Online detection and analysis system and detection and analysis method for Chinese medicine liquid components

Abstract

This invention provides an online detection and analysis system and method for the components of traditional Chinese medicine (TCM) liquid extracts. Belonging to the technical field of liquid extract equipment, the system comprises a liquid sampling device that extracts the target liquid from the TCM extraction tank via a bypass circulation path; a filtration device is installed in the sampling path to filter the extracted liquid; a defoaming device is connected to the filtration device to defoam the filtered liquid; a temperature control device is connected to the periphery of the defoaming device to maintain the temperature of the liquid; and an online detection device is connected downstream of the defoaming device to perform component analysis on the filtered, defoamed, and temperature-controlled liquid using an online spectroscopic detection device, obtaining real-time component information. This invention achieves online detection of the components in the TCM extraction process, overcoming the lag of current offline TCM quality detection methods. It provides data support for real-time standardized control of TCM production, improves production processes, and enhances production efficiency and product quality.

Description

Technical Field

[0001] The present invention relates to the technical field of liquid medicine component detection equipment, and in particular to an online detection and analysis system and a detection and analysis method for liquid medicine components of traditional Chinese medicine. Background Art

[0002] The detection and analysis process of Chinese medicine extraction ingredients is an important link in the production process of Chinese medicine. At present, most domestic Chinese medicine manufacturers rely entirely on employee experience to conduct subjective control and adjustment of the extraction process, which is unable to guarantee product quality and is unfavorable to industrial development.

[0003] Traditional Chinese medicine has complex ingredients, and the quality of the production process is difficult to monitor in real time. At present, the production of traditional Chinese medicine still uses the production quality index endpoint detection standard for quality control, which is lagging. Process analysis technology has begun to be applied to the online quality control of traditional Chinese medicine. Among them, spectral online analysis technology has become an important research direction for online quality analysis of traditional Chinese medicine due to its fast analysis speed, non-destructiveness and wide range of detection samples. In addition, due to the different mechanisms and environments of traditional Chinese medicine production sections, establishing an online detection system for specific production sections is the key to ensuring accurate analysis results. Summary of the invention

[0004] The purpose of the present invention is to provide an online detection and analysis system and a detection and analysis method for Chinese medicine liquid components, which can analyze the liquid components in real time during the production process of Chinese medicine, so as to solve at least one technical problem existing in the above-mentioned background technology.

[0005] In order to achieve the above object, the present invention adopts the following technical solutions:

[0006] In one aspect, the present invention provides an online detection and analysis system for components of a traditional Chinese medicine liquid, comprising:

[0007] Liquid sampling device, filtering device, defoaming device, constant temperature device and online detection device;

[0008] The liquid medicine sampling device constructs a bypass circulation path to extract the liquid medicine to be tested from the traditional Chinese medicine extraction tank;

[0009] The filtering device is arranged in the drug liquid sampling path to filter the extracted drug liquid to be tested;

[0010] The defoaming device is connected to the filtering device to perform defoaming treatment on the filtered drug solution to be tested;

[0011] The constant temperature device is connected to the periphery of the defoaming device and is used to maintain the temperature of the drug solution to be tested;

[0012] The online detection device is connected downstream of the defoaming device, and is used to perform component detection and analysis on the constant temperature test liquid after filtering and defoaming using an online spectrum detection system, so as to obtain liquid composition information in real time.

[0013] Preferably, the online detection device includes a detection circulation pool, a detection light source transmitter, a detection light source receiver, a display screen, an optical fiber and a data analysis module; the detection light source transmitter emits light through the optical fiber to enter the detection circulation pool, the light source is emitted after passing through the test liquid in the circulation pool, and is received by the detection light source receiver through the optical fiber to generate detection spectrum data, which is transmitted to the data analysis module for analysis, to obtain real-time composition information of the liquid, and to display it on the display screen.

[0014] Preferably, the front and rear ends of the detection circulation cell are respectively provided with a light source outlet and a light source entrance, the upper and lower parts of the detection circulation cell are respectively provided with a circulation cell sample inlet and a circulation cell sample outlet, and the interior of the detection circulation cell is provided with a sample guide channel; optical lenses are both provided in the light source outlet and the light source entrance.

[0015] Preferably, the medicinal liquid sampling device comprises: a traditional Chinese medicine extraction tank and a metering pump; a sampling port is provided at the bottom of the traditional Chinese medicine extraction tank, and a sample return port is provided at the top of the traditional Chinese medicine extraction tank; the sampling port is connected to the detection circulation pool, and the medicinal liquid after detection returns to the traditional Chinese medicine extraction tank through the sample return port; the metering pump provides power for the bypass circulation system, and realizes flow-controllable extraction of the medicinal liquid by controlling the pump power.

[0016] Preferably, the debubble device comprises: a debubble liquid storage tank connected to the metering pump; the bottom of the debubble liquid storage tank is connected to the detection circulation pool, and the top of the debubble liquid storage tank is connected to the sampling port; a stirring blade is provided inside the debubble liquid storage tank.

[0017] Preferably, the filtering device includes: a primary filter screen arranged at the bottom of the traditional Chinese medicine extraction tank, a secondary filter arranged on the pipeline between the metering pump and the sampling port, and a tertiary filter arranged on the pipeline between the metering pump and the defoaming liquid storage tank.

[0018] Preferably, the constant temperature device includes: an automatic temperature control module, a temperature sensor arranged in the defoaming liquid storage tank, an electric heating structure arranged outside the defoaming liquid storage tank, and an insulation shell arranged outside the electric heating structure; the temperature sensor collects the temperature information of the medicine liquid inside the defoaming liquid storage tank in real time, and sends it to the automatic temperature control module, and the automatic temperature control module controls the opening or closing of the electric heating structure according to the temperature information.

