Physically targeted hyperthermia system and control method for tumor treatment

Abstract

The present invention discloses a physical targeted hyperthermia system for tumor treatment and a control method thereof, which relate to the technical field of medical equipment. The system mainly comprises a hyperthermia apparatus body, a microwave radiating device, a microwave receiving device, a microwave imaging unit, a microwave temperature measuring unit, a hyperthermia scheme generating unit, a hyperthermia scheme executing unit and a hyperthermia control device. The hyperthermia apparatus body is used to provide a stable support surface for a human body and related functional devices, the microwave radiating device is used to radiate microwaves of set wavelength and frequency in a set direction, the microwave receiving device and the microwave imaging device are used to accurately locate the position of tumor tissue, the hyperthermia scheme generating unit is used to generate hyperthermia parameter information, the hyperthermia scheme executing unit generates corresponding hyperthermia scheme execution information based on the hyperthermia parameter information, the control device controls the microwave radiating device based on the execution information, and utilizes microwave focusing to heat the tumor tissue to accurately kill the tumor tissue of the human body.

Description

Technical Field

[0001] The present invention relates to the technical field of medical equipment, and more specifically, to a physical targeted thermal therapy system for tumor treatment and a control method thereof. Background Art

[0002] Currently, the more commonly used methods for treating tumor diseases are radiotherapy, chemotherapy and surgery. Radiotherapy refers to a local treatment method that uses radiation to treat tumors. For example, α, β, γ rays produced by radioactive isotopes and x-rays, electron beams, proton beams and other particle beams produced by various x-ray therapy machines or accelerators are used to irradiate or bombard tumor cells, so that tumor cells in the target area are eliminated. Chemotherapy is the abbreviation of chemical drug treatment, and its main method is to kill cancer cells by using chemotherapeutic drugs to achieve the purpose of treatment. Surgical treatment, as the name implies, is to remove tumor tissue from normal human tissue through surgical resection to achieve the purpose of treatment.

[0003] Chemotherapy, radiotherapy and surgery are important means of treating malignant tumors. Their advantages are that they can kill tumor cells and inhibit their growth and reproduction. The side effects are also obvious, that is, during the treatment process, they will cause damage to normal human cells or immune cells, leading to decreased immune function, bone marrow suppression, and radiation pneumonia.

[0004] How to kill tumor cells without harming normal human cells or tissues, that is, to achieve precise killing of tumor cells, is a difficult problem that needs to be overcome urgently. Summary of the invention

[0005] In view of the problem that the treatment of tumor diseases is prone to cause damage to normal cells and tissues of the human body and produce treatment side effects, the first purpose of the present invention is to propose a physical targeted thermal therapy system for tumor treatment, which uses the principles of microwave imaging and microwave heating to accurately find the location of tumor tissue and accurately heat it, so as to achieve the effect of killing tumor cells or tissues without causing damage to normal cells or tissues of the human body. Based on the above-mentioned thermal therapy system, the second purpose of the present invention is to provide a control method for a physical targeted thermal therapy system for tumor treatment, which can accurately determine the location of the tumor and quickly generate a corresponding heating control scheme, so as to achieve accurate and rapid heating of the tumor lesion site and achieve the purpose of killing tumor tissue. The specific scheme is as follows:

[0006] A physical targeted hyperthermia system for tumor treatment, comprising:

[0007] Thermotherapy apparatus body, configured to provide at least one stable support surface for the patient undergoing thermotherapy and to provide installation sites for various system functional modules;

[0008] A microwave radiating device, configured to be connected to a microwave source, and used to generate and radiate microwaves of a set wavelength and frequency toward a set direction according to a control signal;

[0009] A microwave receiving device configured to receive and output a scattered echo signal reflected and / or scattered by a radiator;

[0010] A microwave imaging unit is configured to be connected to the microwave receiving device signal, receive the scattered echo signal, generate and confirm the location, shape and size of the tumor tissue according to a set algorithm, and output imaging coordinate information;

[0011] A microwave temperature measurement unit is configured to be connected to the microwave receiving device signal, receive the scattered echo signal, generate thermal imaging data of the tumor tissue location and its vicinity according to a set algorithm, and output temperature measurement information;

[0012] A thermal therapy program generating unit, configured to generate or associate and store thermal therapy parameter information required to kill tumor tissues of different shapes and sizes at different locations of the human body;

[0013] a thermal therapy program execution unit, configured to be data-connected with the microwave imaging unit, the microwave temperature measurement unit and the thermal therapy program generation unit, and to generate thermal therapy program execution information for killing the current tumor tissue based on the collected imaging coordinate information and temperature measurement information combined with the thermal therapy parameter information;

[0014] The heat therapy control device is configured to be in control connection with the microwave radiation device, receive and respond to the heat therapy program execution information, and output a control signal to control the operation of the microwave radiation device.

[0015] Through the above technical solution, when using microwaves to kill tumor cells or tissues in the human body, first, microwaves of set wavelength and frequency are radiated toward the human body through the microwave radiator, and the microwave receiving device receives the scattered echo information reflected and / or scattered by the human body after radiation. The microwave imaging unit uses the scattered echo signal to generate and confirm the specific position of the tumor tissue in the human body, and outputs the imaging coordinate information; the thermal therapy scheme generation unit generates corresponding thermal therapy parameter information based on the imaging coordinate information, and then based on the thermal therapy parameter information, the thermal therapy scheme execution unit generates the corresponding treatment plan. The thermal therapy control device accurately controls the microwave radiator to perform continuous microwave heating on a certain position of the human body according to the thermal therapy scheme execution information, thereby eliminating the tumor cells or tissues at the lesion position.

