A fully automatic luminescence measuring instrument

Abstract

The present invention relates to a fully automatic luminescence measuring instrument, belonging to the technical field of medical equipment. The luminescence measuring instrument comprises a housing, a darkroom, a controller, a photomultiplier tube, a reading head, an X-direction motor, an X-direction pulley, an X-direction belt, a Y-direction motor, a Y-direction belt, a Y-direction pulley and a bracket. The darkroom and the photomultiplier tube are installed inside the housing, the reading head is installed at the end of the photomultiplier tube, the reading head is located inside the darkroom, the photomultiplier tube, the reading head, the X-direction motor and the Y-direction motor are all associated with the controller; the X-direction bracket is installed with a zero position photoelectric switch for entering the warehouse and a zero position photoelectric switch for exiting the warehouse, the Y-direction bracket is installed with an X-direction induction sheet; the Y-direction bracket is installed with a longitudinal photoelectric switch, and the bracket is installed with a Y-direction induction sheet. The microplate of the luminescence measuring instrument adopts two-point positioning, the whole machine does not need to measure and debug the length of entering and exiting the warehouse, the structure is simple, the installation is convenient, and the positioning is accurate.

Description

Technical Field

[0001] The invention relates to a full-automatic luminescence measuring instrument, belonging to the technical field of medical equipment. Background Art

[0002] Luminescence immunoassay is a method that combines luminescence reaction with immune reaction to detect antigens or antibodies. It uses micro-multiplication technology, with good sensitivity and specificity; the detection range is very wide, ranging from traditional proteins, hormones, enzymes to drugs. The photomultiplier tube used is a vacuum electronic device that converts weak light signals into electrical signals, and can measure extremely weak radiation power with a wavelength of 200 to 1200 nanometers in low-energy photometry and spectroscopy.

[0003] For fully automatic luminescence meters, the positioning of the luminescent microplate is very important, which directly affects the detection accuracy and efficiency. Existing luminescence meters often have errors in microplate positioning, or are equipped with a large number of auxiliary component mechanisms to achieve microplate positioning, resulting in complex equipment structure and high maintenance costs. Summary of the invention

[0004] In view of the deficiencies in the prior art, the present invention provides a fully automatic luminescence measuring instrument. The microplate of the luminescence measuring instrument adopts two-point positioning, the whole machine does not need to measure and debug the in-and-out length, has a simple structure, is easy to install, and has accurate positioning.

[0005] The technical solution of the present invention to solve the above technical problems is as follows: a fully automatic luminescence measuring instrument, the luminescence measuring instrument comprises a housing, a darkroom, a controller, a photomultiplier tube, a reading head, an X-direction motor, an X-direction pulley, an X-direction belt, a Y-direction motor, a Y-direction belt, a Y-direction pulley and a bracket, the darkroom and the photomultiplier tube are installed inside the housing, the reading head is installed at the end of the photomultiplier tube, the reading head is located inside the darkroom, and the photomultiplier tube, the reading head, the X-direction motor and the Y-direction motor are all associated with the controller;

[0006] An X-direction bracket is installed in the darkroom, the X-direction motor is installed at one end of the X-direction bracket, the X-direction pulley is installed at the other end of the X-direction bracket, the X-direction belt connects the X-direction motor and the X-direction pulley, and a Y-direction bracket is fixedly installed on the X-direction belt; the Y-direction motor is installed on the Y-direction bracket, the Y-direction belt connects the Y-direction motor and the Y-direction pulley, the bracket is fixedly installed on the Y-direction belt, and a microplate is placed on the upper end of the bracket;

[0007] One end of the X-direction bracket is equipped with a zero-position photoelectric switch for entering the warehouse, and the other end of the X-direction bracket is equipped with a zero-position photoelectric switch for exiting the warehouse. The Y-direction bracket is equipped with an X-direction sensor sheet; the Y-direction bracket is equipped with a longitudinal photoelectric switch, and the bracket is equipped with a Y-direction sensor sheet.

[0008] The beneficial effects of the present invention are as follows: the luminescence meter uses the working principle of the photomultiplier tube to read the sample in the microplate, and uses the operation of the X-axis motor and the Y-axis motor to realize the reading of the sample of each micropore in the microplate by the reading head. The positioning of the microplate adopts the internal and external two-point positioning of the zero position of the entry and exit. When the luminescence meter is running, the microplate enters the warehouse at a zero point, and the exit stop position is another zero point. The whole machine does not need to measure and debug the length of the entry and exit, and the two zero positions do not need special calculations when in use. It is easy to install, simple in structure, and accurate in reading and positioning.