[0019] Preferably, a sampling valve and a third solenoid valve are provided in sequence on the pipeline between the sampling port and the secondary filter; a first solenoid valve is provided on the pipeline between the debubble liquid storage tank and the tertiary filter; a manual check valve and a fifth solenoid valve are provided on the pipeline between the return sample port and the tertiary filter; a second solenoid valve is provided on the pipeline between the detection circulation pool and the metering pump; and a fourth solenoid valve is provided on the pipeline between the debubble liquid storage tank and the detection circulation pool.

[0020] Preferably, the metering pump, the secondary filter, the tertiary filter, the defoaming liquid storage tank and the detection circulation pool are all arranged in a cabinet; the front door of the cabinet is provided with an indicator light, the display screen, the detection switch, a cabinet lock and an emergency stop button; the rear side of the cabinet is provided with an offline detection sampling port, and the offline detection sampling port is connected to the defoaming liquid storage tank; the top of the cabinet is provided with a warning light; the cabinet is provided with an inlet and an outlet respectively connected to the sampling port and the return sample port.

[0021] In a second aspect, the present invention provides a method for detecting and analyzing liquid medicine components using the above-mentioned online detection and analysis system for liquid medicine components, comprising:

[0022] Open the sampling valve, the third solenoid valve, and the first solenoid valve, and start the metering pump. The medicine liquid is pumped into the defoaming liquid storage tank after being filtered; after the medicine liquid in the defoaming liquid storage tank reaches a certain liquid level, close the third solenoid valve, the first solenoid valve and the metering pump, and the stirring blade in the defoaming liquid storage tank stirs the medicine liquid to make it uniform, and the bubbles in the medicine liquid float up and break to complete the defoaming process; the automatic temperature control module controls the operation of the electric heating structure to maintain the temperature of the medicine liquid in the defoaming liquid storage tank at a determined detection temperature; open the second solenoid valve and the fifth solenoid valve, and start the metering pump. The medicine liquid in the defoaming liquid storage tank flows downward through the detection circulation pool, close the second solenoid valve and the metering pump, and turn on the detection switch. The spectral data obtained by the detection is processed and analyzed by the data analysis system to obtain and record the real-time composition information of the medicine liquid, and display it on the display screen; after the online detection is completed, open the second solenoid valve, start the metering pump, and pump the medicine liquid back to the extraction tank to realize bypass circulation.

[0023] The invention has the beneficial effects of realizing online detection of medicinal liquid components in the traditional Chinese medicine extraction process, overcoming the lag of current offline detection of traditional Chinese medicine quality, providing data support for real-time standardized control of traditional Chinese medicine production, improving production technology, and improving production efficiency.

[0024] Additional aspects and advantages of the present invention will be given in part in the following description, which will become obvious from the following description, or may be learned through practice of the present invention. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the accompanying drawings required for use in the description of the embodiments will be briefly introduced below. Obviously, the accompanying drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other accompanying drawings can be obtained based on these accompanying drawings without paying creative work.

[0026] Figure 1 It is a three-dimensional structural diagram of the online detection and analysis system for the components of traditional Chinese medicine liquid described in an embodiment of the present invention.

[0027] Figure 2 This is a rear structural diagram of a cabinet of the online detection and analysis system for traditional Chinese medicine liquid components according to an embodiment of the present invention.

[0028] Figure 3 The figure is a schematic diagram of the piping structure of the online detection and analysis system for the components of traditional Chinese medicine liquid according to an embodiment of the present invention.

[0029] Figure 4 This is a structural diagram of a Chinese medicine extraction tank of an online detection and analysis system for Chinese medicine liquid components described in an embodiment of the present invention.

[0030] Figure 5 This is a structural diagram of the defoaming liquid storage tank of the online detection and analysis system for the components of traditional Chinese medicine liquid described in an embodiment of the present invention.

[0031] Figure 6 The present invention is a schematic diagram of the structure of a detection circulation pool of an online detection and analysis system for components of a traditional Chinese medicine liquid according to an embodiment of the present invention.

[0032] Figure 7 This is a cross-sectional view of the internal structure of a detection circulation pool of an online detection and analysis system for components of a traditional Chinese medicine liquid according to an embodiment of the present invention.

[0033] Among them: 1-sampling valve; 2-secondary filter; 3-detection flow cell; 4-detection light source transmitter; 5-metering pump; 6-detection light source receiver; 7-warning light; 8-defoaming device; 9-traditional Chinese medicine extraction tank; 10-indicator light; 11-display screen; 12-detection switch; 13-cabinet lock; 14-emergency stop button; 15-inlet; 16-beaker; 17-offline detection sampling port; 18-outlet; 19-first solenoid valve; 20-exhaust valve; 21-second solenoid valve; 22-third solenoid valve; 23-three-stage filter; 24-fourth solenoid valve; 25-manual check valve; 26-fifth solenoid valve; 27-pressure gauge; 28-sampling port; 29-first-stage filter; 30-return sample port; 31-stirring blade; 32-insulation shell; 33-electric heating structure; 34-foam removal liquid storage tank; 35-injection micropore; 36-optical path channel; 37-flange; 38-light source outlet; 39-sample guide channel; 40-circulation cell outlet; 41-optical lens; 42-light source entrance; 43-circulation cell inlet. DETAILED DESCRIPTION

[0034] The embodiments of the present invention are described in detail below, and examples of the embodiments are shown in the accompanying drawings, wherein the same or similar reference numerals throughout represent the same or similar elements or elements with the same or similar functions. The embodiments described below by the accompanying drawings are exemplary and are only used to explain the present invention, and cannot be interpreted as limiting the present invention.

[0035] It should be understood by those skilled in the art that unless otherwise defined, all terms (including technical and scientific terms) used herein have the same meaning as commonly understood by those skilled in the art to which this invention belongs.

[0036] It should also be understood that terms, such as those defined in commonly used dictionaries, should be understood to have a meaning consistent with that in the context of the prior art and will not be interpreted in an idealized or overly formal sense unless as defined herein.