[0016] Furthermore, the thermal therapy device body comprises:

[0017] A thermal therapy bed, comprising a bed body and a bed board bracket supporting the bed body;

[0018] The radiation head mounting bracket is annular in shape and is slidably arranged with the thermotherapy bed body;

[0019] A first driving device is configured to be in transmission connection with the thermotherapy bed and / or the radiation head mounting bracket, and is control-connected with the thermotherapy control device, receives a control signal output by the thermotherapy control device, and drives the thermotherapy bed and / or the radiation head mounting bracket to move;

[0020] Wherein, the microwave radiation device includes a plurality of microwave radiators movably arranged along the radiation head mounting bracket, the plurality of microwave radiators are connected to a microwave source and a power adapter, and the microwave radiation direction is arranged toward the bed body.

[0021] Through the above technical scheme, the relative position of the microwave radiator and the human body can be flexibly adjusted, so that multiple microwave radiators movably arranged along the radiation head mounting bracket can accurately focus microwaves to set positions in the human body, thereby heating the human tissue at the set position, killing tumor tissue without damaging normal human tissue.

[0022] Furthermore, a sliding groove is provided on the radiation head mounting bracket along its length direction, a plurality of sliding mounting blocks are slidably engaged in the sliding groove, and a plurality of the microwave radiators are movably arranged on the sliding mounting blocks respectively;

[0023] The sliding groove and / or the sliding mounting block is also provided with a second driving device for driving the sliding mounting block to move along the sliding groove. The second driving device is configured to be control-connected to the thermal therapy control device, receive the control signal output by the thermal therapy control device, and drive the sliding mounting block to move to a set position.

[0024] Through the above technical scheme, the thermal therapy control device can realize automatic adjustment of the microwave emission orientations of the above-mentioned multiple microwave radiators according to the various parameters in the thermal therapy scheme execution information, thereby realizing precise focusing of microwaves, and can quickly and accurately kill human tumor tissue.

[0025] Further, first slide rails are arranged on both sides or two opposite side walls of the bed, a first slider is slidably arranged in the first slide rails, a second slide rail is arranged in the sliding channel along its length direction, and a second slider is slidably arranged in the second slide rails;

[0026] The radiation head mounting bracket comprises a first annular segment and a second annular segment, the first annular segment is in an arc shape and both ends are fixedly connected to the first sliding block, and the second annular segment is in an arc shape and is fixedly connected to the second moving block; or

[0027] The radiation head mounting bracket is arranged in a circular ring shape, the bed body is arranged in parallel with the axial direction of the radiation head mounting bracket and penetrates the radiation head mounting bracket, a bed body mounting seat is arranged between the bed body and the ground, a third slide rail is arranged on the bed body mounting seat, and the bed body is slidably arranged with the bed body mounting seat through the third slide rail;

[0028] The first driving device includes a screw transmission component or a transmission chain component for driving the first sliding block and the second sliding block to synchronously reciprocate along the first slide rail and the second slide rail respectively, or driving the bed body to reciprocate along the third slide rail.

[0029] Through the above technical solution, the radiation head mounting bracket is arranged in a ring shape as a whole, so that the microwave radiator installed thereon can emit microwaves to the human tumor tissue from all directions, thereby achieving precise heating of the tumor tissue and minimizing the damage of microwaves to normal human tissue.

[0030] Furthermore, the microwave radiator is movably connected to the sliding mounting block and an automatic adjustment member and / or a manual adjustment member for adjusting the radiation angle of the microwave radiator are arranged between the two.

[0031] Through the above technical solution, the microwave emission direction on the microwave transmitter can be adjusted by automatic control or manual control, and then the microwave focusing position can be adjusted more accurately to achieve precise heating of tumor cells.

[0032] Furthermore, the thermal therapy program execution unit includes:

[0033] A microwave radiator angle generation module is configured to receive the imaging coordinate information, calculate the relative position of the thermal therapy bed and the radiation head mounting bracket and the deflection angle of each microwave radiator, and output an angle deflection parameter;

[0034] A microwave radiator power generation module, configured to receive the thermal therapy parameter information, generate and output output power parameters, microwave wavelength parameters and frequency parameters of each microwave radiator;

[0035] The thermal therapy control device comprises:

[0036] A temporary data storage unit is configured to be data-connected to the microwave imaging unit, the microwave temperature measurement unit, and the thermal therapy program execution unit, and receive and store the imaging coordinate information, temperature measurement information, angle deflection parameters, output power parameters, microwave wavelength parameters, and frequency parameters;

[0037] A controller, configured to be electrically connected to the first driving device, the second driving device and the power adapters of each microwave radiator, receive the above parameters, and generate a control signal for controlling the movement of the first driving device, the second driving device and the output power of each power adapter;

[0038] The feedback control unit is configured to be connected to the microwave temperature measurement unit signal, receive the temperature measurement information, output an adjustment signal to the controller, and perform feedback adjustment on the control signal.