[0009] On the basis of the above technical solution, the present invention can also be improved as follows:

[0010] Furthermore, the X-direction bracket is provided with an X-direction track, and the Y-direction bracket is slidably connected with the X-direction track;

[0011] The Y-direction bracket is provided with a Y-direction track, the other end of the Y-direction track is provided with the Y-direction pulley, and the lower end of the bracket is slidably connected with the Y-direction track.

[0012] The beneficial effect of adopting the above further solution is that the arrangement of the X-direction track and the Y-direction track enables the movement of the microplate in the X and Y directions to be guided by linear guides, making the operation more stable.

[0013] Furthermore, an exit frame is provided between the darkroom and the side end of the shell, a board slot is provided at the upper end of the bracket, a microboard is placed in the board slot, a slide slot is provided on the bracket, the slide slot is communicated with the board slot, a clamping block is installed in the slide slot, a door frame block is provided at the upper end of the clamping block, a support plate is installed at the lower end of the slide slot, the support plate can drag the clamping block to prevent the clamping block from falling, a torsion spring is installed on the support plate, and a torsion arm of the torsion spring is connected to the clamping block.

[0014] The beneficial effect of adopting the above further scheme is: when the microplate is pushed out of the darkroom, the door frame block is stuck by the door frame, so that the clamping block is separated from the microplate, and the staff can pick up the microplate freely; when the microplate is pushed into the darkroom, under the action of the torsion spring, the clamping block presses the microplate, so that the microplate can be more stable during the entire reading process, avoiding the microplate from shifting due to machine vibration.

[0015] Furthermore, an automatic door is installed at the lower end of the door frame, and the lower end of the automatic door is rotatably connected to the door frame. A long through hole is provided on the door frame. The automatic door is connected to the bottom of the darkroom through a tension spring, and the long through hole is for the tension spring to pass through.

[0016] The beneficial effect of adopting the above further scheme is that the automatic door is rotatably connected to the door frame and a tension spring is installed so that when the micro-board is pushed out, the bracket can push the automatic door open; when the micro-board is pushed into the darkroom, the automatic door automatically closes under the action of the tension spring, ensuring that the darkroom is lightproof; the structure is simple, practical and convenient.

[0017] Furthermore, a support plate is installed at the lower end of the bracket, and the support plate is located below the plate slot, and a heating plate is installed in the plate slot.

[0018] The beneficial effect of adopting the above further solution is that the arrangement of the heating plate facilitates heating treatment of the bottom of the microplate.

[0019] Furthermore, a connecting frame is installed on the inner side of the darkroom, a slide rail is provided on the side of the connecting frame, a reading frame is slidably connected to the side slide rail of the connecting frame, the reading frame and the connecting frame are fixed by bolts, and the reading head is installed on the upper end of the reading frame.

[0020] The beneficial effect of adopting the above further solution is that the structural arrangement of the reading frame and the connecting frame facilitates the adjustment of the height of the reading head, thereby making the luminescence measuring instrument more applicable.

[0021] Furthermore, a heating plate is installed on the upper end of the reading frame.

[0022] The beneficial effect of adopting the above further solution is that the arrangement of the heating plate on the reading rack facilitates heating treatment on the top of the microplate, which is more practical.

[0023] Furthermore, a compression spring is installed inside the reading head.

[0024] The beneficial effect of adopting the above further scheme is: a compression spring is selected inside the reading head so that during the reading process, the reading head can be pressed appropriately on the microplate, and no gap will be generated between the reading head and the microplate, and the reading head will not press the microplate, causing the motor to lose steps during the movement of the microplate.

[0025] Furthermore, the shell is provided with a plurality of heat dissipation holes, and a supporting foot is installed at the lower end of the shell.