[0037] Those skilled in the art will appreciate that, unless otherwise stated, the singular forms "a", "an", "said" and "the" used herein may also include plural forms. It should be further understood that the term "comprising" used in the specification of the present invention refers to the presence of the features, integers, steps, operations, elements and / or components, but does not exclude the presence or addition of one or more other features, integers, steps, operations, elements and / or groups thereof.

[0038] In the description of this specification, the description with reference to the terms "one embodiment", "some embodiments", "example", "specific example", or "some examples" means that the specific features, structures, materials or characteristics described in conjunction with the embodiment or example are included in at least one embodiment or example of the present invention. Moreover, the specific features, structures, materials or characteristics described may be combined in any one or more embodiments or examples in a suitable manner. In addition, those skilled in the art may combine and combine different embodiments or examples described in this specification and the features of different embodiments or examples, unless they are contradictory.

[0039] To facilitate understanding of the present invention, the present invention is further explained below with reference to specific embodiments in conjunction with the accompanying drawings, and the specific embodiments do not constitute a limitation on the embodiments of the present invention.

[0040] Those skilled in the art should understand that the drawings are merely schematic diagrams of embodiments, and the components in the drawings are not necessarily necessary for implementing the present invention.

[0041] Example 1

[0042] like Figures 1 to 7 As shown, Embodiment 1 of the present invention provides an online detection and analysis system for components of a traditional Chinese medicine liquid, the system comprising:

[0043] Liquid sampling device, filtering device, defoaming device, constant temperature device and online detection device;

[0044] The liquid medicine sampling device constructs a bypass circulation path to extract the liquid medicine to be tested from the traditional Chinese medicine extraction tank;

[0045] The filtering device is arranged in the drug liquid sampling path to filter the extracted drug liquid to be tested;

[0046] The defoaming device is connected to the filtering device to perform defoaming treatment on the filtered drug solution to be tested;

[0047] The constant temperature device is connected to the periphery of the defoaming device and is used to maintain the temperature of the drug solution to be tested;

[0048] The online detection device is connected downstream of the defoaming device, and is used to perform component detection and analysis on the constant temperature test liquid after filtering and defoaming using an online spectrum detection system, so as to obtain liquid composition information in real time.

[0049] In this embodiment 1, the online detection device includes a detection circulation pool 3, a detection light source transmitter 4, a detection light source receiver 6, a display screen 11, an optical fiber and a data analysis module; the detection light source transmitter 4 emits a light source which is incident on the detection circulation pool 3 through the optical fiber, and the light source is emitted after passing through the test liquid in the detection circulation pool 3, and is received by the detection light source receiver 6 through the optical fiber, and the detection spectrum data is generated and transmitted to the data analysis module for analysis, so as to obtain the real-time composition information of the liquid and display it through the display screen 11.

[0050] In this embodiment 1, the front and rear ends of the detection circulation pool 3 are respectively provided with a light source outlet 38 and a light source incident port 42, the upper part of the detection circulation pool 3 is provided with a circulation pool sample inlet 43, the lower part of the detection circulation pool 3 is provided with a circulation pool sample outlet 40, the middle part of the detection circulation pool 3 is provided with a sample injection microhole 35 and an optical path channel 36, and the interior of the detection circulation pool 3 is provided with a sample guide channel 39; lenses 41 are provided in the light source outlet 38 and the light source incident port 42; flange structures 37 are provided above and below the detection circulation pool 3.

[0051] In this embodiment 1, the medicinal liquid sampling device includes: a traditional Chinese medicine extraction tank 9 and a metering pump 5; a sampling port 28 is provided at the bottom of the traditional Chinese medicine extraction tank 9, and a return sample port 30 is provided at the top of the traditional Chinese medicine extraction tank 9; the sampling port 28 is connected to the detection circulation pool 3, and the medicinal liquid after detection returns to the traditional Chinese medicine extraction tank 9 through the return sample port 30; the metering pump provides power for the bypass circulation system, and realizes flow-controllable extraction of the medicinal liquid by controlling the pump power.

[0052] The debubble device comprises: a debubble liquid storage tank 34 connected to the metering pump 5, the bottom of the debubble liquid storage tank 34 is connected to the detection circulation pool 3, and the top of the debubble liquid storage tank 34 is connected to the sampling port 30; a stirring blade 31 is provided inside the debubble liquid storage tank 34.

[0053] The filtering device includes: a primary filter screen 29 arranged at the bottom of the Chinese medicine extraction tank 9, a secondary filter 2 arranged on the pipeline between the metering pump 5 and the sampling port 28, and a tertiary filter 23 arranged on the pipeline between the metering pump 5 and the defoaming liquid storage tank 34.

[0054] The constant temperature device includes: an automatic temperature control module, a temperature sensor arranged in the defoaming liquid storage tank 34, an electric heating structure 33 arranged outside the defoaming liquid storage tank 34, and an insulation shell 32 arranged outside the electric heating structure 33; the temperature sensor collects the temperature information of the medicine liquid inside the defoaming liquid storage tank 34 in real time and sends it to the automatic temperature control module, and the automatic temperature control module controls the opening or closing of the electric heating structure 33 according to the temperature information.

[0055] A sampling valve 1 and a third solenoid valve 22 are provided in sequence on the pipeline between the sampling port 28 and the secondary filter 2; a first solenoid valve 19 is provided on the pipeline between the debubble liquid storage tank 34 and the tertiary filter 23; a manual check valve 25 is provided on the pipeline between the return sample port 30 and the tertiary filter 23; a second solenoid valve 21 is provided on the pipeline between the detection circulation pool 3 and the secondary filter 2; a fourth solenoid valve 24 is provided on the pipeline between the debubble liquid storage tank 34 and the detection circulation pool 3; a fifth solenoid valve 26 is provided on the pipeline between the manual check valve 25 and the return sample port 30.