[0039] Through the above technical solution, the thermal therapy execution unit outputs the angle deflection parameter, the output power parameter, microwave wavelength parameter and frequency parameter of each microwave radiator based on the thermal therapy parameter information output by the thermal therapy generation unit, and the controller controls the action of each microwave radiator to ensure that the microwave output by each microwave radiator can be focused to the set position to achieve accurate killing of tumor tissue cells. In the above process, the temporary data storage unit can not only store the various thermal therapy parameter information to be implemented, and provide data guarantee for subsequent treatment, but also the above data information can be stored as historical data during the patient's treatment process, which is convenient for later analysis and review of the patient's treatment process to obtain a more optimized thermal therapy plan. The setting of the above feedback control unit enables the controller to monitor the temperature changes of the tumor tissue in the microwave focus area in real time during the entire treatment process, and adjust the thermal therapy parameters in time according to the above changes, to achieve closed-loop control of thermal therapy, avoid the temperature of the thermal therapy area being too high or too low, and ensure the thermal therapy effect.

[0040] Furthermore, an automatic adjustment member is provided between the microwave radiator and the sliding mounting block, and the automatic adjustment member is control-connected to the controller, receives and adjusts the microwave radiation direction of the microwave radiator in response to a control signal output by the controller;

[0041] The microwave radiator angle generation module is data-connected to a radiation path planning module, which is data-connected to the microwave imaging unit, receives the imaging coordinate information, and calculates and generates a moving path of the radiation center point surrounded by each microwave radiator within a set time period based on the shape and size of the tumor tissue, generates an angle deflection parameter table for each microwave radiator with time as a reference variable based on the moving path, and outputs it to the temporary data storage unit and / or controller.

[0042] Through the above technical solution, the controller can be used to automatically control the microwave radiation direction of each microwave radiator, thereby changing the focus position of each microwave beam. By setting up a radiation path planning module, the microwave focus point, that is, the position of the radiation center point, can be reasonably planned according to the shape and size of the tumor tissue, so that the moving path of the radiation center point covers the entire tumor tissue and does not touch normal tissue cells, so that the tumor tissue is killed more thoroughly.

[0043] Furthermore, the system is also configured with a thermal therapy scheme optimization unit, including:

[0044] A thermal therapy data storage module, configured to be data-connected to the temporary data storage unit, to receive and store imaging coordinate information, temperature measurement information, angle deflection parameters, output power parameters, microwave wavelength parameters and frequency parameters corresponding to each thermal therapy of the patient;

[0045] The thermal therapy effect analysis module is configured to be data-connected to the thermal therapy data storage module, receive the tumor tissue imaging coordinate information of the patient after each thermal therapy, analyze and generate the change data of the tumor tissue imaging coordinate information between the above-mentioned thermal treatments based on its own built-in algorithm module, predict the growth trend of the tumor tissue and the thermal therapy parameter information used, generate a thermal therapy optimization plan and store or output it to the thermal therapy plan generation unit.

[0046] Based on the control system of the physical targeted hyperthermia system for tumor treatment, the present invention further proposes a control method of the physical targeted hyperthermia system for tumor treatment, comprising:

[0047] Using the set plane or site in the thermotherapy device as a reference, calibrate the coordinates of each position in the three-dimensional space, generate and store the coordinate information of each position;

[0048] Calculate and generate a table of hyperthermia parameter information required to kill tumor tissues of different shapes and sizes at each position coordinate and store it;

[0049] Based on the microwave imaging unit and the microwave temperature measurement unit, the shape and size information, the location coordinate information and the current temperature information of the tumor tissue in the human body are scanned and temporarily stored;

[0050] Based on the shape and size information, location coordinate information and temperature information of the tumor tissue, the set thermal therapy parameters are selected according to the thermal therapy parameter information table;

[0051] Based on the selected thermal therapy parameters, corresponding thermal therapy program execution information is generated according to the set algorithm;

[0052] Based on the execution information of the thermal therapy plan, a corresponding control signal is generated to control the action of the microwave radiation device and / or the thermal therapy device body.

[0053] Furthermore, the calculation generates and stores a table of hyperthermia parameter information required to kill tumor tissues of different shapes and sizes at each position coordinate, including:

[0054] Establish a digital model of the human body and calculate the correlation between the hyperthermia parameters and the temperature changes of tissues at various locations in the human body;

[0055] Adding a digital model of tumor tissue of a set shape and size to the human body data model and performing microwave heating simulation, adjusting the thermal therapy parameters and acquiring simulation data;

[0056] Based on the above simulation data, the thermal therapy parameters corresponding to the target simulation data are obtained, and a thermal therapy parameter information table is generated and stored.

[0057] Compared with the prior art, the present invention has the following beneficial effects:

[0058] (1) By setting up multiple microwave radiation probes on the radiation head mounting bracket and using microwave imaging and temperature measurement technology, the tumor tissue can be accurately located and focused for heating, thereby killing tumor tissue cells without affecting normal human tissue, thus achieving the goal of non-invasive tumor treatment;

[0059] (2) By measuring the temperature of the tumor tissue area in real time during the hyperthermia treatment, the output power of the microwave radiator and the position of the radiation center point can be adjusted according to the temperature change during the hyperthermia treatment, thereby achieving precise temperature increase hyperthermia treatment of the tumor tissue;

[0060] (3) By comparing the shape and size of tumor tissue after each treatment, the growth trend of tumor tissue during the treatment process is analyzed, and microwave thermal therapy technology is used to achieve early thermal therapy, block the spread of tumor tissue, and improve the cure rate. BRIEF DESCRIPTION OF THE DRAWINGS

[0061] Figure 1 is an overall schematic diagram of the thermal therapy system of the present invention (Example 1);

[0062] Figure 2 is an overall schematic diagram of the thermal therapy system of the present invention (in the first embodiment, the bed is omitted);

[0063] Figure 3 for Figure 2 A partial enlarged schematic diagram of the middle A part;

[0064] Figure 4 is an overall schematic diagram of the thermal therapy system of the present invention (Example 2);

[0065] Figure 5 is an overall schematic diagram of the thermal therapy system of the present invention (Example 2, omitting the bed mounting base);

[0066] Figure 6 for Figure 5 A partial enlarged schematic diagram of the middle B part;

[0067] Figure 7 It is a schematic diagram of the structural framework of the present invention;

[0068] Figure 8 Schematic diagram of the control method of the thermal therapy system of the present invention.

