High-precision multi-plunger pipetting device

Abstract

The present invention discloses a high-precision multi-plunger linked pipetting device, comprising: a bracket, a first lifting mechanism arranged thereon, and a first lifting mounting frame with a U-shaped structure; a second lifting mechanism is arranged on the first lifting mounting frame, and has a lifting plate located between the upper plate and the lower plate of the first lifting mounting frame; a plurality of plunger pumps located between the lifting plate and the lower plate, and the outlet ends of the plunger pumps are integrally provided with a gun head adapter extending below the lower plate; a puncture head is arranged near each gun head adapter, the top of the puncture head is connected to the lower plate, and the bottom is a spike structure for opening the reagent sealing film; a gun head retracting mechanism, comprising a push plate arranged below the lower plate, a push rod extending upward through the lower plate is arranged on the push plate, a limiter located below the lifting plate is arranged on the top of the push rod, and an elastic return member is arranged between the limiter and the lower plate. The present invention has ingenious design, reliable quality, high pipetting accuracy, good sealing effect, and no leakage during long-term operation.

Description

Technical Field

[0001] The invention relates to the technical field of in vitro diagnostic testing equipment, and in particular to a high-precision multi-plunger linked liquid transfer device. Background Art

[0002] In vitro diagnostic testing is a technology that uses modern physical and chemical methods and means to perform medical diagnosis. It mainly studies how to provide a basis for clinical diagnosis and treatment through laboratory technology and medical instruments and equipment. This technology requires the use of various photoelectric instruments and chemical reagents to complete experimental analysis. As we all know, a plunger pump is a device that uses the reciprocating motion of the plunger in the pump chamber to change the volume formed in the pump chamber and repeatedly inhale and discharge liquids; plunger pumps are usually used in medical and chemical laboratories to absorb and add different amounts of reagents and samples, and inject them into the reaction pool for chemical reactions. Since the amount of each reagent is small, the suction and discharge accuracy of the pump directly affects the test results. Summary of the invention

[0003] In order to solve the above problems, the present invention provides a high-precision multi-plunger linked pipetting device, which can specifically adopt the following technical solutions:

[0004] The high-precision multi-plunger coupled liquid transfer device of the present invention comprises:

[0005] Bracket,

[0006] A first lifting mechanism, disposed on the bracket, having a first lifting mounting frame of a U-shaped structure;

[0007] A second lifting mechanism is disposed on the first lifting mounting frame and has a lifting plate, wherein the lifting plate is located between an upper plate and a lower plate of the first lifting mounting frame;

[0008] A plurality of plunger pumps are provided, each of which comprises a plunger provided on the lifting plate and a pump body provided on the lower plate, wherein the outlet end of the pump body is integrally provided with a gun head adapter extending below the lower plate;

[0009] A puncture head is arranged near each of the gun tip adapters, the top of the puncture head is connected to the lower plate, and the bottom is a spike structure for opening the reagent sealing film;

[0010] The gun head retracting mechanism comprises a push plate arranged below the lower plate, the push plate is provided with a push rod extending upward through the lower plate, the top of the push rod is provided with a limiter located below the lifting plate, and an elastic return member is provided between the limiter and the lower plate.

[0011] The first lifting mechanism comprises

[0012] A first screw motor, arranged on the bracket, having a first screw and a first lifting nut, wherein the first lifting nut is connected to a first lifting mounting frame;

[0013] The first guide rail is arranged on the bracket and is parallel to the first lead screw. The first guide rail is slidably connected to the first lifting mounting frame.

[0014] The second lifting mechanism comprises

[0015] A second screw motor is arranged on the first lifting mounting frame and has a second screw and a second lifting nut, wherein the second lifting nut is connected to the lifting plate;

[0016] The second guide rail is arranged on the first lifting mounting frame and is parallel to the second lead screw. The second guide rail is slidably connected to the lifting plate.