[0056] The metering pump 5, the secondary filter 2, the tertiary filter 23, the defoaming liquid storage tank 34 and the detection circulation pool 3 are all arranged in the cabinet; the front door of the cabinet is provided with an indicator light 10, the display screen 11, the detection switch 12, the cabinet lock 13 and the emergency stop button 14; the top of the cabinet is provided with a warning light 7; the cabinet is provided with an inlet 15 and a sample outlet 18 respectively connected to the sampling port 28 and the return sample port 30.

[0057] In this embodiment 1, the method for detecting and analyzing the components of a Chinese medicine liquid using the above-mentioned online detection and analysis system for the components of a Chinese medicine liquid includes the following steps:

[0058] Open the sampling valve, the third solenoid valve, and the first solenoid valve, and start the metering pump. The medicine liquid is pumped into the defoaming liquid storage tank after being filtered; after the medicine liquid in the defoaming liquid storage tank reaches a certain liquid level, close the third solenoid valve, the first solenoid valve and the metering pump, and the stirring blade in the defoaming liquid storage tank stirs the medicine liquid to make it uniform, and the bubbles in the medicine liquid float up and break to complete the defoaming process; the automatic temperature control module controls the operation of the electric heating structure to maintain the temperature of the medicine liquid in the defoaming liquid storage tank at a determined detection temperature; open the second solenoid valve and the fifth solenoid valve, and start the metering pump. The medicine liquid in the defoaming liquid storage tank flows downward through the detection circulation pool, close the second solenoid valve and the metering pump, and turn on the detection switch. The spectral data obtained by the detection is processed and analyzed by the data analysis system to obtain and record the real-time composition information of the medicine liquid, and display it on the display screen; after the online detection is completed, open the second solenoid valve, start the metering pump, and pump the medicine liquid back to the extraction tank to realize bypass circulation.

[0059] Example 2

[0060] like Figures 1 to 7 As shown, Embodiment 2 of the present invention provides an online detection system for liquid medicinal components in a traditional Chinese medicine extraction process, comprising:

[0061] Liquid sampling device, filtering device, defoaming device, constant temperature device and online detection device;

[0062] The liquid medicine sampling device constructs a bypass circulation path to extract the liquid medicine to be tested from the Chinese medicine extraction tank 9;

[0063] The filtering device is arranged in the drug liquid sampling path, and adopts a three-stage filtering method to filter solid impurities such as drug residues and suspended matter in the drug liquid;

[0064] The defoaming device is arranged after the filtering device to perform defoaming treatment on the sampled drug solution to be tested; the constant temperature device is arranged outside the defoaming system to maintain the drug solution to be tested at a determined detection temperature by using an automatic temperature control system;

[0065] The online detection device is arranged after the defoaming system, and uses the online spectrum detection system to perform component detection and analysis on the constant temperature medicinal liquid after filtering and defoaming, and the real-time component information of the medicinal liquid is obtained by analysis. The completion time of the medicinal liquid extraction can be judged according to the change trend of the component curve.

[0066] The liquid medicine sampling device builds a bypass circulation detection path, and uses the metering pump 5 to provide power to achieve flow-controlled extraction of the Chinese medicine liquid. The bypass circulation detection path includes an online detection path and a bypass circulation path, which are coordinated and controlled by the solenoid valves (the first solenoid valve 19, the second solenoid valve 21, the third solenoid valve 22, the fourth solenoid valve 24, and the fifth solenoid valve 26) arranged in the path, and a manual check valve 25 is arranged in the pipeline to realize the flow of the liquid medicine in the specified path direction.

[0067] The filtering device adopts a three-stage filtering method to filter impurities in the medicinal solution. A primary filter screen 29 is arranged at the bottom of the Chinese medicine extraction tank, and a secondary filter 2 and a tertiary filter 23 are arranged in the bypass circulation path, respectively located before and after the metering pump. The three-stage filtering method can achieve the best filtering effect.

[0068] The secondary filter 2 and the tertiary filter 23 can replace filter elements with different mesh sizes to cope with different filtering conditions. Filter elements with different filtering precisions are selected to meet different liquid medicine filtering requirements. The filter elements can be disassembled, cleaned, and reused to avoid bypass blockage hazards.

[0069] The defoaming device includes a defoaming liquid storage tank 34 and a stirring blade 31 arranged inside. Special inclined structures are arranged on the upper part and the bottom of the tank body, which are respectively used to prevent the secondary bubbles of the liquid medicine from being generated and to ensure that the liquid medicine flows out; the stirring blade 31 is arranged inside the liquid storage tank, and the liquid medicine is stirred to obtain a uniform liquid. The bubbles in the liquid medicine move upward to the liquid surface. After the bubbles are broken, the gas is discharged from the upper exhaust valve 20, and the bubble-free liquid medicine is at the bottom of the liquid storage tank for subsequent detection, thereby realizing the defoaming process.

[0070] The constant temperature device includes an electric heating structure, a heat preservation device and an automatic temperature control system; the electric heating structure 33 is arranged on the periphery of the defoaming liquid storage tank 34 to maintain the temperature of the liquid in the liquid storage tank at a determined detection temperature; a heat preservation device is arranged outside the pipeline between the liquid storage tank and the detection circulation pool for heat preservation.

[0071] The electric heating structure 33 is controlled by an automatic temperature control system. A temperature sensor is provided in the Chinese medicine extraction tank to detect the temperature of the liquid in the tank. The temperature control system automatically controls the operation of the electric heating device (electric heating structure 33) according to the actual detected liquid temperature.

[0072] The online detection device includes a detection light source transmitter 4, a detection light source receiver 6, a detection circulation pool 3, a display screen 11, an optical fiber and a data analysis system; the detection circulation pool 3 is arranged below the debubbling device, and the front and rear interfaces of the circulation pool are respectively connected to the detection light source transmitter 4 and the detection light source receiver 6 through optical fibers, and the upper and lower interfaces are respectively connected to the sample inlet and sample outlet ducts. The detection light source is received again after passing through the medicine in the circulation pool to form online spectral detection data of the medicine, and the data is transmitted to the data analysis system for analysis to obtain and record the real-time composition information of the medicine, and at the same time display it through the display screen.

