is to provide another physiological signal sensing device that can prevent external liquid from penetrating.

[0023] The physiological signal sensing device of the present invention comprises a base, a sensor, a transmitter, and a sealing unit.

[0024] The base comprises a bottom plate used for being arranged on the skin surface of the organism, and a groove peripheral wall protruding from the top surface of the bottom plate, wherein the groove peripheral wall and the bottom plate jointly define a setting groove.

[0025] The sensor includes a fixing seat and a sensing test strip. The fixing seat is arranged in the setting groove. The sensing test strip is arranged in the fixing seat, and the sensing test strip is used to be partially implanted under the skin of the organism to measure at least one analytical substance in the organism and transmit a corresponding physiological signal.

[0026] The transmitter is used to receive and output the physiological signal. The transmitter has a bottom, and the transmitter is covered on the base with the bottom facing the base, so that the fixing base is located between the base and the transmitter, and the sensing test piece is coupled to the transmitter.

[0027] The sealing unit includes a third sealing member, and the third sealing member is sandwiched between the inner wall surface of the groove peripheral wall of the base and the outer peripheral surface of the fixing seat of the sensor to seal the first liquid leakage path.

[0028] The physiological signal sensing device of the present invention has a bottom plate of the base with a perforation for the sensing test strip to pass through so as to be implanted under the skin of the biological body. The first liquid leakage path enters from the perforation and passes through the base and the fixing seat of the sensor, extending toward the place where the sensing test strip is coupled to the transmitter.

[0029] The physiological signal sensing device of the present invention has a fixing seat of the sensor having through holes penetrating the top and bottom surfaces thereof, wherein the through holes are for the sensing test piece to pass through and for the implantation needle to removably pass through so as to guide the sensing test piece to be implanted under the skin of the biological body, and the sealing unit also includes a fourth sealing member arranged at the top of the through hole to seal the implantation needle path.

[0030] In the physiological signal sensing device of the present invention, the fourth sealing member of the sealing unit is made of elastic material.

[0031] The physiological signal sensing device of the present invention has a base with a through hole, and the through hole of the fixing base of the sensor and the through hole of the base are used for the sensing test piece to pass through and for the implantation needle to removably penetrate to guide the sensing test piece to be implanted under the skin of a biological body, and the implantation needle path extends from the through hole and the through hole to the place where the sensing test piece is coupled to the transmitter.

[0032] In the physiological signal sensing device of the present invention, the sealing unit also includes a top abutment located at the bottom of the transmitter, the position of the top abutment corresponds to the through hole of the fixing seat and is tightly combined with the fourth sealing member at the top of the through hole to seal the needle implantation path.

[0033] The beneficial effects of the present invention are: the sealing unit is used to seal different leakage paths to effectively prevent external liquids such as external sewage, blood, body fluids, etc. from entering the sensor device, and can prevent blood or body fluids from gushing out when implanted under the skin of a biological body, thereby reducing the user's fear. BRIEF DESCRIPTION OF THE DRAWINGS

[0034] Other features and effects of the present invention will be clearly presented in the embodiments with reference to the accompanying drawings, in which:

[0035] Figure 1 is a three-dimensional diagram of a first embodiment of a physiological signal sensor device of the present invention;

[0036] Figure 2 is a perspective exploded view of the first embodiment;

[0037] Figure 3 is another exploded perspective view of the first embodiment;

[0038] Figure 4 is along Figure 1 A cross-sectional view taken along line IV-IV;

[0039] Figure 5 is along Figure 1 A sectional view taken along line V-V in FIG.

[0040] Figure 6 is a perspective view of a sensor of the first embodiment;

[0041] Figure 7 is a cross-sectional view of the sensor of the first embodiment;

[0042] Figure 8 is a cross-sectional view of the base and the sensor of the first embodiment, illustrating a state in which the sensor is coupled to a needle implant assembly and has not yet been coupled to the base;

[0043] Fig. 9 is a cross-sectional view of the base and the sensor of the first embodiment, illustrating a state where the sensor is coupled to the base and the implant needle assembly is pulled out;

[0044] Fig.10 is a three-dimensional diagram of a second embodiment of the physiological signal sensor device of the present invention;

[0045] Fig.11 is a cross-sectional view of a sensor according to the second embodiment;

[0046] Fig.12 is a cross-sectional view of the second embodiment;

[0047] Fig.13 is another cross-sectional view of the second embodiment;

[0048] Fig.14 is a cross-sectional view of the base and the sensor of the second embodiment, illustrating a state where the sensor is coupled to the base and the implant needle assembly is withdrawn;

[0049] Fig.15 is a cross-sectional view of a variation of the second embodiment;

[0050] Fig.16 is a cross-sectional view of a third embodiment of the physiological signal sensor device of the present invention;

[0051] Fig.17 is a cross-sectional view of a fourth embodiment of the physiological signal sensor device of the present invention;

[0052] Fig.18 is a cross-sectional view of a fifth embodiment of the physiological signal sensor device of the present invention;

[0053] Fig.19 is a cross-sectional view of a sixth embodiment of the physiological signal sensor device of the present invention;

[0054] Fig. 20 is a cross-sectional view of a seventh embodiment of the physiological signal sensor device of the present invention;

[0055] Fig.21 is a cross-sectional schematic diagram of a variation of the physiological signal sensor device of the present invention; and

[0056] Fig. 22 It is a cross-sectional schematic diagram of another variation of the physiological signal sensor device of the present invention. DETAILED DESCRIPTION

[0057] Before the present invention is described in detail, it should be noted that similar components are denoted by the same reference numerals in the following description.

[0058] In addition, in the description of the present invention, the terms "upper", "lower", "top" and "bottom" are used only to conveniently indicate the relative positions of components, and do not limit the actual use directions of each component.

[0059] See also Figure 1 and Figure 2 A first embodiment of the physiological signal sensor device of the present invention is suitable for use through a needle implant assembly 9 (see Figure 8) is installed on the skin surface of a biological body (not shown) and is used to measure at least one analyte in the biological body and transmit a physiological signal corresponding to the analyte, wherein the analyte can be, but is not limited to, the glucose level in the biological body fluid. Figure 2 As shown, a first axis D1, a second axis D2 perpendicular to the first axis D1, and a third axis D3 perpendicular to the first axis D1 and the second axis D2 are defined. However, in other embodiments, the angle between any two of the first axis D1, the second axis D2, and the third axis D3 is not limited to 90 degrees.