[0017] The bracket is provided with a first sensor for detecting the position of the first lifting installation frame, and the first lifting installation frame is provided with a second sensor for detecting the position of the lifting plate.

[0018] Each pair of plungers and pump bodies are coaxially arranged, and the plungers and lifting plates, the pump body and the lower plate are matched with each other according to the Morse taper standard.

[0019] The inlet end of the pump body is provided with a wear-resistant sealing ring which is interference-fitted with the plunger.

[0020] The gun head adapter is a conical structure matched with the gun head, and a guide ring and a sealing ring are arranged on the gun head adapter.

[0021] The guide ring and the sealing ring are both circular protruding structures arranged on the surface of the gun head adapter, the two are spaced apart, and the guide ring is located above the sealing ring.

[0022] The push plate is provided with through holes corresponding to the puncture head and the gun head adapter respectively.

[0023] The push rods are two equal-height rods diagonally arranged on the push plate, a flexible buffer layer is arranged on the top surface of the limiter, and the elastic return member is a spring passing through the push rod.

[0024] The high-precision multi-plunger linked pipetting device provided by the present invention adopts a set of mechanisms to drive multiple plunger pumps to simultaneously absorb or discharge liquid. Each of the above-mentioned plungers and pump bodies is connected to the first lifting mounting frame in a tapered manner, which fully ensures the verticality of the assembly; at the same time, a wear-resistant sealing ring that is interference-fitted with the plunger is arranged at the inlet of the pump body, so that the airtightness of the plunger pump is improved; thirdly, an integrated gun tip adapter is arranged at the outlet end of the pump body, which reduces the sealing links, reduces the difficulty of assembly, and improves the sealing reliability; the above-mentioned gun tip adapter is a conical structure, and its head adopts a double-ring sealing structure, which has both guiding and sealing functions, and cooperates with the gun tip retracting mechanism to realize the automatic gun tip retracting function, which does not require manual operation and is simple and convenient; finally, a puncturing head is separately arranged to avoid the disadvantages of slow liquid extraction and poor liquid extraction and discharge accuracy caused by the traditional method of using a gun tip to break the sealing film of a reagent strip. The invention has ingenious design, reliable quality, high pipetting accuracy, good sealing effect, and no leakage in long-term operation. It is very suitable for adding multiple and small amounts of reagents in medical, chemical and other laboratories, which not only improves the pipetting efficiency but also ensures the accuracy of the test results. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] Figure 1 It is a structural schematic diagram of the present invention.

[0026] Figure 2 yes Figure 1 Schematic diagram of the structure of the first lifting and mounting frame part.

[0027] Figure 3 yes Figure 2 Cross-sectional view of .

[0028] Figure 4 yes Figure 2 Cross-section of a piston pump. DETAILED DESCRIPTION

[0029] The following is a detailed description of an embodiment of the present invention in conjunction with the accompanying drawings. This embodiment is implemented on the premise of the technical solution of the present invention, and a detailed implementation method and a specific working process are given, but the protection scope of the present invention is not limited to the following embodiment.

[0030] like Figure 1-4As shown, the high-precision multi-plunger row pipetting device of the present invention comprises a bracket 1, on which a first lifting mechanism is mounted, which is composed of a first screw motor 201, a first guide rail 202 and a first lifting mounting frame 203 of a U-shaped structure, wherein the first screw motor 201 has a first screw and a first lifting nut, the first screw and the first guide rail 202 are parallel to each other, the first lifting nut is fixedly connected to the first lifting mounting frame 203, and the first lifting mounting frame 203 is slidably connected to the first guide rail 202. A second lifting mechanism is mounted on the first lifting mounting frame 203, which is composed of a second screw motor 301, a second guide rail 302 and a lifting plate 303, wherein the second screw motor 301 has a second screw and a second lifting nut, the second screw and the second guide rail 302 are parallel to each other, the second lifting nut is fixedly connected to the lifting plate 303, and the lifting plate 303 is slidably connected to the second guide rail 302, and the lifting plate 303 is located between the upper plate and the lower plate of the first lifting mounting frame. In addition, a first sensor 204 for detecting the position of the first lifting installation frame 203 is installed on the bracket 1 , and a second sensor 304 for detecting the position of the lifting plate 303 is installed on the first lifting installation frame 203 .