[0073] The detection space inside the detection circulation pool 3 is enclosed by optical lenses 41 at both ends. This enclosed detection space can eliminate unnecessary interference from environmental factors. A small optical path channel is provided in the middle of the circulation pool for the detection light to pass through. In addition, a small inclined channel structure (i.e., the sample guide channel 39) is opened inside the detection circulation pool to stabilize the flow rate of the drug solution and keep the drug solution in a uniform state.

[0074] The flange structures provided at the upper and lower ends of the detection circulation pool are used to fix the circulation pool. The upper and lower interfaces of the circulation pool are connected to the inlet and outlet pipelines of the drug solution. The special closed space inside the circulation pool can stabilize the flow rate of the drug solution, keep it in a continuous and uniform state, and improve the accuracy and stability of online detection.

[0075] The online detection device adopts a four-way parallel detection method, and the detection data between different paths form a sufficient comparative analysis. That is, it includes two defoaming liquid storage tanks 34, each of which is connected to two detection flow cells 3. The drug solution is transported to the two defoaming liquid storage tanks, and each defoaming liquid storage tank is divided into two detection paths below, which constitutes a sufficient comparative detection analysis, making the detection result more accurate and stable.

[0076] The online detection device is provided with an offline detection sampling port 17 on the rear cover of the cabinet, and a beaker 16 can be used to sample the drug solution to be tested for offline analysis.

[0077] In the present embodiment 2, the online detection device is connected to the Chinese medicine extraction tank 9, and the electromagnetic valves and metering pumps are coordinated to control the operation. The medicinal liquid is extracted from the extraction tank, and is pumped into the defoaming liquid storage tank after filtration. The stirring blades in the liquid storage tank stir the medicinal liquid to make it uniform, and the bubbles in the medicinal liquid float up and break to complete the defoaming treatment; the automatic temperature control system controls the operation of the electric heating device to maintain the temperature of the medicinal liquid in the liquid storage tank at a determined detection temperature; the online detection system is turned on to detect the constant temperature medicinal liquid after filtration and defoaming, and the spectral data obtained by the detection is processed and analyzed by the data analysis system to obtain the real-time component information of the medicinal liquid and record it, and display it on the display screen at the same time; while the online detection is being performed, the offline detection electromagnetic valve (i.e., the fourth electromagnetic valve 24) can be opened for sampling, and the sample liquid is used for offline detection and analysis, and the analysis results can be used to calibrate the online detection model of the medicinal liquid; the medicinal liquid after the online detection is pumped back to the extraction tank to realize the bypass cycle; the above steps are repeated for detection, and the analysis results of each time are counted to form a medicinal liquid component change curve, and the time when the Chinese medicine extraction is completed is accurately judged according to the curve change trend.

[0078] Example 3

[0079] like Figure 1 As shown, Example 3 of the present invention provides an online detection device for liquid medicine components in a Chinese medicine extraction process, comprising a liquid medicine sampling system, a filtration system, a defoaming system, a constant temperature system and an online detection system. The device of Example 3 adopts a bypass circulation sampling method to perform online detection of liquid medicine components in a Chinese medicine extraction process.

[0080] Specifically, a primary filtering device (i.e., a primary filter mesh 29) is provided at the bottom of the Chinese medicine extraction tank 9 to filter the medicine residue. A sampling valve 1 is provided at the sampling port 28 at the bottom of the Chinese medicine extraction tank 9, which is connected to the third solenoid valve 22 through a stainless steel pipe. Both control the injection of the medicine solution at the same time. The metering pump 5 provides power for the entire bypass circulation system. The secondary filter 2 and the tertiary filter 23 are respectively provided before and after the metering pump. Two detection circulation pools are connected under each defoaming device 8 to form four-way parallel online detection. An offline detection sampling port 17 is also provided at the bottom of the defoaming device, which is opened and closed by the fourth solenoid valve 24. The beaker 16 is used to receive the sample solution.

[0081] An indicator light 10 is provided on the front cover of the cabinet of the online detection device to indicate the detection status, a detection switch 12 controls the detection opening and closing, an emergency stop button 14 is provided to deal with emergencies, a display screen 11 is also provided on the front cover to display the detection information in real time, and a warning light 7 is provided above the detection device to generate an alarm signal.

[0082] like Figure 3As shown, the bypass circulation online detection system includes an online detection path and a bypass circulation path, which are simultaneously controlled and switched by the first solenoid valve 19, the second solenoid valve 21, the third solenoid valve 22 and the fifth solenoid valve 26, and a check valve 25 is provided in the pipeline to enable the liquid medicine to flow in the specified path direction.

[0083] like Figure 4 As shown, a sampling port 28 is arranged at the bottom of the Chinese medicine extraction tank, and a return sample port 30 is arranged at the top to receive the returned sample liquid after testing to realize circulation. A pressure gauge 27 is also installed above the extraction tank to detect the pressure inside the tank.

[0084] like Figure 5 As shown, in the defoaming device, an electric heating device 33 is arranged outside the defoaming liquid storage tank 34, a stirring blade 31 is arranged inside, and a heat-insulating shell 32 is arranged at the outermost part of the device.

[0085] like Figure 6 , Figure 7 As shown, flange structures 37 are provided at the upper and lower ends of the detection circulation pool, a light source outlet 38 and a light source entrance 42 are provided at the front and rear of the circulation pool respectively, a circulation pool sample inlet 43 and a sample outlet 40 are provided at the top and bottom respectively, and a special inclined sample guide path 39 is provided inside the circulation pool to stabilize the flow rate of the drug solution.