[0069] Figure numerals: 1. thermal therapy device body; 2. thermal therapy bed; 3. bed body; 4. bed board bracket; 5. radiation head mounting bracket; 6. first annular segment; 7. second annular segment; 8. sliding groove; 9. sliding mounting block; 10. first driving device; 11. bed body mounting seat; 12. first slide rail; 13. first slider; 14. second slide rail; 15. second slider; 16. microwave radiator angle generation module; 17. microwave radiator power generation module; 18. temporary data storage unit; 19. controller; 20. feedback control unit; 21. radiation path planning module; 22. thermal therapy data storage module; 23. thermal therapy effect analysis module; 24. microwave radiator; 25. microwave radiating device; 26. microwave receiving device; 27. microwave imaging unit; 28. microwave temperature measurement unit; 29. ​​thermal therapy plan generation unit; 30. thermal therapy plan execution unit; 31. thermal therapy control device; 32. thermal therapy plan optimization unit. DETAILED DESCRIPTION

[0070] The present invention will be further described in detail below in conjunction with embodiments and figures, but the embodiments of the present invention are not limited thereto.

[0071] A physical targeted hyperthermia system for tumor treatment, such as Figure 1 and Figure 7 As shown, it mainly includes a thermal therapy device body 1, a microwave radiation device 25, a microwave receiving device 26, a microwave imaging unit 27, a microwave temperature measurement unit 28, a thermal therapy plan generating unit 29, a thermal therapy plan executing unit 30 and a thermal therapy control device 31.

[0072] The thermotherapy device body 1 is configured to provide at least one stable support surface for the patient undergoing thermotherapy and to provide installation sites for various system function modules. The purpose of the stable support surface is to enable the patient to maintain a relative stability between the body position and the position of the microwave radiation device 25 during microwave thermotherapy, so as to ensure that the radiation center point of the microwave focus is fixed or the set motion trajectory can be stably achieved.

[0073] The above-mentioned microwave radiation device 25 and microwave receiving device 26 are both arranged on the thermal therapy device body 1, and the remaining microwave imaging unit 27, microwave temperature measurement unit 28, thermal therapy plan generation unit 29, thermal therapy plan execution unit 30 and thermal therapy control device 31 are separately arranged from the above-mentioned thermal therapy device body 1. In a specific embodiment, the microwave radiation device 25, microwave receiving device 26 and the above-mentioned functional units can be remotely connected based on the Internet.

[0074] The microwave radiating device 25 is configured to be connected to a microwave source, and is used to generate and radiate microwaves of a set wavelength and frequency toward a set direction according to a control signal of the thermal therapy control device 31. In detail, in the present invention, the microwave radiating device 25 includes a plurality of microwave radiators 24, and the plurality of microwave radiators 24 are connected to a microwave source and a power adapter.

[0075] In order to enable the above-mentioned plurality of microwave radiators 24 to stably radiate microwaves in a set direction, in the present invention, Figure 1 and Figure 3 As shown, the thermotherapy device body 1 includes: a thermotherapy bed 2, a radiation head mounting bracket 5 slidably arranged with the thermotherapy bed 2, and a first driving device 10 for driving the thermotherapy bed 2 and the radiation head mounting bracket 5 to move relative to each other.

[0076] The above-mentioned thermotherapy bed 2 includes a bed body 3 and a bed board support 4 supporting the bed body 3. In a specific embodiment, in order to adjust the height of the above-mentioned thermotherapy bed 2, the bed board support 4 includes a scissor-type lift, and the support rods of the scissor-type lift are arranged on both sides of the width direction of the bed body 3, and a sliding channel is formed between the bottom of the bed body 3 and the two support rods of the scissor-type lift.

[0077] The radiation head mounting bracket 5 is in an annular shape as a whole and is arranged to slide relative to the bed body 3 of the thermotherapy bed 2 as a whole. The first driving device 10 is configured to be transmission-connected to the thermotherapy bed 2 and / or the radiation head mounting bracket 5, and is control-connected to the thermotherapy control device 31, receives the control signal output by the thermotherapy control device 31, and drives the thermotherapy bed 2 and / or the radiation head mounting bracket 5 to move. The plurality of microwave radiators 24 are movably arranged along the radiation head mounting bracket 5, and the microwave radiation direction is toward the bed body 3.

[0078] In detail, a sliding groove 8 is provided on the radiation head mounting bracket 5 along its length direction, and a plurality of sliding mounting blocks 9 are slidably engaged in the sliding groove 8, and a plurality of the microwave radiators 24 are movably arranged on the sliding mounting blocks 9. The sliding groove 8 and / or the sliding mounting block 9 are also provided with a second driving device for driving the sliding mounting block 9 to move along the sliding groove 8, and the second driving device is configured to be connected to the control of the thermal therapy control device 31, receive the control signal output by the thermal therapy control device 31, and drive the sliding mounting block 9 to move to a set position. In a specific embodiment, a rack can be provided in the sliding groove 8 along its length direction, and the second driving device is configured as a servo motor fixedly mounted on the sliding mounting block 9, and a gear matched with the rack is fixedly provided at the end of the servo motor, and the thermal therapy control device 31 controls the movement of the sliding mounting block 9 by controlling the rotation of the servo motor.