[0026] The beneficial effects of adopting the above further scheme are: the setting of the heat dissipation holes facilitates the dissipation of the internal temperature of the luminescence meter, the setting of the support feet facilitates the support of the luminescence meter, facilitates the balance adjustment of the luminescence meter, and prevents water from entering the luminescence meter due to water on the table. BRIEF DESCRIPTION OF THE DRAWINGS

[0027] Figure 1 Schematic diagram of the external structure of the luminescence measuring instrument described in the embodiment;

[0028] Figure 2Schematic diagram of the internal structure of the housing of the luminescence measuring instrument described in the embodiment;

[0029] Figure 3 Schematic diagram of the internal structure of the darkroom of the luminescence measuring instrument described in the embodiment;

[0030] Figure 4 It is a schematic diagram of the structure when the microplate described in the embodiment is fully pushed out;

[0031] Figure 5 Schematic diagram of the structure of the X-direction bracket and the Y-direction bracket described in the embodiment;

[0032] Figure 6 is a schematic diagram of the three-dimensional structure of the bracket described in the embodiment;

[0033] Figure 7 is a schematic diagram of the three-dimensional structure of the bracket described in the embodiment from another angle;

[0034] Figure 8 It is a schematic diagram of the structure of the clamping block and the torsion spring described in the embodiment;

[0035] Fig. 9 It is a schematic diagram of the structure of the automatic door and the tension spring described in the embodiment;

[0036] Fig.10 It is a structural schematic diagram of the connecting frame and the reading frame described in the embodiment;

[0037] In the figure, 1 is a shell, 2 is a darkroom, 3 is a photomultiplier tube, 4 is a reading head, 5 is an X-axis motor, 6 is an X-axis pulley, 7 is an X-axis belt, 8 is a Y-axis motor, 9 is an Y-axis belt, 10 is an Y-axis pulley, 11 is a bracket, 12 is an X-axis bracket, 13 is an Y-axis bracket, 14 is a microplate, 15 is an in-warehouse zero-position photoelectric switch, 16 is an out-warehouse zero-position photoelectric switch, 17 is an X-axis sensor sheet, 18 is a longitudinal photoelectric switch, 19 is an Y-axis sensor sheet, 20 is an X-axis track, 21 is an Y-axis track, 22 is an outgoing door frame, 23 is a plate groove, 24 is a slide groove, 25 is a clamping block, 26 is a door frame block, 27 is a support sheet, 28 is a torsion spring, 29 is an automatic door, 30 is a long through hole, 31 is a tension spring, 32 is a support plate, 33 is a connecting frame, 34 is a reading frame, 35 is a heat dissipation hole, and 36 is a supporting foot. DETAILED DESCRIPTION

[0038] In order to make the above-mentioned purpose, features and advantages of the present invention more obvious and easy to understand, the specific embodiments of the present invention are described in detail below. In the following description, many specific details are set forth to facilitate a full understanding of the present invention. However, the present invention can be implemented in many other ways different from those described herein, and those skilled in the art can make similar improvements without violating the connotation of the present invention, so the present invention is not limited by the specific embodiments disclosed below.

[0039] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as those commonly understood by those skilled in the art of the present invention. The terms used in the specification of the present invention herein are only for the purpose of describing specific embodiments and are not intended to limit the present invention.

[0040] As shown in the figure, a fully automatic luminescence measuring instrument comprises a housing 1, a darkroom 2, a controller, a photomultiplier tube 3, a reading head 4, an X-direction motor 5, an X-direction pulley 6, an X-direction belt 7, a Y-direction motor 8, a Y-direction belt 9, a Y-direction pulley 10 and a bracket 11. The darkroom 2 and the photomultiplier tube 3 are installed inside the housing 1, the reading head 4 is installed at the end of the photomultiplier tube 3, the reading head 4 is located inside the darkroom 2, and the photomultiplier tube 3, the reading head 4, the X-direction motor 5 and the Y-direction motor 8 are all associated with the controller;

[0041] An X-direction bracket 12 is installed in the darkroom 2, the X-direction motor 5 is installed at one end of the X-direction bracket 12, the X-direction pulley 6 is installed at the other end of the X-direction bracket 12, the X-direction belt 7 connects the X-direction motor 5 and the X-direction pulley 6, and a Y-direction bracket 13 is fixedly installed on the X-direction belt 7; the Y-direction motor 8 is installed on the Y-direction bracket 13, the Y-direction belt 9 connects the Y-direction motor 8 and the Y-direction pulley 10, the bracket 11 is fixedly installed on the Y-direction belt 9, and a microplate 14 is placed on the upper end of the bracket 11;

[0042] One end of the X-axis bracket 12 is equipped with a zero-position photoelectric switch 15 for entering the warehouse, and the other end of the X-axis bracket 12 is equipped with a zero-position photoelectric switch 16 for exiting the warehouse. The Y-axis bracket 13 is equipped with an X-axis sensor sheet 17; the Y-axis bracket 13 is equipped with a longitudinal photoelectric switch 18, and the bracket 11 is equipped with a Y-axis sensor sheet 19.