[0086] In this embodiment, the liquid medicine sampling system can select different devices according to actual requirements. This sampling system preferably uses a 100L micro-Chinese medicine extraction tank, and the sampling pipeline is preferably a 4-branch pipe made of 304 stainless steel. The metering pump model selection must meet the requirements of providing sufficient pressure to realize the bypass circulation of the detection liquid medicine. The metering pump and solenoid valve used in the sampling system are coordinated and controlled by the controller. The operating power of the pump can be adjusted according to actual conditions, and the solenoid valve remains closed when it is not working.

[0087] In this embodiment 3, the filtering system, the bottom of the Chinese medicine extraction tank 9 preferably has a primary filter screen with a mesh size of 80, a secondary filter preferably has a filter element with a pore size of 10 microns, and a tertiary filter preferably has a filter element with a pore size of 1 micron. The three-stage filtering method can achieve a sufficient filtering effect and remove the interference of impurities on the detection of the liquid medicine. The filter screen and filter element selected in this filtering system are made of stainless steel, which is easy to disassemble and wash to prevent pipeline blockage.

[0088] The defoaming system is combined with the constant temperature system. The electric heating device (i.e., the electric heating structure) surrounds the defoaming liquid storage tank to evenly heat the medicine liquid in the defoaming liquid storage tank 34 and maintain the temperature of the medicine liquid at a determined detection temperature. A stirring blade is arranged inside the defoaming liquid storage tank to stir the medicine liquid so as to obtain a uniform medicine liquid and heat the liquid evenly. The bubbles in the medicine liquid float to the surface of the liquid and break, and the gas is discharged from the exhaust valve 20 above the liquid storage tank.

[0089] The online detection system is composed of a detection flow cell 3, a detection light source transmitter 4, a detection light source receiver 6, a display screen 11, an optical fiber and a data analysis system. The liquid medicine enters from the upper end of the detection flow cell, passes through the special space inside the flow cell, and forms a stable and uniform state. The detection light source transmitter 4 emits a light source through the optical fiber from the rear end of the detection flow cell 3, and the light source is emitted from the front end after passing through the liquid medicine in the flow cell, and is received by the detection light source receiver 6 through the optical fiber, and the detection spectrum data is generated and transmitted to the data analysis system for analysis, and the real-time component information of the liquid medicine is obtained, and displayed on the display screen, so as to realize the function of online detection of liquid medicine components in the traditional Chinese medicine extraction process.

[0090] The catheters, battery valves, filters, metering pumps, liquid storage tanks, circulation pools and other devices involved in the entire bypass circulation path are all made of stainless steel. The materials used are food grade and suitable for the production requirements of traditional Chinese medicine.

[0091] The upper part of the defoaming liquid storage tank is provided with an inclined structure (inclined wall), and the liquid medicine entering from the upper inlet flows into the liquid storage tank along the inclined wall and the vertical wall successively, so as to prevent the generation of secondary bubbles in the liquid medicine. The bottom of the liquid storage tank is also provided with an inclined structure, which can ensure that the liquid medicine flows out and avoids accumulation.

[0092] The electric heating device is controlled by an automatic temperature control system. A temperature sensor is provided in the defoaming liquid storage tank 34 to detect the temperature of the liquid in the tank. The temperature control system automatically controls the operation of the electric heating device (electric heating structure 33) according to the actual detected liquid temperature, and maintains the temperature of the medicine liquid in the defoaming liquid storage tank 34 at a determined detection temperature. In addition, the medicine liquid conduit between the liquid storage tank and the detection circulation pool is wrapped with an insulating sponge on the periphery for insulation to eliminate the influence of temperature changes on the medicine liquid detection.

[0093] The detection space inside the detection flow cell is closed by optical lenses 41 at both ends, and a small optical path channel 36 is provided in the middle for the detection light to pass through. This closed detection space can eliminate unnecessary interference from environmental factors. In addition, a small inclined channel structure (sample guide channel 39) is opened inside the detection flow cell to achieve the connection between the flow cell sample inlet 43, the flow cell sample outlet 40 and the detection space. The inclined channel structure can stabilize the flow rate of the drug solution, keep the drug solution state uniform, and improve the accuracy and stability of online detection.

[0094] The online detection system adopts a four-way parallel detection method, and the detection data between different roads form a sufficient comparative analysis. The final detection result takes the average value of the detection results of each road, further improving the accuracy and stability of online detection. The back cover of the online detection device is provided with an offline detection sampling port, which can open the fourth solenoid valve 24 to sample a certain amount of the drug solution to be tested for offline analysis. The analysis results can be used to calibrate and update the online detection model of the drug solution.

[0095] In this embodiment 3, the working method of the above-mentioned device for online detection of liquid medicinal components in a traditional Chinese medicine extraction process specifically comprises the following steps:

[0096] The online detection device is connected to the Chinese medicine extraction tank through a catheter. After the medicinal materials and the solvent are added, the extraction tank starts to work; the sampling valve 1, the third solenoid valve 22, and the first solenoid valve 19 are opened, and the controller controls the metering pump 5 to work at a certain power. The medicinal liquid is pumped into the defoaming liquid storage tank 34 after being filtered; after the medicinal liquid in the defoaming liquid storage tank 34 reaches a certain liquid level, the third solenoid valve, the first solenoid valve and the metering pump are closed, and the stirring blades in the liquid storage tank stir the medicinal liquid to make it uniform, and the bubbles in the medicinal liquid float up and break to complete the defoaming process.

[0097] The automatic temperature control system controls the operation of the electric heating device to maintain the temperature of the medicine liquid in the defoaming liquid storage tank 34 at the determined detection temperature; opens the second solenoid valve 21 and the fifth solenoid valve 26, controls the metering pump 5 to operate at a lower power, and the medicine liquid in the defoaming liquid storage tank 34 flows downward through the detection circulation pool 3, closes the second solenoid valve and the metering pump, and opens the detection switch 12 on the front cover to start the detection system. The spectral data obtained by the detection is processed and analyzed by the data analysis system to obtain and record the real-time composition information of the medicine liquid, and display it on the display screen.