[0060] In this embodiment, the physiological signal sensing device is used to measure the glucose concentration in the interstitial fluid (ISF) of human tissues. The physiological signal sensing device includes a base 1, a sensor 2, and a transmitter 3.

[0061] The base 1 includes a base body 11 and at least one first engaging structure 12 disposed on the base body 11 .

[0062] See also Figure 2 and Figure 5 The base body 11 has a bottom plate 111 perpendicular to the first axial direction D1, a surrounding wall 112 extending from the periphery of the bottom plate 111 along the first axial direction D1, a groove peripheral wall 114 protruding from a top surface 115 of the bottom plate 111 and defining a setting groove 113 together with the bottom plate 111, and at least one opening 117 penetrating the bottom plate 111. The bottom plate 111 has the top surface 115, a bottom surface 116 opposite to the top surface 115 along the first axial direction D1, and a through hole 118 penetrating the top surface 115 and the bottom surface 116 and communicating with the setting groove 113. In this embodiment, the number of the openings 117 is two, and the setting groove 113 is spaced apart along the third axial direction D3.

[0063] In this embodiment, the base 1 has two first engaging structures 12 . The first engaging structures 12 are protruded from the top surface 115 of the bottom plate 111 , and are spaced apart from the setting grooves 113 along the third axial direction D3 and are respectively adjacent to the openings 117 .

[0064] See also Figure 2 and Figure 4, the base body 11 can be attached to the skin surface of the organism through a patch 16. The patch 16 is arranged on the bottom surface 116 of the base body 11, and includes a planting hole 161 corresponding to the through hole 118 of the base body 11, and a waterproof portion 162 surrounding the planting hole 161 and not absorbing water. In this embodiment, the patch 16 is made of a non-woven material and has adhesive on opposite sides, one of which is attached to the bottom surface 116 of the base body 11, and the other is used to attach to the skin surface of the organism. However, the base 1 can also omit the patch 16, and the user can apply glue on the bottom surface 116 of the base body 11 by himself, so that the base 1 adheres to the skin surface of the organism. In detail, the waterproof part 162 of the patch 16 is formed by dispensing glue into the non-woven fabric, which is intended to prevent sewage from penetrating through the patch 16 and contacting the wound after the physiological signal sensor device is set on the skin surface of the organism, thereby causing the risk of wound infection.

[0065] The sensor 2 includes a fixing seat 21 disposed on the base body 11, and a sensing test strip 22 (sensor) disposed on the fixing seat 21 and limited by the fixing seat 21, and the sensing test strip 22 is suitable for measuring the analyte in the biological body and transmitting a physiological signal corresponding to the data of the analyte to the transmitter 3.

[0066] See also Figure 2 , Figures 4 to 7 , the fixing seat 21 is set in the setting groove 113 of the base body 11. The fixing seat 21 has a bottom surface 211, a top surface 212, an outer peripheral surface 213 connecting the bottom surface 211 and the top surface 212, a setting space 210 located between the bottom surface 211 and the top surface 212 and open upward, and a through hole 214 that passes through the bottom surface 211 and the top surface 212 along an implantation direction D4. The through hole 214 is spaced apart from the setting space 210 and is connected to the setting space 210 in an extension direction D5. The implantation direction D4 and the extension direction D5 form an angle θ (such as Figure 7 As shown), in this embodiment, the implantation direction D4 extends along the first axial direction D1, and the extension direction D5 extends along the second axial direction D2, but is not limited thereto.

[0067] The sensing test strip 22 has a sensing section 222 for implantation under the skin of a living body, a signal output section 221 electrically connected to the transmitter 3, and an extension section 223 connecting the sensing section 222 and the signal output section 221 along the extension direction D5. The sensing section 222 is disposed through a bottom 214b of the through hole 214, the signal output section 221 is accommodated in the setting space 210, and the extension section 223 extends from the setting space 210 to the through hole 214. The sensing section 222 is used to measure physiological parameters related to the analyzed substance, and transmit the aforementioned measurement results to the transmitter 3 in sequence via the extension section 223 and the signal output section 221. Figure 6 As shown in the figure, the sensing test strip 22 uses a plurality of electrodes on its surface to extend to the signal output end 226 of the signal output section 221 to electrically connect to the transmitter 3 to transmit physiological signals, and the type and number of the electrodes depend on the analyte to be measured and are not limited to those shown in the figure of this embodiment. To avoid unclear drawings, the configuration of the signal output end 226 of the sensing test strip 22 on the signal output section 221 and the related electrical connection terminals is only shown in the figure. Figure 6 , but not drawn in other diagrams.

[0068] In addition, the installation space 210 has a cavity portion 210a opened to the top surface 212, and a gap portion 210b connected to the cavity portion 210a along the first axial direction D1. Figure 4 , Figure 6 and Figure 7 The signal output section 221 of the sensing test piece 22 is located in the cavity 210a and protrudes from the top surface 212 of the fixing seat 21 along the first axial direction D1. The extension section 223 extends along the extension direction D5 to the slit 210b, and the sensing section 222 passes through the through hole 214 downward along the implantation direction D4 and passes through the bottom surface 116 of the base body 11 through the through hole 118 of the base body 11 to be implanted under the skin of the organism.

[0069] The through hole 214 of the fixing seat 21 and the through hole 118 of the base body 11 together form a needle implantation path c extending along the implantation direction D4. The needle implantation path c is used for an implantation needle assembly 9 of an implantation device (not shown) to pass through (see FIG. Figure 8 ) to implant the sensing segment 222 of the sensing test strip 22 into the subcutaneous tissue of the organism.

[0070] See also Figure 2 , Figure 4 and Figure 5The transmitter 3 can be detachably covered on the base 1 and connected to the sensor 2 . The transmitter 3 is used to receive and output the physiological signals transmitted by the sensor 2 .