[0079] In the above technical solution, the thermal therapy control device 31 can realize automatic adjustment of the microwave emission orientations of the above-mentioned multiple microwave radiators 24, thereby realizing precise focusing of the microwaves, and can quickly and accurately kill tumor tissues in the human body.

[0080] In one embodiment, if Figure 4 and Figure 6 As shown, first slide rails 12 are arranged on both sides or two opposite side walls of the bed body 3, a first slider 13 is slidably arranged in the first slide rail 12, a second slide rail 14 is arranged in the sliding channel along its length direction, and a second slider 15 is slidably arranged in the second slide rail 14. The radiation head mounting bracket 5 includes a first ring segment 6 and a second ring segment 7, the first ring segment 6 is in an arc shape and fixedly connected to the first slider 13 at both ends, and the second ring segment 7 is in an arc shape and fixedly connected to the second moving block. The first ring segment 6 and the second ring segment 7 form a circular ring shape, and microwave radiation can be applied to a certain position of the human body from 360° when the bed body 3 does not move.

[0081] In another embodiment, if Figure 2 and Figure 3 As shown, the radiation head mounting bracket 5 is arranged in a circular ring shape, the bed 3 is arranged in parallel with the axial direction of the radiation head mounting bracket 5 and penetrates the radiation head mounting bracket 5, a bed mounting seat 11 is arranged between the bed 3 and the ground, a third slide rail is arranged on the bed mounting seat 11, and the bed 3 is slidably arranged with the bed mounting seat 11 through the third slide rail. Based on the above arrangement, the microwave radiator 24 arranged on the radiation head mounting bracket 5 can perform omnidirectional microwave radiation on the human body.

[0082] Preferably, the bed 3 is made of a material that does not block microwave beams, such as ceramic, glass or a combination thereof.

[0083] The first driving device 10 includes a screw transmission component or a transmission chain component for driving the first slider 13 and the second slider to synchronously reciprocate along the first slide rail 12 and the second slide rail 14, or driving the bed body 3 to reciprocate along the third slide rail. The first driving device 10 can be configured as a servo motor connected to the control device, etc., and the gear installed on the motor shaft drives the chain to move to achieve power output.

[0084] Through the above technical solution, the radiation head mounting bracket 5 is arranged in a ring shape as a whole, so that the microwave radiator 24 mounted thereon can emit microwaves to the human tumor tissue from all directions, thereby achieving precise heating of the tumor tissue and minimizing the damage of microwaves to normal human tissue.

[0085] In detail, the microwave radiator 24 is movably connected to the sliding mounting block 9 and an automatic adjustment member and / or a manual adjustment member for adjusting the radiation angle of the microwave radiator 24 are arranged between the two. The above technical solution can adjust the microwave emission direction on the microwave emitter by automatic control or manual control, thereby more accurately adjusting the microwave focusing position and achieving precise heating of tumor cells.

[0086] In a preferred embodiment, an automatic adjustment member is provided between the microwave radiator 24 and the sliding mounting block 9 , and the automatic adjustment member is control-connected to the controller 19 , receives and adjusts the microwave radiation direction of the microwave radiator 24 in response to a control signal output by the controller 19 .

[0087] In the present invention, the microwave receiving device 26 is configured to receive and output scattered echo signals reflected and / or scattered by the radiator, such as using a microwave receiver, etc. The above-mentioned microwave receiver is configured in the same way as the microwave radiator 24, and both are movably arranged on the radiation head mounting bracket 5. By changing its position, it can receive scattered echo signals reflected and / or dissipated by the radiator from multiple angles and convert them into electrical signals for output through a set algorithm.

[0088] The microwave imaging unit 27 is configured to be connected to the microwave receiving device 26, receive the scattered echo signal, generate and confirm the location and shape and size of the tumor tissue according to the set algorithm, and output imaging coordinate information. Different human tissues have different reflection shapes, and different tissue cells will have different temperature changes when receiving microwave radiation of the same wavelength or frequency. Through the above different characteristics, it is possible to conveniently image the tumor tissue in the human body and obtain the shape, size and location coordinates of the tumor tissue.

[0089] The microwave temperature measurement unit 28 is configured to be signal-connected to the microwave receiving device 26, receive the scattered echo signal, generate thermal imaging data of the location of the tumor tissue and its vicinity according to a set algorithm, and output temperature measurement information. In practice, it is common to use microwaves for temperature measurement, such as microwave temperature measurement probes, etc., which will not be described in detail here.

[0090] The thermal therapy scheme generating unit 29 is configured to generate or associate and store the thermal therapy parameter information required to kill tumor tissues of different shapes and sizes at different positions of the human body. In practice, the thermal therapy scheme generating unit 29 includes a computer or a dedicated data processor with a built-in specific algorithm module, and is connected to the microwave imaging unit 27 and the microwave temperature measuring unit 28 through the local area network on site or the remote Internet. After the position coordinates and shape and size information of the tumor tissue are input, the corresponding thermal therapy parameter information can be quickly generated or found in the data table, such as the radiation frequency, wavelength, radiation duration, radiation direction of the microwave, and the change of microwave frequency or wavelength during the radiation process.