[0098] During the online detection, the fourth electromagnetic valve 24 for offline detection can be opened for sampling, and the sample liquid is used for offline detection; after the online detection is completed, the second electromagnetic valve is opened, the metering pump is turned on, and the medicinal liquid is pumped back to the extraction tank to realize bypass circulation; after all the medicinal liquid in the storage tank is pumped out, the third electromagnetic valve 22 is opened, the second electromagnetic valve 21 is closed, and the metering pump 5 is adjusted back to the original power to extract the medicinal liquid from the Chinese medicine extraction tank 9 for a certain period of bypass circulation, and the remaining medicinal liquid in the catheter from the last detection is removed, and then the above operation is repeated for subsequent detection; the time interval for each detection is determined by the actual detection requirements, and the analysis results of each time are statistically formed to form a medicinal liquid composition change curve, and the time for the completion of the Chinese medicine extraction is accurately judged according to the curve change trend, which effectively improves the production efficiency of Chinese medicine.

[0099] In summary, the online detection and analysis system for the composition of traditional Chinese medicine liquid described in the embodiment of the present invention comprises a liquid medicine sampling device, a filtering device, a defoaming device, a constant temperature device and an online detection device; the liquid medicine sampling device builds a bypass circulation path to extract the liquid medicine to be tested from the traditional Chinese medicine extraction tank; the filtering device is arranged in the liquid medicine sampling path, and adopts a three-stage filtration method to filter out solid impurities in the liquid medicine; the defoaming device is arranged after the filtering device, and performs defoaming treatment on the sampled liquid medicine to be tested; the constant temperature device is arranged on the periphery of the defoaming device, and uses an automatic temperature control system to maintain the liquid medicine to be tested at a determined detection temperature; the online detection device is arranged after the defoaming device, and uses an online spectral detection system to perform component detection and analysis on the constant temperature liquid medicine after filtration and defoaming, and the real-time component information of the liquid medicine is obtained by analysis, and the completion time of the liquid medicine extraction can be judged according to the change trend of the component curve.

[0100] The online detection and analysis system for the liquid medicine components in the Chinese medicine extraction process described in the embodiment of the present invention realizes the online detection of the liquid medicine components in the Chinese medicine extraction process, overcomes the lag of the current offline detection of the quality of Chinese medicine, provides data support for the real-time standardized control of Chinese medicine production, improves the original method of subjective control based on experience, and improves production efficiency. It realizes the automated analysis of the Chinese medicine extraction process, promotes the informatization and automation of the entire Chinese medicine production process, enhances the understanding of the process, improves the production process, narrows the differences between different production batches of medicines, and achieves stable and uniform quality. It is suitable for online detection of Chinese medicine extraction in different environments and different medicinal materials, has low requirements for the transformation of the Chinese medicine extraction tank, and is suitable for industrial promotion.

[0101] The above description is only a preferred embodiment of the present disclosure and is not intended to limit the present disclosure. For those skilled in the art, the present disclosure may have various modifications and variations. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present disclosure shall be included in the protection scope of the present disclosure.

[0102] Although the above describes the specific implementation methods of the present disclosure in conjunction with the accompanying drawings, it is not intended to limit the scope of protection of the present disclosure. Technical personnel in the relevant field should understand that various modifications or variations that can be made by those skilled in the art without creative work on the basis of the technical solution disclosed in the present invention should be included in the scope of protection of the present invention.

Claims

1. An online detection and analysis system for Chinese medicine liquid components, characterized in that: include: A liquid medicine sampling device, a filtering device, a defoaming device (8), a constant temperature device and an online detection device; The liquid medicine sampling device constructs a bypass circulation path to extract the liquid medicine to be tested from the traditional Chinese medicine extraction tank (9); The filtering device is arranged in the drug liquid sampling path to filter the extracted drug liquid to be tested; The defoaming device (8) is connected to the filtering device to perform defoaming treatment on the filtered drug solution to be tested; The constant temperature device is connected to the periphery of the defoaming device and is used to maintain the temperature of the drug solution to be tested; The online detection device is connected downstream of the defoaming device, and is used to detect and analyze the composition of the constant temperature test liquid after filtering and defoaming using the online spectrum detection device, so as to obtain the composition information of the liquid in real time; The online detection and analysis system is specifically: The filtering device adopts a three-stage filtering method to filter impurities in the medicinal solution. A primary filter (29) is arranged at the bottom of the Chinese medicine extraction tank, and a secondary filter (2) and a tertiary filter (23) are arranged in a bypass circulation path, respectively located before and after the metering pump, so that the three-stage filtering method is adopted to achieve the best filtering effect; The online detection device comprises a detection flow cell (3), a detection light source transmitter (4), a detection light source receiver (6), a display screen (11), an optical fiber and a data analysis module; The online detection and analysis system adopts a four-way parallel detection method, and the detection data between different ways form a sufficient comparative analysis, and the final detection result is the average value of the detection results of each way; the rear cover of the online detection device is provided with an offline detection sampling port (17), and the fourth electromagnetic valve (24) is opened to sample a certain amount of the drug solution to be tested for offline analysis, and the analysis result is used to calibrate and update the drug solution online detection model; The detection circulation pool (3) is provided with a light source outlet (38) and a light source incident port (42) at the front and rear ends respectively; the detection circulation pool (3) is provided with a circulation pool sample inlet (43) and a circulation pool sample outlet (40) at the upper part; the detection circulation pool (3) is provided with a sample inlet microhole (35) and an optical path channel (36) at the middle part; the detection circulation pool (3) is provided with a sample guide channel (39) inside; the light source outlet (38) and the light source incident port (42) are both provided with optical lenses (41); the detection circulation pool (3) is provided with flange structures (37) at the top and bottom; The liquid medicine sampling device comprises: a Chinese medicine extraction tank (9) and a metering pump (5); a sampling port (28) is provided at the bottom of the Chinese medicine extraction tank (9), and a sample return port (30) is provided at the top of the Chinese medicine extraction tank (9); The defoaming device comprises: a defoaming liquid storage tank (34) connected to the metering pump (5); a stirring blade (31) is arranged inside the defoaming liquid storage tank (34); special inclined structures are arranged on the upper part and the bottom of the tank body, respectively used to prevent the secondary bubbles of the liquid medicine from being generated and to ensure that the liquid medicine flows out; the stirring blade (31) is arranged inside the liquid storage tank, stirring the liquid medicine to obtain a uniform liquid, and the bubbles in the liquid medicine move upward to the liquid surface, and the gas is discharged from the upper exhaust valve (20) after the bubbles are broken, and the bubble-free liquid medicine is at the bottom of the liquid storage tank for subsequent detection; A sampling valve (1) and a third solenoid valve (22) are provided in sequence on the pipeline between the sampling port (28) and the secondary filter (2); a first solenoid valve (19) is provided on the pipeline between the debubble liquid storage tank (34) and the tertiary filter (23); a manual check valve (25) is provided on the pipeline between the return sample port (30) and the tertiary filter (23); a second solenoid valve (21) is provided on the pipeline between the detection circulation pool (3) and the secondary filter (2); a fourth solenoid valve (24) is provided on the pipeline between the debubble liquid storage tank (34) and the detection circulation pool (3); and a fifth solenoid valve (26) is provided on the pipeline between the manual check valve (25) and the return sample port (30); The liquid medicine sampling device is provided with a bypass circulation detection path, and a metering pump (5) is used to provide power; the bypass circulation detection path includes an online detection path and a bypass circulation path, and is coordinated and controlled by a first solenoid valve (19), a second solenoid valve (21), a third solenoid valve (22), a fourth solenoid valve (24), and a fifth solenoid valve (26) arranged in the path, and a manual check valve (25) is arranged in the pipeline; The metering pump (5), the secondary filter (2), the tertiary filter (23), the defoaming liquid storage tank (34) and the detection circulation pool (3) are all arranged in a cabinet; the front door of the cabinet is provided with an indicator light (10), the display screen (11), a detection switch (12), a cabinet lock (13) and an emergency stop button (14); the rear side of the cabinet is provided with an offline detection sampling port (17), and the offline detection sampling port (17) is connected to the defoaming liquid storage tank (34); the top of the cabinet is provided with a warning light (7); and the cabinet is provided with a sampling port (15) and a sampling port (18) respectively connected to the sampling port (28) and the sample return port (30).