[0071] The transmitter 3 includes a shell 300 defining an internal space 30, a circuit board 33 located in the internal space 30, a battery 35 located in the internal space 30 and electrically connected to the circuit board 33, a port 36 connected to the bottom surface of the circuit board 33 and protruding out of the internal space 30 toward the base body 11, and at least one second snap-fitting structure 37 disposed on the bottom 31 and capable of being detachably snapped with the first snap-fitting structure 12 of the base body 11.

[0072] See also Figure 3 and Figure 5 The housing 300 includes the bottom 31 and a top 32. In this embodiment, the bottom 31 and the top 32 are two connected shells. The bottom 31 is adjacent to the base body 11 and faces the top surface 115 of the bottom plate 111, and includes a bottom surface 311, a top surface 312, a first groove 313 recessed in the bottom surface 311, and at least one second groove 314 recessed in the bottom surface 311 and corresponding to the first engaging structure 12 of the base 1. The first groove 313 is defined by a groove peripheral surface 315 connected to the bottom surface 311 and a groove bottom surface 316 connected to the groove peripheral surface 315. In this embodiment, the number of the second grooves 314 is two. The transmitter 3 is covered on the base 1 with the bottom 31 facing the base 1, and the bottom surface 311 is close to the bottom plate 111 of the base body 11, and the first groove 313 accommodates the groove wall 114 of the base body 11 and the sensor 2, so that the sensing test piece 22 is coupled to the circuit board 33, and the second groove 314 accommodates the second locking structure 37 and the first locking structure 12, which can effectively reduce the overall thickness.

[0073] The circuit board 33 is provided with a plurality of electronic components (not shown). The electronic components and the circuit board 33 together constitute a signal transmission module (not shown), which is used to receive and output the physiological signals measured by the sensing test strip 22. The electronic components are conventional technologies, such as signal amplifiers, analog digital signal converters, processors, transmitters, etc., and are not described in detail here.

[0074] See also Figure 4 , the battery 35 is connected to the circuit board 33 .

[0075] See also Figure 3 and Figure 5, the port 36 is connected to the bottom surface of the circuit board 33, and protrudes downward along the first axial direction D1 into the first groove 313 of the bottom 31, and the port 36 includes a socket 367. The socket 367 is provided for the signal output section 221 of the sensing test strip 22 to be inserted to allow the sensing test strip 22 to be electrically connected to the circuit board 33. In this embodiment, the sensing test strip 22 is electrically connected to the circuit board 33 using a plurality of conductive members 364 located in the port 36. Specifically, the conductive member 364 in this embodiment is a coil spring, and it abuts against a plurality of electrical contacts (not shown) on the circuit board 33 along its own radial direction, and abuts against the signal output ends 226 (see FIG. 2 ) of a plurality of electrodes on the sensing test strip 22 along its own radial direction. Figure 6 ).

[0076] See also Figure 3 and Figure 5 The second engaging structures 37 are in the form of holes and grooves, and there are two of them, which are respectively disposed in the second grooves 314 of the bottom 31, and the positions and shapes of the second engaging structures 37 correspond to the first engaging structures 12. When the transmitter 3 is covered on the base 1 with the bottom 31 facing the top surface 115 of the bottom plate 111 of the base body 11, the first engaging structure 12 of the base 1 is engaged with the second engaging structure 37. When the transmitter 3 is to be replaced, the second engaging structure 37 and the first engaging structure 12 can be separated from each other by external force. It is to be supplemented that in this embodiment, the user can use a finger or other object to apply force to at least one of the first engaging structure 12 and the second engaging structure 37 or to the engaging portion of the first engaging structure 12 and the second engaging structure 37 through the opening 117 to separate them. However, in other aspects, the opening 117 can be omitted, and the material and structural design of the base 1 can be used to make the base 1 bend and deform by the force applied by the user, so that the second engaging structure 37 and the first engaging structure 12 can be separated. However, in other variations, the physiological signal sensor device can also have both the flexible base body 11 and the opening 117 for disassembly, and the present invention is not limited thereto.

[0077] Back to Figure 2 In this embodiment, before use, the base 1, the sensor 2 and the transmitter 3 are separated from each other and have not been assembled together. When it is to be used, the base 1, the sensor 2 and the transmitter 3 must be combined and placed on the skin surface of the organism. Figure 8During the setting process, the base 1 and the sensor 2 can be first combined into an implantation device (not shown), and then the implant needle assembly 9 of the implantation device carries the sensing segment 222 of the sensing test piece 22 and passes through the through hole 214 of the fixing seat 21 along the implantation direction D4, and then the base body 11 is fixed to the skin surface of the organism through the patch 16, and then, the sensing segment 222 of the sensing test piece 22 is passed through the through hole 118 of the base body 11 through the implantation device along with the implant needle assembly 9 and implanted into the subcutaneous tissue of the organism, and at the same time, the fixing seat 21 of the sensor 2 is placed in the setting groove 113 of the base body 11. Fig. 9 Then, the implant needle assembly 9 is pulled out to separate the implant device from the sensor 2 and the base 1. At this time, the sensor 2 is combined with the base 1, and the sensing section 222 of the sensing test piece 22 is implanted into the subcutaneous tissue of the organism. Figure 4 and Figure 5 Finally, the transmitter 3 is covered on the base body 11. At this time, the second engaging structure 37 of the transmitter 3 and the first engaging structure 12 of the base body 11 are engaged with each other by being pushed by an external force. At the same time, the signal output section 221 of the sensing test piece 22 is inserted into the port 36 of the transmitter 3 through the plug hole 367 along the first axial direction D1. In this way, the overall installation is completed.