[0091] The thermal therapy program execution unit 30 is configured to be data-connected with the microwave imaging unit 27, the microwave temperature measurement unit 28, and the thermal therapy program generation unit 29, and generates thermal therapy program execution information for killing the current tumor tissue based on the collected imaging coordinate information and temperature measurement information combined with the thermal therapy parameter information. The thermal therapy program execution information includes the angle at which the radiation head of each microwave radiator 24 should be deflected (i.e., clarifying the relative position parameters between each microwave radiator 24 and the human body), the driving parameters of the first driving device 10 and the second driving device, and other control execution parameters.

[0092] The thermal therapy control device 31 is configured to be connected to the microwave radiation device 25 for control, receive and respond to the thermal therapy program execution information, and output a control signal to control the operation of the microwave radiation device 25, including changes in the position, angle and radiation power of the microwave radiator 24 or the bed 3.

[0093] Further details, such as Figure 7 As shown, the thermal therapy plan execution unit 30 includes a microwave radiator angle generation module 16 and a microwave radiator power generation module 17 .

[0094] The microwave radiator angle generation module 16 is configured to receive the imaging coordinate information, calculate the relative position of the thermotherapy bed 2 and the radiation head mounting bracket 5 and the deflection angle of each microwave radiator 24, and output information such as angle deflection parameters. The microwave radiator power generation module 17 is configured to receive the thermotherapy parameter information, generate and output the output power parameter, microwave wavelength parameter and frequency parameter of each microwave radiator 24.

[0095] The microwave radiator angle generation module 16 is data-connected to the radiation path planning module 21, and the radiation path planning module 21 is data-connected to the microwave imaging unit 27, receives the imaging coordinate information, and calculates and generates the moving path of the radiation center point surrounded by each microwave radiator 24 within a set time period according to the shape and size of the tumor tissue, and generates an angle deflection parameter table of each microwave radiator 24 with time as a reference variable based on the moving path, and outputs it to the temporary data storage unit 18 and / or the controller 19. Through the above technical solution, the controller 19 can be used to automatically control the microwave radiation direction of each microwave radiator 24, thereby changing the focal position of each microwave beam. By setting the radiation path planning module 21, the microwave focal point, that is, the position of the radiation center point, can be reasonably planned according to the shape and size of the tumor tissue, so that the moving path of the above radiation center point covers the entire tumor tissue and does not touch normal tissue cells, so that the killing of the tumor tissue is more thorough.

[0096] In further detail, the hyperthermia control device 31 includes a temporary data storage unit 18, a controller 19 and a feedback control unit 20. The temporary data storage unit 18 is configured to be data-connected with the microwave imaging unit 27, the microwave temperature measurement unit 28, and the hyperthermia program execution unit 30, and receive and store the imaging coordinate information, temperature measurement information, angle deflection parameters, output power parameters, microwave wavelength parameters, and frequency parameters. The controller 19 is configured to be electrically connected to the first driving device 10, the second driving device, and the power adapters of each microwave radiator 24, receive the above parameters, and generate control signals for controlling the movement of the first driving device 10 and the second driving device and the output power of each power adapter. In the present invention, the hyperthermia control device 31 includes a single-chip microcomputer module, an FPGA module, or a dedicated control circuit module that is control-connected with each driving device, the microwave radiator 25, and other functional devices. The feedback control unit 20 is configured to be signal-connected with the microwave temperature measurement unit 28, receive the temperature measurement information, output an adjustment signal to the controller 19, and feedback-adjust the control signal.

[0097] In the above technical solution, the thermotherapy scheme execution unit 30 outputs the angle deflection parameter, the output power parameter, the microwave wavelength parameter and the frequency parameter of each microwave radiator 24 based on the thermotherapy parameter information output by the thermotherapy scheme generation unit 29, and the controller 19 controls the action of each microwave radiator 24 to ensure that the microwave output by each microwave radiator 24 can be focused to the set position to achieve accurate killing of tumor tissue cells. In the above process, the temporary data storage unit 18 can not only store the thermotherapy parameter information to be implemented, and provide data guarantee for subsequent treatment, but also the above data information can be stored as historical data during the patient's treatment process, which is convenient for later analysis and review of the patient's treatment process to obtain a more optimized thermotherapy scheme. The setting of the above feedback control unit 20 enables the controller 19 to monitor the temperature change of the tumor tissue in the microwave focus area in real time during the entire treatment process, and timely adjust the thermotherapy parameters according to the above changes, so as to achieve closed-loop control of thermotherapy, avoid the temperature of the thermotherapy area being too high or too low, and ensure the thermotherapy effect.

[0098] In order to further improve the effect of thermotherapy, the system is also equipped with a thermotherapy scheme optimization unit 32, including a thermotherapy data storage module 22 and a thermotherapy effect analysis module 23. The thermotherapy data storage module 22 is configured to be data-connected with the temporary data storage unit 18, and receive and store the imaging coordinate information, temperature measurement information, angle deflection parameters, output power parameters, microwave wavelength parameters and frequency parameters corresponding to each thermotherapy of the patient. The thermotherapy effect analysis module 23 is configured to be data-connected with the thermotherapy data storage module 22, receive the imaging coordinate information of the tumor tissue after each thermotherapy of the patient, and analyze and generate the change data of the imaging coordinate information of the tumor tissue between the above-mentioned thermotherapy based on its own built-in algorithm module, including the difference in the shape and size of the tumor tissue after each thermotherapy, predict the growth trend of the tumor tissue and the thermotherapy parameter information used, generate a thermotherapy optimization scheme and store or output it to the thermotherapy scheme generation unit 29, such as performing microwave thermotherapy in advance in the tissue area where the tumor tissue may spread, so as to block the spread of the tumor tissue.