[0043] The X-direction bracket 12 is provided with an X-direction track 20, and the Y-direction bracket 13 is slidably connected with the X-direction track 20; the Y-direction bracket 13 is installed with a Y-direction track 21, and the Y-direction pulley 10 is installed at the other end of the Y-direction track 21, and the lower end of the bracket 11 is slidably connected with the Y-direction track 21.

[0044] An exit frame 22 is provided between the darkroom 2 and the side end of the housing 1, a plate slot 23 is provided at the upper end of the bracket 11, a micro plate 14 is placed in the plate slot 23, a slide slot 24 is provided on the bracket 11, the slide slot 24 is communicated with the plate slot 23, a clamping block 25 is installed in the slide slot 24, a door frame block 26 is provided at the upper end of the clamping block 25, a support piece 27 is installed at the lower end of the slide slot 24, a torsion spring 28 is installed on the support piece 27, and a torsion arm of the torsion spring 28 is connected to the clamping block 25. A support plate 32 is installed at the lower end of the bracket 11, the support plate 32 is located below the plate slot 23, and a heating plate is installed in the plate slot 23.

[0045] like Figure 4 As shown, when the microplate 14 is pushed out of the darkroom 2, the door frame block 26 is stuck by the door frame 22, so that the clamping block 25 is separated from the microplate 14, and the staff can freely pick up the microplate 14; Figure 3 As shown, when the microplate 14 is pushed into the darkroom 2, the clamping block 25 presses the microplate 14 under the action of the torsion spring 28, so that the microplate 14 can be more stable during the entire reading process, avoiding displacement of the microplate 14 due to machine vibration, which is beneficial to accurate reading by the reading head 4.

[0046] An automatic door 29 is installed at the lower end of the door frame 22, and the lower end of the automatic door 29 is rotatably connected to the door frame 22. A long through hole 30 is provided on the door frame 22. The automatic door 29 is connected to the bottom of the darkroom 2 through a tension spring 31, and the long through hole 30 is for the tension spring 31 to pass through. When the microplate 14 is pushed out, the bracket 11 can push the automatic door 29 open, and when the microplate 14 is pushed into the darkroom 2, the automatic door 29 is automatically closed under the action of the tension spring 31.

[0047] A connecting frame 33 is installed on the side of the darkroom 2, and a slide rail is provided on the side of the connecting frame 33. A reading frame 34 is slidably connected to the slide rail on the side of the connecting frame 33. The reading frame 34 is fixed to the connecting frame 33 by bolts, and the reading head 4 is installed on the upper end of the reading frame 34. A heating plate is installed on the upper end of the reading frame 34. A compression spring is installed inside the reading head 4, so that during the reading process, the reading head 4 can be appropriately pressed on the microplate 14, and a gap will not be generated between the reading head 4 and the microplate 14, and the reading head 4 will not press the microplate 14, so that the X-direction motor 5 or the Y-direction motor 8 loses steps during the movement of the microplate 14, so that the reading head 4 can read accurately.

[0048] The housing 1 is provided with a plurality of heat dissipation holes 35 , and a support foot 36 is installed at the lower end of the housing 1 .

[0049] The luminescence meter uses the working principle of the photomultiplier tube 3 to read the sample in the microplate 14, and uses the operation of the X-axis motor 5 and the Y-axis motor 8 to realize the sample reading of each micropore in the microplate 44 by the reading head 4. The positioning of the microplate 14 adopts the internal and external two-point positioning of the in-bin zero position photoelectric switch 15 and the out-bin zero position photoelectric switch 16. When the luminescence meter is running, the microplate 14 enters the bin at a zero position, and the out-bin stop position is another zero position. The whole machine does not need to measure and debug the in-bin length, and the two zero positions do not need special calculations when in use. It is easy to install, simple in structure, and accurate in reading and positioning.

[0050] The technical features of the above-described embodiments may be arbitrarily combined. To make the description concise, not all possible combinations of the technical features in the above-described embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0051] The above-mentioned embodiments only express several implementation methods of the present invention, and the descriptions thereof are relatively specific and detailed, but they cannot be understood as limiting the scope of the invention patent. It should be pointed out that, for ordinary technicians in this field, several variations and improvements can be made without departing from the concept of the present invention, and these all belong to the protection scope of the present invention. Therefore, the protection scope of the patent of the present invention shall be subject to the attached claims.