[0078] See also Figure 4 and Figure 5It can be known from the above description that the base 1, the sensor 2 and the transmitter 3 in the physiological signal sensor device are components that can be assembled and disassembled by the user. In addition, during the implantation process, the implant needle assembly 9 will penetrate the through hole 214 of the fixing seat 21 of the sensor 2 and the through hole 118 of the base 1. Therefore, it is easy for external liquid, such as blood and body fluid gushing out from the implantation site of the biological body, to enter the interior of the transmitter 3 through a first liquid leakage path a and the implant needle path c or through the signal output section 221 of the contact sense test piece 22 through path d, and external sewage to enter the interior of the transmitter 3 through a second liquid leakage path b, and it is even possible to flow back to the implantation site (i.e., the wound) of the biological body along the first liquid leakage path a. In detail, the first liquid leakage path a enters from the perforation 118 and extends between the base 1 and the fixing seat 21 of the sensor 2 toward the place where the sensing test strip 22 and the transmitter 3 are coupled; the second liquid leakage path b enters from the gap between the base 1 and the transmitter 3 and extends from the outer edge of the base 1 and the transmitter 3 toward the place where the sensing test strip 22 and the transmitter 3 are coupled; the needle implantation path c extends from the perforation 118 and the through hole 214 to the place where the sensing test strip 22 and the transmitter 3 are coupled. Therefore, the first embodiment of the physiological signal sensor device of the present invention further includes a sealing unit 4 for preventing external liquid from penetrating through the above path, thereby affecting the measuring function of the sensing test strip 22, damaging the internal electronic components of the transmitter 3, or even causing infection at the wound.

[0079] See also Figure 4 and Figure 5 The sealing unit 4 includes a first sealing member 42 , a second sealing member 41 , a third sealing member 48 , a sixth sealing member 49 , a top abutment member group 47 , and a barrier member 45 .

[0080] In summary, the sealing unit 4 mainly utilizes the first sealing member 42 to be sandwiched between the fixing seat 21 of the sensor 2 and the bottom 31 of the transmitter 3 to seal the first liquid leakage path a; the second sealing member 41 is sandwiched between the base 1 and the transmitter 3 to seal the second liquid leakage path b; the third sealing member 48 is sandwiched between the inner wall surface of the groove peripheral wall 114 of the base 1 and an outer peripheral surface 213 of the fixing seat 21 of the sensor 2 to seal the first liquid leakage path a; the top abutment group 47 is located between the bottom 31 of the transmitter 3 and the through hole 214 of the fixing seat 21 of the sensor 2, and the top abutment group 47 seals the through hole 214 of the fixing seat 21 of the sensor 2 to seal the implantation path c. The specific arrangement of the sealing unit 4 in each embodiment will be described in sequence below.

[0081] The first sealing member 42 is sandwiched between an outer peripheral surface 213 of the fixing seat 21 of the sensor 2 and a groove peripheral surface 315 of the first groove 313 of the transmitter 3 to seal the first liquid leakage path a. In this embodiment, in addition to contacting the fixing seat 21 of the sensor 2 and the first groove 313 of the transmitter 3, the first sealing member 42 can further abut against the upper edge of the groove peripheral wall 114 of the setting groove 113 to simultaneously seal the first liquid leakage path a and the second liquid leakage path b. Therefore, the first seal 42 of the present embodiment can prevent external liquid (especially blood) from flowing from the through hole 118 of the base body 11, through the base body 11 and the fixing seat 21, to between the groove bottom surface 316 of the transmitter 3 and the top surface 212 of the fixing seat 21. It can also prevent blood from flowing from the through hole 118 of the base body 11, following the first liquid leakage path a and the second liquid leakage path b in sequence, out of the physiological signal sensor device, and causing panic to the user. At the same time, the first sealing member 42 of the present embodiment can further prevent external liquid (especially sewage) from flowing from the surrounding wall 112 of the base 1 and the top 32 of the launcher 3, into the groove bottom surface 316 of the launcher 3 and the top surface 212 of the fixing seat 21, and then entering the interior of the launcher 3 through the insertion hole 367 of the port 36. It can also prevent sewage from entering the interior of the device through the second liquid leakage path b and then flowing through the first liquid leakage path a to the perforation 118 and contacting the wound.

[0082] The second sealing member 41 is sandwiched between the base 1 and the emitter 3 to seal the second liquid leakage path b. In this embodiment, the second sealing member 41 is sandwiched between an outer wall surface of the groove peripheral wall 114 of the base 1 and the groove peripheral surface 315 of the first groove 313 of the emitter 3. More specifically, the second sealing member 41 can prevent external liquid (especially sewage) from flowing from the surrounding wall 112 of the base 1 and the top 32 of the emitter 3, into the groove bottom surface 316 of the emitter 3 and the top surface 212 of the fixing seat 21, and then entering the interior of the emitter 3 through the insertion hole 367 of the port 36. At the same time, it can also prevent external liquid (especially blood) from flowing through the through hole 118 of the base body 11, through the base body 11 and the fixing seat 21 (i.e., the first liquid leakage path a), to the bottom 31 of the transmitter 3 and the top surface 115 of the base body 11 (i.e., the second liquid leakage path b), and then seeping out of the physiological signal sensor device, causing panic to the user.

[0083] The third sealing member 48 is sandwiched between an inner wall surface of the groove peripheral wall 114 of the base 1 and an outer peripheral surface 213 of the fixing seat 21 of the sensor 2, so as to seal the first liquid leakage path a together with the first sealing member 42, and mainly prevents external liquid (especially blood) from flowing from the through hole 118 of the base body 11, through the base body 11 and the fixing seat 21, to the groove bottom surface 316 of the transmitter 3 and the top surface 212 of the fixing seat 21. In addition, the third sealing member 48 is elastic, and the outer peripheral surface 213 of the fixing seat 21 of the sensor 2 is tightly against the third sealing member 48, which can further fix the fixing seat 21 to the setting groove 113. It should be noted that in this embodiment, since a third sealing member 48 is disposed in the groove 113 to fix the fixing base 21 of the sensor 2, compared with existing products on the market that commonly use a method of drilling a hole in the base body 11 and using a sealing member to fix the sensor 2, the physiological signal sensor device provided in this embodiment has better sealing performance.