[0099] The working principle and beneficial effects of the present invention are summarized as follows:

[0100] When using microwaves to kill tumor cells or tissues in the human body, first, microwaves of set wavelength and frequency are radiated toward the human body by the microwave radiator 25, and the microwave receiving device 26 receives scattered echo information reflected and / or scattered by the human body after radiation. The microwave imaging unit 27 uses the scattered echo signal to generate and confirm the specific position of the tumor tissue in the human body, and outputs the imaging coordinate information; the thermal therapy scheme generating unit 29 generates corresponding thermal therapy parameter information according to the imaging coordinate information, and then based on the thermal therapy parameter information, the thermal therapy scheme executing unit 30 generates the corresponding treatment scheme. The thermal therapy control device 31 accurately controls the microwave radiator 25 to perform continuous microwave heating on a certain position of the human body according to the thermal therapy scheme execution information, thereby eliminating the tumor cells or tissues at the lesion position.

[0101] Based on the control system of the physical targeted hyperthermia system for tumor treatment, the present invention also proposes a control method of the physical targeted hyperthermia system for tumor treatment, such as Figure 8 As shown, including:

[0102] S1, using the set plane or site in the thermal therapy device body 1 as a reference, calibrating the coordinates of each position in the three-dimensional space, generating and storing the coordinate information of each position;

[0103] S2, calculating and generating a table of hyperthermia parameter information required to kill tumor tissues of different shapes and sizes at various position coordinates and storing the table;

[0104] S3, based on the microwave imaging unit 27 and the microwave temperature measuring unit 28, scan and obtain the shape and size information, location coordinate information and current temperature information of the tumor tissue in the human body and temporarily store them;

[0105] S4, based on the shape and size information, location coordinate information and temperature information of the tumor tissue, select and set the thermal therapy parameters according to the thermal therapy parameter information table;

[0106] S5, based on the selected thermal therapy parameters, generating corresponding thermal therapy program execution information according to the set algorithm;

[0107] S6, generating a corresponding control signal based on the thermal therapy program execution information to control the action of the microwave radiation device 25 and / or the thermal therapy device body 1.

[0108] Furthermore, the step S2 further comprises:

[0109] S21, establishing a human body digital model, and calculating the correlation between the hyperthermia therapy parameters and the temperature changes of tissues at various positions in the human body;

[0110] S22, adding a digital model of tumor tissue of a set shape and size to the human body data model and performing microwave heating simulation, adjusting the thermal therapy parameters and acquiring simulation data;

[0111] S23, acquiring the thermal therapy parameters corresponding to the target simulation data based on the above simulation data, generating and storing a thermal therapy parameter information table.

[0112] In the above step S6, it also includes real-time feedback of temperature changes in the tumor tissue area during the thermal therapy, estimating the trend of temperature changes and adjusting thermal therapy parameters when the above temperature value reaches or is about to reach the set value, thereby realizing closed-loop dynamic control.

[0113] It should be noted that in step S4, the above-mentioned thermal therapy parameters include but are not limited to parameters such as the frequency, wavelength, direction, and movement trajectory of the radiation center point of the microwave radiation.

[0114] The above is only a preferred embodiment of the present invention, and the protection scope of the present invention is not limited to the above embodiments. All technical solutions under the concept of the present invention belong to the protection scope of the present invention. It should be pointed out that for ordinary technicians in this technical field, some improvements and modifications without departing from the principle of the present invention should also be regarded as the protection scope of the present invention.

Claims

1. A physical targeted hyperthermia system for tumor treatment, characterized in that: include: A thermal therapy device body (1) is configured to provide at least one stable support surface for a patient undergoing thermal therapy and to provide installation sites for various system function modules; A microwave radiating device (25) is configured to be connected to a microwave source and used to generate and radiate microwaves of a set wavelength and frequency toward a set direction according to a control signal; A microwave receiving device (26) configured to receive and output a scattered echo signal reflected and / or scattered by a radiator; A microwave imaging unit (27) is configured to be signal-connected to the microwave receiving device (26), receive the scattered echo signal, generate and confirm the location, shape and size of the tumor tissue according to a set algorithm, and output imaging coordinate information; A microwave temperature measurement unit (28) is configured to be signal-connected to the microwave receiving device (26), receive the scattered echo signal, generate thermal imaging data of the location of the tumor tissue and its vicinity according to a set algorithm, and output temperature measurement information; A thermal therapy program generating unit (29) is configured to generate or associate and store thermal therapy parameter information required for killing tumor tissues of different shapes and sizes at different locations on the human body; A thermal therapy program execution unit (30) is configured to be data-connected to the microwave imaging unit (27), the microwave temperature measurement unit (28) and the thermal therapy program generation unit (29), and to generate thermal therapy program execution information for killing the current tumor tissue based on the collected imaging coordinate information and temperature measurement information combined with the thermal therapy parameter information; a thermal therapy control device (31), configured to be in control connection with the microwave radiation device (25), receive and respond to the thermal therapy program execution information, and output a control signal to control the operation of the microwave radiation device (25); The thermal therapy device body (1) comprises: A thermotherapy bed (2) comprises a bed body (3) and a bed board support (4) supporting the bed body (3); the bed board support (4) comprises a scissor-type lift, the support rods of the scissor-type lift are arranged on both sides of the width direction of the bed body (3), and are located at the bottom of the bed body (3) and between the two support rods of the scissor-type lift to form a sliding channel; The radiation head mounting bracket (5) is annular in shape and is slidably arranged with the bed body (3) of the thermal therapy bed (2); a first driving device (10) configured to be in transmission connection with the thermotherapy bed (2) and / or the radiation head mounting bracket (5), and to be control-connected with the thermotherapy control device (31), to receive a control signal output by the thermotherapy control device (31), and to drive the thermotherapy bed (2) and / or the radiation head mounting bracket (5) to move; The microwave radiation device (25) comprises a plurality of microwave radiators (24) movably arranged along the radiation head mounting bracket (5), the plurality of microwave radiators (24) are connected to a microwave source and a power adapter, and the microwave radiation direction is arranged toward the bed (3); The thermal therapy program execution unit (30) comprises: A microwave radiator angle generation module (16) is configured to receive the imaging coordinate information, calculate the relative position of the thermal therapy bed (2) and the radiation head mounting bracket (5) and the deflection angle of each microwave radiator (24), and output an angle deflection parameter; A microwave radiator power generation module (17), configured to receive the thermal therapy parameter information, generate and output output power parameters, microwave wavelength parameters and frequency parameters of each microwave radiator (24); The thermal therapy control device (31) comprises: A temporary data storage unit (18) is configured to be data-connected to the microwave imaging unit (27), the microwave temperature measurement unit (28), and the thermal therapy program execution unit (30), and receive and store the imaging coordinate information, temperature measurement information, angle deflection parameters, output power parameters, microwave wavelength parameters, and frequency parameters; A controller (19) is configured to be electrically connected to the first drive device (10), the second drive device and the power adapters of each microwave radiator (24), receive the above parameters, and generate control signals for controlling the movement of the first drive device (10), the second drive device and the output power of each power adapter; A feedback control unit (20) is configured to be signal-connected to the microwave temperature measurement unit (28), receive the temperature measurement information, output an adjustment signal to the controller (19), and perform feedback adjustment on the control signal.