Claims

1. A fully automatic luminescence measuring instrument, characterized in that: The luminescence measuring instrument comprises a housing (1), a darkroom (2), a controller, a photomultiplier tube (3), a reading head (4), an X-direction motor (5), an X-direction pulley (6), an X-direction belt (7), a Y-direction motor (8), a Y-direction belt (9), a Y-direction pulley (10) and a bracket (11), wherein the darkroom (2) and the photomultiplier tube (3) are installed inside the housing (1), the reading head (4) is installed at the end of the photomultiplier tube (3), the reading head (4) is located inside the darkroom (2), and the photomultiplier tube (3), the reading head (4), the X-direction motor (5) and the Y-direction motor (8) are all associated with the controller; An X-direction bracket (12) is installed in the darkroom (2); the X-direction motor (5) is installed on one end of the X-direction bracket (12); the X-direction pulley (6) is installed on the other end of the X-direction bracket (12); the X-direction belt (7) connects the X-direction motor (5) and the X-direction pulley (6); a Y-direction bracket (13) is fixedly installed on the X-direction belt (7); the Y-direction motor (8) is installed on the Y-direction bracket (13); the Y-direction belt (9) connects the Y-direction motor (8) and the Y-direction pulley (10); the bracket (11) is fixedly installed on the Y-direction belt (9); a microplate (14) is placed on the upper end of the bracket (11); One end of the X-direction bracket (12) is equipped with a zero-position photoelectric switch (15) for entering the bin, and the other end of the X-direction bracket (12) is equipped with a zero-position photoelectric switch (16) for exiting the bin; an X-direction sensor sheet (17) is installed on the Y-direction bracket (13); a longitudinal photoelectric switch (18) is installed on the Y-direction bracket (13); and a Y-direction sensor sheet (19) is installed on the bracket (11); A connecting frame (33) is installed on the inner side of the darkroom (2), and a slide rail is provided on the side of the connecting frame (33). A reading frame (34) is slidably connected to the side slide rail of the connecting frame (33). The reading frame (34) is fixed to the connecting frame (33) by bolts, and the reading head (4) is installed on the upper end of the reading frame (34); a compression spring is installed inside the reading head (4).

2. A fully automatic luminescence measuring instrument according to claim 1, characterized in that: The X-direction bracket (12) is provided with an X-direction track (20), and the Y-direction bracket (13) is slidably connected to the X-direction track (20); A Y-direction track (21) is installed on the Y-direction bracket (13); the Y-direction pulley (10) is installed on the other end of the Y-direction track (21); and the lower end of the bracket (11) is slidably connected to the Y-direction track (21).

3. A fully automatic luminescence measuring instrument according to claim 1, characterized in that: An exit frame (22) is provided between the side ends of the darkroom (2) and the housing (1); a plate groove (23) is provided at the upper end of the bracket (11); a microplate (14) is placed in the plate groove (23); a slide groove (24) is provided on the bracket (11); the slide groove (24) is communicated with the plate groove (23); a clamping block (25) is installed in the slide groove (24); a door frame clamping block (26) is provided at the upper end of the clamping block (25); a support plate (27) is installed at the lower end of the slide groove (24); a torsion spring (28) is installed on the support plate (27); a torsion arm of the torsion spring (28) is connected to the clamping block (25).

4. A fully automatic luminescence measuring instrument according to claim 3, characterized in that: An automatic door (29) is installed at the lower end of the door frame (22), and the lower end of the automatic door (29) is rotatably connected to the door frame (22). The door frame (22) is provided with a long through hole (30). The automatic door (29) is connected to the bottom of the darkroom (2) via a tension spring (31), and the long through hole (30) is for the tension spring (31) to pass through.

5. A fully automatic luminescence measuring instrument according to claim 3, characterized in that: A support plate (32) is installed at the lower end of the bracket (11), and the support plate (32) is located below the plate groove (23), and a heating plate is installed in the plate groove (23); A heating plate is installed on the upper end of the reading frame (34).

6. A fully automatic luminescence measuring instrument according to claim 1, characterized in that: The outer shell (1) is provided with a plurality of heat dissipation holes (35), and a supporting foot (36) is installed at the lower end of the outer shell (1).

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