[0084] The sixth sealing member 49 surrounds the outer side of the groove peripheral wall 114 and is sandwiched between the top surface 115 of the bottom plate 111 of the base 1 and a bottom surface 311 of the transmitter 3, so as to seal the second liquid leakage path b together with the second sealing member 41. It must be noted that the setting of the sixth sealing member 49 is equivalent to the first line of defense for the second liquid leakage path b, which can first block the sewage from the outside and more effectively prevent the sewage from approaching the core position of the overall device (i.e., the setting groove 113, the sensor 22 in the fixing seat 21 and the insertion hole 367 of the transmitter 3), and at the same time can improve the durability of the second sealing member 41 and the first sealing member 42.

[0085] Based on this, in general, in this embodiment, the sixth seal 49 can serve as the first line of defense for preventing sewage, the second seal 41 can serve as the second line of defense, and the first seal 42 is not only the third line of defense for preventing sewage from entering the device, but also can prevent sewage from contacting the wound through the first liquid leakage path a through the perforation 118 and causing infection. As for the blood prevention function, in order to prevent blood from entering through the perforation 118 and flowing to the transmitter 3 along the gap between the fixing seat 21 and the setting groove 113 (i.e., the first liquid leakage path a), the third seal 48 can serve as the first line of defense, while the first seal 42 is the second line of defense, and can also prevent blood from flowing out of the device through the second liquid leakage path b, causing panic to the user.

[0086] See also Fig. 9 In this embodiment, the first seal 42, the second seal 41, the third seal 48 and the sixth seal 49 are made of elastic material, such as rubber, and are formed in an integral manner and arranged on the base 1, but may also be other elastic materials that can prevent liquid leakage, and are not limited thereto. . In detail, in this embodiment, in order to enable one-time injection molding during manufacturing, the first seal 42, the second seal 41, the third seal 48 and the sixth seal 49 are integrally formed on the base 1, and the second seal 41 can be formed by injecting the elastic material around the outer wall surface of the groove peripheral wall 114 of the base body 11 and at least partially extending downward to be embedded in the bottom plate 111, and forming a connecting portion 411 coplanar with the bottom plate 111 or slightly protruding from the bottom surface 116 of the bottom plate 111, and then extending upward and surrounding the inner wall surface of the groove peripheral wall 114 to form the third seal 48. Similarly, the second seal 41 can also partially extend along the top surface 115 of the bottom plate 111 toward the outside of the setting groove 113 to form another connecting portion 412 and then surround the setting groove 113 to form a sixth seal 49. The third seal 48 can also partially extend upward along the inner wall surface of the groove peripheral wall 114 to form another connecting portion 413 and then cover the upper edge of the groove peripheral wall 114 to form the first seal 42. However, it must be noted that the first seal 42, the second seal 41, the third seal 48 and the sixth seal 49 can also be independently arranged on the base 1 without being connected.

[0087] In addition, if Fig. 9 As shown, the connecting portion 411 extending downward from the second sealing member 41 and embedded in the bottom plate 111 can mutually squeeze and interfere with the patch 16 or the skin surface of the organism directly attached, and play the role of the waterproof portion 162 in the patch 16, preventing sewage from penetrating into the wound and contacting the wound to cause wound infection. It must be noted that the waterproof portion 162 or the connecting portion 411 can be provided, and at least one of them can be selected for implementation, and the present invention is not limited thereto.

[0088] See also Figure 4 and Figure 7 , the abutment set 47 seals the top 214a of the through hole 214. In general, the abutment set 47 has a abutment 46 located at the bottom 31 of the transmitter 3. The position of the abutment 46 corresponds to the through hole 214 of the fixing seat 21 and is tightly combined with the top 214a of the through hole 214. Specifically, the abutment set 47 has a abutment 46 located at a groove bottom surface 316 of the first groove 313 of the transmitter 3, and a fourth sealing member 44 disposed at the top 214a of the through hole 214. The abutment 46 is tightly combined with the fourth sealing member 44 to seal the needle path c, preventing blood from entering the interior of the transmitter 3 through the insertion hole 367 of the port 36 and damaging the electronic components inside the transmitter 3. The fourth sealing member 44 is a soft piece and is made of an elastic material, such as rubber, while the abutting member 46 is a hard piece made of a harder material than the fourth sealing member 44 and is formed integrally with the bottom 31 of the transmitter 3. The fourth sealing member 44 and the abutting member 46 are matched in appearance to tightly abut against each other to enhance the effect of sealing the implantation path c. In addition, since the fourth sealing member 44 is a soft piece and is made of an elastic material (such as rubber), it can be placed in the implantation needle assembly 9 (see Figure 8 ) is pulled out and then sealed to further maintain the sealing of the inside of the device. In addition, in this embodiment, the fourth sealing member 44 protrudes upward from the top surface 212 of the fixing seat 21, and the top surface 212 of the fixing seat 21 is further protruded with two elastic members 50, so that the fixing seat 21 can stably contact the transmitter 3.

[0089] Thus, by setting the first seal 42 and / or the third seal 48 on the base 1 and matching the setting of the fourth seal 44 on the fixing seat 21, the present embodiment can guide the base 1 to adhere to the skin surface of a living body by means of an implantation component, so that the sensing test piece 22 of the sensor 2 is partially implanted under the skin surface of the living body, and before the transmitter 3 is installed, all the blood that gushes out instantly is sealed in the gap between the base 1 and the sensor 2 or in the fixing seat 21 of the sensor 2, thereby preventing the user from panicking upon seeing the blood. In addition, the waiting time required for installing the transmitter 3 on the base 1 can be shortened.

[0090] Furthermore, if Figure 4 and Figure 7As shown, the barrier 45 is disposed between the through hole 214 and the setting space 210 and blocks the through hole 214 and the setting space 210. The barrier 45 is made of elastic material and is tightly against the extension section 223 of the sensing test strip 22 to prevent blood from penetrating into the setting space 210 along the path d through the through hole 214, and then contacting the signal output section 221 of the sensing test strip 22 to affect the sensing function of the sensing test strip 22. Preferably, the opposite sides of the extension section 223 of the sensing test strip 22 can be clamped by the barrier 45 to additionally achieve the effect of fixing the sensing test strip 22. In addition, the bottom of the fixing base 21 of the sensor 2 can be further sealed by the glue 23, which is equivalent to double blocking the external liquid (such as blood) entering through the path d or the first liquid leakage path a.