2. The system according to claim 1, characterized in that The radiation head mounting bracket (5) is provided with a sliding groove (8) along its length direction, a plurality of sliding mounting blocks (9) are slidably engaged in the sliding groove (8), and a plurality of microwave radiators (24) are movably arranged on the sliding mounting blocks (9) respectively; The sliding groove (8) and / or the sliding mounting block (9) are also provided with a second driving device for driving the sliding mounting block (9) to move along the sliding groove (8); the second driving device is configured to be control-connected to the thermal therapy control device (31), receive a control signal output by the thermal therapy control device (31), and drive the sliding mounting block (9) to move to a set position.

3. The system according to claim 2, characterized in that A first slide rail (12) is arranged on both sides or two opposite side walls of the bed body (3), a first slider (13) is slidably arranged in the first slide rail (12), a second slide rail (14) is arranged in the sliding channel along its length direction, a second slider (15) is slidably arranged in the second slide rail (14); the radiation head mounting bracket (5) comprises a first annular segment (6) and a second annular segment (7), the first annular segment (6) is in an arc shape and its two ends are fixedly connected to the first slider (13), the second annular segment (7) is in an arc shape and is fixedly connected to the second moving block; or The radiation head mounting bracket (5) is arranged in a circular ring shape, the bed (3) is arranged in parallel with the axial direction of the radiation head mounting bracket (5) and penetrates the radiation head mounting bracket (5), a bed mounting seat (11) is arranged between the bed (3) and the ground, a third slide rail is arranged on the bed mounting seat (11), and the bed (3) is slidably arranged with the bed mounting seat (11) via the third slide rail; The first driving device (10) comprises a screw transmission component or a transmission chain component for driving the first sliding block (13) and the second sliding block to synchronously reciprocate along the first sliding rail (12) and the second sliding rail (14) respectively, or driving the bed body (3) to reciprocate along the third sliding rail.

4. The system according to claim 2, characterized in that The microwave radiator (24) is movably connected to the sliding mounting block (9), and an automatic adjustment member and / or a manual adjustment member for adjusting the radiation angle of the microwave radiator (24) are arranged between the two.

5. The system according to claim 4, characterized in that An automatic adjustment member is arranged between the microwave radiator (24) and the sliding mounting block (9), and the automatic adjustment member is control-connected to the controller (19), and receives and adjusts the microwave radiation direction of the microwave radiator (24) in response to a control signal output by the controller (19); The microwave radiator angle generation module (16) is data-connected to a radiation path planning module (21), and the radiation path planning module (21) is data-connected to the microwave imaging unit (27), receives the imaging coordinate information, and calculates and generates a moving path of the radiation center point surrounded by each microwave radiator (24) within a set time period according to the shape and size of the tumor tissue, and generates an angle deflection parameter table of each microwave radiator (24) with time as a reference variable based on the moving path, and outputs the table to the temporary data storage unit (18) and / or the controller (19).

6. The system according to claim 4, characterized in that The system is also equipped with a thermal therapy program optimization unit (32), comprising: A thermal therapy data storage module (22) is configured to be data-connected to the temporary data storage unit (18) to receive and store imaging coordinate information, temperature measurement information, angle deflection parameters, output power parameters, microwave wavelength parameters, and frequency parameters corresponding to each thermal therapy of the patient; The thermal therapy effect analysis module (23) is configured to be data-connected to the thermal therapy data storage module (22), receive the tumor tissue imaging coordinate information of the patient after each thermal therapy, analyze and generate the change data of the tumor tissue imaging coordinate information between the above-mentioned thermal therapy based on its own built-in algorithm module, predict the growth trend of the tumor tissue and the thermal therapy parameter information used, generate a thermal therapy optimization plan and store or output it to the thermal therapy plan generation unit (29).

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