2. The online detection and analysis system for Chinese medicine liquid components according to claim 1 is characterized in that: The detection light source transmitter (4) emits light through an optical fiber and enters the detection circulation pool (3). The light source is transmitted through the drug solution to be tested in the detection circulation pool (3) and then emitted. The light source is received by the detection light source receiver (6) through the optical fiber, and detection spectrum data is generated and transmitted to the data analysis module for analysis, thereby obtaining real-time component information of the drug solution and displaying it on the display screen (11).

3. The online detection and analysis system for Chinese medicine liquid components according to claim 1 is characterized in that: The sampling port (28) is connected to the detection circulation pool (3), and the detected medicinal liquid returns to the traditional Chinese medicine extraction tank (9) through the sample return port (30); the metering pump (5) provides power for the bypass circulation system, and the flow-controllable extraction of the medicinal liquid is achieved by controlling the pump power.

4. The online detection and analysis system for Chinese medicine liquid components according to claim 1 is characterized in that: The bottom of the debubble liquid storage tank (34) is connected to the detection circulation pool (3), and the top of the debubble liquid storage tank (34) is connected to the sampling port (28).

5. The online detection and analysis system for Chinese medicine liquid components according to claim 1 is characterized in that: The filtering device comprises: a primary filter screen (29) arranged at the bottom of the Chinese medicine extraction tank (9), a secondary filter (2) arranged on the pipeline between the metering pump (5) and the sampling port (28), and a tertiary filter (23) arranged on the pipeline between the metering pump (5) and the defoaming liquid storage tank (34).

6. The online detection and analysis system for Chinese medicine liquid components according to claim 1 is characterized in that: The constant temperature device comprises: an automatic temperature control module, a temperature sensor arranged in the defoaming liquid storage tank (34), an electric heating structure (33) arranged outside the defoaming liquid storage tank (34), and a heat preservation shell (32) arranged outside the electric heating structure (33); the temperature sensor collects temperature information of the medicine liquid in the defoaming liquid storage tank (34) in real time and sends it to the automatic temperature control module, and the automatic temperature control module controls the opening or closing of the electric heating structure (33) according to the temperature information.

7. A method for detecting and analyzing liquid medicine components using the online detection and analysis system for liquid medicine components of traditional Chinese medicine as described in any one of claims 1 to 6, characterized in that: Open the sampling valve, the third solenoid valve, and the first solenoid valve, and start the metering pump. The medicine liquid is pumped into the defoaming liquid storage tank after being filtered; after the medicine liquid in the defoaming liquid storage tank reaches a certain liquid level, close the third solenoid valve, the first solenoid valve and the metering pump, and the stirring blade in the defoaming liquid storage tank stirs the medicine liquid to make it uniform, and the bubbles in the medicine liquid float up and break to complete the defoaming process; the automatic temperature control module controls the operation of the electric heating structure to maintain the temperature of the medicine liquid in the defoaming liquid storage tank at a determined detection temperature; open the second solenoid valve and the fifth solenoid valve, and start the metering pump. The medicine liquid in the defoaming liquid storage tank flows downward through the detection circulation pool, close the second solenoid valve and the metering pump, and turn on the detection switch. The spectral data obtained by the detection is processed and analyzed by the data analysis system to obtain and record the real-time composition information of the medicine liquid, and display it on the display screen; after the online detection is completed, open the second solenoid valve, start the metering pump, and pump the medicine liquid back to the extraction tank to realize bypass circulation.

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