[0091] For additional explanation, see Figure 3 In order to effectively reduce the thickness of the physiological signal sensor device (i.e., the height along the first axis D1), the shape of the bottom 31 of the transmitter 3 is matched with the base 1 and the sensor 2 to form the first groove 313. In this way, a larger internal space can be formed on both sides of the first groove 313 along the second axis D2 inside the transmitter 3 to accommodate the battery 35 and the electronic components (not shown) arranged on the circuit board 33. The electrical connection structure between the sensor 2 and the port 36 can be completely concentrated in the first groove 313, so that the overall space configuration can be fully utilized and densified.

[0092] However, in other implementations (see Fig.21 and Fig. 22 ), the bottom 31 of the transmitter 3 may also be at least partially complementary to the fixing seat 21 of the sensor 2 and the appearance of the base 1, for example, only the port 36 is complementary to the fixing seat 21 and the first groove 313 is omitted (such as Fig. 22 ), and the first seal 42 is clamped between the fixing seat 21 of the sensor 2 and the bottom 31 of the transmitter 3 to seal the first liquid leakage path a, the second seal 41 is clamped between the base 1 and the transmitter 3 to seal the second liquid leakage path b, and the third seal 48 is clamped between the inner wall surface of the groove peripheral wall 114 of the base 1 and an outer peripheral surface 213 of the fixing seat 21 of the sensor 2 to seal the first liquid leakage path a, which can also achieve the effect of bloodproof and waterproof.

[0093] Since the currents measured by the physiological signal sensor device are all tiny currents, even tiny currents as small as nanoamperes (nA), in addition to maintaining the sealing of the entire device, it is necessary to further maintain the dryness of the area around the sensor 2 to avoid problems such as measurement errors caused by moisture. Therefore, the first embodiment of the physiological signal sensor device of the present invention also includes at least one desiccant 5.

[0094] See also Figure 2 and Figure 5 , the desiccant 5 is disposed at any one of the accommodating spaces 100 defined by the first groove 313 and the base 1 after the transmitter 3 is covered on the base 1, so as to achieve the purpose of moisture-proofing and improve the waterproof effect at the same time. In this embodiment, the accommodating space 100 is located between the bottom plate 111 of the base 1 and the bottom 31 of the transmitter 3, and the place where the transmitter 3 is connected to the sensing test piece 22 is located in the accommodating space 100, and the desiccant 5 is disposed on the top surface 212 of the fixing seat 21, and the top surface 212 of the fixing seat 21 has two recesses 217 for accommodating the desiccant 5 respectively.

[0095] However, in another variation of this embodiment, the desiccant 5 can also be disposed on the bottom surface 316 of the groove of the emitter 3, that is, two recesses (not shown) can be added to the bottom surface 316 of the groove to accommodate the desiccant 5. In other embodiments, the desiccant 5 can also be one of the materials used to make the fixing seat 21, that is, when the fixing seat 21 is injection molded, a material with a drying effect is selected or the desiccant is mixed into the injection material for molding together, so that the fixing seat 21 itself has a drying function.

[0096] See also Figures 10 to 14 , is a second embodiment of the physiological signal sensor device of the present invention. The configuration of the sealing unit 4 of the second embodiment is similar to the first embodiment, and the main difference is that:

[0097] First, see Fig.12 The sealing unit 4 omits the third sealing member 48 and includes a fifth sealing member 43 .

[0098] The fifth sealing member 43 is disposed on the base 1 and seals the through hole 118. The fifth sealing member 43 has a hole for the implant needle assembly 9 (see Figure 8) is provided with a pre-opening 431 to reduce resistance during needle implantation, but the fifth sealing member 43 may also be provided without a pre-opening, and the fifth sealing member 43 may be pierced by the needle implant assembly 9 to guide the sensing test piece 22 to pass through, and since the material of the fifth sealing member 43 may be an elastomer (such as rubber), it can be tightly pressed against the sensing section 222 of the sensing test piece 22 after the needle implant assembly 9 is withdrawn to maintain the sealing inside the device. In addition, in this embodiment, the fifth sealing member 43 seals the top of the through hole 118 of the base 1 to form a blood-containing space at the bottom of the through hole 118, and the blood-containing space can be used to accommodate blood seeping out from the implantation site for buffering, thereby preventing the outflowing blood or body fluid from infiltrating from the gap between the fifth sealing member 43 and the sensing test piece 22 due to increased hydraulic pressure due to insufficient space.

[0099] In addition, if Fig.10 and Fig.12 As shown, in this embodiment, the second seal 41 and the fifth seal 43 are integrally formed on the base body 11 in order to be able to be formed by injection molding at one time during manufacturing, but the second seal 41 and the fifth seal 43 can also be independent and unconnected components. In detail, the present embodiment uses elastic material to inject the groove peripheral wall 114 surrounding the base body 11 to form the second seal 41 and at least partially extend downward to embed the bottom plate 111, and form a connecting portion 411 that is coplanar with the bottom plate 111 or slightly protrudes from the bottom surface 116 of the bottom plate 111, and then extends upward and surrounds the perforation 118 to form the fifth seal 43. In this way, the connecting portion 411 can be mutually squeezed and interfered with the patch 16 or the skin surface of the organism directly attached to play the role of the waterproof portion 162 in the patch 16 to prevent sewage from penetrating into the wound and contacting the wound to cause wound infection. It must be noted that the waterproof portion 162 or the connecting portion 411 can be selected to be implemented, and the present invention is not limited to this. In addition, in other embodiments, the connecting portion 411 can also be extended by the fifth sealing member 43 along the hole surface of the through hole 118 to the bottom end of the through hole 118 and the hole surface of the implantation hole 161 of the patch 16, and is used to lean against the skin surface of the biological body when in use and surround the implantation site to block the liquid from the patch 16 to avoid wound infection. In this way, in the embodiment, the waterproof portion 162 in the patch 16 can also be omitted.