[0031] Three plunger pumps 4 are installed between the lifting plate 303 and the lower plate of the first lifting mounting frame 203 (the specific number is determined according to actual conditions). Specifically, the plunger 401 of the plunger pump is connected to the lifting plate 303, the pump body 402 is connected to the lower plate, and the outlet end of the pump body 402 is integrally provided with a gun head adapter 403 extending below the lower plate, which can reduce the sealing links, reduce the difficulty of assembly, and improve the sealing reliability; each pair of plungers 401 and pump bodies 402 are coaxially arranged, and the plungers 401 and the lifting plate 303, the pump body 402 and the lower plate are matched with the Morse taper standard, which can play a good positioning role and ensure the vertical installation degree, which can realize the plunger 4 during operation 01 and the pump body 402 have no contact, and the influence of the air in the pump body 402 on the sampling accuracy can also be reduced; the inlet end of the pump body 402 is provided with a groove, in which a wear-resistant sealing ring 404 (usually a pan-plug seal) that is interference fit with the plunger 401 is installed, and then fixed with a pressure cover to reduce friction, achieve long-term sampling without leakage, and keep the plunger pump 4 in good air tightness; the gun head adapter 403 is a conical structure adapted to the gun head, and two annular protrusion structures are arranged on its outer surface at intervals, the upper one is a guide ring 405, and the lower one is a sealing ring 406, which cooperate with each other to further enhance the air tightness of the plunger pump 4 in pumping and discharging liquid by improving the concentricity of the gun head and the reagent strip.

[0032] The lower plate of the first lifting mounting frame 203 is also equipped with a piercing head 5, which is used to pierce the reagent sealing film to avoid the phenomenon that the liquid inlet is partially or completely blocked by the sealing film when the gun head is used to pierce the film directly. When the gun head is partially blocked, the liquid column rises slowly and the actual amount of liquid pumped by the pump is small, that is, the pumping and injection accuracy is poor, which will lead to inaccurate experimental results. The piercing head 5 in this embodiment is installed near each gun head adapter 403, its top is connected to the lower plate, and the bottom adopts a spike structure that is convenient for opening the reagent sealing film.

[0033] In order to realize automatic withdrawal of the gun head, a gun head withdrawal mechanism is also provided, which includes a rectangular push plate 601 located below the lower plate, on which two diagonally arranged equal-height rods are installed as push rods 602, which extend upward through the lower plate, and a limiter 603 located below the lifting plate 303 is installed on the top, and the top surface of the limiter 603 is covered with a rubber flexible buffer layer, and an elastic return member 604 (ordinary springs can be selected) located between the limiter 603 and the lower plate is installed on the push rod 602. For easy assembly, through holes corresponding to the puncture head 5 and the gun head adapter 403 are also opened on the above-mentioned push plate 601.

[0034] When extracting liquid, start the first lifting mechanism to move the first lifting mounting frame 203 downward, and pierce the reagent sealing film through the piercing head 5; then, the first lifting mounting frame 203 rises back, and the gun head is installed on the gun head adapter 403; then, start the first lifting mechanism again to move the first lifting mounting frame 203 downward until the gun head is inserted below the reagent liquid level; at this time, start the second lifting mechanism to move the lifting plate 303 upward, and the three plungers 401 move upward accordingly, so as to achieve simultaneous liquid aspiration; then, move the first lifting mounting frame 203 upward, and move the bracket 1 to make the gun head The head is aligned with the discharge position, and the second lifting mechanism is started to move the lifting plate 303 downward, and the three plungers 401 move downward accordingly to achieve simultaneous discharge; finally, the bracket 1 is moved to make the gun head correspond to the discarded gun head collection box, and the lifting plate 303 continues to move downward through the action of the second lifting mechanism. At this time, the limit piece 603 at the top of the push rod 602 contacts the lifting plate 303, and then moves downward synchronously with it, and the rectangular push plate 601 at the bottom of the push rod 602 also moves downward accordingly. When it is connected with the gun head, the gun head can be pushed out of the gun head adapter 403 to achieve automatic withdrawal of the gun head.