[0100] Second, see Fig.11 , Fig.13 and Fig.14, the first seal 42 is also sandwiched between the outer circumference 213 of the fixing seat 21 of the sensor 2 and the groove circumference 315 of the first groove 313 of the transmitter 3, but in the second embodiment, the first seal 42 is arranged on the outer circumference 213 of the fixing seat 21 of the sensor 2, and does not abut the upper edge of the groove circumference wall 114. Accordingly, in the second embodiment, for the part of preventing sewage, the second seal 41 is used as the first line of defense, and the first seal 42 is used as the second line of defense to prevent sewage from flowing between the surrounding wall 112 of the base 1 and the top 32 of the transmitter 3 (i.e., the second liquid leakage path b), into the groove bottom surface 316 of the transmitter 3 and the top surface 212 of the fixing seat 21, and then into the interior of the transmitter 3 through the plug hole 367 of the port 36. As for the blood-proof function, in order to prevent blood from entering through the perforation 118 and flowing to the transmitter 3 along the gap between the fixing seat 21 and the setting groove 113 (i.e., the first liquid leakage path a), the fifth seal 43 is used as the first line of defense, which can still immediately prevent blood leakage when implanted in the biological body, and the first seal 42 is used as the second line of defense. In addition, the second seal 41 can also further serve as a line of defense to prevent blood from flowing out of the device along the second liquid leakage path b, thereby avoiding panic of the user, and the fifth seal 43 can also prevent sewage from contacting the wound along the first liquid leakage path a through the perforation 118 and causing infection.

[0101] Also, see Fig.12 In this embodiment, the push member 46 of the push member group 47 is a soft material (such as rubber) and is protruded from the groove bottom surface 316 of the bottom 31 of the transmitter 3. The fourth sealing member 44 is a soft material (such as rubber) and is arranged at the top 214a of the through hole 214. The top 214a of the through hole 214 is in a groove shape for accommodating the fourth sealing member 44. The top of the fourth sealing member 44 is also in a groove shape and is plugged by the push member 46 to enhance the effect of sealing the needle path c.

[0102] It is additionally noted that the second seal 41 and the fifth seal 43, and the first seal 42 and the fourth seal 44, can be integrally connected and respectively disposed on the base 1 and the fixing seat 21 of the sensor 2 according to the manufacturing method, but can also be independent of each other, such as Fig.15 This is a variation of the present embodiment. In the variation, the second seal 41 and the fifth seal 43 of the sealing unit 4 are independent of each other and are not connected. In addition, the second seal 41 and the first seal 42 are O-rings, among which the O-ring with a triangular cross-section has a better effect in preventing liquid leakage, but the present invention is not limited to this.

[0103] In addition, in this embodiment, a clamping member 14 is provided in the setting groove 113 of the base 1 for clamping with the bottom of the fixing seat 21 .

[0104] See also Fig.16 , is a third embodiment of the physiological signal sensor device of the present invention. The third embodiment is similar to the second embodiment, and the difference is that:

[0105] The abutment member group 47 of the sealing unit 4 omits the fourth sealing member 44, and the abutment member 46 directly blocks the top 214a of the through hole 214 of the fixing seat 21. In this embodiment, the abutment member 46 is a soft material (such as rubber) that can utilize extrusion deformation to interfere with the top 214a of the through hole 214 to achieve the effect of sealing the needle path c.

[0106] See also Fig.17 , is a fourth embodiment of the physiological signal sensor device of the present invention. In the fourth embodiment, the configurations of the first seal 42, the second seal 41, the fifth seal 43, etc. are similar to those of the second embodiment, but the configuration of the abutment set 47 is the same as that of the first embodiment. That is, in the fourth embodiment, the fourth seal 44 is a soft piece and is made of an elastic material, such as rubber, while the abutment 46 is a hard piece made of a harder material than the fourth seal 44, and is integrally formed with the bottom 31 of the transmitter 3, and matches the shape of the top of the fourth seal 44, and abuts against the top of the fourth seal 44 to achieve the effect of sealing the implant path c.

[0107] See also Fig.18 , is a fifth embodiment of the physiological signal sensor device of the present invention. The fifth embodiment is similar to the second embodiment, and the difference is that:

[0108] The bottom 31 of the transmitter 3 has another groove at a position corresponding to the top 214a of the through hole 214, and a push piece 46 made of elastic material is arranged in the groove, and the push piece 46 corresponds to the shape of the groove. Therefore, in the fifth embodiment, the push piece 46 of the sealing unit 4 is an upwardly concave groove-shaped structure, and the fourth sealing member 44 protrudes upward and presses against the push piece 46, and they can achieve the effect of sealing the needle path c by squeezing each other.

[0109] See also Fig.19 , is a sixth embodiment of the physiological signal sensor device of the present invention. The sixth embodiment is similar to the fifth embodiment, and the difference is that:

[0110] A groove-like structure that is recessed upward is also formed at the position of the bottom 31 of the transmitter 3 corresponding to the top 214a of the through hole 214. However, in the sixth embodiment, the groove-like structure is used as a stopper 46, and since the stopper 46 and the bottom 31 of the transmitter 3 are integrally formed as hardware, the fourth sealing member 44 is software that protrudes upward from the top 214a of the through hole 214. The fourth sealing member 44 is squeezed on the bottom surface of the stopper 46 and deformed to achieve the effect of sealing the needle path c.

[0111] See also Fig. 20 , is a seventh embodiment of the physiological signal sensor device of the present invention. The seventh embodiment is similar to the second embodiment, and the difference is that:

[0112] In the seventh embodiment, the first seal 42 and the second seal 41 are integrated into a single seal, which is sandwiched between the outer circumference 213 of the fixing seat 21 of the sensor 2, the groove circumference 315 of the first groove 313 of the transmitter 3, and the base 1, so as to simultaneously seal the first liquid leakage path a and the second liquid leakage path b. Specifically, only the first seal 42 is disposed between the fixing seat 21 and the groove circumference 315 of the transmitter 3, and the first seal 42 simultaneously abuts against the top edge of the groove circumference wall 114 of the base 1, so as to simultaneously achieve the effect of preventing blood from entering the first liquid leakage path a and preventing sewage from entering the interior of the transmitter 3 from the second liquid leakage path b.

[0113] In summary, the physiological signal sensor device of the present invention utilizes the sealing unit 4 to seal different leakage paths, so as to effectively prevent external liquids such as external sewage, blood, and body fluids from entering the sensor device, and can prevent blood or body fluids from instantly gushing out and being visible to the user when implanted under the skin of a biological body, thereby reducing the user's fear, so the purpose of the present invention can be achieved.

[0114] The above are merely embodiments of the present invention and should not be used to limit the scope of the present invention. That is, any simple equivalent changes and modifications made according to the claims and description of the present invention still fall within the scope of the present invention.

Claims

1. A physiological signal sensing device, characterized in that: Include: A base, used to be placed on the skin surface of a living organism; Sensors, including The fixing seat has through holes penetrating the top and bottom surfaces thereof; A sensing test piece is disposed on the fixing seat and partially penetrated through the through hole, so as to be implanted under the skin of the organism and measure at least one analytical substance in the organism and transmit a corresponding physiological signal, and the through hole of the fixing seat is used for a needle to removably penetrate to guide the sensing test piece to be partially implanted under the skin of the organism; A transmitter, used for receiving and outputting the physiological signal, the transmitter having a bottom, and the transmitter is covered on the base with the bottom facing the base, so that the fixing base is located between the base and the transmitter, and the sensing test piece is coupled to the transmitter; and Sealing unit, including A top abutment group is located between the bottom of the transmitter and the through hole of the fixing seat of the sensor, the top abutment group seals the through hole of the fixing seat of the sensor, and has a top abutment located at the bottom of the transmitter, and a fourth sealing member arranged at the top of the through hole, the position of the top abutment corresponds to the through hole of the fixing seat and is tightly combined with the top of the through hole, and the top abutment is tightly combined with the fourth sealing member to seal the implant needle path.

2. The physiological signal sensor device according to claim 1, characterized in that: The bottom of the transmitter has a first groove, and the first groove of the transmitter and the base together define an accommodation space to accommodate the fixing seat of the sensor, and the abutting member is arranged on the bottom surface of the first groove.

3. The physiological signal sensor device according to claim 1, characterized in that: The abutting piece of the sealing unit is protruding from the bottom of the emitter, and the top of the fourth sealing piece is in a groove shape for the abutting piece to abut.

4. The physiological signal sensor device according to claim 1, characterized in that: The abutting member of the sealing unit is an upwardly recessed groove-shaped structure, and the fourth sealing member protrudes upwardly and abuts against the abutting member.

5. The physiological signal sensor device according to claim 1, characterized in that: The fourth sealing component is made of elastic material.

6. The physiological signal sensor device according to claim 1, characterized in that: The base has a through hole, and the through hole of the sensor fixing base and the through hole of the base are used for the sensing test strip to pass through, and are used for the implant needle to removably penetrate to guide the sensing test strip to be implanted under the skin of a biological body. The implant needle path extends from the through hole and the through hole to the place where the sensing test strip is coupled to the transmitter.

7. The physiological signal sensor device according to claim 1, characterized in that: The base includes a bottom plate used to be set on the skin surface of the biological body, and a groove wall protruding from the top surface of the bottom plate, the groove wall and the bottom plate together define a setting groove, the fixing seat of the sensor is set in the setting groove, and the sealing unit also includes a third sealing member, which is clamped between the inner wall surface of the groove wall of the base and the outer peripheral surface of the fixing seat of the sensor to seal the first liquid leakage path.

8. The physiological signal sensor device according to claim 7, characterized in that: The base has a through hole connected to the setting groove and for the sensing test strip to pass through so as to be implanted under the skin of the biological body. The first liquid leakage path enters from the through hole and passes between the base and the fixing seat of the sensor, and extends toward the place where the sensing test strip is coupled with the transmitter.

9. A physiological signal sensing device, characterized in that: Include: The base comprises a bottom plate for being arranged on the skin surface of a biological body, and a groove peripheral wall protruding from the top surface of the bottom plate, wherein the groove peripheral wall and the bottom plate jointly define a setting groove; Sensor, including a fixing seat and a sensing piece, The fixing seat is arranged in the setting groove, and has a through hole penetrating the top and bottom surfaces thereof, wherein the through hole is for the sensing test piece to pass through and for the implantation needle to removably pass through to guide the sensing test piece to be implanted under the skin of the organism; The sensing test piece is disposed on the fixing seat and is used to be partially implanted under the skin of the organism to measure at least one analytical substance in the organism and transmit a corresponding physiological signal; A transmitter, used for receiving and outputting the physiological signal, the transmitter having a bottom, and the transmitter is covered on the base with the bottom facing the base, so that the fixing base is located between the base and the transmitter, and the sensing test piece is coupled to the transmitter; and Sealing unit, including a third sealing member, sandwiched between the inner wall surface of the groove peripheral wall of the base and the outer peripheral surface of the fixing seat of the sensor, so as to seal the first liquid leakage path, and The fourth sealing member is arranged at the top of the through hole to seal the implant needle path.

10. The physiological signal sensor device according to claim 9, characterized in that: The bottom plate of the base has a through hole for the sensing test strip to pass through so as to be implanted under the skin of the biological body. The first liquid leakage path enters from the through hole and passes between the base and the fixing seat of the sensor, extending toward the place where the sensing test strip is coupled to the transmitter.

11. The physiological signal sensor device according to claim 9, characterized in that: The fourth sealing component of the sealing unit is made of elastic material.

12. The physiological signal sensor device according to claim 9, characterized in that: The base has a through hole, and the through hole of the sensor fixing base and the through hole of the base are used for the sensing test strip to pass through and for the implant needle to removably penetrate to guide the sensing test strip to be implanted under the skin of a biological body. The implant needle path extends from the through hole and the through hole to the place where the sensing test strip is coupled to the transmitter.

13. The physiological signal sensor device according to claim 9, characterized in that: The sealing unit also includes a top stopper located at the bottom of the transmitter, the position of the top stopper corresponds to the through hole of the fixing seat and is tightly combined with the fourth sealing member at the top of the through hole to seal the implantation needle path.

Images