[0035] It should be noted that, in the description of the present invention, terms indicating orientation or positional relationships, such as "front", "rear", "left", "right", "vertical", "horizontal", "inside", "outside", etc., are based on the orientation or positional relationships shown in the drawings and are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as a limitation on the present invention.

Claims

1. A high-precision multi-plunger linked pipetting device, characterized in that: include Bracket, A first lifting mechanism, disposed on the bracket, having a first lifting mounting frame of a U-shaped structure; A second lifting mechanism is disposed on the first lifting mounting frame and has a lifting plate, wherein the lifting plate is located between an upper plate and a lower plate of the first lifting mounting frame; A plurality of plunger pumps are provided, each of which comprises a plunger provided on the lifting plate and a pump body provided on the lower plate, wherein the outlet end of the pump body is integrally provided with a gun head adapter extending below the lower plate; A puncture head is arranged near each of the gun tip adapters, the top of the puncture head is connected to the lower plate, and the bottom is a spike structure for opening the reagent sealing film; The gun head retracting mechanism comprises a push plate arranged below the lower plate, the push plate is provided with a push rod extending upward through the lower plate, the top of the push rod is provided with a limiter located below the lifting plate, and an elastic return member is provided between the limiter and the lower plate; The first lifting mechanism comprises A first screw motor, arranged on the bracket, having a first screw and a first lifting nut, wherein the first lifting nut is connected to a first lifting mounting frame; A first guide rail is arranged on the bracket and is parallel to the first screw rod, and the first guide rail is slidably connected to the first lifting mounting frame; The second lifting mechanism comprises A second screw motor is arranged on the first lifting mounting frame and has a second screw and a second lifting nut, wherein the second lifting nut is connected to the lifting plate; A second guide rail is provided on the first lifting mounting frame and is parallel to the second screw rod, and the second guide rail is slidably connected to the lifting plate; Each pair of plungers and pump bodies are coaxially arranged, and the plungers and lifting plates, the pump body and the lower plate are matched with each other according to the Morse taper standard.

2. The high-precision multi-plunger linked pipetting device according to claim 1, characterized in that: The bracket is provided with a first sensor for detecting the position of the first lifting installation frame, and the first lifting installation frame is provided with a second sensor for detecting the position of the lifting plate.

3. The high-precision multi-plunger linked pipetting device according to claim 1, characterized in that: The inlet end of the pump body is provided with a wear-resistant sealing ring which is interference-fitted with the plunger.

4. The high-precision multi-plunger linked pipetting device according to claim 1, characterized in that: The gun head adapter is a conical structure matched with the gun head, and a guide ring and a sealing ring are arranged on the gun head adapter.

5. The high-precision multi-plunger linked pipetting device according to claim 4, characterized in that: The guide ring and the sealing ring are both circular protruding structures arranged on the surface of the gun head adapter, the two are spaced apart, and the guide ring is located above the sealing ring.

6. The high-precision multi-plunger linked pipetting device according to claim 1, characterized in that: The push plate is provided with through holes corresponding to the puncture head and the gun head adapter respectively.

7. The high-precision multi-plunger linked pipetting device according to claim 1, characterized in that: The push rods are two equal-height rods diagonally arranged on the push plate, a flexible buffer layer is arranged on the top surface of the limiter, and the elastic return member is a spring passing through the push rod.

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